JP2010533869A5 - - Google Patents

Download PDF

Info

Publication number
JP2010533869A5
JP2010533869A5 JP2010517146A JP2010517146A JP2010533869A5 JP 2010533869 A5 JP2010533869 A5 JP 2010533869A5 JP 2010517146 A JP2010517146 A JP 2010517146A JP 2010517146 A JP2010517146 A JP 2010517146A JP 2010533869 A5 JP2010533869 A5 JP 2010533869A5
Authority
JP
Japan
Prior art keywords
channel
microfluidic device
plasma separation
microfluidic
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010517146A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010533869A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/070232 external-priority patent/WO2009012340A2/en
Publication of JP2010533869A publication Critical patent/JP2010533869A/ja
Publication of JP2010533869A5 publication Critical patent/JP2010533869A5/ja
Pending legal-status Critical Current

Links

JP2010517146A 2007-07-16 2008-07-16 標的分子を検出するためのマイクロ流体装置、方法及びシステム Pending JP2010533869A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95966607P 2007-07-16 2007-07-16
US99898107P 2007-10-15 2007-10-15
PCT/US2008/070232 WO2009012340A2 (en) 2007-07-16 2008-07-16 Microfluidic devices, methods and systems for detecting target molecules

Publications (2)

Publication Number Publication Date
JP2010533869A JP2010533869A (ja) 2010-10-28
JP2010533869A5 true JP2010533869A5 (cg-RX-API-DMAC7.html) 2011-09-01

Family

ID=40260363

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010517146A Pending JP2010533869A (ja) 2007-07-16 2008-07-16 標的分子を検出するためのマイクロ流体装置、方法及びシステム
JP2010517148A Pending JP2010533871A (ja) 2007-07-16 2008-07-16 標的分子を検出するためのアレイ、基板、装置、方法、及び、システム

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010517148A Pending JP2010533871A (ja) 2007-07-16 2008-07-16 標的分子を検出するためのアレイ、基板、装置、方法、及び、システム

Country Status (6)

Country Link
US (6) US20090036324A1 (cg-RX-API-DMAC7.html)
EP (3) EP2167634A4 (cg-RX-API-DMAC7.html)
JP (2) JP2010533869A (cg-RX-API-DMAC7.html)
AU (2) AU2008276024A1 (cg-RX-API-DMAC7.html)
CA (2) CA2694545C (cg-RX-API-DMAC7.html)
WO (2) WO2009012343A2 (cg-RX-API-DMAC7.html)

Families Citing this family (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
CA2636855C (en) 2006-01-11 2016-09-27 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US8460879B2 (en) * 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
ATE540750T1 (de) 2006-05-11 2012-01-15 Raindance Technologies Inc Mikrofluidische vorrichtung und verfahren
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
CA2659745A1 (en) * 2006-08-02 2008-02-07 California Institute Of Technology Methods and systems for detecting and/or sorting targets
US8394590B2 (en) * 2006-08-02 2013-03-12 California Institute Of Technology Capture agents and related methods and systems for detecting and/or sorting targets
EP3536396B1 (en) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
AU2008276024A1 (en) * 2007-07-16 2009-01-22 California Institute Of Technology Microfluidic devices, methods and systems for detecting target molecules
US8380457B2 (en) 2007-08-29 2013-02-19 Canon U.S. Life Sciences, Inc. Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes
US8306773B2 (en) * 2007-08-29 2012-11-06 Canon U.S. Life Sciences, Inc. Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes
US9221056B2 (en) * 2007-08-29 2015-12-29 Canon U.S. Life Sciences, Inc. Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes
EP2201374B1 (en) 2007-08-30 2015-10-07 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
JP5163999B2 (ja) * 2007-11-14 2013-03-13 国立大学法人富山大学 類似植物体および生薬同定用dnaマイクロアレイ
CN102112626A (zh) * 2008-04-09 2011-06-29 加州理工学院 用于检测和/或分类靶标的捕获剂以及相关方法和系统
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP2315629B1 (en) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Droplet libraries
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
WO2010036912A2 (en) * 2008-09-26 2010-04-01 The General Hospital Corporation Capturing particles
JP2012510635A (ja) * 2008-12-02 2012-05-10 カリフォルニア インスティチュート オブ テクノロジー 電源内蔵式マイクロ流体の装置、方法およびシステム
EP2389585A2 (en) * 2009-01-22 2011-11-30 Li-Cor, Inc. Single molecule proteomics with dynamic probes
US9739771B2 (en) 2009-02-27 2017-08-22 Yale University Physiologic sample preparation for nanosensors
WO2010099318A1 (en) * 2009-02-27 2010-09-02 Yale University Physiologic sample preparation for nanosensors
EP3415235B1 (en) 2009-03-23 2025-11-12 Bio-Rad Laboratories, Inc. Manipulation of microfluidic droplets
US20100279882A1 (en) * 2009-05-01 2010-11-04 Mostafa Ronaghi Sequencing methods
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
WO2013134744A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc Microfluidic assay assemblies and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
WO2011063408A1 (en) 2009-11-23 2011-05-26 Cyvek, Inc. Method and apparatus for performing assays
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
CA2789425C (en) 2010-02-12 2020-04-28 Raindance Technologies, Inc. Digital analyte analysis with polymerase error correction
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
JP5729651B2 (ja) 2010-02-23 2015-06-03 ゴードン アトウッド,クリストファー 生体分子及びその相互作用特性の検出方法
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
WO2011109379A1 (en) 2010-03-01 2011-09-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8614056B2 (en) 2010-03-24 2013-12-24 The Board Of Trustees Of The Leland Stanford Junior University Microfluidic method for measurement or detection involving cells or biomolecules
JP2011221009A (ja) * 2010-03-25 2011-11-04 Fujifilm Corp 生体物質検出装置
KR101152791B1 (ko) * 2010-05-10 2012-06-12 광주과학기술원 쯔바이파흐-풍 효과를 이용한 세포 발열량 측정 센서 및 이의 제조방법
IT1400868B1 (it) * 2010-06-23 2013-07-02 Torino Politecnico Dispositivo microfluidico integrato per la purificazione, amplificazione e rivelazione di acidi nucleici per la diagnostica
US9188593B2 (en) 2010-07-16 2015-11-17 The University Of British Columbia Methods for assaying cellular binding interactions
WO2012045012A2 (en) * 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
US20120258881A1 (en) 2010-11-22 2012-10-11 The University Of Chicago Methods and/or Use of Oligonucleotide Conjugates for Assays and Microscopy/Imaging Detections
USD650090S1 (en) * 2011-01-18 2011-12-06 Zach Odeh Microfluidic device
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
EP3859011A1 (en) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Methods for forming mixed droplets
EP3736281A1 (en) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
CN103649759B (zh) * 2011-03-22 2016-08-31 西维克公司 微流体装置以及制造方法和用途
US9252175B2 (en) 2011-03-23 2016-02-02 Nanohmics, Inc. Method for assembly of spectroscopic filter arrays using biomolecules
US9828696B2 (en) 2011-03-23 2017-11-28 Nanohmics, Inc. Method for assembly of analyte filter arrays using biomolecules
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
USD650091S1 (en) * 2011-04-19 2011-12-06 Zach Odeh Microfluidic device
USD650911S1 (en) * 2011-04-19 2011-12-20 Zach Odeh Microfluidic device
US8946389B2 (en) 2011-04-25 2015-02-03 University Of Washington Compositions and methods for multiplex biomarker profiling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
DE202012013668U1 (de) 2011-06-02 2019-04-18 Raindance Technologies, Inc. Enzymquantifizierung
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013060482A1 (de) * 2011-10-28 2013-05-02 Torsten Matthias Vorrichtung und verfahren zum nachweis von in biologischen oder chemischen proben vorliegenden substanzen
US10145842B2 (en) 2012-04-11 2018-12-04 Quidel Cardiovascular Inc. Microfluidic device, system and method
WO2013177046A1 (en) 2012-05-21 2013-11-28 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization
EP4148118A1 (en) * 2012-08-24 2023-03-15 Yale University System, device and method for high-throughput multi-plexed detection
WO2014083496A1 (en) 2012-11-29 2014-06-05 Koninklijke Philips N.V. Cartridge for uptake and processing of a sample
US10248765B1 (en) 2012-12-05 2019-04-02 Theranos Ip Company, Llc Systems, devices, and methods for bodily fluid sample collection, transport, and handling
US9386948B2 (en) 2012-12-05 2016-07-12 Theranos, Inc. Systems, devices, and methods for bodily fluid sample transport
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
KR102060831B1 (ko) * 2013-02-27 2019-12-30 삼성전자주식회사 플립 칩 패키징 방법, 그리고 상기 플립 칩 패키징 방법에 적용되는 플럭스 헤드 및 그 제조 방법
CA3153763A1 (en) 2013-03-11 2014-10-09 Meso Scale Technologies, Llc. Improved methods for conducting multiplexed assays
US20140323911A1 (en) * 2013-03-15 2014-10-30 Theranos, Inc. Methods and devices for sample collection and sample separation
US10983118B2 (en) * 2013-03-15 2021-04-20 Arizona Board Of Regents On Behalf Of Arizona State University Biosensor microarray compositions and methods
US10094762B2 (en) * 2013-05-30 2018-10-09 UNIVERSITé LAVAL Patterned capillary device and process for fabricating thereof
KR101428977B1 (ko) 2013-06-14 2014-08-13 케이맥(주) 미세유체 분석장치
US9857370B2 (en) 2013-07-22 2018-01-02 National Technology & Engineering Solutions Of Sandia, Llc Amplification of biological targets via on-chip culture for biosensing
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
EP3080605B1 (en) 2013-12-11 2019-02-20 The Regents of the University of California Method for labeling dna fragments to reconstruct physical linkage and phase
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US9957554B1 (en) 2013-12-19 2018-05-01 National Technology & Engineering Solutions Of Sandia, Llc Microfluidic platform for multiplexed detection in single cells and methods thereof
EP3090063B1 (en) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Method for detection of latent retrovirus
US9995411B1 (en) 2014-07-16 2018-06-12 National Technology & Engineering Solutions Of Sandia, Llc High-temperature, adhesive-based microvalves and uses thereof
US9636675B2 (en) 2014-11-26 2017-05-02 International Business Machines Corporation Pillar array structure with uniform and high aspect ratio nanometer gaps
EP3227684B1 (en) * 2014-12-03 2019-10-02 Isoplexis Corporation Analysis and screening of cell secretion profiles
US11353448B2 (en) 2015-02-13 2022-06-07 California Institute Of Technology Methods and compositions for quantifying metabolites and proteins from single cells
CA2986072C (en) * 2015-06-01 2023-05-02 California Institute Of Technology Compositions and methods for screening t cells with antigens for specific populations
WO2016209775A1 (en) * 2015-06-20 2016-12-29 The Regents Of The University Of California Monocyte integrin based microfluidic assay for evaluating coronary diseases
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
WO2017044888A1 (en) 2015-09-09 2017-03-16 Theranos, Inc. Methods and devices for sample collection and sample separation
US10498171B2 (en) * 2015-10-12 2019-12-03 Avago Technologies International Sales Pte. Limited Wireless power receiver voltage control enabling simultaneous communications to transmitter in over-voltage state
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US11988662B2 (en) 2015-12-07 2024-05-21 Nanohmics, Inc. Methods for detecting and quantifying gas species analytes using differential gas species diffusion
US10386351B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using gas species diffusion
US10386365B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using ionic species diffusion
JP2019528810A (ja) * 2016-07-07 2019-10-17 ヴァンダービルト ユニヴァーシティ 疾患材料の検出、捕捉、または除去のための流体デバイス
CN109964126B (zh) 2016-09-12 2022-12-27 伊索普莱克西斯公司 用于细胞治疗法和其他免疫治疗法的多重分析的系统和方法
US20190308190A1 (en) * 2016-09-26 2019-10-10 The Johns Hopkins University Non-invasive cancer detection and analysis by single-molecule imaging
JP7348066B2 (ja) 2016-11-11 2023-09-20 アイソプレキシス コーポレイション 単一細胞のゲノム、トランスクリプトームおよびプロテオームの同時解析のための組成物および方法
WO2018098372A1 (en) 2016-11-22 2018-05-31 IsoPlexis Corporation Systems, devices and methods for cell capture and methods of manufacture thereof
WO2018148700A1 (en) 2017-02-13 2018-08-16 Yale University High-throughput single-cell polyomics
WO2018156855A1 (en) * 2017-02-24 2018-08-30 VisuGen Global LLC Systems and methods for capture and detection of low copy targets from large sample volumes
US10850276B2 (en) * 2017-02-24 2020-12-01 VisuGen Global LLC Systems and methods for capture and detection of low copy targets from large sample volumes
US12258613B2 (en) 2017-03-08 2025-03-25 California Institute Of Technology Pairing antigen specificity of a T cell with T cell receptor sequences
US11857966B1 (en) 2017-03-15 2024-01-02 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
WO2018183969A1 (en) * 2017-03-30 2018-10-04 California Institute Of Technology Barcoded rapid assay platform for efficient analysis of candidate molecules and methods of making and using the platform
WO2018194700A1 (en) 2017-04-20 2018-10-25 Hewlett-Packard Development Company, L.P. Microfluidic reaction system
WO2019036055A2 (en) 2017-08-18 2019-02-21 Ignite Biosciences, Inc. METHODS OF SELECTING BINDING REAGENTS
ES2702432B2 (es) 2017-08-31 2019-08-05 Venegas Pedro Manuel Medina Método y dispositivo para el análisis de ácidos nucleicos
KR101906969B1 (ko) 2017-09-15 2018-10-11 삼성전자주식회사 유전자 분석장치 및 이를 이용한 유전자 분석방법
US11890620B2 (en) 2017-10-13 2024-02-06 The Charles Stark Draper Laboratory, Inc. Miniaturized DNA microarray for small-volume sample processing
CA3086405A1 (en) 2018-01-05 2019-07-11 Path Ex, Inc. Device for the capture and removal of disease material from fluids
WO2019147714A1 (en) * 2018-01-23 2019-08-01 Shield Diagnostics Corp. Microfluidic microarray devices and methods
CN108588284B (zh) * 2018-05-10 2022-06-10 山东师范大学 基于酶催化可控自组装生物条码检测htlv-ii dna的方法
JP2022513092A (ja) 2018-11-20 2022-02-07 ノーティラス・バイオテクノロジー・インコーポレイテッド 親和性試薬の設計および選択
CN109387641B (zh) * 2018-12-20 2022-04-15 深圳职业技术学院 一种以磁性氧化铁纳米粒子为信号放大器检测天蚕素b的装置及检测方法
CN113498362B (zh) * 2019-02-27 2023-01-20 京瓷株式会社 粒子分离测量设备以及粒子分离测量装置
CN109985673B (zh) * 2019-04-01 2024-07-12 融智生物科技(青岛)有限公司 微流控芯片
CN110026258B (zh) * 2019-04-26 2023-11-28 珠海市迪奇孚瑞生物科技有限公司 基于数字微流控芯片的检测电路、装置及dna或rna检测装置
WO2020223368A1 (en) 2019-04-29 2020-11-05 Nautilus Biotechnology, Inc. Methods and systems for integrated on-chip single-molecule detection
CN114787348B (zh) 2019-09-30 2025-09-19 耶鲁大学 用于空间组学测序的确定性条形码
US11130994B2 (en) 2019-12-13 2021-09-28 Autonomous Medical Devices Inc. Automated, cloud-based, point-of-care (POC) pathogen and antibody array detection system and method
WO2022125701A1 (en) * 2020-12-09 2022-06-16 Becton, Dickinson And Company Multiplexed single cell immunoassay
WO2022178253A1 (en) 2021-02-19 2022-08-25 IsoPlexis Corporation Methods and devices for spatially resolved analysis of proteomic and genetic information
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
CN113125739B (zh) * 2021-04-16 2022-07-26 杭州浙大迪迅生物基因工程有限公司 一种荧光芯片定量检测试剂盒
US20220341850A1 (en) * 2021-04-23 2022-10-27 Poppy Health, Inc. System and method for characterizing, monitoring, & detecting bioaerosol presence & movement in an indoor environment
US12181401B2 (en) 2021-12-07 2024-12-31 Poppy Health, Inc. Tracer detection system and method for characterizing effectiveness of air removal in an aerosol zone
SE546452C2 (en) * 2022-11-29 2024-11-05 Elfscience AB In vitro detection method and device
WO2024137514A1 (en) 2022-12-22 2024-06-27 Synthego Corporation Systems and method for automated oligonucleotide synthesis
US20250377354A1 (en) * 2024-06-06 2025-12-11 Nautilus Subsidiary, Inc. Analyte characterization by differential binding of binding reagents

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6943034B1 (en) * 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US6632436B2 (en) * 1996-01-25 2003-10-14 Genitrix Llc Vaccine compositions and method of modulating immune responses
US6165739A (en) 1996-03-13 2000-12-26 Compucyte Corporation Multiple simultaneous testing media
US6039897A (en) * 1996-08-28 2000-03-21 University Of Washington Multiple patterned structures on a single substrate fabricated by elastomeric micro-molding techniques
US6924153B1 (en) * 1997-03-06 2005-08-02 Quidel Corporation Quantitative lateral flow assays and devices
US5858801A (en) * 1997-03-13 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Patterning antibodies on a surface
WO1998056956A1 (en) * 1997-06-09 1998-12-17 Caliper Technologies Corporation Apparatus and methods for correcting for variable velocity in microfluidic systems
US20030096232A1 (en) * 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6316193B1 (en) * 1998-10-06 2001-11-13 Origene Technologies, Inc. Rapid-screen cDNA library panels
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6875619B2 (en) * 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US20020090649A1 (en) * 1999-12-15 2002-07-11 Tony Chan High density column and row addressable electrode arrays
US6699665B1 (en) 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
WO2002044695A1 (en) * 2000-11-16 2002-06-06 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
JP2002236131A (ja) * 2000-12-08 2002-08-23 Minolta Co Ltd マイクロチップ
US20020100714A1 (en) * 2001-01-31 2002-08-01 Sau Lan Tang Staats Microfluidic devices
US20020168640A1 (en) * 2001-02-22 2002-11-14 Min Li Biochips comprising nucleic acid/protein conjugates
WO2002080647A2 (en) * 2001-04-03 2002-10-17 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
DE10127221A1 (de) * 2001-05-23 2002-11-28 Lifebits Ag Träger für chemische, biochemische und biologische Substanzen
US7473767B2 (en) * 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US7023007B2 (en) * 2001-07-17 2006-04-04 Caliper Life Sciences, Inc. Methods and systems for alignment of detection optics
US10539561B1 (en) * 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
EP1461606A4 (en) * 2001-12-05 2005-06-29 Univ Washington MICROFLUIDIC DEVICE AND SURFACE DECORATION PROCESS FOR SOLID PHASE AFFINITY BINDING ASSAYS
US20030190689A1 (en) * 2002-04-05 2003-10-09 Cell Signaling Technology,Inc. Molecular profiling of disease and therapeutic response using phospho-specific antibodies
AU2002952384A0 (en) * 2002-10-31 2002-11-14 Swinburne University Of Technology Structures
JP2004354364A (ja) * 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
DE10305050A1 (de) * 2003-02-07 2004-08-19 Roche Diagnostics Gmbh Analytisches Testelement und Verfahren für Blutuntersuchungen
EP1594992A2 (en) * 2003-02-19 2005-11-16 Syntherica Corporation Comositions and methods for screening using populations of surrogate antibodies
US7452678B2 (en) * 2003-06-24 2008-11-18 Bristol-Myers Squibb Company Identification of biomarkers for liver toxicity
WO2005007892A1 (en) * 2003-07-03 2005-01-27 Gentron, Llc Methods and systems for diagnosis of non-cenral nervous system (cns) diseases in cns samples
WO2005043154A2 (en) * 2003-10-27 2005-05-12 Massachusetts Institute Of Technology High density reaction chambers and methods of use
US7981362B2 (en) * 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
EP1682261B1 (en) * 2003-11-12 2012-08-15 BIO-RAD Haifa Ltd. Method for carrying out multiple binding reactions in an array format
KR20070004725A (ko) * 2004-02-20 2007-01-09 더 리전츠 오브 더 유니버시티 오브 캘리포니아 타액 mRNA 프로파일링, 생물 마커 및 관련 방법 및부품 키트
JP4850061B2 (ja) * 2004-03-18 2012-01-11 日水製薬株式会社 抗原の分析装置の製造方法及び分析装置
CN1296492C (zh) 2004-11-18 2007-01-24 博奥生物有限公司 一种基于生物芯片检测能结合特异序列的核酸结合蛋白的方法
JP2008533974A (ja) * 2005-01-21 2008-08-28 サード・ウェーブ・テクノロジーズ・インク 核酸分子の増大したダイナミックレンジ検出のための組成物および方法
GB0508983D0 (en) * 2005-05-03 2005-06-08 Oxford Gene Tech Ip Ltd Cell analyser
US20060286549A1 (en) * 2005-05-06 2006-12-21 The Regents Of The University Of California Microfluidic system for identifying or sizing individual particles passing through a channel
US20060263818A1 (en) * 2005-05-23 2006-11-23 Axel Scherer High throughput multi-antigen microfluidic fluorescence immunoassays
JP2006329767A (ja) * 2005-05-25 2006-12-07 Aisin Seiki Co Ltd 試料分析装置
EP1904653A4 (en) * 2005-07-18 2010-04-14 Us Genomics Inc MICROFLUIDIC PROCESSES AND DEVICES FOR PREPARING AND ANALYZING SAMPLES
US20080220982A1 (en) 2005-07-26 2008-09-11 Vu Tania Q Nanoparticle Probes for Capture, Sorting and Placement of Targets
WO2007033385A2 (en) * 2005-09-13 2007-03-22 Fluidigm Corporation Microfluidic assay devices and methods
WO2007035633A2 (en) 2005-09-16 2007-03-29 President & Fellows Of Harvard College Screening assays and methods
US20070122819A1 (en) * 2005-11-25 2007-05-31 Industrial Technology Research Institute Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same
CN101389960B (zh) 2005-12-21 2013-03-27 梅索斯卡莱科技公司 具有分析试剂的分析模块及其制备和使用方法
US20100009335A1 (en) * 2006-02-07 2010-01-14 Victor Joseph Temperature-regulated culture plates
CA2659745A1 (en) * 2006-08-02 2008-02-07 California Institute Of Technology Methods and systems for detecting and/or sorting targets
WO2008101196A1 (en) * 2007-02-15 2008-08-21 Osmetech Molecular Diagnostics Fluidics devices
AU2008276024A1 (en) * 2007-07-16 2009-01-22 California Institute Of Technology Microfluidic devices, methods and systems for detecting target molecules
EP4148118A1 (en) 2012-08-24 2023-03-15 Yale University System, device and method for high-throughput multi-plexed detection
US9824870B1 (en) * 2014-04-29 2017-11-21 The United States Of America As Represented By The Administrator Of Nasa Portable medical diagnosis instrument

Similar Documents

Publication Publication Date Title
JP2010533869A5 (cg-RX-API-DMAC7.html)
JP2017522546A5 (cg-RX-API-DMAC7.html)
CA2931582C (en) Microfluidic cartridge for molecular diagnosis, docking station using such a microfluidic cartridge, and process for analyzing a biological sample
JP2009517212A5 (cg-RX-API-DMAC7.html)
WO2009008925A3 (en) A particle-based microfluidic device for providing high magnetic field gradients
WO2010054032A3 (en) Apparatus and method using rotary flow distribution mechanisms
JP2011505118A5 (cg-RX-API-DMAC7.html)
EP2845921A3 (en) Method of and apparatus for multiple channel flow ratio controller system
EP2197578A4 (en) METHOD FOR PRODUCING MULTICOMPONENT BISMUTMOLYBDATE CATALYSTS WITH FOUR METAL COMPONENTS AND METHOD FOR PRODUCING 1,3-BUTADIENES USING THE CATALYSTS
WO2011129651A3 (ko) 미세유체장치 및 이것을 이용한 타깃의 분리방법
WO2006009724A3 (en) Microfluidic devices for fluid manipulation and analysis
JP2010008113A5 (cg-RX-API-DMAC7.html)
JP2019180422A5 (ja) 反応処理容器、反応処理方法および反応処理装置
WO2012141880A3 (en) Selectively variable flow restrictor for use in a subterranean well
DE112009001760A5 (de) Vorrichtung zum separieren von Partikeln in und aus Flüssigkeiten und deren Anwendung in Biotechnologie, biologischer Forschung, Diagnostik und Krankheitsbehandlung
JP2009258118A5 (cg-RX-API-DMAC7.html)
JP2018528391A5 (cg-RX-API-DMAC7.html)
JP2009501938A5 (cg-RX-API-DMAC7.html)
RU2016139341A (ru) Входной канал детектора и способ взятия проб
ATE531592T1 (de) Entlüfter mit hydraulischem flüssigkeitssystem mit unabhängigen einlass-/auslassströmungswegen
WO2009092784A3 (en) Apparatus and method for distributing a plurality of fluid flows through a plurality of chambers, particularly for carrying out adsorption processes.
US20160250565A1 (en) Extraction and separation method
WO2010080978A3 (en) Pre-depletion of leukocytes in whole blood samples prior to the capture of whole blood sample components
WO2011129622A3 (ko) 미세유체장치
WO2019067319A3 (en) Microfluidic technique for detection of multi-contact miscibility