JP2010525154A5 - - Google Patents

Info

Publication number

JP2010525154A5

JP2010525154A5 JP2010506488A JP2010506488A JP2010525154A5 JP 2010525154 A5 JP2010525154 A5 JP 2010525154A5 JP 2010506488 A JP2010506488 A JP 2010506488A JP 2010506488 A JP2010506488 A JP 2010506488A JP 2010525154 A5 JP2010525154 A5 JP 2010525154A5

Authority

JP

Japan

Prior art keywords

pva

hydrogel

paa

solution

peg

Prior art date

2008-04-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000017 hydrogel Substances 0.000 claims 42
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 39
• 238000000034 method Methods 0.000 claims 34
• 229920002125 Sokalan® Polymers 0.000 claims 23
• 239000000243 solution Substances 0.000 claims 21
• 229920001223 polyethylene glycol Polymers 0.000 claims 18
• 239000002202 Polyethylene glycol Substances 0.000 claims 10
• 239000007864 aqueous solution Substances 0.000 claims 9
• 239000002904 solvent Substances 0.000 claims 8
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 8
• 238000001816 cooling Methods 0.000 claims 7
• 230000015572 biosynthetic process Effects 0.000 claims 6
• 229920000642 polymer Polymers 0.000 claims 5
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
• 230000018044 dehydration Effects 0.000 claims 3
• 238000006297 dehydration reaction Methods 0.000 claims 3
• 238000007710 freezing Methods 0.000 claims 3
• 230000008014 freezing Effects 0.000 claims 3
• 239000011261 inert gas Substances 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
• 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 2
• 229920002518 Polyallylamine hydrochloride Polymers 0.000 claims 2
• 150000001735 carboxylic acids Chemical class 0.000 claims 2
• 238000009792 diffusion process Methods 0.000 claims 2
• 229920002674 hyaluronan Polymers 0.000 claims 2
• 229960003160 hyaluronic acid Drugs 0.000 claims 2
• 238000002844 melting Methods 0.000 claims 2
• 230000008018 melting Effects 0.000 claims 2
• 239000003960 organic solvent Substances 0.000 claims 2
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
• 229940088594 vitamin Drugs 0.000 claims 2
• 229930003231 vitamin Natural products 0.000 claims 2
• 235000013343 vitamin Nutrition 0.000 claims 2
• 239000011782 vitamin Substances 0.000 claims 2
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
• 102000016611 Proteoglycans Human genes 0.000 claims 1
• 108010067787 Proteoglycans Proteins 0.000 claims 1
• 238000007605 air drying Methods 0.000 claims 1
• 229910052783 alkali metal Inorganic materials 0.000 claims 1
• 150000001340 alkali metals Chemical class 0.000 claims 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
• 239000007853 buffer solution Substances 0.000 claims 1
• 238000001035 drying Methods 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 229920001477 hydrophilic polymer Polymers 0.000 claims 1
• 239000007943 implant Substances 0.000 claims 1
• 239000001301 oxygen Substances 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• 238000010257 thawing Methods 0.000 claims 1
• 150000003722 vitamin derivatives Chemical class 0.000 claims 1
• 238000010792 warming Methods 0.000 claims 1