KR20080105555A - 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법 - Google Patents

중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법 Download PDF

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KR20080105555A
KR20080105555A KR1020070053298A KR20070053298A KR20080105555A KR 20080105555 A KR20080105555 A KR 20080105555A KR 1020070053298 A KR1020070053298 A KR 1020070053298A KR 20070053298 A KR20070053298 A KR 20070053298A KR 20080105555 A KR20080105555 A KR 20080105555A
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mesenchymal stem
stem cells
culture
versus
host disease
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Ceased
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KR1020070053298A
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English (en)
Korean (ko)
Inventor
송순욱
이문희
김철수
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인하대학교 산학협력단
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Priority to KR1020070053298A priority Critical patent/KR20080105555A/ko
Priority to ES08834068.2T priority patent/ES2628362T3/es
Priority to US12/127,743 priority patent/US20080292601A1/en
Priority to JP2010508932A priority patent/JP5683264B2/ja
Priority to EP08834068.2A priority patent/EP2160100B8/en
Priority to CN200880100116A priority patent/CN101754767A/zh
Priority to US12/127,734 priority patent/US9439929B2/en
Priority to PCT/IB2008/003005 priority patent/WO2009040666A2/en
Publication of KR20080105555A publication Critical patent/KR20080105555A/ko
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2066IL-10
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22Immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/418Antigens related to induction of tolerance to non-self
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020070053298A 2005-06-17 2007-05-31 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법 Ceased KR20080105555A (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR1020070053298A KR20080105555A (ko) 2007-05-31 2007-05-31 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법
ES08834068.2T ES2628362T3 (es) 2007-05-25 2008-05-27 Tratamiento de la enfermedad de injerto contra hospedador
US12/127,743 US20080292601A1 (en) 2007-05-25 2008-05-27 Treatment of graft-versus-host disease with il-10 expressing cells
JP2010508932A JP5683264B2 (ja) 2007-05-31 2008-05-27 移植片対宿主病の治療
EP08834068.2A EP2160100B8 (en) 2007-05-25 2008-05-27 Treatment of graft-versus-host disease
CN200880100116A CN101754767A (zh) 2007-05-25 2008-05-27 移植物抗宿主疾病的治疗
US12/127,734 US9439929B2 (en) 2005-06-17 2008-05-27 Treatment of graft-versus-host disease
PCT/IB2008/003005 WO2009040666A2 (en) 2007-05-25 2008-05-27 Treatment of graft-versus-host disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020070053298A KR20080105555A (ko) 2007-05-31 2007-05-31 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법

Publications (1)

Publication Number Publication Date
KR20080105555A true KR20080105555A (ko) 2008-12-04

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KR1020070053298A Ceased KR20080105555A (ko) 2005-06-17 2007-05-31 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법

Country Status (7)

Country Link
US (2) US9439929B2 (enExample)
EP (1) EP2160100B8 (enExample)
JP (1) JP5683264B2 (enExample)
KR (1) KR20080105555A (enExample)
CN (1) CN101754767A (enExample)
ES (1) ES2628362T3 (enExample)
WO (1) WO2009040666A2 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130023797A (ko) * 2011-08-30 2013-03-08 가톨릭대학교 산학협력단 자연살해세포 억제제 및 간엽줄기세포를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료를 위한 세포치료제 조성물
KR20130032465A (ko) * 2011-09-23 2013-04-02 가톨릭대학교 산학협력단 간엽줄기세포 및 ⅰl-21 차단제를 포함하는 이식편대숙주질환의 예방 또는 치료용 조성물
WO2019161494A1 (en) 2018-02-20 2019-08-29 Universite De Montreal Expansion of nk and dc cells in vivo mediating immune response
KR20190138244A (ko) * 2018-06-04 2019-12-12 이화여자대학교 산학협력단 편도 유래 중간엽 줄기세포의 조정 배지를 포함하는 이식편대숙주 질환 예방 혹은 치료용 조성물
WO2020130431A1 (ko) * 2018-12-17 2020-06-25 에스씨엠생명과학 주식회사 클로날 줄기세포를 포함하는 이식편대숙주질환 치료용 약학적 조성물
WO2025192960A1 (ko) * 2024-03-11 2025-09-18 에스씨엠생명과학 주식회사 중간엽 줄기세포의 신속 층분리 배양 방법
KR20250137500A (ko) * 2024-03-11 2025-09-18 에스씨엠생명과학 주식회사 중간엽 줄기세포의 신속 층분리 배양 방법

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080105555A (ko) * 2007-05-31 2008-12-04 인하대학교 산학협력단 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법
US8545888B2 (en) * 2007-06-14 2013-10-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Tendon stem cells
MX339624B (es) 2008-08-20 2016-06-02 Anthrogenesis Corp Composiciones mejoradas de celulas y metodos para preparar las mismas.
CA2767970C (en) 2009-07-13 2019-10-08 Biogencell, Ltd. Method for using directing cells for specific stem/progenitor cell activation and differentiation
US8956870B2 (en) 2012-01-19 2015-02-17 Biogencell, Ltd. Method for using directing cells for specific stem/progenitor cell activation and differentiation
US20180005156A1 (en) * 2015-01-20 2018-01-04 Ge Healthcare Bio-Sciences Corp. Process Simulation in a Cell Processing Facility
AU2018234827B2 (en) 2017-03-15 2024-04-04 Orca Biosystems Inc. Compositions and methods for hematopoietic stem cell transplants
CN109674818A (zh) * 2018-09-29 2019-04-26 南方医科大学南方医院 hAMSCs在制备治疗急性移植物抗宿主病药物中的用途
KR20220143092A (ko) * 2020-02-19 2022-10-24 메조블라스트 인터내셔널 에스에이알엘 만성 이식편 대 숙주 질환의 치료 방법
JP2023521157A (ja) * 2020-04-06 2023-05-23 アールエックスセル インコーポレーテッド 低免疫原性の細胞ならびにそれらの産生のための方法および組成物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US5690926A (en) 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US5426098A (en) * 1993-09-02 1995-06-20 Celtrix Pharmaceuticals, Inc. Increase in hematopoietic progenitor cells in peripheral blood by transforming growth factor beta
US5827742A (en) 1994-09-01 1998-10-27 Beth Israel Deaconess Medical Center, Inc. Method of selecting pluripotent hematopioetic progenitor cells
US6082364A (en) 1997-12-15 2000-07-04 Musculoskeletal Development Enterprises, Llc Pluripotential bone marrow cell line and methods of using the same
CA2320040C (en) * 1998-03-18 2007-05-22 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US7303769B2 (en) * 2000-06-05 2007-12-04 University Of South Florida Method for purifying pluri-differentiated mesenchymal progenitor cells
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
EP2298861B1 (en) * 2004-03-22 2017-09-13 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
US7781211B2 (en) * 2005-06-17 2010-08-24 Homeotherapy, Co. Ltd Isolation of multi-lineage stem cells
KR20080105555A (ko) * 2007-05-31 2008-12-04 인하대학교 산학협력단 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130023797A (ko) * 2011-08-30 2013-03-08 가톨릭대학교 산학협력단 자연살해세포 억제제 및 간엽줄기세포를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료를 위한 세포치료제 조성물
KR20130032465A (ko) * 2011-09-23 2013-04-02 가톨릭대학교 산학협력단 간엽줄기세포 및 ⅰl-21 차단제를 포함하는 이식편대숙주질환의 예방 또는 치료용 조성물
EP3755355A4 (en) * 2018-02-20 2022-01-05 Universite De Montreal Expansion of nk and dc cells in vivo mediating immune response
WO2019161494A1 (en) 2018-02-20 2019-08-29 Universite De Montreal Expansion of nk and dc cells in vivo mediating immune response
US12011460B2 (en) 2018-02-20 2024-06-18 Universite De Montreal Expansion of NK and DC cells in vivo mediating immune response
KR20190138244A (ko) * 2018-06-04 2019-12-12 이화여자대학교 산학협력단 편도 유래 중간엽 줄기세포의 조정 배지를 포함하는 이식편대숙주 질환 예방 혹은 치료용 조성물
WO2019235789A1 (ko) * 2018-06-04 2019-12-12 이화여자대학교 산학협력단 편도 유래 중간엽 줄기세포의 조정 배지를 포함하는 이식편대숙주 질환 예방 혹은 치료용 조성물
KR20200074869A (ko) * 2018-12-17 2020-06-25 에스씨엠생명과학 주식회사 클로날 줄기세포를 포함하는 이식편대숙주질환 치료용 약학적 조성물
CN113194968A (zh) * 2018-12-17 2021-07-30 Scm生命科学有限公司 包含克隆干细胞的用于治疗移植物抗宿主疾病的药学组合物
WO2020130431A1 (ko) * 2018-12-17 2020-06-25 에스씨엠생명과학 주식회사 클로날 줄기세포를 포함하는 이식편대숙주질환 치료용 약학적 조성물
CN113194968B (zh) * 2018-12-17 2024-10-15 Scm生命科学有限公司 包含克隆干细胞的用于治疗移植物抗宿主疾病的药学组合物
WO2025192960A1 (ko) * 2024-03-11 2025-09-18 에스씨엠생명과학 주식회사 중간엽 줄기세포의 신속 층분리 배양 방법
KR20250137500A (ko) * 2024-03-11 2025-09-18 에스씨엠생명과학 주식회사 중간엽 줄기세포의 신속 층분리 배양 방법

Also Published As

Publication number Publication date
CN101754767A (zh) 2010-06-23
US20080292600A1 (en) 2008-11-27
EP2160100B1 (en) 2017-03-15
EP2160100A2 (en) 2010-03-10
US20080292601A1 (en) 2008-11-27
WO2009040666A3 (en) 2009-12-30
ES2628362T3 (es) 2017-08-02
EP2160100A4 (en) 2011-08-31
US20160166614A9 (en) 2016-06-16
JP5683264B2 (ja) 2015-03-11
EP2160100B8 (en) 2017-07-05
JP2010527988A (ja) 2010-08-19
US9439929B2 (en) 2016-09-13
WO2009040666A2 (en) 2009-04-02

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