JP2010523487A5 - - Google Patents
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- Publication number
- JP2010523487A5 JP2010523487A5 JP2010500390A JP2010500390A JP2010523487A5 JP 2010523487 A5 JP2010523487 A5 JP 2010523487A5 JP 2010500390 A JP2010500390 A JP 2010500390A JP 2010500390 A JP2010500390 A JP 2010500390A JP 2010523487 A5 JP2010523487 A5 JP 2010523487A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- regulatory rna
- drug
- resistance
- minicells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 26
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 17
- 230000001105 regulatory effect Effects 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 8
- 230000001580 bacterial effect Effects 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 108091027967 Small hairpin RNA Proteins 0.000 claims 3
- 108020004459 Small interfering RNA Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- -1 nuclear factor κ Proteins 0.000 claims 3
- 239000002924 silencing RNA Substances 0.000 claims 3
- 239000004055 small Interfering RNA Substances 0.000 claims 3
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 2
- 206010059866 Drug resistance Diseases 0.000 claims 2
- 102100029887 Translationally-controlled tumor protein Human genes 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 102000006240 membrane receptors Human genes 0.000 claims 2
- 108091070501 miRNA Proteins 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- WZXXZHONLFRKGG-UHFFFAOYSA-N 2,3,4,5-tetrachlorothiophene Chemical compound ClC=1SC(Cl)=C(Cl)C=1Cl WZXXZHONLFRKGG-UHFFFAOYSA-N 0.000 claims 1
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 1
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 1
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 1
- 101100043388 Arabidopsis thaliana SRK2D gene Proteins 0.000 claims 1
- 102100037152 BAG family molecular chaperone regulator 1 Human genes 0.000 claims 1
- 101710089792 BAG family molecular chaperone regulator 1 Proteins 0.000 claims 1
- 102100026596 Bcl-2-like protein 1 Human genes 0.000 claims 1
- 108060000903 Beta-catenin Proteins 0.000 claims 1
- 102000015735 Beta-catenin Human genes 0.000 claims 1
- 101150012716 CDK1 gene Proteins 0.000 claims 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 1
- 108010037462 Cyclooxygenase 2 Proteins 0.000 claims 1
- 102000010907 Cyclooxygenase 2 Human genes 0.000 claims 1
- 108010009540 DNA (Cytosine-5-)-Methyltransferase 1 Proteins 0.000 claims 1
- 102100036279 DNA (cytosine-5)-methyltransferase 1 Human genes 0.000 claims 1
- 102100035186 DNA excision repair protein ERCC-1 Human genes 0.000 claims 1
- 101150068427 EP300 gene Proteins 0.000 claims 1
- 101100059559 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) nimX gene Proteins 0.000 claims 1
- 102000016621 Focal Adhesion Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 108010067715 Focal Adhesion Protein-Tyrosine Kinases Proteins 0.000 claims 1
- 101710113436 GTPase KRas Proteins 0.000 claims 1
- 102100030943 Glutathione S-transferase P Human genes 0.000 claims 1
- 101000883804 Homo sapiens ATP-dependent RNA helicase DDX54 Proteins 0.000 claims 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims 1
- 101000914211 Homo sapiens CASP8 and FADD-like apoptosis regulator Proteins 0.000 claims 1
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims 1
- 101000876529 Homo sapiens DNA excision repair protein ERCC-1 Proteins 0.000 claims 1
- 101001010139 Homo sapiens Glutathione S-transferase P Proteins 0.000 claims 1
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 claims 1
- 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 claims 1
- 101001030069 Homo sapiens Major vault protein Proteins 0.000 claims 1
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims 1
- 101000891649 Homo sapiens Transcription elongation factor A protein-like 1 Proteins 0.000 claims 1
- 101000653679 Homo sapiens Translationally-controlled tumor protein Proteins 0.000 claims 1
- 241000341655 Human papillomavirus type 16 Species 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102100020677 Krueppel-like factor 4 Human genes 0.000 claims 1
- 102100038884 Major vault protein Human genes 0.000 claims 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 claims 1
- 101000596402 Mus musculus Neuronal vesicle trafficking-associated protein 1 Proteins 0.000 claims 1
- 101000800539 Mus musculus Translationally-controlled tumor protein Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100024924 Protein kinase C alpha type Human genes 0.000 claims 1
- 101710109947 Protein kinase C alpha type Proteins 0.000 claims 1
- 101710141955 RAF proto-oncogene serine/threonine-protein kinase Proteins 0.000 claims 1
- 101100355601 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) RAD53 gene Proteins 0.000 claims 1
- 101000781972 Schizosaccharomyces pombe (strain 972 / ATCC 24843) Protein wos2 Proteins 0.000 claims 1
- 102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 claims 1
- 101001009610 Toxoplasma gondii Dense granule protein 5 Proteins 0.000 claims 1
- 102100040250 Transcription elongation factor A protein-like 1 Human genes 0.000 claims 1
- 101710157927 Translationally-controlled tumor protein Proteins 0.000 claims 1
- 101710175870 Translationally-controlled tumor protein homolog Proteins 0.000 claims 1
- 102000004243 Tubulin Human genes 0.000 claims 1
- 108090000704 Tubulin Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 102000002258 X-ray Repair Cross Complementing Protein 1 Human genes 0.000 claims 1
- 108010000443 X-ray Repair Cross Complementing Protein 1 Proteins 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 108700000711 bcl-X Proteins 0.000 claims 1
- 208000036815 beta tubulin Diseases 0.000 claims 1
- 239000007975 buffered saline Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 1
- 229960002411 imatinib Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108090000743 multidrug resistance protein 3 Proteins 0.000 claims 1
- 102000004233 multidrug resistance protein 3 Human genes 0.000 claims 1
- 230000000242 pagocytic effect Effects 0.000 claims 1
- 108010056274 polo-like kinase 1 Proteins 0.000 claims 1
- 108010014186 ras Proteins Proteins 0.000 claims 1
- 230000010837 receptor-mediated endocytosis Effects 0.000 claims 1
- 101150087667 spk1 gene Proteins 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90907407P | 2007-03-30 | 2007-03-30 | |
| US60/909,074 | 2007-03-30 | ||
| PCT/IB2008/002984 WO2009027830A2 (en) | 2007-03-30 | 2008-03-26 | Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523487A JP2010523487A (ja) | 2010-07-15 |
| JP2010523487A5 true JP2010523487A5 (enExample) | 2010-08-26 |
| JP5167338B2 JP5167338B2 (ja) | 2013-03-21 |
Family
ID=40386454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500390A Active JP5167338B2 (ja) | 2007-03-30 | 2008-03-26 | 哺乳動物細胞へのｉｎｖｉｖｏ送達のための、プラスミド非含有機能性核酸を含有するインタクトな細菌由来ミニセル |
Country Status (17)
| Country | Link |
|---|---|
| EP (5) | EP3564372A1 (enExample) |
| JP (1) | JP5167338B2 (enExample) |
| CN (2) | CN105854029B (enExample) |
| AU (1) | AU2008291833B2 (enExample) |
| CA (3) | CA2933978C (enExample) |
| CY (1) | CY1119031T1 (enExample) |
| DK (2) | DK2145002T3 (enExample) |
| ES (2) | ES2534435T3 (enExample) |
| HR (2) | HRP20150328T1 (enExample) |
| LT (1) | LT2865755T (enExample) |
| MX (1) | MX2009010411A (enExample) |
| NZ (1) | NZ580487A (enExample) |
| PL (2) | PL2865755T3 (enExample) |
| PT (2) | PT2865755T (enExample) |
| SG (2) | SG10201507969PA (enExample) |
| SI (2) | SI2145002T1 (enExample) |
| WO (1) | WO2009027830A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006021894A2 (en) | 2004-08-26 | 2006-03-02 | Engeneic Gene Therapy Pty Limited | Delivering functional nucleic acids to mammalian cells via bacterially derived, intact minicells |
| SG10201507969PA (en) * | 2007-03-30 | 2015-10-29 | Engeneic Molecular Delivery Pty Ltd | Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells |
| DE102009017908A1 (de) * | 2009-04-17 | 2010-10-21 | Kist-Europe Forschungsgesellschaft Mbh | Vektor für den Transport von mikrobiologischen Organismen zu Krankheitsherden |
| WO2011034421A1 (en) * | 2009-09-16 | 2011-03-24 | Stichting Het Nederlands Kanker Instituut | Fra-1 target genes as drug targets for treating cancer |
| SI2790668T1 (sl) | 2011-12-13 | 2021-01-29 | Engeneic Molecular Delivery Pty Ltd. | Iz bakterij izhajajoče intaktne minicelice za dostavo terapevtskih sredstev v možganske tumorje |
| US9006200B2 (en) * | 2013-03-13 | 2015-04-14 | Asbestos Diseases Research Foundation | MicroRNA-based approach to treating malignant pleural mesothelioma |
| CN105658233B (zh) | 2013-10-04 | 2020-09-04 | 安吉尼科分子传输公司 | 使用携带药物的、双特异性配体靶向的微细胞和干扰素-γ的联合肿瘤治疗 |
| SG11201702627UA (en) * | 2014-10-03 | 2017-04-27 | Engeneic Molecular Delivery Pty Ltd | Enhanced loading of intact, bacterially derived vesicles with small molecule compounds |
| EP3522935A4 (en) * | 2016-10-06 | 2020-05-13 | EnGeneIC Molecular Delivery Pty Ltd. | BACTERIAL MINICELLS FOR THE DELIVERY OF NUCLEIC ACID ADJUVANTS AND METHODS OF USE THEREOF |
| WO2018201160A1 (en) | 2017-04-28 | 2018-11-01 | Agrospheres, Inc. | Compositions and methods for enzyme immobilization |
| US11649265B2 (en) | 2017-04-28 | 2023-05-16 | Agrospheres, Inc. | Compositions and methods for the encapsulation and scalable delivery of agrochemicals |
| CA3073449A1 (en) | 2017-09-25 | 2019-03-28 | Agrospheres, Inc. | Compositions and methods for scalable production and delivery of biologicals |
| EP3826654A4 (en) | 2018-07-23 | 2022-07-06 | EnGeneIC Molecular Delivery Pty Ltd | COMPOSITIONS COMPRISING MINICELLS OF BACTERIAL ORIGIN AND THEIR METHODS OF USE |
| SG11202107306WA (en) | 2019-01-04 | 2021-08-30 | Engeneic Molecular Delivery Pty Ltd | Encapsulated glycolipid antigens for treatment of neoplastic diseases |
| EP4061802A4 (en) * | 2019-12-23 | 2024-01-24 | Agrospheres, Inc. | COMPOSITIONS AND METHODS FOR IMPROVED ABSORPTION OF ACTIVE INGREDIENTS FOR ANIMAL HEALTH AND NUTRITION |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4496778A (en) | 1983-10-03 | 1985-01-29 | Exxon Research & Engineering Co. | Process for the hydroxylation of olefins using molecular oxygen, an osmium containing catalyst, a copper Co-catalyst, and an aromatic amine based promoter |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| CA2372782A1 (en) | 1999-05-11 | 2000-11-16 | Wing Cheung | Pharmacokinetic and pharmacodynamic modeling of erythropoietin administration |
| CN102172406B (zh) | 2001-10-15 | 2013-03-13 | 恩吉尼克分子传递私人有限公司 | 用作体外和体内dna转染与基因治疗载体的完整微细胞 |
| US20040053289A1 (en) * | 2002-09-09 | 2004-03-18 | The Regents Of The University Of California | Short interfering nucleic acid hybrids and methods thereof |
| US7611885B2 (en) | 2003-06-24 | 2009-11-03 | Engeneic Molecular Delivery Pty, Ltd. | Pharmaceutically compatible method for purifying intact bacterial minicells |
| WO2005056749A2 (en) | 2003-12-09 | 2005-06-23 | Engeneic Molecular Delivery Pty Ltd. | Targeted gene delivery to non-phagocytic mammalian cells via bacterially derived intact minicells |
| CA2788707C (en) | 2004-02-02 | 2014-02-25 | Engeneic Molecular Delivery Pty Ltd. | Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
| WO2006021894A2 (en) * | 2004-08-26 | 2006-03-02 | Engeneic Gene Therapy Pty Limited | Delivering functional nucleic acids to mammalian cells via bacterially derived, intact minicells |
| SG10201507969PA (en) * | 2007-03-30 | 2015-10-29 | Engeneic Molecular Delivery Pty Ltd | Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells |
-
2008
- 2008-03-26 SG SG10201507969PA patent/SG10201507969PA/en unknown
- 2008-03-26 LT LTEP15150129.3T patent/LT2865755T/lt unknown
- 2008-03-26 CA CA2933978A patent/CA2933978C/en active Active
- 2008-03-26 SI SI200831411T patent/SI2145002T1/sl unknown
- 2008-03-26 CN CN201610277472.0A patent/CN105854029B/zh active Active
- 2008-03-26 CN CN200880018076.XA patent/CN101715489B/zh active Active
- 2008-03-26 PL PL15150129T patent/PL2865755T3/pl unknown
- 2008-03-26 NZ NZ580487A patent/NZ580487A/en unknown
- 2008-03-26 EP EP19172998.7A patent/EP3564372A1/en active Pending
- 2008-03-26 EP EP15150129.3A patent/EP2865755B1/en active Active
- 2008-03-26 SI SI200831798A patent/SI2865755T1/sl unknown
- 2008-03-26 JP JP2010500390A patent/JP5167338B2/ja active Active
- 2008-03-26 HR HRP20150328TT patent/HRP20150328T1/hr unknown
- 2008-03-26 CA CA2844647A patent/CA2844647C/en active Active
- 2008-03-26 WO PCT/IB2008/002984 patent/WO2009027830A2/en not_active Ceased
- 2008-03-26 PT PT151501293T patent/PT2865755T/pt unknown
- 2008-03-26 EP EP17153863.0A patent/EP3205724B1/en active Active
- 2008-03-26 PL PL08828079T patent/PL2145002T3/pl unknown
- 2008-03-26 EP EP12178465.6A patent/EP2532746A3/en not_active Withdrawn
- 2008-03-26 AU AU2008291833A patent/AU2008291833B2/en active Active
- 2008-03-26 SG SG10201804257RA patent/SG10201804257RA/en unknown
- 2008-03-26 CA CA2682704A patent/CA2682704C/en active Active
- 2008-03-26 ES ES08828079.7T patent/ES2534435T3/es active Active
- 2008-03-26 DK DK08828079.7T patent/DK2145002T3/en active
- 2008-03-26 MX MX2009010411A patent/MX2009010411A/es active IP Right Grant
- 2008-03-26 ES ES15150129.3T patent/ES2626179T3/es active Active
- 2008-03-26 DK DK15150129.3T patent/DK2865755T3/en active
- 2008-03-26 EP EP08828079.7A patent/EP2145002B1/en active Active
- 2008-03-26 PT PT88280797T patent/PT2145002E/pt unknown
-
2017
- 2017-05-02 HR HRP20170662TT patent/HRP20170662T1/hr unknown
- 2017-05-02 CY CY20171100476T patent/CY1119031T1/el unknown
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