JP2010523501A - Ｇｈｒｈ分子の医薬製剤 - Google Patents
Ｇｈｒｈ分子の医薬製剤 Download PDFInfo
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- JP2010523501A JP2010523501A JP2010501341A JP2010501341A JP2010523501A JP 2010523501 A JP2010523501 A JP 2010523501A JP 2010501341 A JP2010501341 A JP 2010501341A JP 2010501341 A JP2010501341 A JP 2010501341A JP 2010523501 A JP2010523501 A JP 2010523501A
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- 208000011580 syndromic disease Diseases 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- YODZTKMDCQEPHD-UHFFFAOYSA-N thiodiglycol Chemical compound OCCSCCO YODZTKMDCQEPHD-UHFFFAOYSA-N 0.000 description 1
- 229950006389 thiodiglycol Drugs 0.000 description 1
- 229940035024 thioglycerol Drugs 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90998507P | 2007-04-04 | 2007-04-04 | |
| PCT/CA2008/000637 WO2008122118A1 (en) | 2007-04-04 | 2008-04-04 | Pharmaceutical formulations of ghrh molecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523501A true JP2010523501A (ja) | 2010-07-15 |
| JP2010523501A5 JP2010523501A5 (enExample) | 2011-05-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501341A Pending JP2010523501A (ja) | 2007-04-04 | 2008-04-04 | Ｇｈｒｈ分子の医薬製剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080249017A1 (enExample) |
| EP (1) | EP2142207A4 (enExample) |
| JP (1) | JP2010523501A (enExample) |
| KR (1) | KR20090130044A (enExample) |
| CN (1) | CN101678083A (enExample) |
| AU (1) | AU2008235215A1 (enExample) |
| BR (1) | BRPI0809441A2 (enExample) |
| CA (1) | CA2680329A1 (enExample) |
| IL (1) | IL200810A0 (enExample) |
| MX (1) | MX2009010675A (enExample) |
| RU (1) | RU2009140731A (enExample) |
| WO (1) | WO2008122118A1 (enExample) |
| ZA (1) | ZA200906179B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014080784A1 (ja) * | 2012-11-20 | 2014-05-30 | 大蔵製薬株式会社 | 長期間安定なオランザピンの水性医薬製剤 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2615173C (en) | 2005-07-14 | 2012-01-03 | Lipothera, Inc. | Sustained release enhanced lipolytic formulation for regional adipose tissue treatment |
| JP2010506941A (ja) * | 2006-10-17 | 2010-03-04 | リセラ，インク． | 甲状腺眼症の治療のための方法、組成物及び製剤 |
| US9132084B2 (en) | 2009-05-27 | 2015-09-15 | Neothetics, Inc. | Methods for administration and formulations for the treatment of regional adipose tissue |
| GB2487868B (en) * | 2010-01-15 | 2014-12-10 | Neothetics Inc | Lyophilized cake formulations |
| JP5582983B2 (ja) * | 2010-11-24 | 2014-09-03 | 楠本化成株式会社 | 水系沈降防止剤 |
| UA111822C2 (uk) | 2010-11-24 | 2016-06-24 | Общєство С Огранічєнной Отвєтствєнностью "Новамедіка" | Монотерапевтичий препарат селективного ліпофільного бета-агоніста тривалої дії і спосіб косметичного лікування ожиріння і контурного випинання |
| US8871713B2 (en) * | 2013-03-01 | 2014-10-28 | Theratechnologies Inc. | Formulations of growth hormone releasing factor (GRF) molecules with improved stability |
| SG11202110469PA (en) * | 2019-03-29 | 2021-10-28 | Massachusetts Gen Hospital | Ghrh or analogues thereof for use in treatment of hepatic disease |
| CN115884783A (zh) * | 2020-07-05 | 2023-03-31 | 瑟瑞技术公司 | Ghrh类似物的低剂量药物组合物及其用途 |
| WO2024133908A1 (en) * | 2022-12-23 | 2024-06-27 | Syna Therapeutics, S.L. | Stable pharmaceutical compositions comprising romiplostim |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2006042408A1 (en) * | 2004-10-20 | 2006-04-27 | Theratechnologies Inc. | Gh secretagogues and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5137872A (en) * | 1989-09-18 | 1992-08-11 | Pitman-Moore, Inc. | Growth hormone-releasing factor analogs |
| DE4242863A1 (de) * | 1992-12-18 | 1994-06-23 | Boehringer Mannheim Gmbh | Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US6685940B2 (en) * | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| US5876992A (en) * | 1996-07-03 | 1999-03-02 | Molecular Biology Resources, Inc. | Method and formulation for stabilization of enzymes |
| EP0880969A1 (en) * | 1997-05-28 | 1998-12-02 | Applied Research Systems ARS Holdings N.V. | Pharmaceutical compositions of peptides having low solubility in physiological medium |
| US6991790B1 (en) * | 1997-06-13 | 2006-01-31 | Genentech, Inc. | Antibody formulation |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| FR2776520B1 (fr) * | 1998-03-25 | 2000-05-05 | Sod Conseils Rech Applic | Nouvelles compositions pharmaceutiques destinees a la liberation prolongee de peptides et leur procede de preparation |
| AU5247599A (en) * | 1998-07-30 | 2000-02-21 | Point Biomedical Corporation | A novel excipient for the lyophilization of aqueous suspensions of microparticles |
| EP1064934A1 (en) * | 1999-06-30 | 2001-01-03 | Applied Research Systems ARS Holding N.V. | GRF-containing lyophilized pharmaceutical composition |
| US20020061838A1 (en) * | 2000-05-17 | 2002-05-23 | Barton Holmquist | Peptide pharmaceutical formulations |
| CA2422707A1 (en) * | 2000-10-05 | 2002-04-11 | Ares Trading S.A. | Regioselective liquid phase pegylation |
| MXPA04000747A (es) * | 2001-07-25 | 2004-07-08 | Protein Desing Labs Inc | Formulacion farmaceutica liofilizada estable de anticuerpos igg. |
| WO2003068805A2 (en) * | 2002-02-14 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Formulation strategies in stabilizing peptides in organic solvents and in dried states |
| KR20050071498A (ko) * | 2002-09-18 | 2005-07-07 | 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 | 성장 호르몬 방출 호르몬 유사체 |
| WO2004105789A1 (en) * | 2003-05-29 | 2004-12-09 | Theratechnologies Inc. | Grf analog compositions and their use |
| BRPI0508798A (pt) * | 2004-04-07 | 2007-09-04 | Ares Trading Sa | formulação lìquida de hormÈnio de crescimento, composição farmacêutica, forma de apresentação da formulação lìquida de hormÈnio de crescimento e uso da formulação lìquida de hormÈnio de crescimento |
| CA2593112A1 (en) * | 2005-01-21 | 2006-07-27 | Alza Corporation | Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion |
-
2008
- 2008-04-04 CN CN200880010959A patent/CN101678083A/zh active Pending
- 2008-04-04 AU AU2008235215A patent/AU2008235215A1/en not_active Abandoned
- 2008-04-04 JP JP2010501341A patent/JP2010523501A/ja active Pending
- 2008-04-04 MX MX2009010675A patent/MX2009010675A/es not_active Application Discontinuation
- 2008-04-04 RU RU2009140731/15A patent/RU2009140731A/ru not_active Application Discontinuation
- 2008-04-04 CA CA002680329A patent/CA2680329A1/en not_active Abandoned
- 2008-04-04 EP EP08733718A patent/EP2142207A4/en not_active Withdrawn
- 2008-04-04 KR KR1020097021319A patent/KR20090130044A/ko not_active Withdrawn
- 2008-04-04 US US12/098,298 patent/US20080249017A1/en not_active Abandoned
- 2008-04-04 BR BRPI0809441-1A patent/BRPI0809441A2/pt not_active IP Right Cessation
- 2008-04-04 WO PCT/CA2008/000637 patent/WO2008122118A1/en not_active Ceased
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2009
- 2009-09-07 ZA ZA200906179A patent/ZA200906179B/xx unknown
- 2009-09-08 IL IL200810A patent/IL200810A0/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006042408A1 (en) * | 2004-10-20 | 2006-04-27 | Theratechnologies Inc. | Gh secretagogues and uses thereof |
Non-Patent Citations (4)
| Title |
|---|
| JPN6012065596; 低温生物工学会誌 Ｖｏｌ．４９，Ｎｏ．１, 2003, ｐ４７-５３ * |
| JPN6012065599; Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．９１，Ｎｏ．４, 2002, ｐ９１４-９２２ * |
| JPN6012065601; Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．９０，Ｎｏ．３, 2001, ｐ３１０-３２１ * |
| JPN6012065603; Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．８６，Ｎｏ．１１, 1997, ｐ１２５０-１２５５ * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014080784A1 (ja) * | 2012-11-20 | 2014-05-30 | 大蔵製薬株式会社 | 長期間安定なオランザピンの水性医薬製剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL200810A0 (en) | 2010-05-17 |
| RU2009140731A (ru) | 2011-05-10 |
| ZA200906179B (en) | 2010-05-26 |
| EP2142207A4 (en) | 2013-01-16 |
| WO2008122118A1 (en) | 2008-10-16 |
| US20080249017A1 (en) | 2008-10-09 |
| KR20090130044A (ko) | 2009-12-17 |
| MX2009010675A (es) | 2009-10-23 |
| AU2008235215A2 (en) | 2011-02-24 |
| EP2142207A1 (en) | 2010-01-13 |
| CA2680329A1 (en) | 2008-10-16 |
| AU2008235215A1 (en) | 2008-10-16 |
| BRPI0809441A2 (pt) | 2015-06-23 |
| CN101678083A (zh) | 2010-03-24 |
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