JP2010529128A5 - - Google Patents
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- JP2010529128A5 JP2010529128A5 JP2010511198A JP2010511198A JP2010529128A5 JP 2010529128 A5 JP2010529128 A5 JP 2010529128A5 JP 2010511198 A JP2010511198 A JP 2010511198A JP 2010511198 A JP2010511198 A JP 2010511198A JP 2010529128 A5 JP2010529128 A5 JP 2010529128A5
- Authority
- JP
- Japan
- Prior art keywords
- igf
- igf1
- composition
- pro
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 18
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 16
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 15
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 15
- 230000001225 therapeutic effect Effects 0.000 claims 11
- JJGBXTYGTKWGAT-YUMQZZPRSA-N Gly-Pro-Glu Chemical compound NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(O)=O JJGBXTYGTKWGAT-YUMQZZPRSA-N 0.000 claims 3
- 108010079413 glycyl-prolyl-glutamic acid Proteins 0.000 claims 3
- 102100033367 Appetite-regulating hormone Human genes 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- -1 optionally Proteins 0.000 claims 2
- 210000000225 synapse Anatomy 0.000 claims 2
- 230000027912 synapse maturation Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
- 101710111255 Appetite-regulating hormone Proteins 0.000 claims 1
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 1
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 1
- 101710103504 CXXC-type zinc finger protein 1 Proteins 0.000 claims 1
- 102100036168 CXXC-type zinc finger protein 1 Human genes 0.000 claims 1
- 150000008574 D-amino acids Chemical group 0.000 claims 1
- 102000018997 Growth Hormone Human genes 0.000 claims 1
- 108010051696 Growth Hormone Proteins 0.000 claims 1
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 claims 1
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 claims 1
- QLROSWPKSBORFJ-BQBZGAKWSA-N L-Prolyl-L-glutamic acid Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1 QLROSWPKSBORFJ-BQBZGAKWSA-N 0.000 claims 1
- KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 claims 1
- 229940084576 Neurotransmitter agonist Drugs 0.000 claims 1
- 229940123247 Neurotransmitter antagonist Drugs 0.000 claims 1
- 208000006289 Rett Syndrome Diseases 0.000 claims 1
- 101710142969 Somatoliberin Proteins 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 108010077689 gamma-aminobutyryl-2-methyltryptophyl-2-methyltryptophyl-2-methyltryptophyl-lysinamide Proteins 0.000 claims 1
- KZNQNBZMBZJQJO-YFKPBYRVSA-N glyclproline Chemical compound NCC(=O)N1CCC[C@H]1C(O)=O KZNQNBZMBZJQJO-YFKPBYRVSA-N 0.000 claims 1
- 108010077515 glycylproline Proteins 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 239000003324 growth hormone secretagogue Substances 0.000 claims 1
- 102000044162 human IGF1 Human genes 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000007996 neuronal plasticity Effects 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 108010070643 prolylglutamic acid Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000580 secretagogue effect Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000003977 synaptic function Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93373807P | 2007-06-08 | 2007-06-08 | |
| PCT/US2008/007107 WO2008153929A1 (en) | 2007-06-08 | 2008-06-06 | Igf for the treatment of rett syndrome and synaptic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529128A JP2010529128A (ja) | 2010-08-26 |
| JP2010529128A5 true JP2010529128A5 (https=) | 2011-07-21 |
Family
ID=39891784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511198A Pending JP2010529128A (ja) | 2007-06-08 | 2008-06-06 | レット症候群および他の障害の処置 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7994127B2 (https=) |
| EP (1) | EP2164509A1 (https=) |
| JP (1) | JP2010529128A (https=) |
| CN (1) | CN101820896A (https=) |
| AU (1) | AU2008262387A1 (https=) |
| BR (1) | BRPI0812768A2 (https=) |
| CA (1) | CA2689549A1 (https=) |
| WO (1) | WO2008153929A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130066695A (ko) | 2004-08-23 | 2013-06-20 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| MX373000B (es) | 2005-09-14 | 2020-05-21 | Mannkind Corp | Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas. |
| CA2650140A1 (en) * | 2006-04-14 | 2007-10-25 | Mriganka Sur | Identifying and modulating molecular pathways that mediate nervous system plasticity |
| TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| AU2010204995A1 (en) | 2009-01-16 | 2011-08-18 | Massachusetts Institute Of Technology | Diagnosis and treatment of autism spectrum disorders |
| EP2571515B1 (en) * | 2010-05-17 | 2016-11-30 | Icahn School of Medicine at Mount Sinai | Methods and assays for treating subjects with shank3 deletion, mutation or reduced expression |
| AU2012209466C1 (en) | 2011-01-27 | 2016-06-23 | Neuren Pharmaceuticals Limited | Treatment of Autism Spectrum Disorders using Glycyl-L-2-Methylprolyl-L-Glutamic Acid |
| SG194034A1 (en) * | 2011-04-01 | 2013-11-29 | Mannkind Corp | Blister package for pharmaceutical cartridges |
| EP3628325A1 (en) * | 2011-07-22 | 2020-04-01 | The University of Chicago | Treatments for migraine and related disorders |
| MX2014004983A (es) | 2011-10-24 | 2014-09-22 | Mannkid Corp | Metodos y composiciones para tratar dolor. |
| CA2929286A1 (en) * | 2012-11-28 | 2014-06-05 | Neuren Pharmaceuticals Limited | Treatment of autism spectrum disorders using glycyl-l-2-methylprolyl-l-glutamic acid |
| ES2495266B8 (es) * | 2013-02-13 | 2015-11-12 | Consejo Superior De Investigaciones Científicas (Csic) | Uso de igf-1 como reactivo de diagnóstico y/o pronóstico precoz de la enfermedad de alzheimer |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| ES2927649T3 (es) | 2014-09-25 | 2022-11-08 | Cold Spring Harbor Laboratory | Tratamiento del síndrome de Rett |
| US10507196B2 (en) | 2016-01-26 | 2019-12-17 | Anavex Life Sciences Corp. | Neurodevelopmental disorder therapy |
| TWI601821B (zh) * | 2016-04-15 | 2017-10-11 | 中央研究院 | 治療神經發展性疾病 |
| WO2018217766A1 (en) | 2017-05-22 | 2018-11-29 | Whitehead Institute For Biomedical Research | Kcc2 expression enhancing compounds and uses thereof |
| CN108187031A (zh) * | 2018-02-11 | 2018-06-22 | 中国人民解放军第四军医大学 | rhIGF1在制备治疗脆性X综合征药物中的应用 |
| JP2022547948A (ja) | 2019-09-09 | 2022-11-16 | ザ・ユニバーシティ・オブ・シカゴ | 片頭痛の処置のための併用療法 |
| JP7764992B2 (ja) * | 2019-11-19 | 2025-11-06 | 国立大学法人京都大学 | 大豆ペプチド及び／又はコラーゲンペプチド含有神経心理学的機能改善剤 |
| WO2022055045A1 (ko) * | 2020-09-08 | 2022-03-17 | 주식회사 선마린바이오테크 | 콜라게나제 저해 활성 펩타이드 유도체 및 이의 용도 |
| US20240148835A1 (en) * | 2021-01-28 | 2024-05-09 | University Of Florida Research Foundation, Incorporated | Treating disorders associated with dyrk1a dysfunction |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411890A (en) | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| DE68922602T2 (de) | 1988-01-28 | 1995-12-07 | Polygen Holding Corp | Polypeptide mit hormonwachstumsbefreiender wirkung. |
| AU628322B2 (en) | 1988-01-28 | 1992-09-17 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| SE8803847A0 (sv) * | 1988-10-27 | 1990-04-28 | Kabigen Ab | Neuromodulerande peptid |
| US5093317A (en) * | 1989-06-05 | 1992-03-03 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factor |
| DE69218948T2 (de) | 1991-08-01 | 1997-07-31 | Auckland Uniservices Ltd | IGF-I zur Verbesserung der neuronale Lage |
| US5861373A (en) * | 1991-08-01 | 1999-01-19 | Genentech, Inc | IGF-1 to improve the neural condition |
| US5420112A (en) | 1992-06-12 | 1995-05-30 | Lewis; Michael E. | Prevention and treatment of peripheral neuropathy |
| US5446024A (en) | 1993-12-17 | 1995-08-29 | Genentech, Inc. | Purification of insulin-like growth factor |
| WO1995017204A1 (en) | 1993-12-23 | 1995-06-29 | Auckland Uniservices Limited | Composition and methods to improve neural outcome |
| US5565428A (en) | 1995-05-22 | 1996-10-15 | Genentech, Inc. | Method of administration of IGF-I |
| US7074897B2 (en) | 1997-06-16 | 2006-07-11 | Genentech, Inc. | Pro943 polypeptides |
| US6358951B1 (en) | 1998-08-21 | 2002-03-19 | Pfizer Inc. | Growth hormone secretagogues |
| CN1261158C (zh) | 1998-09-03 | 2006-06-28 | 诺兰兹公司 | 生长激素在制备用于诱导神经保护作用的药剂中的应用 |
| PT1141014E (pt) | 1999-01-06 | 2005-04-29 | Genentech Inc | Variante mutante do factor de crescimento semelhante a insulina (igf-i) |
| EP1351976A2 (en) | 2000-08-24 | 2003-10-15 | Neuronz Limited | Gpe analogs |
| WO2002056873A2 (en) | 2000-12-22 | 2002-07-25 | Bayer Pharmaceuticals Corporation | 2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones as growth hormone secretagogues |
| WO2002057241A1 (en) | 2000-12-22 | 2002-07-25 | Bayer Pharmaceuticals Corporation | 8-(AMINOALKOXYMINO)-8H-DIBENZO[a,e]TRIAZOLO[4,5-c]CYCLOHEPTENES AS GROWTH HORMONE SECRETAGOGUES |
| IL156435A0 (en) | 2001-02-09 | 2004-01-04 | Genentech Inc | Crystallization of igf-1 |
| US7863304B2 (en) | 2001-05-24 | 2011-01-04 | Neuren Pharmaceuticals Limited | Analogs of glycyl-prolyl-glutamate |
| ATE435852T1 (de) | 2001-05-24 | 2009-07-15 | Neuren Pharmaceuticals Ltd | Gpe-analoga und peptidomimetika |
| EP1648873A4 (en) | 2003-03-20 | 2008-06-25 | Neuren Pharmaceuticals Ltd | NEUROPROTECTIVE MACROCYLIC COMPOUNDS AND METHODS OF THEIR APPLICATION |
| US20050027110A1 (en) | 2003-07-24 | 2005-02-03 | Michael Russell | Drug delivery in the nervous system |
| DK2274978T3 (en) | 2003-09-12 | 2015-06-15 | Ipsen Biopharmaceuticals Inc | Methods of treating an insulin-like growth factor-I (IGF-I) deficiency |
| EP1684783A4 (en) | 2003-10-23 | 2009-07-08 | Neuren Pharmaceuticals Ltd | NEUROPROTECTIVE EFFECTS OF GLY-PRO-GLU AFTER INTRAVENOUS INFUSION |
| WO2006023530A2 (en) * | 2004-08-16 | 2006-03-02 | Massachusetts Institute Of Technology | Compositions and methods for enhancing structural and functional nervous system reorganization and recovery |
| JP2008511838A (ja) | 2004-08-30 | 2008-04-17 | テルシカ・インク | インシュリン様成長因子欠乏疾患の診断及び治療のための方法及び装置 |
| KR20060040550A (ko) | 2004-11-05 | 2006-05-10 | 마루이시세이야쿠가부시키가이샤 | 인슐린유사 성장인자-1 분비촉진제 |
| JP2008545752A (ja) | 2005-06-02 | 2008-12-18 | テルシカ インコーポレーティッド | 成長障害を処置するための方法 |
| CA2650140A1 (en) | 2006-04-14 | 2007-10-25 | Mriganka Sur | Identifying and modulating molecular pathways that mediate nervous system plasticity |
-
2008
- 2008-06-06 JP JP2010511198A patent/JP2010529128A/ja active Pending
- 2008-06-06 BR BRPI0812768-9A2A patent/BRPI0812768A2/pt not_active IP Right Cessation
- 2008-06-06 US US12/134,707 patent/US7994127B2/en active Active
- 2008-06-06 AU AU2008262387A patent/AU2008262387A1/en not_active Abandoned
- 2008-06-06 EP EP08768183A patent/EP2164509A1/en not_active Withdrawn
- 2008-06-06 WO PCT/US2008/007107 patent/WO2008153929A1/en not_active Ceased
- 2008-06-06 CN CN200880024937A patent/CN101820896A/zh active Pending
- 2008-06-06 CA CA002689549A patent/CA2689549A1/en not_active Abandoned
-
2011
- 2011-08-08 US US13/204,817 patent/US20120177630A1/en not_active Abandoned
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