JP2010531659A5 - - Google Patents
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- Publication number
- JP2010531659A5 JP2010531659A5 JP2010514108A JP2010514108A JP2010531659A5 JP 2010531659 A5 JP2010531659 A5 JP 2010531659A5 JP 2010514108 A JP2010514108 A JP 2010514108A JP 2010514108 A JP2010514108 A JP 2010514108A JP 2010531659 A5 JP2010531659 A5 JP 2010531659A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- modified
- composition according
- reducing agent
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 10
- 102000035118 modified proteins Human genes 0.000 claims 8
- 108091005573 modified proteins Proteins 0.000 claims 8
- 239000003638 chemical reducing agent Substances 0.000 claims 7
- 229910052742 iron Inorganic materials 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 4
- 150000003278 haem Chemical class 0.000 claims 4
- 230000027756 respiratory electron transport chain Effects 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 108010054147 Hemoglobins Proteins 0.000 claims 2
- 102000001554 Hemoglobins Human genes 0.000 claims 2
- 239000000539 dimer Substances 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- -1 iron ions Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 150000004032 porphyrins Chemical class 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- TZXKOCQBRNJULO-UHFFFAOYSA-N Ferriprox Chemical compound CC1=C(O)C(=O)C=CN1C TZXKOCQBRNJULO-UHFFFAOYSA-N 0.000 claims 1
- 102100027685 Hemoglobin subunit alpha Human genes 0.000 claims 1
- 108091005902 Hemoglobin subunit alpha Proteins 0.000 claims 1
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 claims 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 229960003266 deferiprone Drugs 0.000 claims 1
- 229960000958 deferoxamine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 1
- 229940116269 uric acid Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0712685.7A GB0712685D0 (en) | 2007-06-29 | 2007-06-29 | Improvements relating to oxygen-carrying proteins (2) |
| PCT/GB2008/002199 WO2009004309A1 (en) | 2007-06-29 | 2008-06-26 | Modified globin proteins with altered electron transport pathway |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010531659A JP2010531659A (ja) | 2010-09-30 |
| JP2010531659A5 true JP2010531659A5 (enExample) | 2011-08-04 |
Family
ID=38420974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514108A Pending JP2010531659A (ja) | 2007-06-29 | 2008-06-26 | 変化した電子伝達経路を有する改変グロビンタンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8609814B2 (enExample) |
| EP (1) | EP2170948B1 (enExample) |
| JP (1) | JP2010531659A (enExample) |
| CN (1) | CN101711255A (enExample) |
| AU (1) | AU2008272721B2 (enExample) |
| BR (1) | BRPI0812403B8 (enExample) |
| CA (1) | CA2690370A1 (enExample) |
| GB (1) | GB0712685D0 (enExample) |
| WO (1) | WO2009004309A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2858495A4 (en) | 2012-04-30 | 2016-06-01 | Dow Agrosciences Llc | VEHICLES FOR RELEASING PESTICIDE COMPOSITIONS |
| GB201704006D0 (en) * | 2017-03-13 | 2017-04-26 | Univ Essex | Modified globin proteins |
| JP7387597B2 (ja) | 2017-07-18 | 2023-11-28 | ヴァーテック・バイオ・インコーポレイテッド | ヘモグロビンを含む代用血液及び作製方法 |
| GB201721503D0 (en) * | 2017-12-20 | 2018-01-31 | Univ Essex | Modified globin proteins |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8711614D0 (en) * | 1987-05-16 | 1987-06-24 | Medical Res Council | Proteins |
| US5884323A (en) * | 1995-10-13 | 1999-03-16 | 3Com Corporation | Extendible method and apparatus for synchronizing files on two different computer systems |
| EP0859789A1 (en) | 1995-10-23 | 1998-08-26 | Rice University | Hemoglobin mutants that reduce heme loss |
| GB0712683D0 (en) | 2007-06-29 | 2007-08-08 | Wivenhoe Technology Ltd | Improvements relating to oxygen-carrying proteins(1) |
-
2007
- 2007-06-29 GB GBGB0712685.7A patent/GB0712685D0/en not_active Ceased
-
2008
- 2008-06-26 AU AU2008272721A patent/AU2008272721B2/en active Active
- 2008-06-26 WO PCT/GB2008/002199 patent/WO2009004309A1/en not_active Ceased
- 2008-06-26 JP JP2010514108A patent/JP2010531659A/ja active Pending
- 2008-06-26 US US12/452,075 patent/US8609814B2/en active Active
- 2008-06-26 CN CN200880021531A patent/CN101711255A/zh active Pending
- 2008-06-26 BR BRPI0812403A patent/BRPI0812403B8/pt active IP Right Grant
- 2008-06-26 EP EP08775775.3A patent/EP2170948B1/en active Active
- 2008-06-26 CA CA2690370A patent/CA2690370A1/en not_active Abandoned
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