JP2010523598A5 - - Google Patents

Info

Publication number

JP2010523598A5

JP2010523598A5 JP2010502350A JP2010502350A JP2010523598A5 JP 2010523598 A5 JP2010523598 A5 JP 2010523598A5 JP 2010502350 A JP2010502350 A JP 2010502350A JP 2010502350 A JP2010502350 A JP 2010502350A JP 2010523598 A5 JP2010523598 A5 JP 2010523598A5

Authority

JP

Japan

Prior art keywords

peptide

terminus

modified

peptide chain

compound according

Prior art date

2008-04-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 55
• 150000001875 compounds Chemical class 0.000 claims 25
• 230000002401 inhibitory effect Effects 0.000 claims 14
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 125000003368 amide group Chemical group 0.000 claims 8
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 5
• 125000002252 acyl group Chemical group 0.000 claims 4
• 102000003923 Protein Kinase C Human genes 0.000 claims 3
• 108090000315 Protein Kinase C Proteins 0.000 claims 3
• RAVVEEJGALCVIN-AGVBWZICSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-2-[[2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-(diamino Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@@H](N)CC1=CC=C(O)C=C1 RAVVEEJGALCVIN-AGVBWZICSA-N 0.000 claims 1
• 108700031308 Antennapedia Homeodomain Proteins 0.000 claims 1
• 108700000788 Human immunodeficiency virus 1 tat peptide (47-57) Proteins 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
• YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical group [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 claims 1
• 230000014725 late viral mRNA transcription Effects 0.000 claims 1
• 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
• 108010011110 polyarginine Proteins 0.000 claims 1
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1