JP2010528672A5 - - Google Patents
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- Publication number
- JP2010528672A5 JP2010528672A5 JP2010511663A JP2010511663A JP2010528672A5 JP 2010528672 A5 JP2010528672 A5 JP 2010528672A5 JP 2010511663 A JP2010511663 A JP 2010511663A JP 2010511663 A JP2010511663 A JP 2010511663A JP 2010528672 A5 JP2010528672 A5 JP 2010528672A5
- Authority
- JP
- Japan
- Prior art keywords
- mrna
- editing
- adar
- cells
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 43
- 108020004999 messenger RNA Proteins 0.000 claims 39
- 102100029791 Double-stranded RNA-specific adenosine deaminase Human genes 0.000 claims 33
- 101000865408 Homo sapiens Double-stranded RNA-specific adenosine deaminase Proteins 0.000 claims 33
- 101000761348 Homo sapiens 5-hydroxytryptamine receptor 2C Proteins 0.000 claims 29
- 239000000523 sample Substances 0.000 claims 27
- 102100024959 5-hydroxytryptamine receptor 2C Human genes 0.000 claims 25
- 210000004927 skin cell Anatomy 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 16
- 230000017156 mRNA modification Effects 0.000 claims 16
- 239000012472 biological sample Substances 0.000 claims 14
- 210000000601 blood cell Anatomy 0.000 claims 14
- 210000003491 skin Anatomy 0.000 claims 11
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 9
- 241000282414 Homo sapiens Species 0.000 claims 9
- 210000004369 blood Anatomy 0.000 claims 9
- 239000008280 blood Substances 0.000 claims 9
- 230000014509 gene expression Effects 0.000 claims 9
- 102000001708 Protein Isoforms Human genes 0.000 claims 8
- 108010029485 Protein Isoforms Proteins 0.000 claims 8
- 210000001519 tissue Anatomy 0.000 claims 7
- 230000003321 amplification Effects 0.000 claims 6
- 238000003199 nucleic acid amplification method Methods 0.000 claims 6
- 230000007170 pathology Effects 0.000 claims 6
- 101000742223 Homo sapiens Double-stranded RNA-specific editase 1 Proteins 0.000 claims 5
- 238000012408 PCR amplification Methods 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102100038191 Double-stranded RNA-specific editase 1 Human genes 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 210000000265 leukocyte Anatomy 0.000 claims 4
- 238000007857 nested PCR Methods 0.000 claims 4
- 238000010839 reverse transcription Methods 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- 102000053602 DNA Human genes 0.000 claims 3
- 241000699666 Mus <mouse, genus> Species 0.000 claims 3
- 241000700159 Rattus Species 0.000 claims 3
- 230000004075 alteration Effects 0.000 claims 3
- 210000004556 brain Anatomy 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 210000004207 dermis Anatomy 0.000 claims 3
- 230000001747 exhibiting effect Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 210000003780 hair follicle Anatomy 0.000 claims 3
- 210000002510 keratinocyte Anatomy 0.000 claims 3
- 210000002752 melanocyte Anatomy 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 241000699670 Mus sp. Species 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000002615 epidermis Anatomy 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 231100000915 pathological change Toxicity 0.000 claims 2
- 230000036285 pathological change Effects 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 claims 1
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 claims 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 claims 1
- 102000055025 Adenosine deaminases Human genes 0.000 claims 1
- 206010010144 Completed suicide Diseases 0.000 claims 1
- 101150034590 DAR1 gene Proteins 0.000 claims 1
- 108091006027 G proteins Proteins 0.000 claims 1
- 102000030782 GTP binding Human genes 0.000 claims 1
- 108091000058 GTP-Binding Proteins 0.000 claims 1
- 102000018899 Glutamate Receptors Human genes 0.000 claims 1
- 108010027915 Glutamate Receptors Proteins 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 101000829171 Hypocrea virens (strain Gv29-8 / FGSC 10586) Effector TSP1 Proteins 0.000 claims 1
- 101100468236 Mus musculus Adarb1 gene Proteins 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 101100393304 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GPD1 gene Proteins 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000005251 capillar electrophoresis Methods 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 230000003001 depressive effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000020595 eating behavior Effects 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 210000000744 eyelid Anatomy 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 102000044898 human ADARB1 Human genes 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000001821 langerhans cell Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000000716 merkel cell Anatomy 0.000 claims 1
- 108700007949 mouse ADAR2 Proteins 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000001742 protein purification Methods 0.000 claims 1
- 238000010791 quenching Methods 0.000 claims 1
- 230000000171 quenching effect Effects 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94368507P | 2007-06-13 | 2007-06-13 | |
| US60/943,685 | 2007-06-13 | ||
| US2323908P | 2008-01-24 | 2008-01-24 | |
| US61/023,239 | 2008-01-24 | ||
| PCT/EP2008/057519 WO2008152146A1 (en) | 2007-06-13 | 2008-06-13 | Peripherical tissue sample containing cells expressing the 5htr2c and/or adars as markers of the alteration of the mechanism of the 5htr2c mrna editing and its applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010528672A JP2010528672A (ja) | 2010-08-26 |
| JP2010528672A5 true JP2010528672A5 (enExample) | 2011-07-28 |
| JP5661458B2 JP5661458B2 (ja) | 2015-01-28 |
Family
ID=39776384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511663A Active JP5661458B2 (ja) | 2007-06-13 | 2008-06-13 | ５ＨＴＲ２Ｃ ｍＲＮＡ編集機構の変更のマーカーとしての５ＨＴＲ２Ｃおよび／またはＡＤＡＲを発現する細胞を含有する末梢組織サンプル、ならびにその適用 |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP2162550B1 (enExample) |
| JP (1) | JP5661458B2 (enExample) |
| CN (1) | CN101743322B (enExample) |
| CA (1) | CA2690909C (enExample) |
| ES (2) | ES2646592T3 (enExample) |
| WO (1) | WO2008152146A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2202321A1 (en) | 2008-12-17 | 2010-06-30 | Biocortech | Evaluation of the potential risk of drug induced mood disturbance and suicide:use of a dedicated platform |
| PT2585613T (pt) | 2010-06-24 | 2021-06-25 | Alcediag | Perfil de edição do pré-arnm de pde8a: uso como biomarcador específico de atividades de adars em tecidos humanos para diagnosticar e prevenir e avaliar a eficácia terapêutica e / ou eficiência ou efeitos colaterais potenciais de medicamentos |
| US11873531B2 (en) * | 2010-06-24 | 2024-01-16 | Alcediag | Editing profiling of PDE8A pre-mRNA: use as specific biomarker of ADARs activities in human tissues to diagnose and to predict and assess therapeutic efficacy and/or efficiency or potential drug side effects |
| CN102146119A (zh) * | 2011-01-17 | 2011-08-10 | 山东大学齐鲁医院 | 一种小鼠表皮总蛋白的提取方法 |
| WO2017153849A1 (en) | 2016-03-11 | 2017-09-14 | Alcediag | Algorithm and an in vitro method based on rna editing to select particular effect induced by active compounds |
| CN109642256A (zh) * | 2016-07-28 | 2019-04-16 | 阿利瑟迪亚格公司 | 作为用于情绪障碍测试的生物标志物的rna编辑 |
| NZ751483A (en) * | 2016-09-01 | 2022-07-01 | Proqr Therapeutics Ii Bv | Chemically modified single-stranded rna-editing oligonucleotides |
| EP3819386A1 (en) * | 2019-11-08 | 2021-05-12 | Alcediag | Diagnosing of mood disorders using blood rna editing biomarkers |
| EP3819387A1 (en) * | 2019-11-08 | 2021-05-12 | Alcediag | Differential diagnosis of bipolar disorder and unipolar depression by blood rna editing biomarkers |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763174A (en) * | 1994-02-17 | 1998-06-09 | The Wistar Institute Of Anatomy & Biology | RNA editing enzyme and methods of use thereof |
| FR2842827B1 (fr) * | 2002-07-26 | 2004-10-22 | Biocortech | NOUVELLE METHODE D'ANALYSE D'ACIDE NUCLEIQUE ET SON UTILISATION POUR EVALUER LE DEGRE D'EDITION DE L'ARNm DU RECEPTEUR 5-HT2c |
| WO2005087949A1 (en) * | 2004-03-12 | 2005-09-22 | Compugen Ltd. | Systematic mapping of adenosine to inosine editing sites in the human transcriptome |
| GB0420873D0 (en) * | 2004-09-20 | 2004-10-20 | Curidium Ltd | Methods of diagnosis |
| JP2008546379A (ja) * | 2005-06-16 | 2008-12-25 | エボテツク・ニユーロサイエンシーズ・ゲー・エム・ベー・ハー | 神経変性疾患のための診断および治療の標的ａｄａｒｂ２タンパク質 |
-
2008
- 2008-06-13 ES ES08761038.2T patent/ES2646592T3/es active Active
- 2008-06-13 ES ES17185202T patent/ES2952748T3/es active Active
- 2008-06-13 EP EP08761038.2A patent/EP2162550B1/en not_active Not-in-force
- 2008-06-13 JP JP2010511663A patent/JP5661458B2/ja active Active
- 2008-06-13 EP EP17185202.3A patent/EP3272881B9/en active Active
- 2008-06-13 CA CA2690909A patent/CA2690909C/en active Active
- 2008-06-13 WO PCT/EP2008/057519 patent/WO2008152146A1/en not_active Ceased
- 2008-06-13 CN CN200880019753.XA patent/CN101743322B/zh active Active
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