JP2010535026A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010535026A5 JP2010535026A5 JP2010518815A JP2010518815A JP2010535026A5 JP 2010535026 A5 JP2010535026 A5 JP 2010535026A5 JP 2010518815 A JP2010518815 A JP 2010518815A JP 2010518815 A JP2010518815 A JP 2010518815A JP 2010535026 A5 JP2010535026 A5 JP 2010535026A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- influenza
- peptide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 32
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 101710154606 Hemagglutinin Proteins 0.000 claims 15
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 15
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 15
- 101710176177 Protein A56 Proteins 0.000 claims 15
- 239000000185 hemagglutinin Substances 0.000 claims 15
- 102000011931 Nucleoproteins Human genes 0.000 claims 11
- 108010061100 Nucleoproteins Proteins 0.000 claims 11
- 206010022000 influenza Diseases 0.000 claims 11
- 241000712461 unidentified influenza virus Species 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 238000006116 polymerization reaction Methods 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 229920001400 block copolymer Polymers 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95349807P | 2007-08-02 | 2007-08-02 | |
| US60/953,498 | 2007-08-02 | ||
| PCT/IL2008/001062 WO2009016639A2 (en) | 2007-08-02 | 2008-08-03 | Multimeric multiepitope influenza vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535026A JP2010535026A (ja) | 2010-11-18 |
| JP2010535026A5 true JP2010535026A5 (cg-RX-API-DMAC7.html) | 2011-09-15 |
| JP5654345B2 JP5654345B2 (ja) | 2015-01-14 |
Family
ID=40305020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518815A Expired - Fee Related JP5654345B2 (ja) | 2007-08-02 | 2008-08-03 | 多量体マルチエピトープインフルエンザワクチン |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8747861B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2173376B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5654345B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101580660B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101795709B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008281384C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0815008B8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2695399C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2173376T3 (cg-RX-API-DMAC7.html) |
| EA (1) | EA017887B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2539818T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20150479T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE025149T2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010001284A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2173376T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2173376E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009016639A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006206647C1 (en) | 2005-01-19 | 2011-01-20 | Vaxinnate Corporation | Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| EP2772267B1 (en) * | 2007-08-27 | 2016-04-27 | Longhorn Vaccines and Diagnostics, LLC | Immunogenic compositions and methods |
| WO2009128951A2 (en) | 2008-04-18 | 2009-10-22 | Vaxinnate Corporation | Compositions of respiratory synctial virus proteins and methods of use |
| WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
| PL2620156T3 (pl) | 2010-08-23 | 2019-10-31 | Kang Stem Biotech Co Ltd | Kompozycja farmaceutyczna do zapobiegania lub leczenia chorób immunologicznych lub chorób zapalnych, zawierająca komórki macierzyste traktowane agonistą NOD2 lub jego produktem hodowlanym |
| WO2012115715A2 (en) * | 2011-02-21 | 2012-08-30 | Vaxinnate Corporation | Compositions with enhanced immunogenicity and/or reduced reactogenicity and methods of use |
| US9303070B2 (en) | 2011-02-22 | 2016-04-05 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| CN103732749B (zh) * | 2011-06-20 | 2017-03-29 | 高等教育联邦系统-匹兹堡大学 | 计算优化的宽反应性的h1n1流感抗原 |
| ES2490915B1 (es) * | 2011-09-12 | 2015-09-17 | Laboratorios Del Dr. Esteve, S.A. | Método para monitorizar las respuestas de linfocitos T citotóxicos (LTC) mediante una reacción de hipersensibilidad de tipo retardado usando epítopos de LTC definidos |
| CA3207612A1 (en) | 2012-01-26 | 2013-08-01 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| JP2015514097A (ja) * | 2012-04-02 | 2015-05-18 | フォリア バイオテック インコーポレイテッド | 組換えパパイヤモザイクウイルスコートタンパク質およびインフルエンザワクチンにおけるその使用 |
| CN103055311B (zh) * | 2012-12-28 | 2014-05-21 | 中山大学 | 一种传染性喉气管炎粘膜疫苗及其制备方法和应用 |
| CA2897752A1 (en) * | 2013-01-10 | 2014-07-17 | Novartis Ag | Influenza virus immunogenic compositions and uses thereof |
| CA2944768C (en) * | 2014-04-03 | 2022-08-30 | Biondvax Pharmaceuticals Ltd. | Compositions of multimeric-multiepitope influenza polypeptides and their production |
| CN109073639B (zh) * | 2016-02-03 | 2022-04-01 | Cg探索股份有限公司 | 具有异源表位和/或改变的成熟切割位点的流感血凝素的组合物 |
| JP2019064924A (ja) * | 2016-02-24 | 2019-04-25 | Ａｇｃ株式会社 | インフルエンザワクチン |
| US11111277B2 (en) | 2016-12-28 | 2021-09-07 | Invvax, Inc. | Influenza vaccines |
| WO2019061297A1 (zh) * | 2017-09-29 | 2019-04-04 | 苏州工业园区唯可达生物科技有限公司 | 一种cd4辅助性t细胞表位融合肽及其疫苗 |
| WO2019124557A1 (ja) | 2017-12-21 | 2019-06-27 | 株式会社グリーンバイオメッド | 交差免疫抗原ワクチン及びその調製方法 |
| KR20210052389A (ko) | 2018-08-27 | 2021-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 다운스트림 정제에서의 라만 분광법의 사용 |
| EP3851120A4 (en) * | 2018-09-11 | 2022-04-27 | Shanghai Public Health Clinical Center | Immunogen for broad-spectrum influenza vaccine and application thereof |
| US20220273790A1 (en) * | 2019-06-18 | 2022-09-01 | Citranvi Biosciences, Llc | Rationally engineered carrier proteins for vaccines |
| JP2023513720A (ja) * | 2020-02-14 | 2023-04-03 | ユニバーシティ オブ ワシントン | 感染症の治療又は発症を制限するためのポリペプチド、組成物、及びそれらの使用 |
| US11149286B1 (en) * | 2020-08-17 | 2021-10-19 | Mayo Foundation For Medical Education And Research | Adenovirus vectors and methods for using adenovirus vectors |
| WO2022061297A1 (en) * | 2020-09-21 | 2022-03-24 | Brown Kathlynn C | Targeted antigen delivery system and uses thereof |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767842A (en) * | 1973-05-07 | 1988-08-30 | The Ohio State University | Antigenic modification of polypeptides |
| IL61904A (en) * | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
| US4866034A (en) * | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4436727A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4539205A (en) * | 1982-11-09 | 1985-09-03 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
| US4643992A (en) * | 1982-11-09 | 1987-02-17 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
| US4987237A (en) * | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
| US5093318A (en) * | 1983-11-01 | 1992-03-03 | Scripps Clinic And Research Foundation | Immunostimulating guanosine derivatives and their pharmaceutical compositions |
| US5011828A (en) * | 1985-11-15 | 1991-04-30 | Michael Goodman | Immunostimulating guanine derivatives, compositions and methods |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US6130082A (en) * | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5709879A (en) * | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| US5837268A (en) * | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
| GB9201139D0 (en) | 1992-01-20 | 1992-03-11 | Connaught Lab | Synthetic peptides for a rubella vaccine |
| IL101639A0 (en) | 1992-04-17 | 1992-12-30 | Yeda Res & Dev | Recombinant influenza vaccines |
| CA2138997C (en) * | 1992-06-25 | 2003-06-03 | Jean-Paul Prieels | Vaccine composition containing adjuvants |
| CA2123579C (en) * | 1992-09-16 | 2005-05-10 | James B. Dale | Recombinant multivalent m protein vaccine |
| US5683695A (en) * | 1993-02-10 | 1997-11-04 | United Biomedical, Inc. | Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains |
| EP0812593B8 (en) * | 1993-03-23 | 2010-11-10 | SmithKline Beecham Biologicals S.A. | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| EP1167378B1 (en) | 1994-07-15 | 2011-05-11 | University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| RS50101B (sr) | 1996-02-24 | 2009-01-22 | Boehringer Ingelheim International Gmbh., | Farmaceutski preparati za imunomodulaciju |
| US6303347B1 (en) * | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6355257B1 (en) * | 1997-05-08 | 2002-03-12 | Corixa Corporation | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US6113918A (en) * | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US7063967B2 (en) * | 1997-05-08 | 2006-06-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| EP0996451B1 (en) * | 1997-05-20 | 2005-01-05 | Galenica Pharmaceuticals, Inc. | Triterpene saponin analogs having adjuvant and immunostimulatory activity |
| US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| EP0996717B1 (en) | 1997-08-05 | 2005-12-07 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Immunoprotective influenza antigen and its use in vaccination |
| GB9718901D0 (en) | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
| EP1279401B1 (en) * | 1997-09-05 | 2008-01-09 | GlaxoSmithKline Biologicals S.A. | Oil in water emulsions containing saponins |
| ATE215385T1 (de) * | 1997-12-16 | 2002-04-15 | Chiron Corp | Verwendung von mikropartikeln mit submikron öl/wasser emulsionen |
| TR200002930T2 (tr) | 1998-04-09 | 2000-12-21 | Smithkline Beecham Biologicals S.A. | Kolaylaştırıcı kompozisyonlar |
| GB9807805D0 (en) | 1998-04-09 | 1998-06-10 | Smithkline Beecham Biolog | Vaccine |
| PT1075276E (pt) | 1998-05-07 | 2008-01-22 | Corixa Corp | Composição adjuvante e métodos para sua utilização |
| CA2337754C (en) * | 1998-08-21 | 2011-05-24 | Altaf A. Lal | Recombinant multivalent malarial vaccine against plasmodium falciparum |
| IL127331A0 (en) | 1998-11-30 | 1999-09-22 | Yeda Res & Dev | Peptide-based vaccine for influenza |
| CA2377525A1 (en) | 1999-07-19 | 2001-03-29 | Epimmune, Inc. | Inducing cellular immune responses to hepatitis c virus using peptide and nucleic acid compositions |
| CA2386499A1 (en) | 1999-10-05 | 2001-04-12 | Epimmune, Inc. | Inducing cellular immune responses to human immunodeficiency virus-1 using peptide and nucleic acid compositions |
| US6843781B2 (en) * | 1999-10-14 | 2005-01-18 | Becton, Dickinson And Company | Intradermal needle |
| KR100877019B1 (ko) | 2000-06-23 | 2009-01-07 | 와이어쓰 홀딩스 코포레이션 | 야생형 및 키메릭 인플루엔자 바이러스성입자(브이엘피)의 조립 |
| JP2005537244A (ja) * | 2002-06-28 | 2005-12-08 | ナステック・ファーマシューティカル・カンパニー・インコーポレーテッド | 療法化合物の粘膜搬送を増進させるための、上皮接合部接着分子の生理機能を調節する組成物および方法 |
| JP2006519775A (ja) * | 2003-03-07 | 2006-08-31 | メルク エンド カムパニー インコーポレーテッド | インフルエンザウイルスワクチン |
| US7108679B2 (en) * | 2004-03-11 | 2006-09-19 | Becton, Dickinson And Company | Intradermal syringe and needle assembly |
| CA2589556A1 (en) * | 2004-12-16 | 2006-08-03 | Wake Forest University Health Sciences | Use of flagellin in tumor immunotherapy |
| EP1831259A2 (en) | 2004-12-21 | 2007-09-12 | Vaxinnate Corporation | Compositions of influenza viral proteins and methods of use thereof |
| AU2006206647C1 (en) | 2005-01-19 | 2011-01-20 | Vaxinnate Corporation | Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response |
| CN101227919B (zh) * | 2005-06-01 | 2011-10-05 | 变异生物技术公司 | 基于肽的流感疫苗制剂 |
| US7260958B2 (en) * | 2005-09-14 | 2007-08-28 | National Taipei University Technology | Electrohydrodynamic condenser device |
| WO2007052057A2 (en) * | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Adminstration routes for priming/boosting with influenza vaccines |
| WO2007066334A1 (en) | 2005-12-06 | 2007-06-14 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Improved influenza vaccine |
| GB0613977D0 (en) | 2006-02-07 | 2006-08-23 | Peptcell Ltd | Peptide sequences and compositions |
| CA2658559A1 (en) * | 2006-07-21 | 2008-04-03 | Pharmexa Inc. | Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions |
| TW200908994A (en) * | 2007-04-20 | 2009-03-01 | Glaxosmithkline Biolog Sa | Vaccine |
| KR20100075843A (ko) | 2007-08-21 | 2010-07-05 | 다이나박스 테크놀로지 코퍼레이션 | 인플루엔자 단백질 조성물 및 그 제조 및 사용 방법 |
-
2008
- 2008-08-03 WO PCT/IL2008/001062 patent/WO2009016639A2/en not_active Ceased
- 2008-08-03 DK DK08789738.5T patent/DK2173376T3/en active
- 2008-08-03 PT PT87897385T patent/PT2173376E/pt unknown
- 2008-08-03 CA CA2695399A patent/CA2695399C/en not_active Expired - Fee Related
- 2008-08-03 AU AU2008281384A patent/AU2008281384C1/en not_active Ceased
- 2008-08-03 BR BRPI0815008A patent/BRPI0815008B8/pt not_active IP Right Cessation
- 2008-08-03 HR HRP20150479TT patent/HRP20150479T1/hr unknown
- 2008-08-03 HU HUE08789738A patent/HUE025149T2/hu unknown
- 2008-08-03 EP EP08789738.5A patent/EP2173376B1/en active Active
- 2008-08-03 ES ES08789738.5T patent/ES2539818T3/es active Active
- 2008-08-03 CN CN2008801015810A patent/CN101795709B/zh not_active Expired - Fee Related
- 2008-08-03 PL PL08789738T patent/PL2173376T3/pl unknown
- 2008-08-03 JP JP2010518815A patent/JP5654345B2/ja not_active Expired - Fee Related
- 2008-08-03 US US12/671,617 patent/US8747861B2/en active Active
- 2008-08-03 EA EA201070219A patent/EA017887B1/ru not_active IP Right Cessation
- 2008-08-03 MX MX2010001284A patent/MX2010001284A/es active IP Right Grant
- 2008-08-03 KR KR1020107003351A patent/KR101580660B1/ko not_active Expired - Fee Related
-
2014
- 2014-04-28 US US14/263,359 patent/US9353159B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010535026A5 (cg-RX-API-DMAC7.html) | ||
| US20240075125A1 (en) | Expression systems | |
| JP6957580B2 (ja) | 新規多価ナノ粒子に基づくワクチン | |
| HRP20150479T1 (hr) | Multimeriäśna multiepitopska cjepiva protiv influence | |
| Kim et al. | Multiple heterologous M2 extracellular domains presented on virus-like particles confer broader and stronger M2 immunity than live influenza A virus infection | |
| KR101736897B1 (ko) | 인플루엔자 항원 수송 벡터 및 구조물 | |
| JP2014507146A5 (cg-RX-API-DMAC7.html) | ||
| JP2012501959A5 (cg-RX-API-DMAC7.html) | ||
| JP2012511914A5 (cg-RX-API-DMAC7.html) | ||
| JP2015506705A5 (cg-RX-API-DMAC7.html) | ||
| US11160858B2 (en) | Live recombinant measles-M2 virus—its use in eliciting immunity against influenza viruses | |
| WO2019092002A1 (en) | Pharmaceutical compositions for treatment or prevention of viral infections | |
| Du et al. | Flu universal vaccines: new tricks on an old virus | |
| WO2006037038B1 (en) | Optimized vaccines to provide protection against ebola and other viruses | |
| Park et al. | Mucosal immunity induced by adenovirus-based H5N1 HPAI vaccine confers protection against a lethal H5N2 avian influenza virus challenge | |
| Hong et al. | Highly immunogenic influenza virus-like particles containing B-cell-activating factor (BAFF) for multi-subtype vaccine development | |
| JP2014527526A5 (cg-RX-API-DMAC7.html) | ||
| JP7403733B2 (ja) | インフルエンザｈａスプリットワクチンの製造方法 | |
| JP2016505538A5 (cg-RX-API-DMAC7.html) | ||
| CN103732249A (zh) | 含有经修饰腺病毒载体的流感疫苗 | |
| Wang et al. | Improving cross-protection against influenza virus using recombinant vaccinia vaccine expressing NP and M2 ectodomain tandem repeats | |
| RU2013102929A (ru) | Пан-лиссавирусные вакцины против бешенства | |
| JP2019534242A5 (cg-RX-API-DMAC7.html) | ||
| JP2014530610A5 (cg-RX-API-DMAC7.html) | ||
| HK40059786A (en) | Expression system |