JP2010529994A5 - - Google Patents

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Publication number
JP2010529994A5
JP2010529994A5 JP2010512352A JP2010512352A JP2010529994A5 JP 2010529994 A5 JP2010529994 A5 JP 2010529994A5 JP 2010512352 A JP2010512352 A JP 2010512352A JP 2010512352 A JP2010512352 A JP 2010512352A JP 2010529994 A5 JP2010529994 A5 JP 2010529994A5
Authority
JP
Japan
Prior art keywords
compound
deuterium
hydrogen
independently
enantiomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010512352A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010529994A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/066730 external-priority patent/WO2008157240A1/en
Publication of JP2010529994A publication Critical patent/JP2010529994A/ja
Publication of JP2010529994A5 publication Critical patent/JP2010529994A5/ja
Pending legal-status Critical Current

Links

JP2010512352A 2007-06-13 2008-06-12 置換ピペラジン Pending JP2010529994A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94373107P 2007-06-13 2007-06-13
PCT/US2008/066730 WO2008157240A1 (en) 2007-06-13 2008-06-12 Substituted piperazines

Publications (2)

Publication Number Publication Date
JP2010529994A JP2010529994A (ja) 2010-09-02
JP2010529994A5 true JP2010529994A5 (OSRAM) 2011-07-28

Family

ID=39609397

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010512352A Pending JP2010529994A (ja) 2007-06-13 2008-06-12 置換ピペラジン

Country Status (9)

Country Link
US (2) US20080312247A1 (OSRAM)
EP (1) EP2155697B1 (OSRAM)
JP (1) JP2010529994A (OSRAM)
KR (1) KR20100047190A (OSRAM)
CN (1) CN101835761A (OSRAM)
AU (1) AU2008266124A1 (OSRAM)
CA (1) CA2690379A1 (OSRAM)
IL (1) IL202666A0 (OSRAM)
WO (1) WO2008157240A1 (OSRAM)

Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
US7943620B2 (en) * 2007-03-07 2011-05-17 Concert Pharmaceuticals, Inc. Anti-anginal compounds
US20110053968A1 (en) * 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
EP2483407A2 (en) 2009-09-30 2012-08-08 President and Fellows of Harvard College Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products
CN101811941A (zh) * 2010-03-12 2010-08-25 重庆欣欣向荣精细化工有限公司 邻羟基苯基烷基醚的制备方法
CN102295622A (zh) 2010-06-25 2011-12-28 上海冠杰生物医药科技有限公司 一种雷诺嗪的制备方法
ES2414384T3 (es) * 2011-05-11 2013-07-19 Ratiopharm Gmbh Composición de liberación modificada que comprende ranolazina
US10463611B2 (en) * 2011-06-08 2019-11-05 Sti Pharma, Llc Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration
PT2968316T (pt) 2013-03-13 2019-10-29 Forma Therapeutics Inc Derivados de 2-hidroxi-1-{4-[(4-fenilfenil)carbonil]piperazin-1-il}etano-1-ona e compostos relacionados como inibidores da sintase de ácidos gordos (fasn) para o tratamento do cancro
EP2968327A4 (en) * 2013-03-14 2016-09-28 Celgene Avilomics Res Inc HETEROARYL COMPOUNDS AND USES THEREOF
CN105764512A (zh) * 2013-09-25 2016-07-13 科尔泰多公众股份公司 表现细胞色素p450抑制的新型官能化5-(苯氧基甲基)-1,3-二噁烷类似物及其应用方法
CA2938244A1 (en) 2014-02-07 2015-08-13 Auspex Pharamaceuticals, Inc. Novel pharmaceutical formulations
CN113382633A (zh) 2018-10-29 2021-09-10 福马治疗股份有限公司 (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式
CN116251072B (zh) * 2023-03-14 2023-09-15 郑州大学第一附属医院 一种吲哚布芬片及其制备方法、用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567264A (en) * 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US6884429B2 (en) * 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
US6479496B1 (en) * 1998-09-10 2002-11-12 Cv Therapeutics, Inc. Methods for treating angina with ranolazine
US6303607B1 (en) * 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
US6440710B1 (en) * 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
ES2193921T3 (es) * 1999-12-03 2003-11-16 Pfizer Prod Inc Compuestos de sulfamoilheteroaril-pirazol como agentes antinflamatorios/analgesicos.
US6396062B1 (en) * 1999-12-03 2002-05-28 Cymer, Inc. Portable laser beam monitor
EP1134290A3 (en) * 2000-03-14 2004-01-02 Pfizer Products Inc. Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors
TW200413273A (en) * 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
WO2006008753A1 (en) * 2004-07-19 2006-01-26 Unichem Laboratories Limited Crystalline and amorphous form of ranolazine and the process for manufacturing them
EP1912947A1 (en) * 2005-07-26 2008-04-23 Nycomed GmbH Isotopically substituted pantoprazole
US20080033011A1 (en) * 2005-07-29 2008-02-07 Concert Pharmaceuticals Inc. Novel benzo[d][1,3]-dioxol derivatives
WO2007016431A2 (en) * 2005-07-29 2007-02-08 Concert Pharmaceuticals Inc. Novel benzo [d] [1,3]-dioxol derivatives
US7598273B2 (en) * 2005-10-06 2009-10-06 Auspex Pharmaceuticals, Inc Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties
US7750168B2 (en) * 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
US7943620B2 (en) * 2007-03-07 2011-05-17 Concert Pharmaceuticals, Inc. Anti-anginal compounds

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