JP2010536388A5 - - Google Patents
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- JP2010536388A5 JP2010536388A5 JP2010522134A JP2010522134A JP2010536388A5 JP 2010536388 A5 JP2010536388 A5 JP 2010536388A5 JP 2010522134 A JP2010522134 A JP 2010522134A JP 2010522134 A JP2010522134 A JP 2010522134A JP 2010536388 A5 JP2010536388 A5 JP 2010536388A5
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- 239000002671 adjuvant Substances 0.000 claims description 2
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- 101000763314 Homo sapiens Thrombomodulin Proteins 0.000 claims 1
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- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 2
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- 108010041986 DNA Vaccines Proteins 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96911807P | 2007-08-30 | 2007-08-30 | |
| US5286508P | 2008-05-13 | 2008-05-13 | |
| PCT/AU2008/001294 WO2009026660A1 (en) | 2007-08-30 | 2008-08-29 | Dendritic cell marker and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014150520A Division JP6095616B2 (ja) | 2007-08-30 | 2014-07-24 | 樹状細胞マーカーおよびその使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010536388A JP2010536388A (ja) | 2010-12-02 |
| JP2010536388A5 true JP2010536388A5 (enExample) | 2011-09-22 |
Family
ID=40386591
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010522134A Pending JP2010536388A (ja) | 2007-08-30 | 2008-08-29 | 樹状細胞マーカーおよびその使用法 |
| JP2014150520A Active JP6095616B2 (ja) | 2007-08-30 | 2014-07-24 | 樹状細胞マーカーおよびその使用法 |
| JP2016206463A Active JP6433470B2 (ja) | 2007-08-30 | 2016-10-21 | 樹状細胞マーカーおよびその使用法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014150520A Active JP6095616B2 (ja) | 2007-08-30 | 2014-07-24 | 樹状細胞マーカーおよびその使用法 |
| JP2016206463A Active JP6433470B2 (ja) | 2007-08-30 | 2016-10-21 | 樹状細胞マーカーおよびその使用法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8426565B2 (enExample) |
| EP (1) | EP2195346B1 (enExample) |
| JP (3) | JP2010536388A (enExample) |
| CN (1) | CN101970491A (enExample) |
| AU (1) | AU2008294074B2 (enExample) |
| BR (1) | BRPI0815848A2 (enExample) |
| CA (1) | CA2697448C (enExample) |
| IL (1) | IL204157A (enExample) |
| WO (1) | WO2009026660A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0815848A2 (pt) | 2007-08-30 | 2017-06-06 | The Burnet Inst | composto, linhagem de célula que produz anticorpo estável, composição, métodos para modular uma resposta imune em um indivíduo e para tratar e/ou prevenir uma doença, usos de um composto e/ou uma composição e de células dendríticas ou precursores das mesmas, métodos para enriquecer e detectar células dendríticas ou um subconjunto ou precursores das mesmas, polipeptídeo, polinucleotídeo vetor, célula hospedeira, planta transgênica, animal não humano transgênico, extrato, processo para preparar um composto ou um polipeptídeo, população enriquecida de células dendríticas e/ou precursores das mesmas, população de célula dendrítica expandida e/ou precursores das mesmas, métodos para identificar uma molécula que se liga a um polipeptídeo e para triar quanto a um composto que se liga a um polipeptídeo, uso de um polipeptídeo, um polinucleotídeo, um vetor, uma célula hospedeira, uma planta transgênica, um extrato, uma população de célula e/ou uma composição, método para produzir um composto, e, kit. |
| US20110110861A1 (en) * | 2008-05-13 | 2011-05-12 | Mireille Hanna Lahoud | Methods of Detecting Cells with a Disrupted Cell Membrane, Cells Infected with A Pathogen, Dying Cells or Dead Cells |
| EP2424560A4 (en) * | 2009-03-23 | 2013-11-27 | Inst Medical W & E Hall | COMPOUNDS AND METHOD FOR MODULATING THE IMMUNE REACTION |
| PE20121647A1 (es) | 2009-08-29 | 2012-12-31 | Abbvie Inc | Proteinas terapeuticas de union a dll4 |
| SG10201501562VA (en) | 2010-03-02 | 2015-04-29 | Abbvie Inc | Therapeutic dll4 binding proteins |
| RU2612903C2 (ru) | 2010-08-02 | 2017-03-13 | Ридженерон Фармасьютикалз, Инк. | Мыши, у которых вырабатываются связывающие белки, содержащие vl-домены |
| HUE068728T2 (hu) | 2011-08-05 | 2025-01-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| EP2568051A1 (en) | 2011-09-07 | 2013-03-13 | Stallergenes S.A. | Methods for identifying dendritic cell subsets, for determining if a patient is developing a regulatory or an effector immune response, and for determining response to immunotherapy |
| PL2809150T3 (pl) * | 2012-02-01 | 2020-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizowane myszy wykazujące ekspresję łańcuchów ciężkich zawierających domeny VL |
| CN103483441A (zh) * | 2012-06-10 | 2014-01-01 | 复旦大学 | 恒河猴ny-eso-1蛋白、其编码基因及应用 |
| CN103720719B (zh) * | 2013-10-11 | 2016-07-06 | 长沙赢润生物技术有限公司 | 一项DC和Treg细胞治疗红斑狼疮的技术 |
| WO2015143406A2 (en) | 2014-03-21 | 2015-09-24 | Regeneron Pharmaceuticals, Inc. | Vl antigen binding proteins exhibiting distinct binding characteristics |
| RU2016141307A (ru) | 2014-03-21 | 2018-04-24 | Регенерон Фармасьютикалз, Инк. | Отличные от человека животные, которые вырабатывают однодоменные связывающие белки |
| CN104387453A (zh) * | 2014-12-08 | 2015-03-04 | 深圳市同康生物医药有限公司 | 树突状细胞靶向肽及编码基因及应用 |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| EP3397645A1 (en) * | 2015-12-28 | 2018-11-07 | Innate Pharma | VARIABLE REGIONS FOR NKp46 BINDING PROTEINS |
| US11517627B2 (en) * | 2017-01-20 | 2022-12-06 | Juno Therapeutics Gmbh | Cell surface conjugates and related cell compositions and methods |
| US20210277354A1 (en) * | 2018-06-19 | 2021-09-09 | Fondazione Telethon | Production of engineered dendritic cells and uses thereof |
| US12233356B2 (en) | 2019-03-21 | 2025-02-25 | Lonza Sales Ag | Process for preparing extracellular vesicles |
| SG11202109702QA (en) | 2019-03-21 | 2021-10-28 | Codiak Biosciences Inc | Extracellular vesicles for vaccine delivery |
| EP3956456A1 (en) | 2019-04-17 | 2022-02-23 | Codiak BioSciences, Inc. | Compositions of exosomes and aav |
| US20230181758A1 (en) | 2019-07-03 | 2023-06-15 | Codiak Biosciences, Inc. | Extracellular vesicles targeting dendritic cells and uses thereof |
| IL272194A (en) * | 2020-01-22 | 2021-07-29 | Yeda Res & Dev | Multi-target antibodies for use in the treatment of diseases |
| EP4117717A1 (en) | 2020-03-13 | 2023-01-18 | Codiak BioSciences, Inc. | Extracellular vesicles for treating neurological disorders |
| EP4121450A2 (en) | 2020-03-20 | 2023-01-25 | Codiak BioSciences, Inc. | Extracellular vesicles for therapy |
| EP4216993A2 (en) | 2020-09-23 | 2023-08-02 | Codiak BioSciences, Inc. | Methods of producing extracellular vesicles |
| WO2022066883A1 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Extracellular vesicles comprising kras antigens and uses thereof |
| JP2023544614A (ja) * | 2020-10-05 | 2023-10-24 | モナッシュ ユニバーシティ | Clec9a抗体 |
| CN114563574B (zh) * | 2020-11-27 | 2025-03-04 | 中国科学院北京基因组研究所(国家生物信息中心) | 分子标记物组合及其用途 |
| IL286430A (en) | 2021-09-14 | 2023-04-01 | Yeda Res & Dev | Multispecific antibodies for use in the treatment of diseases |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
| WO2025079599A1 (ja) * | 2023-10-11 | 2025-04-17 | 国立大学法人金沢大学 | サブセットレベルで細胞を標的化可能な担体およびその製造方法 |
| CN119661686B (zh) * | 2024-09-30 | 2025-09-30 | 中国农业大学 | 一种重组clec9a基因及其在提高动物的免疫和抗病能力中的应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5118606A (en) | 1988-09-02 | 1992-06-02 | The Regents Of The University Of California | Methods for detecting cellular pathology by assaying spectrin and spectrin breakdown products |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5643578A (en) | 1992-03-23 | 1997-07-01 | University Of Massachusetts Medical Center | Immunization by inoculation of DNA transcription unit |
| US5536642A (en) * | 1993-09-09 | 1996-07-16 | Barbera-Guillem; Emilio | Diagnostic and prognostic methods for solid non-lymphoid tumors and their metastases |
| US5597569A (en) | 1993-10-25 | 1997-01-28 | Bristol-Myers Squibb Company | Bryodin 2 a ribosome-inactivating protein isolated from the plant Bryonia dioica |
| DE69536091D1 (de) | 1994-01-27 | 2010-09-09 | Univ Massachusetts Medical | Immunisierung durch Impfung von DNS Transkriptionseinheit |
| US6117985A (en) | 1995-06-16 | 2000-09-12 | Stemcell Technologies Inc. | Antibody compositions for preparing enriched cell preparations |
| US5939400A (en) | 1996-02-26 | 1999-08-17 | The Board Of Trustees Of The Leland Stanford Junior University | DNA vaccination for induction of suppressive T cell response |
| AU3210997A (en) | 1996-05-24 | 1997-12-09 | University Of Maryland At Baltimore | Dna vaccines for eliciting a mucosal immune response |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| ES2374290T3 (es) | 1998-03-20 | 2012-02-15 | Commonwealth Scientific And Industrial Research Organisation | Genes sintéticos y constructos genéticos que comprenden los mismos. |
| EP1068311B2 (en) | 1998-04-08 | 2020-12-09 | Commonwealth Scientific and Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
| EP1046651A1 (en) | 1999-04-19 | 2000-10-25 | Koninklijke Universiteit Nijmegen | Composition and method for modulating dendritic cell-T interaction |
| AUPQ002399A0 (en) | 1999-04-28 | 1999-05-20 | Australian National University, The | Model membrane systems |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| US20020132753A1 (en) | 2000-01-31 | 2002-09-19 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| US20030190598A1 (en) * | 2000-05-26 | 2003-10-09 | Jasmid Tanha | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| CA2459137A1 (en) | 2001-09-14 | 2003-03-27 | Incyte Genomics, Inc. | Receptors and membrane-associated proteins |
| CA2469941A1 (en) | 2001-12-10 | 2003-07-03 | Nuvelo, Inc. | Novel nucleic acids and polypeptides |
| WO2003091435A1 (fr) * | 2002-04-23 | 2003-11-06 | Riken | Nouvelles proteines et differents adn les codant |
| US6813008B2 (en) | 2002-06-10 | 2004-11-02 | Palantyr Research, Llc | Microdissection optical system |
| US9259459B2 (en) * | 2003-01-31 | 2016-02-16 | Celldex Therapeutics Inc. | Antibody vaccine conjugates and uses therefor |
| WO2004108079A2 (en) | 2003-05-30 | 2004-12-16 | University Of Massachusetts | Parkin-interacting proteins |
| CN102172397B (zh) | 2003-08-21 | 2013-01-30 | 利普泰克有限公司 | 树突细胞的体内靶向 |
| ZA200604620B (en) * | 2003-12-10 | 2007-10-31 | Medarex Inc | IP-10 antibodies and their uses |
| CA2597431A1 (en) | 2005-02-11 | 2006-08-17 | Cambridge Scientific Pty Ltd | A method of producing an analgesic composition from plasma or serum and use in treating pain |
| US20070026047A1 (en) | 2005-06-21 | 2007-02-01 | Li-Chun Tsou | Thermal effect on crystalinity for drug delivery devices |
| CA2625403A1 (en) | 2005-10-17 | 2007-04-26 | Institute For System Biology | Tissue-and serum-derived glycoproteins and methods of their use |
| GB0805159D0 (en) | 2008-03-19 | 2008-04-23 | Sancho Madrid David | Immune modulation via C-type lectin |
| BRPI0815848A2 (pt) | 2007-08-30 | 2017-06-06 | The Burnet Inst | composto, linhagem de célula que produz anticorpo estável, composição, métodos para modular uma resposta imune em um indivíduo e para tratar e/ou prevenir uma doença, usos de um composto e/ou uma composição e de células dendríticas ou precursores das mesmas, métodos para enriquecer e detectar células dendríticas ou um subconjunto ou precursores das mesmas, polipeptídeo, polinucleotídeo vetor, célula hospedeira, planta transgênica, animal não humano transgênico, extrato, processo para preparar um composto ou um polipeptídeo, população enriquecida de células dendríticas e/ou precursores das mesmas, população de célula dendrítica expandida e/ou precursores das mesmas, métodos para identificar uma molécula que se liga a um polipeptídeo e para triar quanto a um composto que se liga a um polipeptídeo, uso de um polipeptídeo, um polinucleotídeo, um vetor, uma célula hospedeira, uma planta transgênica, um extrato, uma população de célula e/ou uma composição, método para produzir um composto, e, kit. |
| US20110110861A1 (en) | 2008-05-13 | 2011-05-12 | Mireille Hanna Lahoud | Methods of Detecting Cells with a Disrupted Cell Membrane, Cells Infected with A Pathogen, Dying Cells or Dead Cells |
| EP2424560A4 (en) | 2009-03-23 | 2013-11-27 | Inst Medical W & E Hall | COMPOUNDS AND METHOD FOR MODULATING THE IMMUNE REACTION |
-
2008
- 2008-08-29 BR BRPI0815848A patent/BRPI0815848A2/pt not_active Application Discontinuation
- 2008-08-29 CA CA2697448A patent/CA2697448C/en active Active
- 2008-08-29 JP JP2010522134A patent/JP2010536388A/ja active Pending
- 2008-08-29 EP EP08783037.8A patent/EP2195346B1/en active Active
- 2008-08-29 US US12/675,392 patent/US8426565B2/en active Active
- 2008-08-29 CN CN2008801106595A patent/CN101970491A/zh active Pending
- 2008-08-29 WO PCT/AU2008/001294 patent/WO2009026660A1/en not_active Ceased
- 2008-08-29 AU AU2008294074A patent/AU2008294074B2/en active Active
-
2010
- 2010-02-25 IL IL204157A patent/IL204157A/en active IP Right Grant
-
2013
- 2013-03-21 US US13/848,503 patent/US9988431B2/en active Active
-
2014
- 2014-07-24 JP JP2014150520A patent/JP6095616B2/ja active Active
-
2016
- 2016-10-21 JP JP2016206463A patent/JP6433470B2/ja active Active
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