EP1093348A4 - Methods and transdermal compositions for pain relief - Google Patents

Methods and transdermal compositions for pain relief

Info

Publication number
EP1093348A4
EP1093348A4 EP99932017A EP99932017A EP1093348A4 EP 1093348 A4 EP1093348 A4 EP 1093348A4 EP 99932017 A EP99932017 A EP 99932017A EP 99932017 A EP99932017 A EP 99932017A EP 1093348 A4 EP1093348 A4 EP 1093348A4
Authority
EP
European Patent Office
Prior art keywords
methods
pain relief
transdermal compositions
transdermal
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99932017A
Other languages
German (de)
French (fr)
Other versions
EP1093348A1 (en
Inventor
Robert W Murdock
C Donald Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHARMACEUTICALS APPLICATIONS ASOCIATES LLC
PHARMACEUTICALS APPLIC ASOCIAT
Original Assignee
PHARMACEUTICALS APPLICATIONS ASOCIATES LLC
PHARMACEUTICALS APPLIC ASOCIAT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/106,684 external-priority patent/US6290986B1/en
Application filed by PHARMACEUTICALS APPLICATIONS ASOCIATES LLC, PHARMACEUTICALS APPLIC ASOCIAT filed Critical PHARMACEUTICALS APPLICATIONS ASOCIATES LLC
Publication of EP1093348A1 publication Critical patent/EP1093348A1/en
Publication of EP1093348A4 publication Critical patent/EP1093348A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP99932017A 1998-06-29 1999-06-29 Methods and transdermal compositions for pain relief Withdrawn EP1093348A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US106684 1998-06-29
US09/106,684 US6290986B1 (en) 1996-10-24 1998-06-29 Method and composition for transdermal administration of pharmacologic agents
US12290399P 1999-03-05 1999-03-05
US122903P 1999-03-05
PCT/US1999/014653 WO2000000120A1 (en) 1998-06-29 1999-06-29 Methods and transdermal compositions for pain relief

Publications (2)

Publication Number Publication Date
EP1093348A1 EP1093348A1 (en) 2001-04-25
EP1093348A4 true EP1093348A4 (en) 2003-07-16

Family

ID=26803907

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99932017A Withdrawn EP1093348A4 (en) 1998-06-29 1999-06-29 Methods and transdermal compositions for pain relief

Country Status (18)

Country Link
EP (1) EP1093348A4 (en)
JP (1) JP2002519310A (en)
KR (1) KR20010078754A (en)
CN (1) CN1331576A (en)
AU (1) AU4841599A (en)
BG (1) BG105175A (en)
BR (1) BR9912508A (en)
CA (1) CA2335837A1 (en)
HR (1) HRP20000905A2 (en)
HU (1) HUP0102728A3 (en)
ID (1) ID28213A (en)
IL (1) IL140420A0 (en)
MX (1) MXPA00012767A (en)
NO (1) NO20006604L (en)
PL (1) PL345216A1 (en)
SK (1) SK20012000A3 (en)
TR (1) TR200003801T2 (en)
WO (1) WO2000000120A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6572880B2 (en) * 1996-10-24 2003-06-03 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
ATE289295T1 (en) 1997-04-22 2005-03-15 Euro Celtique Sa THE USE OF SEMICARBAZONES AND THIOSEMICARBAZONES SUBSTITUTED BY CARBOCYCLIC AND HETEROCYCLIC MATERIALS AS SODIUM CHANNEL BLOCKERS
DK1459748T3 (en) * 1999-07-01 2005-07-04 Pharmacia & Upjohn Co Llc (S, S) reboxetine for the treatment of peripheral neuropathy
DE60020613T2 (en) 1999-07-01 2006-03-16 Pharmacia & Upjohn Co. Llc, Kalamazoo (S, S) reboxetine for the treatment of fibromyalgia and other somatoform disorders
CA2325106A1 (en) * 1999-12-06 2001-06-06 Stanley L. Gore Compositions and methods for intranasal delivery of active agents to the brain
IN191512B (en) * 2000-01-21 2003-12-06 Panacea Biotech
DE10032132A1 (en) * 2000-07-01 2002-01-17 Lohmann Therapie Syst Lts Dermal therapeutic system containing non-steroidal anti-inflammatory drugs with selective COX-2 inhibition
DE10042412B4 (en) * 2000-08-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag Transceiver for bus subscriber of bus system of building system engineering, has two wires, where microcontroller is connected with receiver unit over connection on one hand, which is connected to two wires of bus system
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
ES2350689T3 (en) 2002-12-13 2011-01-26 Durect Corporation ORAL DRUG SUPPLY SYSTEM THAT INCLUDES HIGH VISCOSITY LIQUID VEHICLE MATERIALS.
JP2005154368A (en) * 2003-11-27 2005-06-16 Teikoku Seiyaku Co Ltd Analgesic agent for neuropathic pain containing disopyramide
JP4807721B2 (en) * 2004-01-29 2011-11-02 株式会社 メドレックス Anti-inflammatory analgesic topical
KR101492361B1 (en) 2004-09-17 2015-02-11 듀렉트 코퍼레이션 Sustained local anesthetic composition containing preferably a sugar ester such as SAIB
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
JP2007308403A (en) * 2006-05-17 2007-11-29 Kenji Yoshida Skin care preparation
KR100880748B1 (en) * 2006-08-29 2009-02-02 정헌택 Pharmaceutical composition containing demethoxycurcumin to prevent restenosis
AU2007325918B2 (en) 2006-11-03 2013-10-17 Durect Corporation Transdermal delivery systems comprising bupivacaine
US9511016B2 (en) * 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
JP2011506318A (en) 2007-12-06 2011-03-03 デュレクト コーポレーション Oral pharmaceutical formulation
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN102421440B (en) * 2009-05-07 2017-06-09 东国制药（株） Pharmaceutical compositions for preventing or treating neurogenic pain
US8491927B2 (en) 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
WO2014144975A1 (en) 2013-03-15 2014-09-18 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
WO2015123272A1 (en) * 2014-02-11 2015-08-20 Dr. Reddy's Laboratories Ltd. Parenteral compositions of celecoxib
EP3870150A1 (en) 2018-10-26 2021-09-01 Viramal Limited Mucoadhesive gel composition
BR112022013784A2 (en) 2020-01-13 2022-10-11 Durect Corp DISTRIBUTION SYSTEMS FOR PROLONGED RELEASE DRUGS WITH REDUCED IMPURITIES AND RELATED METHODS
FR3108841B1 (en) * 2020-04-06 2023-11-03 Algotherapeutix TOPICAL PHARMACEUTICAL COMPOSITION IN AQUEOUS GEL FORM COMPRISING AT LEAST AMITRIPTYLINE

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395420A (en) * 1981-12-09 1983-07-26 Bernstein Joel E Method and composition for treating pruritis
WO1994008623A1 (en) * 1992-10-14 1994-04-28 F. Hoffmann-La Roche Ag Injectable lecithin gel
US5731000A (en) * 1993-07-30 1998-03-24 Glaxo Wellcome Inc. Stabilized pharmaceutical composition containing bupropion

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654337A (en) * 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
US5837289A (en) * 1996-07-23 1998-11-17 Grasela; John C. Transdermal delivery of medications using a combination of penetration enhancers
US5885597A (en) * 1997-10-01 1999-03-23 Medical Research Industries,Inc. Topical composition for the relief of pain

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395420A (en) * 1981-12-09 1983-07-26 Bernstein Joel E Method and composition for treating pruritis
WO1994008623A1 (en) * 1992-10-14 1994-04-28 F. Hoffmann-La Roche Ag Injectable lecithin gel
US5731000A (en) * 1993-07-30 1998-03-24 Glaxo Wellcome Inc. Stabilized pharmaceutical composition containing bupropion

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAILEY: "percutaneous Absorption of tricyclic antidepressants", J.ANAL.TOXICOL., vol. 14, 1990, pages 217 - 218, XP009010975 *
EGBUNIKE ET AL: "Antidepressants in the management of chronic pain syndromes", PHARMACOTHERAPY, vol. 10, no. 4, 1990, pages 262 - 270, XP002241432 *
SCOTT ET AL: "Use of Transdermal Amitripyline gel in a patient with chronic pai and depression.", PHAMACOTHERAPY, vol. 19, no. 2, 1999, pages 236 - 239, XP000909357 *
See also references of WO0000120A1 *
WATSON: "Antidepressant Drugs as Adjuvant Analgesics", J.PAIN AND SYMPTOM MANAGEMENT, vol. 9, no. 6, 1994, pages 392 - 405, XP009011036 *
WILLIMANN H ET AL: "LECITHIN ORGANOGEL AS MATRIX FOR TRANSDERMAL TRANSPORT OF DRUGS", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 81, no. 19, 1 September 1992 (1992-09-01), pages 871 - 874, XP000371811, ISSN: 0022-3549 *

Also Published As

Publication number Publication date
HRP20000905A2 (en) 2001-08-31
KR20010078754A (en) 2001-08-21
SK20012000A3 (en) 2001-08-06
NO20006604L (en) 2001-02-28
MXPA00012767A (en) 2002-08-09
WO2000000120A9 (en) 2000-03-30
IL140420A0 (en) 2002-02-10
CN1331576A (en) 2002-01-16
TR200003801T2 (en) 2001-06-21
JP2002519310A (en) 2002-07-02
PL345216A1 (en) 2001-12-03
CA2335837A1 (en) 2000-01-06
BR9912508A (en) 2001-05-02
HUP0102728A3 (en) 2002-12-28
ID28213A (en) 2001-05-10
AU4841599A (en) 2000-01-17
NO20006604D0 (en) 2000-12-22
BG105175A (en) 2001-11-30
WO2000000120A1 (en) 2000-01-06
EP1093348A1 (en) 2001-04-25
HUP0102728A2 (en) 2002-03-28

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A4 Supplementary search report drawn up and despatched

Effective date: 20030602

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