JP2010532761A5 - - Google Patents

Info

Publication number

JP2010532761A5

JP2010532761A5 JP2010515262A JP2010515262A JP2010532761A5 JP 2010532761 A5 JP2010532761 A5 JP 2010532761A5 JP 2010515262 A JP2010515262 A JP 2010515262A JP 2010515262 A JP2010515262 A JP 2010515262A JP 2010532761 A5 JP2010532761 A5 JP 2010532761A5

Authority

JP

Japan

Prior art keywords

patient

pharmaceutical composition

anxiety

seq

composition according

Prior art date

2008-07-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 19
• 208000019901 Anxiety disease Diseases 0.000 claims 16
• 230000036506 anxiety Effects 0.000 claims 15
• 239000003814 drug Substances 0.000 claims 7
• 229940079593 drug Drugs 0.000 claims 7
• 230000002265 prevention Effects 0.000 claims 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 3
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
• 206010034912 Phobia Diseases 0.000 claims 2
• 150000001413 amino acids Chemical group 0.000 claims 2
• 108091006116 chimeric peptides Proteins 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 230000003492 excitotoxic effect Effects 0.000 claims 2
• 231100000063 excitotoxicity Toxicity 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 208000019899 phobic disease Diseases 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• AJXONGJARXYRDO-YVNDNENWSA-N (4s)-4-amino-5-[[(2s)-1-[[(2s)-3-carboxy-1-[[(1s)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCC(O)=O AJXONGJARXYRDO-YVNDNENWSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 206010002869 Anxiety symptoms Diseases 0.000 claims 1
• 206010008479 Chest Pain Diseases 0.000 claims 1
• 108700019745 Disks Large Homolog 4 Proteins 0.000 claims 1
• 102000047174 Disks Large Homolog 4 Human genes 0.000 claims 1
• 208000000059 Dyspnea Diseases 0.000 claims 1
• 206010013975 Dyspnoeas Diseases 0.000 claims 1
• 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 1
• 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 1
• 206010028813 Nausea Diseases 0.000 claims 1
• 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
• 206010033557 Palpitations Diseases 0.000 claims 1
• 208000000810 Separation Anxiety Diseases 0.000 claims 1
• 206010041250 Social phobia Diseases 0.000 claims 1
• 206010043269 Tension headache Diseases 0.000 claims 1
• 208000008548 Tension-Type Headache Diseases 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 239000005557 antagonist Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 101150069842 dlg4 gene Proteins 0.000 claims 1
• XWQVQFBTSBCKLI-FKXNDIMNSA-N dnc008987 Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](N)CC1=CC=C(O)C=C1 XWQVQFBTSBCKLI-FKXNDIMNSA-N 0.000 claims 1
• 238000010253 intravenous injection Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 230000008693 nausea Effects 0.000 claims 1
• 208000019906 panic disease Diseases 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 230000035807 sensation Effects 0.000 claims 1
• 208000013220 shortness of breath Diseases 0.000 claims 1
• 230000009870 specific binding Effects 0.000 claims 1
• 238000010254 subcutaneous injection Methods 0.000 claims 1
• 239000007929 subcutaneous injection Substances 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1