JP2010535830A - デュシェンヌ型筋ジストロフィーの治療用化合物の製造 - Google Patents

デュシェンヌ型筋ジストロフィーの治療用化合物の製造 Download PDF

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JP2010535830A
JP2010535830A JP2010520499A JP2010520499A JP2010535830A JP 2010535830 A JP2010535830 A JP 2010535830A JP 2010520499 A JP2010520499 A JP 2010520499A JP 2010520499 A JP2010520499 A JP 2010520499A JP 2010535830 A JP2010535830 A JP 2010535830A
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formula
compound
solvent
production method
compounds
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チャルレス ウエイモウトフ‐ウイルソン アレクアンデル
ミチャエル ウインネ グラハム
クラルクソン ロベルト
バンウエルル レナテ
パウル ウレン ステプヘン
デ モオル オリビエル
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ビオマリン アイジーエー リミテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57Aryl or substituted aryl radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2010520499A 2007-08-15 2008-08-14 デュシェンヌ型筋ジストロフィーの治療用化合物の製造 Pending JP2010535830A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0715937.9A GB0715937D0 (en) 2007-08-15 2007-08-15 Method of treatment og duchenne muscular dystrophy
PCT/EP2008/006719 WO2009021749A2 (en) 2007-08-15 2008-08-14 Preparation of a compound for the treatment of duchenne muscular dystrophy

Publications (1)

Publication Number Publication Date
JP2010535830A true JP2010535830A (ja) 2010-11-25

Family

ID=38566447

Family Applications (2)

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JP2010520499A Pending JP2010535830A (ja) 2007-08-15 2008-08-14 デュシェンヌ型筋ジストロフィーの治療用化合物の製造
JP2010520498A Pending JP2010535829A (ja) 2007-08-15 2008-08-14 デュシェンヌ型筋ジストロフィーの治療用の化合物の多形体

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JP2010520498A Pending JP2010535829A (ja) 2007-08-15 2008-08-14 デュシェンヌ型筋ジストロフィーの治療用の化合物の多形体

Country Status (17)

Country Link
US (2) US20090048314A1 (cg-RX-API-DMAC7.html)
EP (2) EP2188270A2 (cg-RX-API-DMAC7.html)
JP (2) JP2010535830A (cg-RX-API-DMAC7.html)
KR (1) KR20100075777A (cg-RX-API-DMAC7.html)
CN (2) CN101896475A (cg-RX-API-DMAC7.html)
AR (1) AR068810A1 (cg-RX-API-DMAC7.html)
AU (2) AU2008286325A1 (cg-RX-API-DMAC7.html)
BR (2) BRPI0811315A2 (cg-RX-API-DMAC7.html)
CA (2) CA2685590A1 (cg-RX-API-DMAC7.html)
CL (1) CL2008002391A1 (cg-RX-API-DMAC7.html)
GB (1) GB0715937D0 (cg-RX-API-DMAC7.html)
IL (1) IL201908A0 (cg-RX-API-DMAC7.html)
MX (2) MX2009011967A (cg-RX-API-DMAC7.html)
PE (1) PE20090604A1 (cg-RX-API-DMAC7.html)
RU (1) RU2009141831A (cg-RX-API-DMAC7.html)
TW (1) TW200911767A (cg-RX-API-DMAC7.html)
WO (2) WO2009021749A2 (cg-RX-API-DMAC7.html)

Cited By (1)

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WO2017175842A1 (ja) * 2016-04-07 2017-10-12 国立大学法人京都大学 スプライシングの改変に関する化合物及び医薬組成物

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GB201412010D0 (en) 2014-07-04 2014-08-20 Summit Corp Plc Treatment of hypertransaminasemia
MX2018012018A (es) 2016-03-30 2019-07-04 Summit Oxford Ltd Composicion para el tratamiento de la distrofía muscular de duchenne.
KR102019048B1 (ko) 2017-02-06 2019-09-09 가톨릭대학교 산학협력단 MG53과 Orai1의 결합을 이용한 근육긴장저하 치료제 스크리닝 방법
KR101886788B1 (ko) 2017-02-07 2018-08-09 가톨릭대학교 산학협력단 MG53과 Orai1의 결합을 이용한 뒤시엔느 골격근 위축증 치료제 스크리닝 방법
EP3641741B1 (en) 2017-06-19 2024-03-20 University of Maryland, Baltimore Microtubule polymerization inhibitor prodrugs and methods of using the same

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017175842A1 (ja) * 2016-04-07 2017-10-12 国立大学法人京都大学 スプライシングの改変に関する化合物及び医薬組成物

Also Published As

Publication number Publication date
WO2009021748A2 (en) 2009-02-19
BRPI0811548A2 (pt) 2014-11-18
MX2009011967A (es) 2009-11-19
CA2685590A1 (en) 2009-02-19
AR068810A1 (es) 2009-12-09
CL2008002391A1 (es) 2009-05-22
WO2009021749A2 (en) 2009-02-19
US20100267961A1 (en) 2010-10-21
CN101896475A (zh) 2010-11-24
US20090048314A1 (en) 2009-02-19
KR20100075777A (ko) 2010-07-05
US8138351B2 (en) 2012-03-20
AU2008286324A1 (en) 2009-02-19
RU2009141831A (ru) 2011-05-20
MX2009011916A (es) 2009-11-18
JP2010535829A (ja) 2010-11-25
AU2008286325A1 (en) 2009-02-19
WO2009021749A8 (en) 2009-09-11
WO2009021748A3 (en) 2009-04-02
CN101679323A (zh) 2010-03-24
EP2176246A2 (en) 2010-04-21
BRPI0811315A2 (pt) 2015-01-27
IL201908A0 (en) 2010-06-16
GB0715937D0 (en) 2007-09-26
CA2685939A1 (en) 2009-02-19
TW200911767A (en) 2009-03-16
PE20090604A1 (es) 2009-05-16
EP2188270A2 (en) 2010-05-26
WO2009021749A3 (en) 2009-04-02

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