JP2010531189A5 - - Google Patents

Info

Publication number

JP2010531189A5

JP2010531189A5 JP2010514105A JP2010514105A JP2010531189A5 JP 2010531189 A5 JP2010531189 A5 JP 2010531189A5 JP 2010514105 A JP2010514105 A JP 2010514105A JP 2010514105 A JP2010514105 A JP 2010514105A JP 2010531189 A5 JP2010531189 A5 JP 2010531189A5

Authority

JP

Japan

Prior art keywords

wound

care product

wound care

polypeptide

healing properties

Prior art date

2008-06-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 206010052428 Wound Diseases 0.000 claims 43
• 208000027418 Wounds and injury Diseases 0.000 claims 43
• 239000000463 material Substances 0.000 claims 10
• 230000029663 wound healing Effects 0.000 claims 10
• 229920001184 polypeptide Polymers 0.000 claims 8
• 102000004196 processed proteins & peptides Human genes 0.000 claims 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims 8
• POIUWJQBRNEFGX-XAMSXPGMSA-N cathelicidin Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)C1=CC=CC=C1 POIUWJQBRNEFGX-XAMSXPGMSA-N 0.000 claims 7
• 239000000017 hydrogel Substances 0.000 claims 6
• 229920005830 Polyurethane Foam Polymers 0.000 claims 5
• 239000011496 polyurethane foam Substances 0.000 claims 5
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
• 102000014509 cathelicidin Human genes 0.000 claims 3
• 108060001132 cathelicidin Proteins 0.000 claims 3
• 235000010443 alginic acid Nutrition 0.000 claims 2
• 229920000615 alginic acid Polymers 0.000 claims 2
• 210000000416 exudates and transudate Anatomy 0.000 claims 2
• 239000006260 foam Substances 0.000 claims 2
• 239000000499 gel Substances 0.000 claims 2
• 239000000416 hydrocolloid Substances 0.000 claims 2
• 229920001059 synthetic polymer Polymers 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
• 229920001661 Chitosan Polymers 0.000 claims 1
• 102000008186 Collagen Human genes 0.000 claims 1
• 108010035532 Collagen Proteins 0.000 claims 1
• 229920001605 Dextranomer Polymers 0.000 claims 1
• 229920000896 Ethulose Polymers 0.000 claims 1
• 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims 1
• JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 1
• 229920000084 Gum arabic Polymers 0.000 claims 1
• 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
• 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
• 241000978776 Senegalia senegal Species 0.000 claims 1
• 229920002125 Sokalan® Polymers 0.000 claims 1
• 229920002472 Starch Polymers 0.000 claims 1
• 101100244894 Sus scrofa PR39 gene Proteins 0.000 claims 1
• 235000010489 acacia gum Nutrition 0.000 claims 1
• 239000000205 acacia gum Substances 0.000 claims 1
• 229940072056 alginate Drugs 0.000 claims 1
• 230000000844 anti-bacterial effect Effects 0.000 claims 1
• 229920001400 block copolymer Polymers 0.000 claims 1
• 229950010083 cadexomer Drugs 0.000 claims 1
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
• 235000010418 carrageenan Nutrition 0.000 claims 1
• 239000000679 carrageenan Substances 0.000 claims 1
• 229920001525 carrageenan Polymers 0.000 claims 1
• 229940113118 carrageenan Drugs 0.000 claims 1
• 125000002091 cationic group Chemical group 0.000 claims 1
• 229920003086 cellulose ether Polymers 0.000 claims 1
• 229940045110 chitosan Drugs 0.000 claims 1
• 229920001436 collagen Polymers 0.000 claims 1
• 229960002864 dextranomer Drugs 0.000 claims 1
• 210000000981 epithelium Anatomy 0.000 claims 1
• 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• -1 hydrofiber Substances 0.000 claims 1
• 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
• USSYUMHVHQSYNA-SLDJZXPVSA-N indolicidin Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)CC1=CNC2=CC=CC=C12 USSYUMHVHQSYNA-SLDJZXPVSA-N 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229920000609 methyl cellulose Polymers 0.000 claims 1
• 239000001923 methylcellulose Substances 0.000 claims 1
• 235000010981 methylcellulose Nutrition 0.000 claims 1
• 230000000813 microbial effect Effects 0.000 claims 1
• 229920001206 natural gum Polymers 0.000 claims 1
• 229920001277 pectin Polymers 0.000 claims 1
• 239000001814 pectin Substances 0.000 claims 1
• 235000010987 pectin Nutrition 0.000 claims 1
• 229960000292 pectin Drugs 0.000 claims 1
• 229920001983 poloxamer Polymers 0.000 claims 1
• 229960000502 poloxamer Drugs 0.000 claims 1
• 239000004584 polyacrylic acid Substances 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 229920002635 polyurethane Polymers 0.000 claims 1
• 239000004814 polyurethane Substances 0.000 claims 1
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 239000004627 regenerated cellulose Substances 0.000 claims 1
• 230000008929 regeneration Effects 0.000 claims 1
• 238000011069 regeneration method Methods 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 239000008107 starch Substances 0.000 claims 1
• 235000019698 starch Nutrition 0.000 claims 1
• 229940032147 starch Drugs 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 229920001285 xanthan gum Polymers 0.000 claims 1
• 239000000230 xanthan gum Substances 0.000 claims 1
• 235000010493 xanthan gum Nutrition 0.000 claims 1
• 229940082509 xanthan gum Drugs 0.000 claims 1
• UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1