JP2010537206A5 - - Google Patents
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- Publication number
- JP2010537206A5 JP2010537206A5 JP2010522176A JP2010522176A JP2010537206A5 JP 2010537206 A5 JP2010537206 A5 JP 2010537206A5 JP 2010522176 A JP2010522176 A JP 2010522176A JP 2010522176 A JP2010522176 A JP 2010522176A JP 2010537206 A5 JP2010537206 A5 JP 2010537206A5
- Authority
- JP
- Japan
- Prior art keywords
- cinnamic acid
- use according
- cyano cinnamic
- matrix
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011159 matrix material Substances 0.000 claims 8
- 238000004949 mass spectrometry Methods 0.000 claims 5
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- CDUQMGQIHYISOP-UHFFFAOYSA-N 2-cyano-3-phenylprop-2-enoic acid Chemical class OC(=O)C(C#N)=CC1=CC=CC=C1 CDUQMGQIHYISOP-UHFFFAOYSA-N 0.000 claims 3
- 239000012491 analyte Substances 0.000 claims 3
- WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 claims 2
- 150000001450 anions Chemical class 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims 1
- 235000001785 ferulic acid Nutrition 0.000 claims 1
- 229940114124 ferulic acid Drugs 0.000 claims 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- PCMORTLOPMLEFB-ONEGZZNKSA-N sinapic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-ONEGZZNKSA-N 0.000 claims 1
- PCMORTLOPMLEFB-UHFFFAOYSA-N sinapinic acid Natural products COC1=CC(C=CC(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-UHFFFAOYSA-N 0.000 claims 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims 1
- AFVLVVWMAFSXCK-UHFFFAOYSA-N α-cyano-4-hydroxycinnamic acid Chemical compound OC(=O)C(C#N)=CC1=CC=C(O)C=C1 AFVLVVWMAFSXCK-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007040251.3 | 2007-08-27 | ||
| DE102007040251A DE102007040251B3 (de) | 2007-08-27 | 2007-08-27 | Verwendung von Cyanozimtsäurederivaten als Matrizes in MALDI-Massenspektrometrie |
| PCT/DE2008/001149 WO2009026867A1 (de) | 2007-08-27 | 2008-07-10 | Verwendung von cyanozimtsäurederivaten als matrizes in maldi-massenspektrometrie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010537206A JP2010537206A (ja) | 2010-12-02 |
| JP2010537206A5 true JP2010537206A5 (enExample) | 2013-05-16 |
| JP5529020B2 JP5529020B2 (ja) | 2014-06-25 |
Family
ID=39942809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010522176A Expired - Fee Related JP5529020B2 (ja) | 2007-08-27 | 2008-07-10 | Ｍａｌｄｉ質量分析におけるマトリックスとしてのシアノ桂皮酸誘導体の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8980642B2 (enExample) |
| EP (1) | EP2183600B1 (enExample) |
| JP (1) | JP5529020B2 (enExample) |
| CA (1) | CA2697151A1 (enExample) |
| DE (1) | DE102007040251B3 (enExample) |
| WO (1) | WO2009026867A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010010155A1 (de) | 2010-03-04 | 2011-09-08 | Johann Wolfgang Goethe-Universität | Verwendung von halogenierten Cyanozimtsäurederivaten als Matrizes in MALDI-Massenspektrometrie |
| JP6083595B2 (ja) * | 2011-11-21 | 2017-02-22 | 公立大学法人横浜市立大学 | タンパク質とリン酸化ペプチドのペプチド主鎖のＮ−Ｃα結合又はＣα−Ｃ結合の特異的切断方法 |
| JP5980517B2 (ja) * | 2012-02-13 | 2016-08-31 | 株式会社島津製作所 | 質量分析用マトリックスの添加剤 |
| NL2022038B1 (en) | 2018-11-21 | 2020-06-05 | Biosparq B V | Method for analysing an analyte sample and matrix material therefore |
| CN116917726A (zh) * | 2021-02-10 | 2023-10-20 | 株式会社岛津制作所 | 有机合成化合物的质谱分析法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020142982A1 (en) * | 1999-09-02 | 2002-10-03 | Timothy Hla | Method for regulating angiogenesis |
| DE10158860B4 (de) * | 2001-11-30 | 2007-04-05 | Bruker Daltonik Gmbh | Massenspektrometrische Proteingemischanalyse |
| JP4606028B2 (ja) * | 2002-04-04 | 2011-01-05 | エレクトロフォレティクス リミテッド | 被分析物の分析方法 |
| DE10322701B4 (de) * | 2003-05-20 | 2006-12-28 | Humboldt-Universität Zu Berlin | Probenträger unter Verwendung eines porösen, Metalloxidpartikel umfassenden Films, Verfahren zur Herstellung eines Probenträgers, Verwendung des Probenträgers sowie Verfahren zum selektiven Nachweis von phosphorylierten/sulfatierten Biopolymeren, insbesondere Peptiden/Proteinen |
| JP4165501B2 (ja) * | 2004-04-13 | 2008-10-15 | 株式会社島津製作所 | Ｍａｌｄｉ質量分析装置による疎水性ペプチドの測定方法 |
| US20060261267A1 (en) * | 2005-05-20 | 2006-11-23 | Agency For Science, Technology And Research | Composite MALDI matrix material and methods of using it and kits thereof in MALDI |
-
2007
- 2007-08-27 DE DE102007040251A patent/DE102007040251B3/de not_active Expired - Fee Related
-
2008
- 2008-07-10 EP EP08784332.2A patent/EP2183600B1/de not_active Not-in-force
- 2008-07-10 WO PCT/DE2008/001149 patent/WO2009026867A1/de not_active Ceased
- 2008-07-10 CA CA2697151A patent/CA2697151A1/en not_active Abandoned
- 2008-07-10 US US12/675,569 patent/US8980642B2/en not_active Expired - Fee Related
- 2008-07-10 JP JP2010522176A patent/JP5529020B2/ja not_active Expired - Fee Related
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