JP2010536327A5 - - Google Patents
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- JP2010536327A5 JP2010536327A5 JP2010519932A JP2010519932A JP2010536327A5 JP 2010536327 A5 JP2010536327 A5 JP 2010536327A5 JP 2010519932 A JP2010519932 A JP 2010519932A JP 2010519932 A JP2010519932 A JP 2010519932A JP 2010536327 A5 JP2010536327 A5 JP 2010536327A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- ala
- amino acid
- gpcr
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 63
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 63
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 63
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 57
- 238000000034 method Methods 0.000 claims description 40
- 150000001875 compounds Chemical class 0.000 claims description 38
- 102000005962 receptors Human genes 0.000 claims description 29
- 108020003175 receptors Proteins 0.000 claims description 29
- 108090000445 Parathyroid hormone Proteins 0.000 claims description 22
- 239000000556 agonist Substances 0.000 claims description 16
- 238000009739 binding Methods 0.000 claims description 13
- 230000027455 binding Effects 0.000 claims description 11
- 239000012528 membrane Substances 0.000 claims description 11
- 101001135738 Homo sapiens Parathyroid hormone-related protein Proteins 0.000 claims description 10
- 101000589873 Homo sapiens Parathyroid hormone/parathyroid hormone-related peptide receptor Proteins 0.000 claims description 10
- 102100036899 Parathyroid hormone-related protein Human genes 0.000 claims description 10
- 108091006027 G proteins Proteins 0.000 claims description 9
- 102000030782 GTP binding Human genes 0.000 claims description 9
- 108091000058 GTP-Binding Proteins 0.000 claims description 9
- 108010058828 Parathyroid Hormone Receptors Proteins 0.000 claims description 8
- 102000006461 Parathyroid Hormone Receptors Human genes 0.000 claims description 8
- 239000003446 ligand Substances 0.000 claims description 8
- 238000012875 competitive assay Methods 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 6
- 108700020797 Parathyroid Hormone-Related Proteins 0.000 claims description 6
- 102000043299 Parathyroid hormone-related Human genes 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- XOFLBQFBSOEHOG-UUOKFMHZSA-N γS-GTP Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=S)[C@@H](O)[C@H]1O XOFLBQFBSOEHOG-UUOKFMHZSA-N 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- 108010086019 Secretin Proteins 0.000 claims description 4
- 102100037505 Secretin Human genes 0.000 claims description 4
- 238000013262 cAMP assay Methods 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 230000003111 delayed effect Effects 0.000 claims description 4
- 230000003834 intracellular effect Effects 0.000 claims description 4
- 229930014626 natural product Natural products 0.000 claims description 4
- 230000006461 physiological response Effects 0.000 claims description 4
- 229960002101 secretin Drugs 0.000 claims description 4
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims 54
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 37
- 125000003275 alpha amino acid group Chemical group 0.000 claims 27
- 235000001014 amino acid Nutrition 0.000 claims 20
- 229940024606 amino acid Drugs 0.000 claims 17
- 150000001413 amino acids Chemical class 0.000 claims 17
- 102100036893 Parathyroid hormone Human genes 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 7
- 235000004279 alanine Nutrition 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000000038 Hypoparathyroidism Diseases 0.000 claims 3
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 201000005991 hyperphosphatemia Diseases 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 208000005368 osteomalacia Diseases 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 238000007920 subcutaneous administration Methods 0.000 claims 3
- 206010043554 thrombocytopenia Diseases 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 241000024188 Andala Species 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 230000002308 calcification Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001483 mobilizing effect Effects 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 239000002287 radioligand Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 4
- 238000003556 assay Methods 0.000 description 3
- 239000000700 radioactive tracer Substances 0.000 description 3
- 101001135770 Homo sapiens Parathyroid hormone Proteins 0.000 description 2
- 101001135995 Homo sapiens Probable peptidyl-tRNA hydrolase Proteins 0.000 description 2
- 230000004094 calcium homeostasis Effects 0.000 description 2
- 102000058004 human PTH Human genes 0.000 description 2
- 239000000199 parathyroid hormone Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 102000034345 heterotrimeric G proteins Human genes 0.000 description 1
- 108091006093 heterotrimeric G proteins Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96311707P | 2007-08-01 | 2007-08-01 | |
| US60/963,117 | 2007-08-01 | ||
| US96308207P | 2007-08-02 | 2007-08-02 | |
| US60/963,082 | 2007-08-02 | ||
| US96386707P | 2007-08-06 | 2007-08-06 | |
| US60/963,867 | 2007-08-06 | ||
| PCT/US2008/009288 WO2009017809A2 (en) | 2007-08-01 | 2008-08-01 | Screening methods using g-protein coupled receptors and related compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536327A JP2010536327A (ja) | 2010-12-02 |
| JP2010536327A5 true JP2010536327A5 (cg-RX-API-DMAC7.html) | 2014-02-27 |
| JP5711966B2 JP5711966B2 (ja) | 2015-05-07 |
Family
ID=40305140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010519932A Active JP5711966B2 (ja) | 2007-08-01 | 2008-08-01 | Ｇタンパク質共役受容体および関連組成物を使用するスクリーニング方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8568737B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2650009B8 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5711966B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101661730B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN101784281B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008282805B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0814962B8 (cg-RX-API-DMAC7.html) |
| CA (2) | CA3017668C (cg-RX-API-DMAC7.html) |
| MX (2) | MX353986B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2506274C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009017809A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2650009B8 (en) | 2007-08-01 | 2018-07-18 | The General Hospital Corporation | Screening methods using G-protein coupled receptors and related compositions |
| CN102448482A (zh) * | 2009-03-27 | 2012-05-09 | 范安德尔研究所 | 甲状旁腺素肽和甲状旁腺素相关蛋白肽及使用方法 |
| NZ595437A (en) * | 2009-04-24 | 2014-03-28 | Cadila Healthcare Ltd | Short-chain peptides as parathyroid hormone (pth) receptor agonist |
| WO2011143406A2 (en) * | 2010-05-13 | 2011-11-17 | The General Hospital Corporation | Parathyroid hormone analogs and uses thereof |
| EP4286400A3 (en) * | 2011-05-18 | 2024-06-05 | Eumederis Pharmaceuticals, Inc. | Improved peptide pharmaceuticals |
| WO2015037764A1 (ko) * | 2013-09-16 | 2015-03-19 | 서울대학교 산학협력단 | Gpcr19 경로의 활성화에 의한 골수 유래 면역 조절 세포 및 면역 조절 b 림프구의 체내외 증폭 |
| CA2972739A1 (en) * | 2014-09-11 | 2016-03-17 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Methods of producing mogrosides and compositions comprising same and uses thereof |
| US20190119348A1 (en) * | 2016-04-01 | 2019-04-25 | The General Hospital Corporation | Parathyroid hormone receptor 1 antagonist and inverse agonist polypeptides and methods of their use |
| CN106267162A (zh) * | 2016-08-25 | 2017-01-04 | 浙江省新华医院 | 促胰液素在制备治疗骨质疏松症药物中的用途 |
| JP2021516222A (ja) | 2018-03-16 | 2021-07-01 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモンポリペプチドコンジュゲートおよびその使用方法 |
| US11298701B2 (en) | 2018-11-26 | 2022-04-12 | King Instrumentation Technologies | Microtiter plate mixing control system |
| FR3092115B1 (fr) * | 2019-01-30 | 2021-11-12 | Cisbio Bioassays | analogues de GTP fluorescents et utilisation |
| KR102264116B1 (ko) * | 2019-06-19 | 2021-06-14 | 한국과학기술연구원 | 세포 소포체 내 g-단백질 연결 수용체(gpcr)의 실시간 활성 상태 분석 방법 및 컴퓨터 프로그램 |
| CN112111003B (zh) * | 2019-06-20 | 2022-02-11 | 中国农业大学 | 含有me序列的一类新型抑制血小板聚集和抗血栓形成寡肽 |
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