JP2010523714A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010523714A5 JP2010523714A5 JP2010503249A JP2010503249A JP2010523714A5 JP 2010523714 A5 JP2010523714 A5 JP 2010523714A5 JP 2010503249 A JP2010503249 A JP 2010503249A JP 2010503249 A JP2010503249 A JP 2010503249A JP 2010523714 A5 JP2010523714 A5 JP 2010523714A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- melatonin
- individual
- ketone bodies
- ketone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 52
- 150000002576 ketones Chemical class 0.000 claims description 28
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims description 28
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims description 26
- 229960003987 melatonin Drugs 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical group CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- WHBMMWSBFZVSSR-GSVOUGTGSA-M (R)-3-hydroxybutyrate Chemical compound C[C@@H](O)CC([O-])=O WHBMMWSBFZVSSR-GSVOUGTGSA-M 0.000 claims description 4
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 claims description 4
- 150000001449 anionic compounds Chemical class 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 229910001412 inorganic anion Inorganic materials 0.000 claims description 2
- 208000028867 ischemia Diseases 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000010410 reperfusion Effects 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 101100366935 Caenorhabditis elegans sto-2 gene Proteins 0.000 description 5
- 230000037396 body weight Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91146007P | 2007-04-12 | 2007-04-12 | |
| US2632108P | 2008-02-05 | 2008-02-05 | |
| PCT/US2008/060100 WO2008128095A1 (en) | 2007-04-12 | 2008-04-11 | Ischemia/reperfusion protection compositions and methods of using |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523714A JP2010523714A (ja) | 2010-07-15 |
| JP2010523714A5 true JP2010523714A5 (https=) | 2012-04-26 |
Family
ID=42269849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503249A Pending JP2010523714A (ja) | 2007-04-12 | 2008-04-11 | 虚血／再灌流保護組成物および使用法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9186340B2 (https=) |
| EP (1) | EP2146711A4 (https=) |
| JP (1) | JP2010523714A (https=) |
| KR (1) | KR20100016456A (https=) |
| CN (1) | CN101677996A (https=) |
| AU (1) | AU2008240211A1 (https=) |
| BR (1) | BRPI0811052A2 (https=) |
| CA (1) | CA2684213A1 (https=) |
| IL (1) | IL201406A0 (https=) |
| MX (1) | MX2009011002A (https=) |
| RU (1) | RU2459624C2 (https=) |
| WO (1) | WO2008128095A1 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0811052A2 (pt) * | 2007-04-12 | 2015-01-27 | Univ Minnesota | Composições de proteção de isquemia/reperfusão e métodos de uso. |
| SG10201908576VA (en) * | 2010-04-08 | 2019-10-30 | Hospital For Sick Children | Use of remote ischemic conditioning for traumatic injury |
| NL2004569C2 (en) * | 2010-04-16 | 2011-10-18 | Angteq B V | Compounds for prevention of cell injury. |
| WO2012103411A2 (en) | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
| US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
| US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| RU2488388C1 (ru) | 2012-05-24 | 2013-07-27 | Ооо "Валента Интеллект" | Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств |
| ITMI20120913A1 (it) * | 2012-05-28 | 2013-11-29 | Nicoletta Maxia | Uso della n-acetil-5-metossitriptamina o suoi analoghi per favorire il meccanismo di impianto dell' embrione, e relative composizioni e mezzi di coltura |
| UA107653U (uk) | 2012-10-01 | 2016-06-24 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів |
| KR102499654B1 (ko) * | 2013-03-19 | 2023-02-13 | 유니버시티 오브 사우스 플로리다 | 상승되고 지속되는 케톤증을 생성하기 위한 조성물 및 방법 |
| CN104208059A (zh) * | 2014-09-05 | 2014-12-17 | 中国医学科学院北京协和医院 | 褪黑素在制备保护吸烟引起血管损伤药物中的应用 |
| US10596131B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10596130B2 (en) | 2017-12-19 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US10973786B2 (en) | 2016-03-11 | 2021-04-13 | Axcess Global Sciences, Llc | R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions |
| US10245243B1 (en) | 2017-12-19 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US11185518B2 (en) | 2017-12-19 | 2021-11-30 | Axcess Global Sciences, Llc | S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer |
| US10245242B1 (en) | 2017-11-22 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10973792B2 (en) | 2019-02-13 | 2021-04-13 | Axcess Global Sciences, Llc | Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use |
| US10292952B2 (en) | 2016-03-11 | 2019-05-21 | Axcess Global Sciences, Llc | Mixed salt compositions for maintaining or restoring electrolyte balance while producing elevated and sustained ketosis |
| US10736861B2 (en) | 2016-03-11 | 2020-08-11 | Axcess Global Sciences, Llc | Mixed salt compositions for producing elevated and sustained ketosis |
| US10596129B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US20170266147A1 (en) * | 2016-03-18 | 2017-09-21 | Csilla Ari D'Agostino | Methods of increasing latency of anesthetic induction using ketone supplementation |
| WO2017165443A1 (en) * | 2016-03-21 | 2017-09-28 | Csilla Ari D'agostino | Methods of improving motor function using ketone supplementation |
| US12533346B2 (en) | 2016-04-19 | 2026-01-27 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US12599579B2 (en) | 2016-04-19 | 2026-04-14 | Axcess Global Sciences, Llc | Compositions and compounds containing ketone bodies and/or ketone body precursors and one or more amino acids |
| US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
| US20230346721A1 (en) | 2018-04-18 | 2023-11-02 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies |
| US12521378B2 (en) | 2016-04-19 | 2026-01-13 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
| CN109890381A (zh) * | 2016-09-12 | 2019-06-14 | 南佛罗里达大学 | 酮改善神经再生 |
| US10307398B2 (en) | 2016-09-20 | 2019-06-04 | Regents Of The University Of Minnesota | Resuscitation composition and methods of making and using |
| US9925164B1 (en) | 2017-01-12 | 2018-03-27 | Neuroenergy Ventures, Inc. | Glyceryl 3-hydroxybutyrates for traumatic brain injury |
| WO2018167273A1 (en) * | 2017-03-16 | 2018-09-20 | Repoceuticals Aps | Compositions for retarding the decomposition of melatonin in solution |
| EP3609484A4 (en) * | 2017-04-12 | 2020-12-16 | Cavaleri, Franco | BUTYRATE AND BETA HYDROXYBUTYRATE COMPOSITIONS AND METHODS FOR THEIR USE |
| JP7136807B2 (ja) | 2017-04-17 | 2022-09-13 | ザ・ユニバーシティ・オブ・シカゴ | ヒトの健康及び疾患の治療用途向けの短鎖脂肪酸の腸への送達用ポリマー材料 |
| US10179095B2 (en) * | 2017-06-07 | 2019-01-15 | Dr. Raymond Laboratories | Autophage activating resveratrol topical composition for skin improvement and treatment |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11241401B2 (en) | 2020-02-06 | 2022-02-08 | Axcess Global Sciences, Llc | Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions |
| US11129802B2 (en) | 2018-08-27 | 2021-09-28 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
| US11419836B2 (en) | 2019-02-13 | 2022-08-23 | Axcess Global Sciences, Llc | Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions |
| US10512615B1 (en) | 2018-08-27 | 2019-12-24 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
| US10980772B2 (en) | 2018-08-27 | 2021-04-20 | Axcess Global Sciences, Llc | Compositions and methods for delivering tetrahydrocannabinol and ketone bodies |
| AU2018260927B1 (en) * | 2018-05-25 | 2019-02-21 | Graham Sherard Baldwin | Methods and compositions for inhibiting a noxious insult |
| BR112020023132A2 (pt) * | 2018-06-21 | 2021-02-09 | Société des Produits Nestlé S.A. | composições e métodos que usam um precursor de nicotinamida adenina dinucleotídeo (nad+) e pelo menos uma cetona ou um precursor de cetona |
| JP2020125254A (ja) * | 2019-02-04 | 2020-08-20 | 株式会社協和 | 化粧料、紫外線に対する細胞保護剤、光老化防止剤 |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| PL3976021T3 (pl) * | 2019-05-30 | 2025-07-21 | Neuroenergy Ventures, Inc. | Tri(beta-hydroksymaślan) glicerolu do zastosowania w leczeniu i zapobieganiu przemijającym atakom niedokrwiennym neuronów |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US11033553B2 (en) | 2019-06-21 | 2021-06-15 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| US20230277484A1 (en) * | 2022-03-04 | 2023-09-07 | Guardian Biosciences, LLC | Compositions and methods to promote brain health |
| CN119345192B (zh) * | 2024-11-27 | 2025-10-28 | 广西医科大学 | N-乙酰血清素在防治糖尿病中的应用 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4298601A (en) | 1972-03-06 | 1981-11-03 | Technutra, S.A. | Method and formulations for the treatment of obesity |
| FR2490631A1 (fr) | 1980-09-24 | 1982-03-26 | Roussel Uclaf | Nouvelle composition lipidique utilisable en dietetique, reanimation et therapeutique |
| US5141674A (en) | 1984-03-08 | 1992-08-25 | Phares Pharmaceutical Research N.V. | Methods of preparing pro-liposome dispersions and aerosols |
| ATE82500T1 (de) | 1984-06-22 | 1992-12-15 | Richard L Veech | Elektrolytloesungen und deren (in vivo) verwendung. |
| DE3581407D1 (de) * | 1985-09-06 | 1991-02-21 | Nestle Sa | Bewahrung lebender gewebe. |
| US5719119A (en) | 1985-12-18 | 1998-02-17 | British Technology Group, Ltd. | Parenteral nutrition therapy with amino acids |
| JPS63502274A (ja) | 1985-12-18 | 1988-09-01 | ビ−チ，リチヤ−ド エル | Ｌ↓−乳酸および／またはピルビン酸アニオンを用いた流体式治療法 |
| US5049388A (en) | 1986-11-06 | 1991-09-17 | Research Development Foundation | Small particle aerosol liposome and liposome-drug combinations for medical use |
| US5120763A (en) | 1986-11-26 | 1992-06-09 | Bar Ilan University | Physiologically active and nutritional composition |
| WO1991002535A1 (en) | 1989-08-11 | 1991-03-07 | Basil, Inc. | Cancer prevention composition and method |
| US5257985A (en) | 1989-12-04 | 1993-11-02 | Richard Puhl | Multi-chamber intravenous bag apparatus |
| US5098409A (en) | 1991-01-04 | 1992-03-24 | Massachusetts Institute Of Technology | Intravenous bag and monitoring method |
| US5654266A (en) * | 1992-02-10 | 1997-08-05 | Chen; Chung-Ho | Composition for tissues to sustain viability and biological functions in surgery and storage |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US5405333A (en) * | 1992-12-28 | 1995-04-11 | Richmond; Frank M. | Liquid medicament bag with needleless connector fitting using boat assembly |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| US5814663A (en) | 1994-08-29 | 1998-09-29 | Wisconsin Alumni Research Foundation | Method for maintaining an existing level of body fat |
| JP4598203B2 (ja) | 1995-12-01 | 2010-12-15 | ビーティージー・インターナショナル・リミテッド | 脳機能改善剤 |
| US5700828A (en) * | 1995-12-07 | 1997-12-23 | Life Resuscitation Technologies, Inc. | Treatment or prevention of anoxic or ischemic brain injury with melatonin-containing compositions |
| CA2283642C (en) | 1997-03-17 | 2012-05-15 | Btg International Limited | Therapeutic compositions |
| US6316038B1 (en) | 1997-03-17 | 2001-11-13 | Btg International Limited | Therapeutic compositions |
| US6323237B1 (en) | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
| US6262111B1 (en) | 1997-05-21 | 2001-07-17 | Sloan-Kettering Institute For Cancer Research | Method for increasing the concentration of ascorbic acid in brain tissues of a subject |
| US5853388A (en) | 1997-08-21 | 1998-12-29 | Semel; David | Intravenous bag with separate compartment |
| US6107349A (en) | 1998-04-16 | 2000-08-22 | Mantynen; Philip R. | Method and composition for treating psoriasis |
| US6353015B1 (en) | 1998-08-26 | 2002-03-05 | St. Elizabeth's Medical Center | Method of treating neurodegenerative disorders |
| WO2000015216A1 (en) | 1998-09-15 | 2000-03-23 | Btg International Limited | Therapeutic compositions (ii) |
| US6232354B1 (en) * | 1999-01-25 | 2001-05-15 | Seng C. Tan | Microcellular polymer foams and method for their production |
| DE60038100T2 (de) | 1999-02-26 | 2009-02-12 | Johnson & Johnson Consumer Companies, Inc. | Bioadhäsive antibakterielle wundheilungszusammensetzungen |
| US20010051652A1 (en) * | 1999-04-28 | 2001-12-13 | Ajinomoto Co., Inc. | Method of treating paralysis of the extremities caused by cerebral infarction |
| US6890896B1 (en) | 1999-11-18 | 2005-05-10 | Ceremedix, Inc. | Compositions and methods for counteracting effects of reactive oxygen species and free radicals |
| US6579852B2 (en) | 2000-01-14 | 2003-06-17 | Genset S.A. | OBG3 globular head and uses thereof for decreasing body mass |
| US6391345B1 (en) | 2000-05-12 | 2002-05-21 | Tim Heeg | Cranberry seed oil, cranberry seed flour and a method for making |
| DE10028837A1 (de) | 2000-06-15 | 2001-12-20 | Roche Diagnostics Gmbh | Verfahren zum Nachweis von Influenza A/B-Viren |
| US20020077317A1 (en) | 2000-12-15 | 2002-06-20 | Das Undurti Narasimha | Method of potentating the action of 2-methoxyoestradiol, statins and C-peptide of proinsulin |
| US20050129783A1 (en) | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
| WO2004047871A2 (en) | 2002-11-26 | 2004-06-10 | Nobex Corporation | Modified naturetic compounds, conjugates, and uses thereof |
| EP1587510A4 (en) | 2003-01-31 | 2007-08-08 | Univ Hong Kong | METHOD OF TREATING ISCHEMIC BUST WITH MELATONIN |
| IL155666A (en) * | 2003-04-29 | 2013-12-31 | Neurim Pharma 1991 | Insomnia treatment |
| US6919483B2 (en) | 2003-05-23 | 2005-07-19 | Mediquest Therapeutics, Inc. | Immunomodulation with novel pharmaceutical compositions |
| EP1648952B1 (en) | 2003-06-03 | 2018-03-07 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives |
| GB0410266D0 (en) | 2004-05-07 | 2004-06-09 | Ketocytonyx Inc | Treatment of apoptosis |
| GB0420856D0 (en) | 2004-09-20 | 2004-10-20 | Ketocytonyx Inc | Cns modulators |
| EP1778213B1 (en) | 2004-07-16 | 2017-04-05 | BTG International Limited | A method for the synthesis of oligomeric compounds |
| WO2006020179A2 (en) | 2004-07-20 | 2006-02-23 | Ketocytonyx Inc. | Oligomeric ketone compounds |
| WO2006012490A2 (en) | 2004-07-23 | 2006-02-02 | Ketocytonyx Inc. | Ketogenic saccharides |
| US20070281892A1 (en) | 2004-09-21 | 2007-12-06 | Martin Keith F | Dopaminergic Mimetics |
| WO2006098767A2 (en) | 2004-09-21 | 2006-09-21 | Ketocytonyx Inc. | Treatment of adhd |
| GB0427145D0 (en) | 2004-12-10 | 2005-01-12 | Ketocytonyx Inc | Compositions for use in surgery |
| BRPI0811052A2 (pt) | 2007-04-12 | 2015-01-27 | Univ Minnesota | Composições de proteção de isquemia/reperfusão e métodos de uso. |
-
2008
- 2008-04-11 BR BRPI0811052-2A2A patent/BRPI0811052A2/pt not_active IP Right Cessation
- 2008-04-11 RU RU2009141713/15A patent/RU2459624C2/ru not_active IP Right Cessation
- 2008-04-11 MX MX2009011002A patent/MX2009011002A/es not_active Application Discontinuation
- 2008-04-11 US US12/595,586 patent/US9186340B2/en active Active
- 2008-04-11 KR KR1020097023554A patent/KR20100016456A/ko not_active Withdrawn
- 2008-04-11 AU AU2008240211A patent/AU2008240211A1/en not_active Abandoned
- 2008-04-11 WO PCT/US2008/060100 patent/WO2008128095A1/en not_active Ceased
- 2008-04-11 JP JP2010503249A patent/JP2010523714A/ja active Pending
- 2008-04-11 CA CA002684213A patent/CA2684213A1/en not_active Abandoned
- 2008-04-11 EP EP08745661A patent/EP2146711A4/en not_active Withdrawn
- 2008-04-11 CN CN200880016109A patent/CN101677996A/zh active Pending
- 2008-04-11 US US12/082,526 patent/US8728532B2/en active Active
-
2009
- 2009-10-11 IL IL201406A patent/IL201406A0/en unknown
-
2014
- 2014-04-24 US US14/260,377 patent/US9149450B2/en active Active
-
2015
- 2015-09-23 US US14/862,416 patent/US20160008325A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010523714A5 (https=) | ||
| RU2009141713A (ru) | Защитные композиции от ишемии/реперфузии и способы применения | |
| JP2019515908A5 (https=) | ||
| CN103167877A (zh) | 包含谷胱甘肽还原酶和氧化型谷胱甘肽的组合物，以及其治疗用途 | |
| JP2015524444A5 (https=) | ||
| JP2011528333A5 (https=) | ||
| Smith et al. | Therapeutic drug monitoring when using cefepime in continuous renal replacement therapy: seizures associated with cefepime | |
| CA2393437A1 (en) | Exo-s-mecamylamine formulation and use in treatment | |
| JP2011225596A5 (https=) | ||
| ES2971959T3 (es) | Terlipresina para el tratamiento de la ascitis debida a cirrosis hepática administrada como una infusión continua | |
| ES2704229T3 (es) | Agonistas selectivos del receptor AT2 para su uso en el tratamiento de la caquexia | |
| JP2010511596A5 (https=) | ||
| RU2018121615A (ru) | Модуляторы активности комплемента | |
| WO2007087241A3 (en) | Treatment of ischemic disease using thrombopoietin | |
| JP2012525358A5 (https=) | ||
| WO2005065429B1 (en) | Composition and method for treatment of hepatic encephalopathy | |
| Goldschmidt et al. | Compound cardiac toxicity of oral erythromycin and verapamil | |
| JP2008520681A5 (https=) | ||
| JP2012526099A5 (https=) | ||
| JP2006502231A5 (https=) | ||
| JP2009504668A5 (https=) | ||
| CN101491527A (zh) | 四氢嘧啶在制备治疗肝炎或肝硬化药物中的应用 | |
| CA2482687A1 (en) | Treatment of mesothelioma | |
| JP2008526816A5 (https=) | ||
| Hatori et al. | Beneficial effects of coronary venous retroinfusion but not left atrial administration of superoxide dismutase on myocardial necrosis in pigs |