JP2010527911A5 - - Google Patents

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Publication number
JP2010527911A5
JP2010527911A5 JP2009554721A JP2009554721A JP2010527911A5 JP 2010527911 A5 JP2010527911 A5 JP 2010527911A5 JP 2009554721 A JP2009554721 A JP 2009554721A JP 2009554721 A JP2009554721 A JP 2009554721A JP 2010527911 A5 JP2010527911 A5 JP 2010527911A5
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JP
Japan
Prior art keywords
alkyl
formula
compound
mmol
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009554721A
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English (en)
Japanese (ja)
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JP5450108B2 (ja
JP2010527911A (ja
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Publication date
Priority claimed from PCT/US2007/007444 external-priority patent/WO2007117381A2/en
Application filed filed Critical
Priority claimed from PCT/US2008/057543 external-priority patent/WO2008118718A2/en
Publication of JP2010527911A publication Critical patent/JP2010527911A/ja
Publication of JP2010527911A5 publication Critical patent/JP2010527911A5/ja
Application granted granted Critical
Publication of JP5450108B2 publication Critical patent/JP5450108B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009554721A 2007-03-23 2008-03-19 グルコキナーゼ活性化剤としての２−アミノピリジン類似体 Expired - Fee Related JP5450108B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US91971907P 2007-03-23 2007-03-23
USPCT/US2007/007444 2007-03-23
PCT/US2007/007444 WO2007117381A2 (en) 2006-03-24 2007-03-23 2 -aminopyridine analogs as glucokinase activators
US60/919,719 2007-03-23
US97426007P 2007-09-21 2007-09-21
US60/974,260 2007-09-21
PCT/US2008/057543 WO2008118718A2 (en) 2007-03-23 2008-03-19 2-aminopyridine analogs as glucokinase activators

Publications (3)

Publication Number Publication Date
JP2010527911A JP2010527911A (ja) 2010-08-19
JP2010527911A5 true JP2010527911A5 (enExample) 2012-05-10
JP5450108B2 JP5450108B2 (ja) 2014-03-26

Family

ID=39711955

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009554721A Expired - Fee Related JP5450108B2 (ja) 2007-03-23 2008-03-19 グルコキナーゼ活性化剤としての２−アミノピリジン類似体

Country Status (7)

Country Link
US (1) US8362037B2 (enExample)
EP (1) EP2173745A2 (enExample)
JP (1) JP5450108B2 (enExample)
CN (1) CN101679405A (enExample)
CA (1) CA2681695A1 (enExample)
TW (1) TW200843765A (enExample)
WO (1) WO2008118718A2 (enExample)

Families Citing this family (30)

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US8431713B2 (en) * 2007-01-24 2013-04-30 Array Biopharma, Inc. 2-aminopyridine derivatives as glucokinase activators
EA019104B1 (ru) * 2007-09-21 2014-01-30 Эррей Биофарма Инк. Активаторы глюкокиназы
KR20100090250A (ko) * 2007-10-09 2010-08-13 메르크 파텐트 게엠베하 글루코키나제 활성체로서 유용한 피리딘 유도체
EP2402332A3 (en) * 2008-01-25 2014-10-29 E.I. Du Pont De Nemours And Company Fungicidal heterocyclic compounds
AR077821A1 (es) * 2009-08-11 2011-09-28 Sanofi Aventis Us Llc Procedimiento para preparar hidrocloruro de 4-metil-3-tienilamina
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
CA2800498C (en) 2010-03-31 2021-11-16 The Scripps Research Institute Reprogramming cells
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
KR20140051834A (ko) 2011-03-09 2014-05-02 다이이찌 산쿄 가부시키가이샤 디피리딜아민 유도체
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2850057A4 (en) 2012-05-18 2016-01-27 Amgen Inc PROCESS FOR THE PREPARATION OF THIADIAZOLENE
JP2016512511A (ja) 2013-03-13 2016-04-28 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ヒト免疫不全ウイルス複製の阻害剤
JP2016516692A (ja) 2013-03-13 2016-06-09 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ヒト免疫不全ウイルス複製の阻害剤
CN105829296A (zh) 2013-12-18 2016-08-03 巴斯夫欧洲公司 带有亚胺衍生的取代基的唑类化合物
BR112016022575A2 (pt) 2014-03-28 2017-08-15 Azevan Pharmaceuticals Inc Composições e métodos para o tratamento de doenças neurodegenerativas
CN106349159B (zh) * 2016-08-29 2019-03-22 山东省联合农药工业有限公司 一种3-氯-2-氰基-5-三氟甲基吡啶的制备方法
CN107286087B (zh) * 2017-04-16 2020-01-07 内蒙古佳瑞米精细化工有限公司 一种2-氰基-3-氯-5-三氟甲基吡啶的合成方法
KR102790657B1 (ko) 2017-09-15 2025-04-02 아제반 파마슈티칼스, 인코퍼레이티드 뇌 손상을 치료하기 위한 조성물 및 방법
BR112020008727A2 (pt) 2017-10-30 2020-10-20 Neuropore Therapies, Inc. fenil sulfonil fenil triazol tionas substituídas e usos destas
EP3846793B1 (en) 2018-09-07 2024-01-24 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
BR112022012153A2 (pt) 2019-12-19 2022-08-30 Curia Spain S A U Processo para preparar um composto e composto
AR121506A1 (es) 2020-03-03 2022-06-08 Pic Therapeutics Inc Inhibidores del eif4e y sus usos
IL310924A (en) 2021-08-25 2024-04-01 Pic Therapeutics Inc Eif4e inhibitors and uses thereof
US12157732B2 (en) 2021-08-25 2024-12-03 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
EP4514807B1 (en) 2022-04-27 2025-12-17 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing

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DE3703435A1 (de) * 1987-02-05 1988-08-18 Thomae Gmbh Dr K Neue thiazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
BRPI0407283A (pt) * 2003-02-13 2006-01-31 Banyu Pharma Co Ltd Composto, composição farmacêutica, e, agente ativador de glucoquinase, agentes terapêuticos e/ou agentes preventivos para diabetes melito e obesidade
AR049418A1 (es) * 2004-02-27 2006-08-02 Bayer Pharmaceuticals Corp Derivados de heteroarilaminopirazol y composiciones farmaceuticas para el tratamiento de la diabetes.
AU2005223610B2 (en) * 2004-03-23 2008-05-29 Banyu Pharmaceutical Co., Ltd. Substituted quinazoline or pyridopyrimidine derivative
EP1948652B1 (en) * 2005-11-01 2011-08-24 Array Biopharma, Inc. Glucokinase activators
JP5236499B2 (ja) * 2006-01-27 2013-07-17 アレイ バイオファーマ、インコーポレイテッド グルコキナーゼ活性化剤
RS53981B1 (sr) * 2006-03-24 2015-10-30 Array Biopharma Inc. Analozi 2-aminopiridina kao aktivatori glukokinaze

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