JP2010533869A5 - - Google Patents

Download PDF

Info

Publication number
JP2010533869A5
JP2010533869A5 JP2010517146A JP2010517146A JP2010533869A5 JP 2010533869 A5 JP2010533869 A5 JP 2010533869A5 JP 2010517146 A JP2010517146 A JP 2010517146A JP 2010517146 A JP2010517146 A JP 2010517146A JP 2010533869 A5 JP2010533869 A5 JP 2010533869A5
Authority
JP
Japan
Prior art keywords
channel
microfluidic device
plasma separation
microfluidic
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010517146A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010533869A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/070232 external-priority patent/WO2009012340A2/en
Publication of JP2010533869A publication Critical patent/JP2010533869A/ja
Publication of JP2010533869A5 publication Critical patent/JP2010533869A5/ja
Pending legal-status Critical Current

Links

JP2010517146A 2007-07-16 2008-07-16 標的分子を検出するためのマイクロ流体装置、方法及びシステム Pending JP2010533869A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95966607P 2007-07-16 2007-07-16
US99898107P 2007-10-15 2007-10-15
PCT/US2008/070232 WO2009012340A2 (en) 2007-07-16 2008-07-16 Microfluidic devices, methods and systems for detecting target molecules

Publications (2)

Publication Number Publication Date
JP2010533869A JP2010533869A (ja) 2010-10-28
JP2010533869A5 true JP2010533869A5 (enExample) 2011-09-01

Family

ID=40260363

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010517148A Pending JP2010533871A (ja) 2007-07-16 2008-07-16 標的分子を検出するためのアレイ、基板、装置、方法、及び、システム
JP2010517146A Pending JP2010533869A (ja) 2007-07-16 2008-07-16 標的分子を検出するためのマイクロ流体装置、方法及びシステム

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2010517148A Pending JP2010533871A (ja) 2007-07-16 2008-07-16 標的分子を検出するためのアレイ、基板、装置、方法、及び、システム

Country Status (6)

Country Link
US (6) US20090053732A1 (enExample)
EP (3) EP3628729B1 (enExample)
JP (2) JP2010533871A (enExample)
AU (2) AU2008276027B2 (enExample)
CA (2) CA2694541A1 (enExample)
WO (2) WO2009012343A2 (enExample)

Families Citing this family (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
US8460879B2 (en) * 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US20080014589A1 (en) 2006-05-11 2008-01-17 Link Darren R Microfluidic devices and methods of use thereof
US8394590B2 (en) * 2006-08-02 2013-03-12 California Institute Of Technology Capture agents and related methods and systems for detecting and/or sorting targets
WO2008016680A1 (en) * 2006-08-02 2008-02-07 California Institute Of Technology Methods and systems for detecting and/or sorting targets
EP3536396B1 (en) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2009012343A2 (en) * 2007-07-16 2009-01-22 California Institute Of Technology Arrays, substrates, devices, methods and systems for detecting target molecules
US8380457B2 (en) * 2007-08-29 2013-02-19 Canon U.S. Life Sciences, Inc. Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes
US8306773B2 (en) * 2007-08-29 2012-11-06 Canon U.S. Life Sciences, Inc. Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes
US9492826B2 (en) * 2007-08-29 2016-11-15 Canon U.S. Life Sciences, Inc. Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes
US20110195852A1 (en) 2007-08-30 2011-08-11 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution
JP5163999B2 (ja) * 2007-11-14 2013-03-13 国立大学法人富山大学 類似植物体および生薬同定用ｄｎａマイクロアレイ
EP2274443A4 (en) * 2008-04-09 2012-03-28 California Inst Of Techn MUG AND PROCESSES AND SYSTEMS ASSOCIATED WITH DETECTING AND / OR SORTING TARGETS
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
JP2012504243A (ja) 2008-09-26 2012-02-16 ザ ジェネラル ホスピタル コーポレイション 粒子の捕獲
US8557199B2 (en) * 2008-12-02 2013-10-15 California Institute Of Technology Self-powered microfluidic devices, methods and systems
WO2010085548A2 (en) * 2009-01-22 2010-07-29 Li-Cor, Inc. Single molecule proteomics with dynamic probes
US9739771B2 (en) 2009-02-27 2017-08-22 Yale University Physiologic sample preparation for nanosensors
WO2010099318A1 (en) * 2009-02-27 2010-09-02 Yale University Physiologic sample preparation for nanosensors
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
EP2427572B1 (en) * 2009-05-01 2013-08-28 Illumina, Inc. Sequencing methods
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
ES2649559T3 (es) * 2009-11-23 2018-01-12 Cyvek, Inc. Método y aparato para realizar ensayos
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US8535889B2 (en) 2010-02-12 2013-09-17 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
AU2011218847B2 (en) 2010-02-23 2015-03-12 Christopher Gordon Atwood Methods for the detection of biologically relevant molecules and their interaction characteristics
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
CA2791655C (en) 2010-03-01 2014-11-04 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8415171B2 (en) * 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8614056B2 (en) 2010-03-24 2013-12-24 The Board Of Trustees Of The Leland Stanford Junior University Microfluidic method for measurement or detection involving cells or biomolecules
JP2011221009A (ja) * 2010-03-25 2011-11-04 Fujifilm Corp 生体物質検出装置
KR101152791B1 (ko) * 2010-05-10 2012-06-12 광주과학기술원 쯔바이파흐-풍 효과를 이용한 세포 발열량 측정 센서 및 이의 제조방법
IT1400868B1 (it) * 2010-06-23 2013-07-02 Torino Politecnico Dispositivo microfluidico integrato per la purificazione, amplificazione e rivelazione di acidi nucleici per la diagnostica
US9188593B2 (en) 2010-07-16 2015-11-17 The University Of British Columbia Methods for assaying cellular binding interactions
WO2012045012A2 (en) * 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
US20130123121A1 (en) 2010-11-22 2013-05-16 The University Of Chicago Methods and/or Use of Oligonucleotide-Bead Conjugates for Assays and Detections
USD650090S1 (en) * 2011-01-18 2011-12-06 Zach Odeh Microfluidic device
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
EP3736281A1 (en) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
CN106552682B (zh) * 2011-03-22 2020-06-19 西维克公司 微流体装置以及制造方法和用途
US9252175B2 (en) 2011-03-23 2016-02-02 Nanohmics, Inc. Method for assembly of spectroscopic filter arrays using biomolecules
US9828696B2 (en) 2011-03-23 2017-11-28 Nanohmics, Inc. Method for assembly of analyte filter arrays using biomolecules
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
USD650091S1 (en) * 2011-04-19 2011-12-06 Zach Odeh Microfluidic device
USD650911S1 (en) * 2011-04-19 2011-12-20 Zach Odeh Microfluidic device
US8946389B2 (en) 2011-04-25 2015-02-03 University Of Washington Compositions and methods for multiplex biomarker profiling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
WO2012167142A2 (en) 2011-06-02 2012-12-06 Raindance Technolgies, Inc. Enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
ES2929040T3 (es) * 2011-10-28 2022-11-24 Aeneas Gmbh & Co Kg Dispositivo y procedimiento para detectar sustancias presentes en muestras biológicas o químicas
KR102114734B1 (ko) 2012-03-08 2020-05-25 싸이벡, 아이엔씨 미세유체 분석 장치용 마이크로튜브 입자 및 제조방법
WO2013154946A1 (en) * 2012-04-11 2013-10-17 Alere San Diego, Inc. Microfluidic device, system and method
WO2013177046A1 (en) 2012-05-21 2013-11-28 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization
JP6197039B2 (ja) 2012-08-24 2017-09-13 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ ハイスループット多重検出用システム、装置及び方法
CN104870092A (zh) 2012-11-29 2015-08-26 皇家飞利浦有限公司 用于样本的摄取和处理的盒
US10248765B1 (en) 2012-12-05 2019-04-02 Theranos Ip Company, Llc Systems, devices, and methods for bodily fluid sample collection, transport, and handling
US9386948B2 (en) 2012-12-05 2016-07-12 Theranos, Inc. Systems, devices, and methods for bodily fluid sample transport
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
KR102060831B1 (ko) * 2013-02-27 2019-12-30 삼성전자주식회사 플립 칩 패키징 방법, 그리고 상기 플립 칩 패키징 방법에 적용되는 플럭스 헤드 및 그 제조 방법
AU2014249190C1 (en) * 2013-03-11 2021-11-18 Meso Scale Technologies, Llc. Improved methods for conducting multiplexed assays
EP3462174B1 (en) 2013-03-15 2021-12-29 Arizona Board of Regents on behalf of Arizona State University Biosensor microarray compositions and methods
US20140323911A1 (en) * 2013-03-15 2014-10-30 Theranos, Inc. Methods and devices for sample collection and sample separation
US10094762B2 (en) * 2013-05-30 2018-10-09 UNIVERSITé LAVAL Patterned capillary device and process for fabricating thereof
KR101428977B1 (ko) 2013-06-14 2014-08-13 케이맥(주) 미세유체 분석장치
US9857370B2 (en) 2013-07-22 2018-01-02 National Technology & Engineering Solutions Of Sandia, Llc Amplification of biological targets via on-chip culture for biosensing
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US11091758B2 (en) 2013-12-11 2021-08-17 The Regents Of The University Of California Methods for labeling DNAa fragments to reconstruct physical linkage and phase
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US9957554B1 (en) 2013-12-19 2018-05-01 National Technology & Engineering Solutions Of Sandia, Llc Microfluidic platform for multiplexed detection in single cells and methods thereof
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
US9995411B1 (en) 2014-07-16 2018-06-12 National Technology & Engineering Solutions Of Sandia, Llc High-temperature, adhesive-based microvalves and uses thereof
US9636675B2 (en) 2014-11-26 2017-05-02 International Business Machines Corporation Pillar array structure with uniform and high aspect ratio nanometer gaps
WO2016090148A1 (en) 2014-12-03 2016-06-09 IsoPlexis Corporation Analysis and screening of cell secretion profiles
US11353448B2 (en) 2015-02-13 2022-06-07 California Institute Of Technology Methods and compositions for quantifying metabolites and proteins from single cells
WO2016196691A2 (en) * 2015-06-01 2016-12-08 California Institute Of Technology Compositions and methods for screening t cells with antigens for specific populations
WO2016209775A1 (en) * 2015-06-20 2016-12-29 The Regents Of The University Of California Monocyte integrin based microfluidic assay for evaluating coronary diseases
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US11247208B2 (en) 2015-09-09 2022-02-15 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
US10498171B2 (en) * 2015-10-12 2019-12-03 Avago Technologies International Sales Pte. Limited Wireless power receiver voltage control enabling simultaneous communications to transmitter in over-voltage state
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US10386351B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using gas species diffusion
US11988662B2 (en) 2015-12-07 2024-05-21 Nanohmics, Inc. Methods for detecting and quantifying gas species analytes using differential gas species diffusion
US10386365B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using ionic species diffusion
JP2019528810A (ja) 2016-07-07 2019-10-17 ヴァンダービルト ユニヴァーシティ 疾患材料の検出、捕捉、または除去のための流体デバイス
CN109964126B (zh) 2016-09-12 2022-12-27 伊索普莱克西斯公司 用于细胞治疗法和其他免疫治疗法的多重分析的系统和方法
WO2018058085A1 (en) * 2016-09-26 2018-03-29 The Johns Hopkins University Non-invasive cancer detection and analysis by single-molecule imaging
DK3538891T3 (da) 2016-11-11 2022-03-28 Isoplexis Corp Sammensætninger og fremgangsmåder til samtidig genomisk, transkriptomisk og proteomisk analyse af enkeltceller
US11525783B2 (en) 2016-11-22 2022-12-13 IsoPlexis Corporation Systems, devices and methods for cell capture and methods of manufacture thereof
WO2018148700A1 (en) 2017-02-13 2018-08-16 Yale University High-throughput single-cell polyomics
US10850276B2 (en) * 2017-02-24 2020-12-01 VisuGen Global LLC Systems and methods for capture and detection of low copy targets from large sample volumes
WO2018156855A1 (en) * 2017-02-24 2018-08-30 VisuGen Global LLC Systems and methods for capture and detection of low copy targets from large sample volumes
US12258613B2 (en) 2017-03-08 2025-03-25 California Institute Of Technology Pairing antigen specificity of a T cell with T cell receptor sequences
US11857966B1 (en) 2017-03-15 2024-01-02 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
WO2018183969A1 (en) * 2017-03-30 2018-10-04 California Institute Of Technology Barcoded rapid assay platform for efficient analysis of candidate molecules and methods of making and using the platform
WO2018194700A1 (en) 2017-04-20 2018-10-25 Hewlett-Packard Development Company, L.P. Microfluidic reaction system
CN111566261B (zh) 2017-08-18 2025-03-25 诺迪勒思附属公司 选择结合试剂的方法
ES2702432B2 (es) 2017-08-31 2019-08-05 Venegas Pedro Manuel Medina Método y dispositivo para el análisis de ácidos nucleicos
KR101906969B1 (ko) 2017-09-15 2018-10-11 삼성전자주식회사 유전자 분석장치 및 이를 이용한 유전자 분석방법
WO2019075321A1 (en) 2017-10-13 2019-04-18 The Charles Stark Draper Laboratory, Inc. MINIATURIZED DNA MICROARRAY FOR SMALL VOLUME SAMPLE PROCESSING
WO2019136289A1 (en) 2018-01-05 2019-07-11 Path Ex, Inc. Device for the capture and removal of disease material from fluids
WO2019147714A1 (en) * 2018-01-23 2019-08-01 Shield Diagnostics Corp. Microfluidic microarray devices and methods
CN108588284B (zh) * 2018-05-10 2022-06-10 山东师范大学 基于酶催化可控自组装生物条码检测htlv-ii dna的方法
EP3884048A4 (en) 2018-11-20 2022-08-17 Nautilus Biotechnology, Inc. DESIGN AND SELECTION OF AFFINITY REAGENTS
CN109387641B (zh) * 2018-12-20 2022-04-15 深圳职业技术学院 一种以磁性氧化铁纳米粒子为信号放大器检测天蚕素b的装置及检测方法
WO2020175381A1 (ja) * 2019-02-27 2020-09-03 京セラ株式会社 粒子分離計測デバイスおよび粒子分離計測装置
CN109985673B (zh) * 2019-04-01 2024-07-12 融智生物科技（青岛）有限公司 微流控芯片
CN110026258B (zh) * 2019-04-26 2023-11-28 珠海市迪奇孚瑞生物科技有限公司 基于数字微流控芯片的检测电路、装置及dna或rna检测装置
CA3135206A1 (en) 2019-04-29 2020-11-05 Pierre Indermuhle Methods and systems for integrated on-chip single-molecule detection
AU2020357801A1 (en) 2019-09-30 2022-04-14 Yale University Deterministic Barcoding for spatial omics sequencing
US11130994B2 (en) * 2019-12-13 2021-09-28 Autonomous Medical Devices Inc. Automated, cloud-based, point-of-care (POC) pathogen and antibody array detection system and method
CN116569042A (zh) * 2020-12-09 2023-08-08 贝克顿迪金森公司 多重化的单细胞免疫测定
WO2022178253A1 (en) 2021-02-19 2022-08-25 IsoPlexis Corporation Methods and devices for spatially resolved analysis of proteomic and genetic information
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
CN113125739B (zh) * 2021-04-16 2022-07-26 杭州浙大迪迅生物基因工程有限公司 一种荧光芯片定量检测试剂盒
US20220341850A1 (en) * 2021-04-23 2022-10-27 Poppy Health, Inc. System and method for characterizing, monitoring, & detecting bioaerosol presence & movement in an indoor environment
US12181401B2 (en) 2021-12-07 2024-12-31 Poppy Health, Inc. Tracer detection system and method for characterizing effectiveness of air removal in an aerosol zone
SE546452C2 (en) * 2022-11-29 2024-11-05 Elfscience AB In vitro detection method and device
US12415172B2 (en) 2022-12-22 2025-09-16 Synthego Corporation Systems and method for automated oligonucleotide synthesis
US20250377354A1 (en) * 2024-06-06 2025-12-11 Nautilus Subsidiary, Inc. Analyte characterization by differential binding of binding reagents

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6943034B1 (en) * 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US6632436B2 (en) * 1996-01-25 2003-10-14 Genitrix Llc Vaccine compositions and method of modulating immune responses
US6165739A (en) 1996-03-13 2000-12-26 Compucyte Corporation Multiple simultaneous testing media
US6039897A (en) * 1996-08-28 2000-03-21 University Of Washington Multiple patterned structures on a single substrate fabricated by elastomeric micro-molding techniques
US6924153B1 (en) * 1997-03-06 2005-08-02 Quidel Corporation Quantitative lateral flow assays and devices
US5858801A (en) * 1997-03-13 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Patterning antibodies on a surface
AU730827B2 (en) * 1997-06-09 2001-03-15 Caliper Technologies Corporation Apparatus and methods for correcting for variable velocity in microfluidic systems
US20030096232A1 (en) * 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6316193B1 (en) * 1998-10-06 2001-11-13 Origene Technologies, Inc. Rapid-screen cDNA library panels
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6875619B2 (en) * 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US20020090649A1 (en) * 1999-12-15 2002-07-11 Tony Chan High density column and row addressable electrode arrays
US6699665B1 (en) 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
AU2002241602A1 (en) * 2000-11-16 2002-06-11 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
JP2002236131A (ja) * 2000-12-08 2002-08-23 Minolta Co Ltd マイクロチップ
US20020100714A1 (en) * 2001-01-31 2002-08-01 Sau Lan Tang Staats Microfluidic devices
US20020168640A1 (en) * 2001-02-22 2002-11-14 Min Li Biochips comprising nucleic acid/protein conjugates
AU2002307090A1 (en) * 2001-04-03 2002-10-21 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
DE10127221A1 (de) * 2001-05-23 2002-11-28 Lifebits Ag Träger für chemische, biochemische und biologische Substanzen
US7473767B2 (en) * 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US7023007B2 (en) * 2001-07-17 2006-04-04 Caliper Life Sciences, Inc. Methods and systems for alignment of detection optics
US10539561B1 (en) * 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
JP4191608B2 (ja) * 2001-12-05 2008-12-03 ユニヴァーシティ オブ ワシントン 固相アフィニティー結合アッセイのための、微小流体デバイスおよび表面修飾プロセス
US20030190689A1 (en) * 2002-04-05 2003-10-09 Cell Signaling Technology,Inc. Molecular profiling of disease and therapeutic response using phospho-specific antibodies
AU2002952384A0 (en) * 2002-10-31 2002-11-14 Swinburne University Of Technology Structures
JP2004354364A (ja) * 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
DE10305050A1 (de) * 2003-02-07 2004-08-19 Roche Diagnostics Gmbh Analytisches Testelement und Verfahren für Blutuntersuchungen
JP2006518469A (ja) * 2003-02-19 2006-08-10 シンセリカ・コーポレイション 代替抗体の集合を用いてスクリーニングするための組成物及び方法
US7452678B2 (en) * 2003-06-24 2008-11-18 Bristol-Myers Squibb Company Identification of biomarkers for liver toxicity
CA2531281A1 (en) * 2003-07-03 2005-01-27 Gentron, Llc Methods and systems for diagnosis of non-central nervous system (cns) diseases in cns samples
US20050277125A1 (en) * 2003-10-27 2005-12-15 Massachusetts Institute Of Technology High-density reaction chambers and methods of use
US7981362B2 (en) * 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
WO2005046859A2 (en) * 2003-11-12 2005-05-26 Bio-Rad Haifa Ltd. System and method for carrying out multiple binding reactions in an array format
WO2005081867A2 (en) * 2004-02-20 2005-09-09 The Regents Of The University Of C Alifornia Salivary mrna profiling, biomarkers, and related methods and kits of parts
JP4850061B2 (ja) * 2004-03-18 2012-01-11 日水製薬株式会社 抗原の分析装置の製造方法及び分析装置
CN1296492C (zh) 2004-11-18 2007-01-24 博奥生物有限公司 一种基于生物芯片检测能结合特异序列的核酸结合蛋白的方法
WO2006079049A2 (en) * 2005-01-21 2006-07-27 Third Wave Technologies, Inc. Methods and compositions for increased dynamic range detection of nucleic acid molecules
GB0508983D0 (en) * 2005-05-03 2005-06-08 Oxford Gene Tech Ip Ltd Cell analyser
EP1888790A2 (en) * 2005-05-06 2008-02-20 The Regents of the University of California Microfluidic system for identifying or sizing individual particles passing through a channel
US20060263818A1 (en) * 2005-05-23 2006-11-23 Axel Scherer High throughput multi-antigen microfluidic fluorescence immunoassays
JP2006329767A (ja) * 2005-05-25 2006-12-07 Aisin Seiki Co Ltd 試料分析装置
JP2009501938A (ja) * 2005-07-18 2009-01-22 ユー．エス． ジェノミクス， インコーポレイテッド サンプルの調製および分析のための微小流動による方法および微小流動装置
CA2616404A1 (en) 2005-07-26 2007-02-01 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
US20070074972A1 (en) * 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
US7776553B2 (en) 2005-09-16 2010-08-17 Presidents And Fellows Of Harvard College Screening assays and methods
US20070122819A1 (en) * 2005-11-25 2007-05-31 Industrial Technology Research Institute Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same
KR101489804B1 (ko) 2005-12-21 2015-02-05 메소 스케일 테크놀러지즈, 엘엘시 분석 시약을 갖는 분석 모듈 및 그것의 제조 및 사용 방법
AU2007212306A1 (en) * 2006-02-07 2007-08-16 Wafergen, Inc. Temperature-regulated culture plates
WO2008016680A1 (en) 2006-08-02 2008-02-07 California Institute Of Technology Methods and systems for detecting and/or sorting targets
US7863035B2 (en) * 2007-02-15 2011-01-04 Osmetech Technology Inc. Fluidics devices
WO2009012343A2 (en) 2007-07-16 2009-01-22 California Institute Of Technology Arrays, substrates, devices, methods and systems for detecting target molecules
JP6197039B2 (ja) 2012-08-24 2017-09-13 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ ハイスループット多重検出用システム、装置及び方法
US9824870B1 (en) * 2014-04-29 2017-11-21 The United States Of America As Represented By The Administrator Of Nasa Portable medical diagnosis instrument

Similar Documents

Publication Publication Date Title
JP2010533869A5 (enExample)
JP2017522546A5 (enExample)
JP2009517212A5 (enExample)
WO2009008925A3 (en) A particle-based microfluidic device for providing high magnetic field gradients
WO2010054032A3 (en) Apparatus and method using rotary flow distribution mechanisms
JP2011505118A5 (enExample)
EP2845921A3 (en) Method of and apparatus for multiple channel flow ratio controller system
WO2011129651A3 (ko) 미세유체장치 및 이것을 이용한 타깃의 분리방법
EP2197578A4 (en) METHOD FOR PRODUCING MULTICOMPONENT BISMUTMOLYBDATE CATALYSTS WITH FOUR METAL COMPONENTS AND METHOD FOR PRODUCING 1,3-BUTADIENES USING THE CATALYSTS
WO2006009724A3 (en) Microfluidic devices for fluid manipulation and analysis
JP2010008113A5 (enExample)
WO2008121229A3 (en) Method and apparatus for concentrating molecules
WO2012141880A3 (en) Selectively variable flow restrictor for use in a subterranean well
DE112009001760A5 (de) Vorrichtung zum separieren von Partikeln in und aus Flüssigkeiten und deren Anwendung in Biotechnologie, biologischer Forschung, Diagnostik und Krankheitsbehandlung
JP2009258118A5 (enExample)
JP2011502741A5 (enExample)
WO2009072003A3 (en) Sample processing system and methods
DK2189174T3 (da) Fremgangsmåde til administration af lægemiddel
WO2008011486A3 (en) Detection or isolation of target molecules using a microchannel apparatus
WO2007143540A3 (en) Devices and methods for positioning dried reagent in microfluidic devices
JP2018528391A5 (enExample)
JP2009501938A5 (enExample)
RU2016139341A (ru) Входной канал детектора и способ взятия проб
ATE531592T1 (de) Entlüfter mit hydraulischem flüssigkeitssystem mit unabhängigen einlass-/auslassströmungswegen
WO2009092784A3 (en) Apparatus and method for distributing a plurality of fluid flows through a plurality of chambers, particularly for carrying out adsorption processes.