JP2010530371A - 神経学的機能を増強するための作用物質、組成物および方法 - Google Patents

神経学的機能を増強するための作用物質、組成物および方法 Download PDF

Info

Publication number
JP2010530371A
JP2010530371A JP2010512322A JP2010512322A JP2010530371A JP 2010530371 A JP2010530371 A JP 2010530371A JP 2010512322 A JP2010512322 A JP 2010512322A JP 2010512322 A JP2010512322 A JP 2010512322A JP 2010530371 A JP2010530371 A JP 2010530371A
Authority
JP
Japan
Prior art keywords
composition
thp
pregnan
hydroxy
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010512322A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010530371A5 (enExample
Inventor
ロベルタ ディアス ブリントン,
ユン ミン ワン,
Original Assignee
ユニバーシティ オブ サザン カリフォルニア
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニバーシティ オブ サザン カリフォルニア filed Critical ユニバーシティ オブ サザン カリフォルニア
Publication of JP2010530371A publication Critical patent/JP2010530371A/ja
Publication of JP2010530371A5 publication Critical patent/JP2010530371A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010512322A 2007-06-11 2008-06-11 神経学的機能を増強するための作用物質、組成物および方法 Pending JP2010530371A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94318707P 2007-06-11 2007-06-11
PCT/US2008/066558 WO2008154579A1 (en) 2007-06-11 2008-06-11 Allopregnanolone in a method for enhancing neurological function (alzheimer disease)

Publications (2)

Publication Number Publication Date
JP2010530371A true JP2010530371A (ja) 2010-09-09
JP2010530371A5 JP2010530371A5 (enExample) 2012-06-07

Family

ID=39672702

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010512322A Pending JP2010530371A (ja) 2007-06-11 2008-06-11 神経学的機能を増強するための作用物質、組成物および方法

Country Status (4)

Country Link
US (1) US8969329B2 (enExample)
EP (1) EP2167098B1 (enExample)
JP (1) JP2010530371A (enExample)
WO (1) WO2008154579A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011010682A1 (ja) * 2009-07-24 2011-01-27 協和発酵キリン株式会社 ステロール誘導体
DK2806877T3 (da) 2012-01-23 2019-11-04 Sage Therapeutics Inc Neuroaktive steroidformuleringer omfattende et kompleks af allopregnanolon og sulfobutylether beta-cyclodekstrin
CA2882708A1 (en) 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
EP2916846B1 (en) 2012-11-09 2025-09-17 Drawbridge Pharmaceuticals Pty Ltd Neuroactive steroids and their use to facilitate neuroprotection
JP2016501876A (ja) 2012-11-30 2016-01-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ステロイドの抗痙攣活性
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2017156103A1 (en) 2016-03-08 2017-09-14 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
IL265225B (en) * 2016-09-07 2022-08-01 Glia Llc Treatment of symptoms related to neurodegenerative disorders through pharmacological dermal activation of cranial nerves
CA3151334C (en) * 2019-08-19 2024-04-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Topical neurosteroid formulations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506034A (ja) * 1998-03-11 2002-02-26 ベクストルム,トルビエーン Cns疾患の治療におけるエピアロプレグナノロン
JP2004532796A (ja) * 2000-10-11 2004-10-28 エモリー ユニバーシティ 外傷性中枢神経系損傷の処置のための方法
WO2005009359A2 (en) * 2003-07-15 2005-02-03 Roberta Diaz Brinton Agents, compositions and methods for enhancing neurological function
WO2006037016A2 (en) * 2004-09-27 2006-04-06 The Regents Of The University Of California Novel therapy for treatment of chronic degenerative brain diseases and nervous system injury

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897388A (en) 1988-12-20 1990-01-30 Geriatric Research Institute, Inc. Method of treating Alzheimer's disease
IL110309A0 (en) 1993-07-15 1994-10-21 Univ Kentucky Res Found A method of protecting against neuron loss
US5939545A (en) 1994-02-14 1999-08-17 Cocensys, Inc. Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
DE69634039T2 (de) 1995-06-06 2005-12-08 Euro-Celtique S.A. Steroidderivate der Androstan- und der Pregnanreihe
US6552010B1 (en) 1999-11-12 2003-04-22 Genelabs Technologies, Inc. Treatment of SLE with dehydroepiandrosterone
KR20070086866A (ko) 2003-02-13 2007-08-27 화이자 프로덕츠 인크. 항-인슐린양 성장인자 i 수용체 항체의 용도
US20050020552A1 (en) 2003-07-16 2005-01-27 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US20070093460A1 (en) * 2005-08-24 2007-04-26 Morris David J Methods of using selective 11beta-HSD inhibitors to treat gluocorticoid associated states

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506034A (ja) * 1998-03-11 2002-02-26 ベクストルム,トルビエーン Cns疾患の治療におけるエピアロプレグナノロン
JP2004532796A (ja) * 2000-10-11 2004-10-28 エモリー ユニバーシティ 外傷性中枢神経系損傷の処置のための方法
WO2005009359A2 (en) * 2003-07-15 2005-02-03 Roberta Diaz Brinton Agents, compositions and methods for enhancing neurological function
WO2006037016A2 (en) * 2004-09-27 2006-04-06 The Regents Of The University Of California Novel therapy for treatment of chronic degenerative brain diseases and nervous system injury

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6013021963; BRINTON,R.D. et al: Current Alzheimer research Vol.3, No.1, 2006, p.11-7 *
JPN6013021965; BRINTON,R.D. et al: Current Alzheimer research Vol.3, No.3, 2006, p.185-90 *
JPN6013021967; DATABASE CAPLUS ON STN , 2006 *

Also Published As

Publication number Publication date
US20100105646A1 (en) 2010-04-29
EP2167098B1 (en) 2018-09-05
EP2167098A1 (en) 2010-03-31
US8969329B2 (en) 2015-03-03
WO2008154579A1 (en) 2008-12-18

Similar Documents

Publication Publication Date Title
JP2010530371A (ja) 神経学的機能を増強するための作用物質、組成物および方法
Nguyen et al. Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPPL/S transgenic mice
Tweedie et al. Tumor necrosis factor-α synthesis inhibitor 3, 6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease
US20100178277A1 (en) Methods and compositions for stimulating cells
Cunningham et al. The cyclin-dependent kinase inhibitors p19Ink4d and p27Kip1 are coexpressed in select retinal cells and act cooperatively to control cell cycle exit
WO2009135091A1 (en) Use of asenapine and related compounds for the treatment of neuronal or non-neuronal diseases or conditions
CN102065858A (zh) 使用唑尼沙胺和阿坎酸治疗阿尔茨海默病和相关病症的组合组合物
Lattke et al. Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration
US11207331B2 (en) Agents, compositions and methods for enhancing neurological function
WO2017199042A1 (en) Treatment of neurological pathologies with inhibitors of dna damage repair
WO2019115711A1 (en) Compounds for treatment of diseases related to dux4 expression
Schintu et al. Studies of depression-related states in animal models of Parkinsonism
US10918697B2 (en) Co-activation of mTOR and STAT3 pathways to promote neuronal survival and regeneration
US20240277712A1 (en) Treatment and prevention of developmental disorders and mental diseases
WO2020165802A1 (en) Compositions and methods relating to use of agonists of alpha5-containing gabaa receptors
JP2024542257A (ja) 直接トランス分化誘導用組成物およびこれにより処理された幹細胞
PT1638559E (pt) Utilização de pirazolidinas para o tratamento de défices cognitivos
WO2005009359A2 (en) Agents, compositions and methods for enhancing neurological function
Vliet New insights in AD research as a result of 3D cell cultures
JP2025510556A (ja) アルツハイマー型認知症に罹患している患者の治療において使用するためのスフィンゴシン-1-リン酸受容体(s1pr)モジュレーター
WO2024211430A2 (en) Methods and compositions for treating neurodegenerative conditions
Santhosh Brain Region Specific Neurovascular Signaling and Germinal Matrix Hemmorhage
TWI650121B (zh) 化合物用於製備Tau蛋白病變類疾病之醫藥組成物上之用途
CN119158016A (zh) BDNF-TrkB信号通路在预防和/或治疗CDKL5缺乏症相关癫痫中的应用
HK40080299A (en) Compositions and methods of promoting myelination

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110525

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110525

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120404

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130509

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20131015