|
US4086196A
(en)
*
|
1975-03-28 |
1978-04-25 |
Armour Pharmaceutical Company |
Parathyroid hormone
|
|
JPS5825980B2
(ja)
|
1976-02-12 |
1983-05-31 |
ヤマサ醤油株式会社 |
サイクリックヌクレオチドの定量法
|
|
US4843000A
(en)
*
|
1979-12-26 |
1989-06-27 |
Syntex (U.S.A.) Inc. |
Simultaneous calibration heterogeneous immunoassay
|
|
US4849338A
(en)
*
|
1982-07-16 |
1989-07-18 |
Syntex (U.S.A.) Inc. |
Simultaneous calibration heterogeneous immunoassay
|
|
US4366241A
(en)
*
|
1980-08-07 |
1982-12-28 |
Syva Company |
Concentrating zone method in heterogeneous immunoassays
|
|
US4675189A
(en)
*
|
1980-11-18 |
1987-06-23 |
Syntex (U.S.A.) Inc. |
Microencapsulation of water soluble active polypeptides
|
|
JPS5896052A
(ja)
|
1981-11-30 |
1983-06-07 |
Toyo Jozo Co Ltd |
高活性h−PTH(1−34)アミドの製造法
|
|
US4423037A
(en)
*
|
1982-05-13 |
1983-12-27 |
The General Hospital Corporation |
Inhibitors of peptide hormone action
|
|
US4620948A
(en)
*
|
1982-12-22 |
1986-11-04 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4512922A
(en)
*
|
1982-12-22 |
1985-04-23 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4518526A
(en)
*
|
1982-12-22 |
1985-05-21 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4511502A
(en)
*
|
1982-12-22 |
1985-04-16 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
JPS59204159A
(ja)
|
1983-04-28 |
1984-11-19 |
Toyo Jozo Co Ltd |
〔Met(O)↑8’↑1↑8〕hPTH−(1−34)ペプチド
|
|
JPS60201244A
(ja)
|
1984-03-26 |
1985-10-11 |
Ricoh Co Ltd |
湿度センサ
|
|
US4736866A
(en)
*
|
1984-06-22 |
1988-04-12 |
President And Fellows Of Harvard College |
Transgenic non-human mammals
|
|
IL78342A
(en)
*
|
1985-04-04 |
1991-06-10 |
Gen Hospital Corp |
Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
|
|
US4761406A
(en)
*
|
1985-06-06 |
1988-08-02 |
The Procter & Gamble Company |
Regimen for treating osteoporosis
|
|
WO1987001130A1
(en)
|
1985-08-15 |
1987-02-26 |
Stauffer Chemical Company |
Tryptophan producing microorganism
|
|
US5010010A
(en)
*
|
1986-10-22 |
1991-04-23 |
Selmer-Sande, A.S. |
Production of human parathyroid hormone from microorganisms
|
|
US4771124A
(en)
*
|
1987-05-26 |
1988-09-13 |
Merck & Co., Inc. |
Parathyroid hormone antagonists with simplified synthetic methodology
|
|
US5527772A
(en)
*
|
1987-10-20 |
1996-06-18 |
Holick; Michael F. |
Regulation of cell proliferation and differentiation using peptides
|
|
US5605815A
(en)
*
|
1988-03-14 |
1997-02-25 |
Yale University |
Nucleic acids encoding and expression of parathyroid hormone-like peptide
|
|
EP0341962B1
(en)
|
1988-05-09 |
1995-03-15 |
Merck & Co. Inc. |
Humoral hypercalcemic factor antagonists
|
|
US5217896A
(en)
*
|
1988-12-30 |
1993-06-08 |
Oncogene Science, Inc. |
Monoclonal antibodies recognizing parathyroid hormone-like protein
|
|
CA2045129A1
(en)
*
|
1989-02-01 |
1990-08-02 |
Alfred I. Geller |
Herpes simplex virus type i expression vector
|
|
AU6448990A
(en)
|
1989-09-29 |
1991-04-28 |
Her Majesty in Right of Canada, as represented by National Research Council Canada |
Synthesis of mature human parathyroid hormone
|
|
US5350836A
(en)
*
|
1989-10-12 |
1994-09-27 |
Ohio University |
Growth hormone antagonists
|
|
AU635844B2
(en)
*
|
1989-11-06 |
1993-04-01 |
Cell Genesys, Inc. |
Production of proteins using homologous recombination
|
|
IT1238348B
(it)
*
|
1989-11-16 |
1993-07-13 |
|
Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.
|
|
US5459276A
(en)
*
|
1994-05-20 |
1995-10-17 |
Molecular Probes, Inc. |
Benzazolylcoumarin-based ion indicators for heavy metals
|
|
US5453517A
(en)
*
|
1992-02-25 |
1995-09-26 |
Molecular Probes, Inc. |
Reactive derivatives of bapta used to make ion-selective chelators
|
|
US5433896A
(en)
*
|
1994-05-20 |
1995-07-18 |
Molecular Probes, Inc. |
Dibenzopyrrometheneboron difluoride dyes
|
|
US5274113A
(en)
*
|
1991-11-01 |
1993-12-28 |
Molecular Probes, Inc. |
Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
|
|
US5326692B1
(en)
*
|
1992-05-13 |
1996-04-30 |
Molecular Probes Inc |
Fluorescent microparticles with controllable enhanced stokes shift
|
|
US5648270A
(en)
*
|
1995-02-06 |
1997-07-15 |
Molecular Probes, Inc. |
Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles
|
|
US5405975A
(en)
*
|
1993-03-29 |
1995-04-11 |
Molecular Probes, Inc. |
Fluorescent ion-selective diaryldiaza crown ether conjugates
|
|
US5227487A
(en)
*
|
1990-04-16 |
1993-07-13 |
Molecular Probes, Inc. |
Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes
|
|
US5723218A
(en)
*
|
1990-04-16 |
1998-03-03 |
Molecular Probes, Inc. |
Dipyrrometheneboron difluoride labeled flourescent microparticles
|
|
US5266490A
(en)
|
1991-03-28 |
1993-11-30 |
Regeneron Pharmaceuticals, Inc. |
Mammalian expression vector
|
|
DK0835939T3
(da)
|
1990-06-28 |
2006-03-13 |
Sanofi Aventis Deutschland |
Fusionsproteiner med andele af immunglobulin, deres fremstilling og anvendelse
|
|
US7253264B1
(en)
*
|
1990-06-28 |
2007-08-07 |
Sanofi-Arentideutschland GmbH |
Immunoglobulin fusion proteins, their production and use
|
|
US5462856A
(en)
*
|
1990-07-19 |
1995-10-31 |
Bunsen Rush Laboratories, Inc. |
Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
|
|
JPH0532696A
(ja)
*
|
1990-09-28 |
1993-02-09 |
Takeda Chem Ind Ltd |
副甲状腺ホルモン誘導体
|
|
US7132260B2
(en)
*
|
1991-04-05 |
2006-11-07 |
The General Hospital Corporation |
DNA encoding parathyroid hormone receptor
|
|
US7150974B1
(en)
|
1991-04-05 |
2006-12-19 |
The General Hospital Corporation |
Parathyroid hormone receptor binding method
|
|
US5261686A
(en)
*
|
1992-04-06 |
1993-11-16 |
Buckler Clive E |
Semi-recumbent
|
|
JP3464796B2
(ja)
|
1991-04-05 |
2003-11-10 |
ザ ジェネラル ホスピタル コーポレーション |
副甲状腺ホルモンのレセプターとそれをコードしているdna
|
|
US5208041A
(en)
*
|
1991-05-23 |
1993-05-04 |
Allelix Biopharmaceuticals Inc. |
Essentially pure human parathyroid hormone
|
|
US5770358A
(en)
|
1991-09-18 |
1998-06-23 |
Affymax Technologies N.V. |
Tagged synthetic oligomer libraries
|
|
AU2807892A
(en)
|
1991-10-10 |
1993-05-03 |
Peter K.T. Pang |
Parathyroid hormone analogues and use in osteoporosis treatment
|
|
PT101031B
(pt)
|
1991-11-05 |
2002-07-31 |
Transkaryotic Therapies Inc |
Processo para o fornecimento de proteinas por terapia genetica
|
|
DE4138621A1
(de)
|
1991-11-25 |
1993-06-17 |
Boehringer Ingelheim Int |
Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg
|
|
CA2124792C
(en)
*
|
1991-12-17 |
2000-07-04 |
Ann D. Geddes |
Methods for the treatment of osteoporosis using bisphosphonates and parathyroid hormone
|
|
US5434246A
(en)
|
1992-03-19 |
1995-07-18 |
Takeda Chemical Industries, Ltd. |
Parathyroid hormone derivatives
|
|
US5382658A
(en)
*
|
1992-04-03 |
1995-01-17 |
Allelix Biopharmaceuticals Inc. |
Stability-enhanced variants of parathyroid hormone
|
|
US5814603A
(en)
*
|
1992-06-12 |
1998-09-29 |
Affymax Technologies N.V. |
Compounds with PTH activity
|
|
US5589452A
(en)
*
|
1992-07-14 |
1996-12-31 |
Syntex (U.S.A.) Inc. |
Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
|
|
US5977070A
(en)
*
|
1992-07-14 |
1999-11-02 |
Piazza; Christin Teresa |
Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
|
|
US5821225A
(en)
*
|
1992-07-14 |
1998-10-13 |
Syntex (U.S.A.) Inc. |
Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
|
|
AU672790B2
(en)
|
1992-07-15 |
1996-10-17 |
Novartis Ag |
Variants of parathyroid hormone and its fragments
|
|
IT1255723B
(it)
*
|
1992-10-09 |
1995-11-13 |
|
Uso di paratormone,suoi frammenti biologicamente attivi e peptidi correlati, per la preparazione di composizioni farmaceutiche utili nella prevenzione e terapia dell'aborto e del parto pretermine ed in generale per il trattamento della gestazione
|
|
TW402639B
(en)
|
1992-12-03 |
2000-08-21 |
Transkaryotic Therapies Inc |
Protein production and protein delivery
|
|
US5871486A
(en)
*
|
1993-01-21 |
1999-02-16 |
Acumed, Inc. |
Variable pitch bone screw
|
|
EP0705334A1
(en)
*
|
1993-06-14 |
1996-04-10 |
Basf Aktiengesellschaft |
Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
|
|
CN1070500C
(zh)
|
1993-07-13 |
2001-09-05 |
森德克斯(美国)股份有限公司 |
甲状旁腺激素类似物和甲状旁腺激素相关肽:合成和治疗骨质疏松症的用途
|
|
US5496801A
(en)
*
|
1993-12-23 |
1996-03-05 |
Allelix Biopharmaceuticals Inc. |
Parathyroid hormone formulation
|
|
US5763416A
(en)
*
|
1994-02-18 |
1998-06-09 |
The Regent Of The University Of Michigan |
Gene transfer into bone cells and tissues
|
|
US5656465A
(en)
*
|
1994-05-04 |
1997-08-12 |
Therion Biologics Corporation |
Methods of in vivo gene delivery
|
|
US5714353A
(en)
*
|
1994-05-24 |
1998-02-03 |
Research Corporation Technologies, Inc. |
Safe vectors for gene therapy
|
|
CA2126132A1
(en)
|
1994-06-17 |
1995-12-18 |
Witold Neugebauer |
Peptide synthesis on chitosan
|
|
CA2126299C
(en)
|
1994-06-20 |
2000-12-12 |
Gordon E. Willick |
Parathyroid hormone analogues for the treatment of osteoporosis
|
|
US5836905A
(en)
*
|
1994-06-20 |
1998-11-17 |
Lemelson; Jerome H. |
Apparatus and methods for gene therapy
|
|
CO4410206A1
(es)
|
1994-07-28 |
1997-01-09 |
Sandoz Ag |
DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN
|
|
DE4434551A1
(de)
*
|
1994-09-28 |
1996-04-04 |
Forssmann Wolf Georg Prof Dr D |
Peptide aus der Sequenz des hPTH (1-37)
|
|
EP0806945B1
(en)
|
1994-12-22 |
2003-04-23 |
AstraZeneca AB |
Therapeutic preparation for inhalation containing parathyro d hormone, pth
|
|
US5717062A
(en)
*
|
1995-06-07 |
1998-02-10 |
Beth Israel Hospital Association |
Cyclic analogs of PTH and PTHrP
|
|
CA2178894A1
(en)
|
1995-06-15 |
1996-12-16 |
Tsunehiko Fukuda |
Parathyroid hormone derivatives and their use
|
|
JPH09157294A
(ja)
|
1995-06-15 |
1997-06-17 |
Takeda Chem Ind Ltd |
副甲状腺ホルモン誘導体
|
|
US6544949B1
(en)
|
1995-07-13 |
2003-04-08 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Analogs of parathyroid hormone
|
|
US5723577A
(en)
*
|
1995-07-13 |
1998-03-03 |
Biomeasure Inc. |
Analogs of parathyroid hormone
|
|
US5955574A
(en)
|
1995-07-13 |
1999-09-21 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. |
Analogs of parathyroid hormone
|
|
RU2157699C2
(ru)
*
|
1996-03-29 |
2000-10-20 |
Биомежер Инкорпорэйтед |
Пептиды, обладающие сродством к рецептору паратгормона (ртн) и стимулирующие активность аденилатциклазы
|
|
EP0917537B1
(en)
*
|
1996-07-31 |
2005-09-07 |
The General Hospital Corporation |
Novel parathyroid hormone-related peptide analogs
|
|
CA2261564C
(en)
|
1996-08-02 |
2007-10-30 |
National Research Council Of Canada |
Parathyroid hormone analogues for the treatment of osteoporosis
|
|
US5917123A
(en)
*
|
1997-03-14 |
1999-06-29 |
University Of Pittsburgh |
Transgenic mice containing a nucleic acid encoding tumor necrosis factor-α under the control of a cardiac specific regulatory region
|
|
US6183974B1
(en)
*
|
1997-07-31 |
2001-02-06 |
The General Hospital Corporation |
Screening assays for G protein coupled receptor agonists and antagonists
|
|
AU9682098A
(en)
|
1997-10-14 |
1999-05-03 |
Eli Lilly And Company |
Method of building and maintaining bone
|
|
HUP0300891A2
(hu)
*
|
1998-05-05 |
2003-07-28 |
Beth Israel Deaconess Medical Center, Inc. |
PTH2 receptor szelektív vegyületek és alkalmazásuk gyógyszerkészítmények előállÍtására
|
|
US6495662B1
(en)
*
|
1998-10-22 |
2002-12-17 |
The General Hospital Corporation |
Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
|
|
WO2000031137A1
(en)
|
1998-11-25 |
2000-06-02 |
The General Hospital Corporation |
Amino-terminal modified parathyroid hormone (pth) analogs
|
|
JP4486258B2
(ja)
*
|
1998-11-25 |
2010-06-23 |
ザ・ジェネラル・ホスピタル・コーポレイション |
ヒト副甲状腺ホルモンの改変、調製および使用
|
|
WO2000032771A1
(en)
|
1998-11-30 |
2000-06-08 |
The General Hospital Corporation |
Pth1r and pth3r receptors, methods and uses thereof
|
|
AU2023499A
(en)
|
1998-12-31 |
2000-07-24 |
General Hospital Corporation, The |
Pth receptor and screening assay utilizing the same
|
|
US7057012B1
(en)
*
|
1998-12-31 |
2006-06-06 |
The General Hospital Corporation |
PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
|
|
ATE403678T1
(de)
|
1998-12-31 |
2008-08-15 |
Gen Hospital Corp |
Peptide, bestehend aus zwei funktionellen pth- domänen, die durch ein linkermolekül verknüpft sind, und derivate davon
|
|
DE60040678D1
(en)
|
1999-09-29 |
2008-12-11 |
Gen Hospital Corp |
Parathyroid hormon (pth) polypeptidderivate
|
|
US7022815B1
(en)
|
1999-09-29 |
2006-04-04 |
The General Hospital Corporation |
Polypeptide derivatives of parathyroid hormone (PTH)
|
|
AU7734800A
(en)
*
|
1999-09-29 |
2001-04-30 |
General Hospital Corporation, The |
Polypeptide derivatives of parathyroid hormone (pth)
|
|
US6756480B2
(en)
*
|
2000-04-27 |
2004-06-29 |
Amgen Inc. |
Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
|
|
US20050124537A1
(en)
*
|
2000-04-27 |
2005-06-09 |
Amgen Inc. |
Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
|
|
US7371721B2
(en)
|
2000-09-18 |
2008-05-13 |
Sanos Bioscience A/S |
Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
|
|
US6838264B2
(en)
*
|
2000-12-05 |
2005-01-04 |
Immutopics, Inc. |
Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84
|
|
JP2004524844A
(ja)
*
|
2001-01-17 |
2004-08-19 |
ザ・ジェネラル・ホスピタル・コーポレイション |
Tip39ポリペプチド
|
|
AU2002339843B2
(en)
*
|
2001-07-23 |
2007-12-06 |
The General Hospital Corporation |
Conformationally constrained parathyroid hormone (PTH) analogs
|
|
JP2005525312A
(ja)
*
|
2002-01-10 |
2005-08-25 |
オステオトロフィン エルエルシー |
骨同化物質を用いた骨疾患の治療方法
|
|
US7521528B2
(en)
*
|
2003-01-24 |
2009-04-21 |
The General Hospital Corporation |
Conformationally constrained parathyroid hormone (PTH) analogs with lactam bridges
|
|
EP1610813A4
(en)
*
|
2003-03-19 |
2009-07-01 |
Gen Hospital Corp |
CONFORMATION RESTRICTED PARATHORMONE WITH A HELIX STABILIZERS
|
|
JP4871128B2
(ja)
|
2003-07-17 |
2012-02-08 |
ザ ジェネラル ホスピタル コーポレイション |
高次構造的に制約された副甲状腺ホルモン(pth)アナログ
|
|
CA2504920C
(en)
*
|
2004-05-14 |
2014-04-01 |
Euroscreen S.A. |
Ligand for g-protein coupled receptor fprl2 and uses thereof
|
|
CA2580281A1
(en)
*
|
2004-09-16 |
2006-03-30 |
Osteotrophin Llc |
Treatment of bone disorders with skeletal anabolic drugs
|
|
US8143374B2
(en)
|
2006-08-04 |
2012-03-27 |
The General Hospital Corporation |
Polypeptide derivatives of parathyroid hormone (PTH)
|
|
EP1961765A1
(en)
|
2006-12-08 |
2008-08-27 |
Zealand Pharma A/S |
Truncated PTH peptides with a cyclic conformation
|
|
MX353986B
(es)
|
2007-08-01 |
2017-11-06 |
Massachusetts Gen Hospital |
Metodos de analisis y seleccion usando receptores acoplados a proteina g y composiciones relacionadas.
|