DK2175873T3 - Peptide inhibitors of nmda receptors for use for the treatment of anxiety disorders - Google Patents

Peptide inhibitors of nmda receptors for use for the treatment of anxiety disorders Download PDF

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Publication number
DK2175873T3
DK2175873T3 DK08772390.4T DK08772390T DK2175873T3 DK 2175873 T3 DK2175873 T3 DK 2175873T3 DK 08772390 T DK08772390 T DK 08772390T DK 2175873 T3 DK2175873 T3 DK 2175873T3
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DK
Denmark
Prior art keywords
anxiety
patient
arg
agent
peptide
Prior art date
Application number
DK08772390.4T
Other languages
Danish (da)
English (en)
Inventor
Michael Tymianski
Kenneth Mendoza
Michael P Belmares
Peter S Lu
David Garman
Andrew Tasker
Tracy Doucette
Original Assignee
Nono Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nono Inc filed Critical Nono Inc
Application granted granted Critical
Publication of DK2175873T3 publication Critical patent/DK2175873T3/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1787Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK08772390.4T 2007-07-03 2008-07-02 Peptide inhibitors of nmda receptors for use for the treatment of anxiety disorders DK2175873T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94789207P 2007-07-03 2007-07-03
PCT/US2008/069085 WO2009006548A2 (en) 2007-07-03 2008-07-02 Treatment for anxiety

Publications (1)

Publication Number Publication Date
DK2175873T3 true DK2175873T3 (en) 2015-12-14

Family

ID=40226818

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08772390.4T DK2175873T3 (en) 2007-07-03 2008-07-02 Peptide inhibitors of nmda receptors for use for the treatment of anxiety disorders

Country Status (10)

Country Link
US (2) US8008253B2 (enExample)
EP (1) EP2175873B1 (enExample)
JP (2) JP5775303B2 (enExample)
KR (1) KR101604428B1 (enExample)
CN (1) CN101827604B (enExample)
AU (1) AU2008272903B2 (enExample)
CA (1) CA2692412C (enExample)
DK (1) DK2175873T3 (enExample)
ES (1) ES2555172T3 (enExample)
WO (1) WO2009006548A2 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008253B2 (en) 2007-07-03 2011-08-30 Andrew Tasker Treatment for anxiety
AU2009246316B2 (en) * 2008-05-16 2014-06-19 Nono Inc. Treatment for epilepsy
CN102202677A (zh) * 2008-09-03 2011-09-28 阿尔伯维塔公司 治疗疼痛的活性剂和方法
AU2013251426A1 (en) * 2012-04-27 2014-11-20 Indiana University Research And Technology Corporation Compositions and methods for treating PTSD and related diseases
WO2015068558A1 (ja) 2013-11-05 2015-05-14 三菱樹脂株式会社 粘着剤組成物
WO2015137178A1 (ja) 2014-03-10 2015-09-17 三菱樹脂株式会社 画像表示装置構成用積層体の製造方法
SMT202000307T1 (it) * 2014-05-28 2020-07-08 Nono Inc Sale cloruro di tat-nr2b9c
WO2017093354A1 (en) 2015-11-30 2017-06-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Nmdar antagonists for the treatment of diseases associated with angiogenesis
TWI818233B (zh) 2016-02-08 2023-10-11 日商三菱化學股份有限公司 透明雙面黏著片及黏著片積層體
KR20260049689A (ko) 2016-02-08 2026-04-14 미쯔비시 케미컬 주식회사 투명 양면 점착 시트 및 점착 시트 적층체
KR102253900B1 (ko) * 2016-04-27 2021-05-18 바이오셀즈(베이징) 바이오테크 코., 엘티디. 흥분성 신경독성 관련 손상 치료용 펩타이드
CN107312069B (zh) * 2016-04-27 2018-11-06 拜西欧斯(北京)生物技术有限公司 兴奋性神经毒性相关损伤的治疗肽
CN106632601B (zh) * 2016-11-16 2020-10-20 中国科学院昆明动物研究所 一种阻断突触长时程增强(ltp)的短肽及其应用
EP3650460A4 (en) * 2017-07-05 2021-03-17 Biocells (Beijing) Biotech Co., Ltd. PHARMACEUTICAL SALT OF A POLYPEPTID AND ITS USES
EA202090802A1 (ru) * 2017-09-30 2020-08-05 Биоселз (Бейдзин) Биотек Ко., Лтд. Пептидная композиция для лечения повреждений, связанных с возбуждающей нейротоксичностью
FR3075038B1 (fr) 2017-12-15 2020-03-06 Melchior Material And Life Science France Utilisation de la fluoroethylnormemantine pour la prevention de l'apparition et le traitement de l'anxiete
CN114641484B (zh) * 2019-11-05 2024-08-09 国立大学法人京都大学 肽、组合物及治疗、预防或改善心境障碍的方法
CN111285923B (zh) * 2020-03-05 2023-02-03 成都奥达生物科技有限公司 一种psd-95抑制剂
CN113735938B (zh) 2021-07-30 2024-11-08 英纳氏(珠海)药业有限公司 一种神经保护多肽化合物及其应用

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US6723838B1 (en) 1998-04-22 2004-04-20 Johns Hopkins University Signal transducing synaptic molecules and uses thereof
US6942981B1 (en) 1999-05-14 2005-09-13 Arbor Vita Corporation Method of determining interactions with PDZ-domain polypeptides
US20060148711A1 (en) * 1999-05-14 2006-07-06 Arbor Vita Corporation Molecular interactions in neurons
US7595297B2 (en) * 1999-06-02 2009-09-29 Michael Tymianski Method of reducing injury to mammalian cells
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6432985B2 (en) * 2000-04-25 2002-08-13 Hoffmann-La Roche Inc. Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
JP2004501901A (ja) * 2000-06-26 2004-01-22 メルク エンド カムパニー インコーポレーテッド イミノピリミジン系nmdanr2b受容体拮抗薬
FI20012082A0 (fi) 2001-10-26 2001-10-26 Paeivi Liesi Biologisesti aktiiviset peptidit hermovauroiden korjaamiseksi
US6713490B2 (en) 2002-04-26 2004-03-30 Pfizer, Inc. 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
EP1578365A4 (en) 2002-11-14 2009-09-23 Arbor Vita Corp MOLECULAR INTERACTIONS IN NEURONS
GB0303613D0 (en) * 2003-02-17 2003-03-19 Novartis Ag Use of organic compounds
US20050084880A1 (en) 2003-07-11 2005-04-21 Ronald Duman Systems and methods for diagnosing & treating psychological and behavioral conditions
US20070105902A1 (en) 2003-11-12 2007-05-10 Lindsley Craig W 4-Phenyl piperdine sulfonyl glycine transporter inhibitors
HU226977B1 (en) * 2004-07-29 2010-04-28 Richter Gedeon Nyrt Kynurenic acid amide derivatives, pharmaceutical compositions containing them and process for producing them
US20060167075A1 (en) 2005-01-25 2006-07-27 Pearson James P Modulators of FAAH
US20060216331A1 (en) 2005-02-28 2006-09-28 Lines Thomas C Composition for treating mental health disorders
US7588911B2 (en) * 2005-06-23 2009-09-15 Arbor Vita Corporation Assays for detecting inhibitors of binding between COX-2 and PDZ proteins
KR101384572B1 (ko) 2005-12-30 2014-04-24 아버 비타 코포레이션 Pdz 상호작용의 소형 분자 억제제
US8262847B2 (en) * 2006-12-29 2012-09-11 Lam Research Corporation Plasma-enhanced substrate processing method and apparatus
US8008253B2 (en) 2007-07-03 2011-08-30 Andrew Tasker Treatment for anxiety
US8080518B2 (en) * 2007-12-05 2011-12-20 Arbor Vita Corporation Co-administration of an agent linked to an internalization peptide with an anti-inflammatory

Also Published As

Publication number Publication date
JP5775303B2 (ja) 2015-09-09
JP2010532761A (ja) 2010-10-14
JP2014129353A (ja) 2014-07-10
WO2009006548A3 (en) 2009-03-19
CA2692412A1 (en) 2009-01-08
US20090036376A1 (en) 2009-02-05
AU2008272903A8 (en) 2010-05-06
ES2555172T3 (es) 2015-12-29
AU2008272903A1 (en) 2009-01-08
US20120083449A1 (en) 2012-04-05
US8536129B2 (en) 2013-09-17
KR20100038366A (ko) 2010-04-14
AU2008272903B2 (en) 2013-08-29
EP2175873A2 (en) 2010-04-21
CA2692412C (en) 2017-02-07
CN101827604B (zh) 2014-05-07
US8008253B2 (en) 2011-08-30
EP2175873A4 (en) 2011-10-05
EP2175873B1 (en) 2015-11-11
WO2009006548A2 (en) 2009-01-08
CN101827604A (zh) 2010-09-08
KR101604428B1 (ko) 2016-03-17

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