JP2010527911A5 - - Google Patents

Download PDF

Info

Publication number
JP2010527911A5
JP2010527911A5 JP2009554721A JP2009554721A JP2010527911A5 JP 2010527911 A5 JP2010527911 A5 JP 2010527911A5 JP 2009554721 A JP2009554721 A JP 2009554721A JP 2009554721 A JP2009554721 A JP 2009554721A JP 2010527911 A5 JP2010527911 A5 JP 2010527911A5
Authority
JP
Japan
Prior art keywords
alkyl
formula
compound
mmol
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009554721A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010527911A (ja
JP5450108B2 (ja
Filing date
Publication date
Priority claimed from PCT/US2007/007444 external-priority patent/WO2007117381A2/en
Application filed filed Critical
Priority claimed from PCT/US2008/057543 external-priority patent/WO2008118718A2/en
Publication of JP2010527911A publication Critical patent/JP2010527911A/ja
Publication of JP2010527911A5 publication Critical patent/JP2010527911A5/ja
Application granted granted Critical
Publication of JP5450108B2 publication Critical patent/JP5450108B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009554721A 2007-03-23 2008-03-19 グルコキナーゼ活性化剤としての２−アミノピリジン類似体 Expired - Fee Related JP5450108B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US91971907P 2007-03-23 2007-03-23
PCT/US2007/007444 WO2007117381A2 (en) 2006-03-24 2007-03-23 2 -aminopyridine analogs as glucokinase activators
US60/919,719 2007-03-23
USPCT/US2007/007444 2007-03-23
US97426007P 2007-09-21 2007-09-21
US60/974,260 2007-09-21
PCT/US2008/057543 WO2008118718A2 (en) 2007-03-23 2008-03-19 2-aminopyridine analogs as glucokinase activators

Publications (3)

Publication Number Publication Date
JP2010527911A JP2010527911A (ja) 2010-08-19
JP2010527911A5 true JP2010527911A5 (enExample) 2012-05-10
JP5450108B2 JP5450108B2 (ja) 2014-03-26

Family

ID=39711955

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009554721A Expired - Fee Related JP5450108B2 (ja) 2007-03-23 2008-03-19 グルコキナーゼ活性化剤としての２−アミノピリジン類似体

Country Status (7)

Country Link
US (1) US8362037B2 (enExample)
EP (1) EP2173745A2 (enExample)
JP (1) JP5450108B2 (enExample)
CN (1) CN101679405A (enExample)
CA (1) CA2681695A1 (enExample)
TW (1) TW200843765A (enExample)
WO (1) WO2008118718A2 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8431713B2 (en) * 2007-01-24 2013-04-30 Array Biopharma, Inc. 2-aminopyridine derivatives as glucokinase activators
UA101166C2 (ru) 2007-09-21 2013-03-11 Аррей Биофарма Инк. Производные пиридин-2-иламино-1,2,4-тиадиазола как активаторы глюкокиназы для лечения сахарного диабета
EA201000561A1 (ru) * 2007-10-09 2010-10-29 Мерк Патент Гмбх Производные пиридина, пригодные в качестве активаторов глюкокиназы
JP5529044B2 (ja) * 2008-01-25 2014-06-25 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 殺菌性複素環化合物
AR077821A1 (es) * 2009-08-11 2011-09-28 Sanofi Aventis Us Llc Procedimiento para preparar hidrocloruro de 4-metil-3-tienilamina
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2553086B1 (en) 2010-03-31 2017-04-19 The Scripps Research Institute Reprogramming cells
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
JPWO2012121314A1 (ja) 2011-03-09 2014-07-17 第一三共株式会社 ジピリジルアミン誘導体
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9296735B2 (en) 2012-05-18 2016-03-29 Amgen Inc. Method for the preparation of thiadiazoles
US9663536B2 (en) 2013-03-13 2017-05-30 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
US9580431B2 (en) 2013-03-13 2017-02-28 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
CN105829296A (zh) 2013-12-18 2016-08-03 巴斯夫欧洲公司 带有亚胺衍生的取代基的唑类化合物
AU2015237253B2 (en) 2014-03-28 2019-11-14 Azevan Pharmaceuticals, Inc. Compositions and methods for treating neurodegenerative diseases
CN106349159B (zh) * 2016-08-29 2019-03-22 山东省联合农药工业有限公司 一种3-氯-2-氰基-5-三氟甲基吡啶的制备方法
CN107286087B (zh) * 2017-04-16 2020-01-07 内蒙古佳瑞米精细化工有限公司 一种2-氰基-3-氯-5-三氟甲基吡啶的合成方法
MY208313A (en) 2017-09-15 2025-04-30 Azevan Pharmaceuticals Inc Compositions and methods for treating brain injury
EP3703675A4 (en) 2017-10-30 2021-06-16 Neuropore Therapies, Inc. SUBSTITUTED PHENYLSULFONYLPHÉNYLTRIAZOLETHIONES AND ASSOCIATED USES
EP3846793B1 (en) 2018-09-07 2024-01-24 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
JP7648027B2 (ja) 2019-12-19 2025-03-18 クリア、スペイン、エセ、ア、ウ ウパダシチニブの調製のための方法及び中間体
MX2022010944A (es) 2020-03-03 2022-11-09 Pic Therapeutics Inc Inhibidores del factor de iniciacion de traduccion eucariotica 4e (eif4e) y sus usos.
TW202315621A (zh) 2021-08-25 2023-04-16 美商皮克醫療公司 Ｅｉｆ４ｅ抑制劑及其用途
JP2024532276A (ja) 2021-08-25 2024-09-05 ピク セラピューティクス， インコーポレイテッド ｅＩＦ４Ｅ阻害剤及びその使用
US20250340570A1 (en) 2022-04-27 2025-11-06 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3703435A1 (de) * 1987-02-05 1988-08-18 Thomae Gmbh Dr K Neue thiazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
US7629362B2 (en) * 2003-02-13 2009-12-08 Banyu Pharmaceutical Co., Ltd. 2-pyridine carboxamide derivatives
AR049418A1 (es) * 2004-02-27 2006-08-02 Bayer Pharmaceuticals Corp Derivados de heteroarilaminopirazol y composiciones farmaceuticas para el tratamiento de la diabetes.
AU2005223610B2 (en) 2004-03-23 2008-05-29 Banyu Pharmaceutical Co., Ltd. Substituted quinazoline or pyridopyrimidine derivative
ATE521608T1 (de) * 2005-11-01 2011-09-15 Array Biopharma Inc Glucokinaseaktivatoren
ES2378704T3 (es) * 2006-01-27 2012-04-17 Array Biopharma, Inc. Activadores de la glucocinasa
EP2543667B1 (en) * 2006-03-24 2015-01-28 Array Biopharma, Inc. A method of preparing 2-aminopyridine analogs as glucokinase activators

Similar Documents

Publication Publication Date Title
JP5450108B2 (ja) グルコキナーゼ活性化剤としての２−アミノピリジン類似体
KR101566042B1 (ko) 진성 당뇨병을 치료하기 위한 글루코키나제 활성화제로서의 피리딘-２-일-아미노-１,２,４-티아디아졸 유도체
US8431713B2 (en) 2-aminopyridine derivatives as glucokinase activators
US8022222B2 (en) Glucokinase activators
AU2007235558B2 (en) 2 -aminopyridine analogs as glucokinase activators
EP1598349A1 (en) Novel 2-pyridinecarboxamide derivatives
HK1230179A1 (en) Pyridin-2-yl-amino-1,2,4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus
HK1183482A (en) Pyridin-2-yl-amino-1,2,4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus
HK1197821B (en) Pyridin-2-yl-thiourea and pyridin-2-yl-amine derivatives as intermediates for the preparation of pyridin-2yl-amino-1,2,4-thiadiazole glucokinase activators
HK1145498B (en) Pyridin-2 -yl-amino-i, 2, 4 -thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus
HK1178901A (en) 2-aminopyridine analogs as glucokinase activators