JP2010523477A - 線維芽細胞活性化タンパク質の阻害剤、およびそれを使用する方法 - Google Patents

線維芽細胞活性化タンパク質の阻害剤、およびそれを使用する方法 Download PDF

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JP2010523477A
JP2010523477A JP2009554735A JP2009554735A JP2010523477A JP 2010523477 A JP2010523477 A JP 2010523477A JP 2009554735 A JP2009554735 A JP 2009554735A JP 2009554735 A JP2009554735 A JP 2009554735A JP 2010523477 A JP2010523477 A JP 2010523477A
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amino acid
compound according
carbonyl
side chain
acid residue
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JP2010523477A5 (cg-RX-API-DMAC7.html
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ダブリュ バチョフチン,ウィリアム
ライ,ホゥン−セン
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Tufts University
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009554735A 2007-03-20 2008-03-20 線維芽細胞活性化タンパク質の阻害剤、およびそれを使用する方法 Abandoned JP2010523477A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89578707P 2007-03-20 2007-03-20
PCT/US2008/057636 WO2008116054A1 (en) 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof

Publications (2)

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JP2010523477A true JP2010523477A (ja) 2010-07-15
JP2010523477A5 JP2010523477A5 (cg-RX-API-DMAC7.html) 2011-05-12

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JP2009554735A Abandoned JP2010523477A (ja) 2007-03-20 2008-03-20 線維芽細胞活性化タンパク質の阻害剤、およびそれを使用する方法

Country Status (6)

Country Link
US (1) US20100105753A1 (cg-RX-API-DMAC7.html)
EP (1) EP2139337A4 (cg-RX-API-DMAC7.html)
JP (1) JP2010523477A (cg-RX-API-DMAC7.html)
AU (1) AU2008228863A1 (cg-RX-API-DMAC7.html)
CA (1) CA2681351A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008116054A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014508116A (ja) * 2010-12-14 2014-04-03 メルク・シャープ・アンド・ドーム・コーポレーション 大環状ラクタムの調製のための方法および中間体
JP2014527070A (ja) * 2011-08-30 2014-10-09 トラスティーズ オブ タフツ カレッジ 固形腫瘍を治療するためのfap活性化プロテアソーム阻害剤

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010083570A1 (en) * 2009-01-23 2010-07-29 The University Of Sydney Novel metabolic disease therapy
CA2856379A1 (en) 2011-11-22 2013-05-30 Trustees Of Tufts College Small molecule enhancer for dendritic cell cancer vaccines
JP7162592B2 (ja) 2016-12-14 2022-10-28 パーデュー・リサーチ・ファウンデイション 線維芽細胞活性化タンパク質(fap)標的イメージングおよび治療
EP3997104A1 (en) 2019-07-08 2022-05-18 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
EP3763726A1 (en) 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
CN118406106A (zh) 2019-07-08 2024-07-30 3B制药有限公司 包含成纤维细胞活化蛋白配体的化合物及其用途
CN115943312A (zh) 2020-05-07 2023-04-07 法国居里学院 免疫抑制性成纤维细胞群体的生物标志物antxr1及其在预测对免疫疗法的反应中的用途
IL303925A (en) 2021-01-07 2023-08-01 3B Pharmaceuticals Gmbh Compounds comprising a fibroblast activation protein ligand and use thereof
EP4050018A1 (en) 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
CN114316136B (zh) * 2022-01-13 2023-01-31 西华师范大学 一种氢键增强型水合物抑制剂及其制备方法
CA3263725A1 (en) * 2022-08-25 2024-02-29 The Regents Of The University Of California PRO-PEPTIDES CLIVABLE BY ALPHA FIBROBLAST ACTIVATING PROTEIN AND METHODS OF USE
WO2025046043A1 (en) 2023-08-31 2025-03-06 Stichting Radboud Universitair Medisch Centrum Endometriosis tracer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999038501A2 (en) * 1998-02-02 1999-08-05 Trustees Of Tufts College Method of regulating glucose metabolism, and reagents related thereto
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US7041696B2 (en) * 2002-06-17 2006-05-09 The Procter & Gamble Company Interleukin-1β converting enzyme inhibitors
CA2633803A1 (en) * 2005-12-19 2007-09-07 Trustees Of Tufts College Soft protease inhibitors and pro-soft forms thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014508116A (ja) * 2010-12-14 2014-04-03 メルク・シャープ・アンド・ドーム・コーポレーション 大環状ラクタムの調製のための方法および中間体
JP2014527070A (ja) * 2011-08-30 2014-10-09 トラスティーズ オブ タフツ カレッジ 固形腫瘍を治療するためのfap活性化プロテアソーム阻害剤
JP2018016629A (ja) * 2011-08-30 2018-02-01 トラスティーズ オブ タフツ カレッジ 固形腫瘍を治療するためのfap活性化プロテアソーム阻害剤
US10517955B2 (en) 2011-08-30 2019-12-31 Trustees Of Tufts College FAP-activated proteasome inhibitors for treating solid tumors
US11065339B2 (en) 2011-08-30 2021-07-20 Trustees Of Tufts College FAP-activated proteasome inhibitors for treating solid tumors
US12214047B2 (en) 2011-08-30 2025-02-04 Trustees Of Tufts College FAP-activated proteasome inhibitors for treating solid tumors

Also Published As

Publication number Publication date
EP2139337A1 (en) 2010-01-06
US20100105753A1 (en) 2010-04-29
WO2008116054A1 (en) 2008-09-25
EP2139337A4 (en) 2012-09-19
CA2681351A1 (en) 2008-09-25
AU2008228863A1 (en) 2008-09-25

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