CN101720237A - 新型医用产品 - Google Patents
新型医用产品 Download PDFInfo
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- CN101720237A CN101720237A CN200880022090A CN200880022090A CN101720237A CN 101720237 A CN101720237 A CN 101720237A CN 200880022090 A CN200880022090 A CN 200880022090A CN 200880022090 A CN200880022090 A CN 200880022090A CN 101720237 A CN101720237 A CN 101720237A
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- wound care
- wound
- care products
- polypeptide
- healing performance
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| WO2012031457A1 (zh) * | 2010-09-08 | 2012-03-15 | 上海市肿瘤研究所 | 用于治疗肿瘤的药物缓释血管栓塞凝胶剂及其制备方法 |
| CN103536960A (zh) * | 2013-10-30 | 2014-01-29 | 无锡灵锡医疗器械科技有限公司 | 一种可缓释抗菌肽的水凝胶及其制备方法 |
| CN103611181A (zh) * | 2013-10-25 | 2014-03-05 | 无锡灵锡医疗器械科技有限公司 | 一种抗菌肽水凝胶及其制备方法 |
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| GB0224986D0 (en) * | 2002-10-28 | 2002-12-04 | Smith & Nephew | Apparatus |
| GB0821687D0 (en) * | 2008-11-28 | 2008-12-31 | Secr Defence | Peptides |
| US10174081B2 (en) * | 2011-04-21 | 2019-01-08 | George Mason Research Foundation, Inc. | Antimicrobial peptides and uses therefore |
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| KR101678402B1 (ko) * | 2014-11-20 | 2016-12-06 | 금오공과대학교 산학협력단 | 창상치료용 알긴산 하이드로젤 및 그 제조방법 |
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Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06104874B2 (ja) * | 1990-04-10 | 1994-12-21 | 大同メタル工業株式会社 | 低剛性ハウジング用アルミニウム合金軸受及びその製造方法 |
| US6008058A (en) * | 1993-06-18 | 1999-12-28 | University Of Louisville | Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis |
| SE505000C2 (sv) * | 1996-05-14 | 1997-06-09 | Moelnlycke Ab | Sårförband samt tillverkningsförfarande därför |
| US20030149406A1 (en) * | 2002-02-07 | 2003-08-07 | Lucie Martineau | Multi-layer dressing as medical drug delivery system |
| DE10222838A1 (de) * | 2002-05-21 | 2003-12-04 | Marconi Comm Gmbh | Sektorantenne in Hohlleitertechnik |
| JP5330230B2 (ja) * | 2006-05-16 | 2013-10-30 | ペルガモン アクティエボラーグ | 改良型抗菌ペプチド |
| KR100777908B1 (ko) * | 2006-12-19 | 2007-11-28 | 주식회사 바이오폴 | 보수율이 향상된 폴리우레탄 폼 드레싱재 |
-
2008
- 2008-06-25 KR KR1020107001436A patent/KR20100049039A/ko not_active Ceased
- 2008-06-25 CA CA002691645A patent/CA2691645A1/en not_active Abandoned
- 2008-06-25 JP JP2010514105A patent/JP2010531189A/ja active Pending
- 2008-06-25 WO PCT/GB2008/002192 patent/WO2009001087A2/en not_active Ceased
- 2008-06-25 CN CN200880022090A patent/CN101720237A/zh active Pending
- 2008-06-25 US US12/666,116 patent/US20100178320A1/en not_active Abandoned
- 2008-06-25 AU AU2008269575A patent/AU2008269575A1/en not_active Abandoned
- 2008-06-25 EP EP08775773A patent/EP2173389A2/en not_active Withdrawn
-
2012
- 2012-10-19 US US13/655,551 patent/US20130108682A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1744913A (zh) * | 2003-01-29 | 2006-03-08 | 利波佩普泰德公司 | Cathelicidin ll－37及其衍生物在伤口愈合中的用途 |
| WO2007062060A2 (en) * | 2005-11-22 | 2007-05-31 | Ted Reid | Methods and compositions using substance p to promote wound healing |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012031457A1 (zh) * | 2010-09-08 | 2012-03-15 | 上海市肿瘤研究所 | 用于治疗肿瘤的药物缓释血管栓塞凝胶剂及其制备方法 |
| CN104870026A (zh) * | 2013-02-21 | 2015-08-26 | G-集团有限责任公司 | 等同于组织的生物塑料材料 |
| CN103611181A (zh) * | 2013-10-25 | 2014-03-05 | 无锡灵锡医疗器械科技有限公司 | 一种抗菌肽水凝胶及其制备方法 |
| CN103611181B (zh) * | 2013-10-25 | 2015-06-17 | 无锡灵锡医疗器械科技有限公司 | 一种抗菌肽水凝胶及其制备方法 |
| CN103536960A (zh) * | 2013-10-30 | 2014-01-29 | 无锡灵锡医疗器械科技有限公司 | 一种可缓释抗菌肽的水凝胶及其制备方法 |
| CN105939726A (zh) * | 2013-11-19 | 2016-09-14 | 利波佩普泰德公司 | 慢性溃疡的新治疗 |
| CN106687153A (zh) * | 2014-07-18 | 2017-05-17 | 伊西康公司 | 组合纤维素材料及其制备和使用方法 |
| US11083822B2 (en) | 2014-07-18 | 2021-08-10 | Ethicon, Inc. | Combination cellulose material and method of making same |
| CN104586899A (zh) * | 2015-02-09 | 2015-05-06 | 广东海洋大学 | 一种治疗褥疮的气雾剂及其制备方法 |
| CN104586899B (zh) * | 2015-02-09 | 2018-07-24 | 广东海洋大学 | 一种治疗褥疮的气雾剂及其制备方法 |
| CN106492268A (zh) * | 2016-12-07 | 2017-03-15 | 中国石油大学(华东) | 一种短肽/二氧化硅/透明质酸复合水凝胶的制备方法 |
| CN106492268B (zh) * | 2016-12-07 | 2019-04-19 | 中国石油大学(华东) | 一种短肽/二氧化硅/透明质酸复合水凝胶的制备方法 |
| CN110650970A (zh) * | 2017-02-06 | 2020-01-03 | 长春艾迪尔医用科技发展有限公司 | 抗菌肽及其药品 |
| CN110650970B (zh) * | 2017-02-06 | 2023-06-02 | 长春艾迪尔医用科技发展有限公司 | 抗菌肽及其药品 |
| CN107693836A (zh) * | 2017-09-30 | 2018-02-16 | 广东泰宝医疗科技股份有限公司 | 一种抗菌藻酸盐水胶体敷料及其制备方法 |
| CN107670099A (zh) * | 2017-11-28 | 2018-02-09 | 苏州汇涵医用科技发展有限公司 | 一种液体敷料及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008269575A1 (en) | 2008-12-31 |
| EP2173389A2 (en) | 2010-04-14 |
| CA2691645A1 (en) | 2008-12-31 |
| KR20100049039A (ko) | 2010-05-11 |
| WO2009001087A2 (en) | 2008-12-31 |
| US20130108682A1 (en) | 2013-05-02 |
| WO2009001087A3 (en) | 2010-01-14 |
| JP2010531189A (ja) | 2010-09-24 |
| US20100178320A1 (en) | 2010-07-15 |
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