JP2010531298A5 - - Google Patents
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- JP2010531298A5 JP2010531298A5 JP2010512189A JP2010512189A JP2010531298A5 JP 2010531298 A5 JP2010531298 A5 JP 2010531298A5 JP 2010512189 A JP2010512189 A JP 2010512189A JP 2010512189 A JP2010512189 A JP 2010512189A JP 2010531298 A5 JP2010531298 A5 JP 2010531298A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- pain
- formulation according
- item
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 58
- 238000009472 formulation Methods 0.000 claims description 52
- 208000002193 Pain Diseases 0.000 claims description 29
- -1 fatty acid ester Chemical class 0.000 claims description 20
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 13
- 239000000194 fatty acid Substances 0.000 claims description 13
- 229930195729 fatty acid Natural products 0.000 claims description 13
- 239000000499 gel Substances 0.000 claims description 11
- 230000000699 topical effect Effects 0.000 claims description 11
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 7
- 239000006071 cream Substances 0.000 claims description 7
- 239000006185 dispersion Substances 0.000 claims description 7
- 239000006260 foam Substances 0.000 claims description 7
- 239000000787 lecithin Substances 0.000 claims description 7
- 229940067606 lecithin Drugs 0.000 claims description 7
- 235000010445 lecithin Nutrition 0.000 claims description 7
- 239000006210 lotion Substances 0.000 claims description 7
- 239000002674 ointment Substances 0.000 claims description 7
- 239000006072 paste Substances 0.000 claims description 7
- 239000007921 spray Substances 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 229930182558 Sterol Natural products 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 6
- 150000002632 lipids Chemical class 0.000 claims description 6
- 210000003205 muscle Anatomy 0.000 claims description 6
- 239000003961 penetration enhancing agent Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 150000003432 sterols Chemical class 0.000 claims description 6
- 235000003702 sterols Nutrition 0.000 claims description 6
- 229920000742 Cotton Polymers 0.000 claims description 4
- 230000036528 appetite Effects 0.000 claims description 4
- 235000019789 appetite Nutrition 0.000 claims description 4
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 4
- 210000002435 tendon Anatomy 0.000 claims description 4
- 208000006820 Arthralgia Diseases 0.000 claims description 3
- 230000007883 bronchodilation Effects 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 208000024891 symptom Diseases 0.000 claims description 3
- 208000000094 Chronic Pain Diseases 0.000 claims description 2
- 206010019233 Headaches Diseases 0.000 claims description 2
- 206010065390 Inflammatory pain Diseases 0.000 claims description 2
- 208000001294 Nociceptive Pain Diseases 0.000 claims description 2
- 208000037656 Respiratory Sounds Diseases 0.000 claims description 2
- 206010047924 Wheezing Diseases 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 208000005298 acute pain Diseases 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 239000002390 adhesive tape Substances 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 231100000869 headache Toxicity 0.000 claims description 2
- 210000001503 joint Anatomy 0.000 claims description 2
- 239000007934 lip balm Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 201000008482 osteoarthritis Diseases 0.000 claims description 2
- 239000011505 plaster Substances 0.000 claims description 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 208000009935 visceral pain Diseases 0.000 claims description 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims 5
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 2
- 206010006811 Bursitis Diseases 0.000 claims 2
- 206010052904 Musculoskeletal stiffness Diseases 0.000 claims 2
- 208000023835 Tendon disease Diseases 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 claims 1
- 241000254032 Acrididae Species 0.000 claims 1
- 208000036487 Arthropathies Diseases 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 208000012659 Joint disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 229940099429 polyoxyl 40 stearate Drugs 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 239000008347 soybean phospholipid Substances 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 12
- 239000001993 wax Substances 0.000 description 4
- 239000003623 enhancer Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 206010066371 Tendon pain Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 208000001797 obstructive sleep apnea Diseases 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94355207P | 2007-06-12 | 2007-06-12 | |
| US11/851,241 US9511016B2 (en) | 2007-06-12 | 2007-09-06 | Topical composition for treating pain |
| PCT/US2008/007354 WO2008156646A1 (en) | 2007-06-12 | 2008-06-11 | Topical composition for treating pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010531298A JP2010531298A (ja) | 2010-09-24 |
| JP2010531298A5 true JP2010531298A5 (cg-RX-API-DMAC10.html) | 2012-07-12 |
Family
ID=40132558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512189A Pending JP2010531298A (ja) | 2007-06-12 | 2008-06-11 | 疼痛を治療するための局所用組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US9511016B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2164476A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2010531298A (cg-RX-API-DMAC10.html) |
| CN (1) | CN101842090A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2008266971B2 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2008156646A1 (cg-RX-API-DMAC10.html) |
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-
2007
- 2007-09-06 US US11/851,241 patent/US9511016B2/en active Active
-
2008
- 2008-06-11 JP JP2010512189A patent/JP2010531298A/ja active Pending
- 2008-06-11 WO PCT/US2008/007354 patent/WO2008156646A1/en not_active Ceased
- 2008-06-11 CN CN200880100902A patent/CN101842090A/zh active Pending
- 2008-06-11 AU AU2008266971A patent/AU2008266971B2/en active Active
- 2008-06-11 EP EP08768401A patent/EP2164476A1/en not_active Withdrawn
- 2008-06-12 US US12/138,304 patent/US20080311218A1/en not_active Abandoned
- 2008-06-12 US US12/138,300 patent/US20080311217A1/en not_active Abandoned
- 2008-06-16 US US12/140,080 patent/US20080312583A1/en not_active Abandoned
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