JP2010527988A5 - - Google Patents
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- Publication number
- JP2010527988A5 JP2010527988A5 JP2010508932A JP2010508932A JP2010527988A5 JP 2010527988 A5 JP2010527988 A5 JP 2010527988A5 JP 2010508932 A JP2010508932 A JP 2010508932A JP 2010508932 A JP2010508932 A JP 2010508932A JP 2010527988 A5 JP2010527988 A5 JP 2010527988A5
- Authority
- JP
- Japan
- Prior art keywords
- surface antigen
- cell surface
- bone marrow
- cells
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710160107 Outer membrane protein A Proteins 0.000 claims 39
- 210000004027 cell Anatomy 0.000 claims 21
- 210000000130 stem cell Anatomy 0.000 claims 19
- 210000001185 bone marrow Anatomy 0.000 claims 18
- 239000003795 chemical substances by application Substances 0.000 claims 16
- 230000000735 allogeneic effect Effects 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 10
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 8
- 208000024908 graft versus host disease Diseases 0.000 claims 8
- 208000024891 symptom Diseases 0.000 claims 8
- 102000003814 Interleukin-10 Human genes 0.000 claims 7
- 108090000174 Interleukin-10 Proteins 0.000 claims 7
- 229940076144 interleukin-10 Drugs 0.000 claims 7
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 6
- 102000018866 Hyaluronan Receptors Human genes 0.000 claims 6
- 102100025304 Integrin beta-1 Human genes 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 239000006228 supernatant Substances 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 210000002798 bone marrow cell Anatomy 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 102000004008 5'-Nucleotidase Human genes 0.000 claims 3
- 102000012085 Endoglin Human genes 0.000 claims 3
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 3
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 3
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 3
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 3
- 238000000432 density-gradient centrifugation Methods 0.000 claims 3
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 2
- 108010049003 Fibrinogen Proteins 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 108010039918 Polylysine Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 238000012136 culture method Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 229940012952 fibrinogen Drugs 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 208000016332 liver symptom Diseases 0.000 claims 2
- 229920000656 polylysine Polymers 0.000 claims 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000024340 acute graft versus host disease Diseases 0.000 claims 1
- 208000017760 chronic graft versus host disease Diseases 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 208000013220 shortness of breath Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2007-0053298 | 2007-05-31 | ||
| KR1020070053298A KR20080105555A (ko) | 2007-05-31 | 2007-05-31 | 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법 |
| PCT/IB2008/003005 WO2009040666A2 (en) | 2007-05-25 | 2008-05-27 | Treatment of graft-versus-host disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527988A JP2010527988A (ja) | 2010-08-19 |
| JP2010527988A5 true JP2010527988A5 (enExample) | 2012-07-05 |
| JP5683264B2 JP5683264B2 (ja) | 2015-03-11 |
Family
ID=40072607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508932A Active JP5683264B2 (ja) | 2007-05-31 | 2008-05-27 | 移植片対宿主病の治療 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9439929B2 (enExample) |
| EP (1) | EP2160100B8 (enExample) |
| JP (1) | JP5683264B2 (enExample) |
| KR (1) | KR20080105555A (enExample) |
| CN (1) | CN101754767A (enExample) |
| ES (1) | ES2628362T3 (enExample) |
| WO (1) | WO2009040666A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080105555A (ko) * | 2007-05-31 | 2008-12-04 | 인하대학교 산학협력단 | 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법 |
| US8545888B2 (en) * | 2007-06-14 | 2013-10-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tendon stem cells |
| MX339624B (es) | 2008-08-20 | 2016-06-02 | Anthrogenesis Corp | Composiciones mejoradas de celulas y metodos para preparar las mismas. |
| CA2767970C (en) | 2009-07-13 | 2019-10-08 | Biogencell, Ltd. | Method for using directing cells for specific stem/progenitor cell activation and differentiation |
| KR101694554B1 (ko) * | 2011-08-30 | 2017-01-18 | 가톨릭대학교 산학협력단 | 자연살해세포 억제제 및 간엽줄기세포를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료를 위한 세포치료제 조성물 |
| KR101705378B1 (ko) * | 2011-09-23 | 2017-02-13 | 가톨릭대학교 산학협력단 | 간엽줄기세포 및 ⅰｌ-21 차단제를 포함하는 이식편대숙주질환의 예방 또는 치료용 조성물 |
| US8956870B2 (en) | 2012-01-19 | 2015-02-17 | Biogencell, Ltd. | Method for using directing cells for specific stem/progenitor cell activation and differentiation |
| US20180005156A1 (en) * | 2015-01-20 | 2018-01-04 | Ge Healthcare Bio-Sciences Corp. | Process Simulation in a Cell Processing Facility |
| AU2018234827B2 (en) | 2017-03-15 | 2024-04-04 | Orca Biosystems Inc. | Compositions and methods for hematopoietic stem cell transplants |
| JP7467358B2 (ja) | 2018-02-20 | 2024-04-15 | ウニヴェルシテ・ドゥ・モントリオール | 免疫応答を媒介するｉｎ ｖｉｖｏでのＮＫ細胞およびＤＣ細胞の拡大 |
| KR102096886B1 (ko) * | 2018-06-04 | 2020-04-03 | 이화여자대학교 산학협력단 | 편도 유래 중간엽 줄기세포의 조정 배지를 포함하는 이식편대숙주 질환 예방 혹은 치료용 조성물 |
| CN109674818A (zh) * | 2018-09-29 | 2019-04-26 | 南方医科大学南方医院 | hAMSCs在制备治疗急性移植物抗宿主病药物中的用途 |
| US20220387504A1 (en) * | 2018-12-17 | 2022-12-08 | Scm Lifescience Co., Ltd. | Pharmaceutical composition comprising clonal stem cells for treating graft-versus-host disease |
| KR20220143092A (ko) * | 2020-02-19 | 2022-10-24 | 메조블라스트 인터내셔널 에스에이알엘 | 만성 이식편 대 숙주 질환의 치료 방법 |
| JP2023521157A (ja) * | 2020-04-06 | 2023-05-23 | アールエックスセル インコーポレーテッド | 低免疫原性の細胞ならびにそれらの産生のための方法および組成物 |
| KR102880848B1 (ko) * | 2024-03-11 | 2025-11-04 | 에스씨엠생명과학 주식회사 | 중간엽 줄기세포의 신속 층분리 배양 방법 |
| WO2025192960A1 (ko) * | 2024-03-11 | 2025-09-18 | 에스씨엠생명과학 주식회사 | 중간엽 줄기세포의 신속 층분리 배양 방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| US5690926A (en) | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
| US5426098A (en) * | 1993-09-02 | 1995-06-20 | Celtrix Pharmaceuticals, Inc. | Increase in hematopoietic progenitor cells in peripheral blood by transforming growth factor beta |
| US5827742A (en) | 1994-09-01 | 1998-10-27 | Beth Israel Deaconess Medical Center, Inc. | Method of selecting pluripotent hematopioetic progenitor cells |
| US6082364A (en) | 1997-12-15 | 2000-07-04 | Musculoskeletal Development Enterprises, Llc | Pluripotential bone marrow cell line and methods of using the same |
| CA2320040C (en) * | 1998-03-18 | 2007-05-22 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| US7303769B2 (en) * | 2000-06-05 | 2007-12-04 | University Of South Florida | Method for purifying pluri-differentiated mesenchymal progenitor cells |
| US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| EP2298861B1 (en) * | 2004-03-22 | 2017-09-13 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| US7781211B2 (en) * | 2005-06-17 | 2010-08-24 | Homeotherapy, Co. Ltd | Isolation of multi-lineage stem cells |
| KR20080105555A (ko) * | 2007-05-31 | 2008-12-04 | 인하대학교 산학협력단 | 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법 |
-
2007
- 2007-05-31 KR KR1020070053298A patent/KR20080105555A/ko not_active Ceased
-
2008
- 2008-05-27 US US12/127,734 patent/US9439929B2/en active Active
- 2008-05-27 JP JP2010508932A patent/JP5683264B2/ja active Active
- 2008-05-27 ES ES08834068.2T patent/ES2628362T3/es active Active
- 2008-05-27 CN CN200880100116A patent/CN101754767A/zh active Pending
- 2008-05-27 WO PCT/IB2008/003005 patent/WO2009040666A2/en not_active Ceased
- 2008-05-27 US US12/127,743 patent/US20080292601A1/en not_active Abandoned
- 2008-05-27 EP EP08834068.2A patent/EP2160100B8/en active Active
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