JP2010522240A5 - - Google Patents
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- Publication number
- JP2010522240A5 JP2010522240A5 JP2010501103A JP2010501103A JP2010522240A5 JP 2010522240 A5 JP2010522240 A5 JP 2010522240A5 JP 2010501103 A JP2010501103 A JP 2010501103A JP 2010501103 A JP2010501103 A JP 2010501103A JP 2010522240 A5 JP2010522240 A5 JP 2010522240A5
- Authority
- JP
- Japan
- Prior art keywords
- tetracycline
- compound
- composition
- inhibitor
- tetracycline compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004098 Tetracycline Substances 0.000 claims 20
- 235000019364 tetracycline Nutrition 0.000 claims 20
- 229960002180 tetracycline Drugs 0.000 claims 18
- 229930101283 tetracycline Natural products 0.000 claims 18
- -1 tetracycline compounds Chemical class 0.000 claims 11
- 150000003522 tetracyclines Chemical class 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 7
- 229910052751 metal Inorganic materials 0.000 claims 6
- 239000002184 metal Substances 0.000 claims 6
- 238000010521 absorption reaction Methods 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 210000000936 intestine Anatomy 0.000 claims 4
- 210000002784 stomach Anatomy 0.000 claims 4
- 230000003110 anti-inflammatory effect Effects 0.000 claims 3
- 231100000252 nontoxic Toxicity 0.000 claims 3
- 230000003000 nontoxic effect Effects 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000003637 steroidlike Effects 0.000 claims 2
- 229940040944 tetracyclines Drugs 0.000 claims 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000030767 Autoimmune encephalitis Diseases 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 208000002177 Cataract Diseases 0.000 claims 1
- 239000004099 Chlortetracycline Substances 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 239000004100 Oxytetracycline Substances 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims 1
- 229960004475 chlortetracycline Drugs 0.000 claims 1
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims 1
- 235000019365 chlortetracycline Nutrition 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 229960003722 doxycycline Drugs 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000003054 hormonal effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229940041616 menthol Drugs 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000036473 myasthenia Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 229960000625 oxytetracycline Drugs 0.000 claims 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims 1
- 235000019366 oxytetracycline Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 201000003068 rheumatic fever Diseases 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims 1
- 206010043778 thyroiditis Diseases 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89656407P | 2007-03-23 | 2007-03-23 | |
| US60/896,564 | 2007-03-23 | ||
| PCT/US2008/057646 WO2008118744A1 (en) | 2007-03-23 | 2008-03-20 | Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010522240A JP2010522240A (ja) | 2010-07-01 |
| JP2010522240A5 true JP2010522240A5 (https=) | 2011-03-31 |
| JP5395052B2 JP5395052B2 (ja) | 2014-01-22 |
Family
ID=39651298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501103A Expired - Fee Related JP5395052B2 (ja) | 2007-03-23 | 2008-03-20 | 炎症を処置するための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080233206A1 (https=) |
| EP (1) | EP2125018A1 (https=) |
| JP (1) | JP5395052B2 (https=) |
| KR (2) | KR20090122994A (https=) |
| CN (2) | CN102688492A (https=) |
| AP (1) | AP2657A (https=) |
| AU (1) | AU2008231033B2 (https=) |
| EA (1) | EA016206B1 (https=) |
| WO (1) | WO2008118744A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040773A (zh) | 2003-07-25 | 2013-04-17 | 沃纳奇尔科特有限责任公司 | 多西环素金属络合物固体剂型 |
| AU2006206359B2 (en) * | 2005-01-21 | 2011-03-31 | Allergan Pharmaceuticals International Limited | A tetracycline metal complex in a solid dosage form |
| KR101799304B1 (ko) * | 2010-05-12 | 2017-11-20 | 렘펙스 파머수티클스 인코퍼레이티드 | 테트라사이클린 조성물 |
| US9119793B1 (en) | 2011-06-28 | 2015-09-01 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for doxycycline |
| CN103536607A (zh) * | 2012-07-10 | 2014-01-29 | 邵金辉 | 土霉素，普罗帕酮和安乃近的抗肿瘤作用 |
| PT106679B (pt) * | 2012-11-27 | 2015-03-25 | Hovione Farmaciencia Sa | Formulações tópicas de tetraciclinas, sua preparação e usos |
| US10842802B2 (en) | 2013-03-15 | 2020-11-24 | Medicis Pharmaceutical Corporation | Controlled release pharmaceutical dosage forms |
| ITMI20132066A1 (it) * | 2013-12-11 | 2015-06-12 | Farmatron Ltd | Sistemi terapeutici a rilascio modificato per la somministrazione orale di mentolo nel trattamento delle malattie intestinali |
| WO2015153864A2 (en) * | 2014-04-02 | 2015-10-08 | Hopkins Patricia T | Methods for treating inflammatory conditions |
| CN103933539B (zh) * | 2014-04-16 | 2017-01-11 | 西北农林科技大学 | 一种含有四环素的药物组合物及其应用 |
| KR20170134514A (ko) | 2015-03-23 | 2017-12-06 | 바이오팜엑스 인코포레이티드 | 피부과 사용을 위한 약학 테트라사이클린 조성물 |
| CN105998037A (zh) * | 2016-06-16 | 2016-10-12 | 汕头大学 | 多西环素在制备治疗或预防衰老性疾病的药物中的用途 |
| CO2017001953A1 (es) * | 2017-02-27 | 2018-08-31 | Corporacion Univ Lasallista | Método de encapsulación de tetraciclinas |
| BR112021007969A2 (pt) * | 2018-10-29 | 2021-07-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | complexos de tetraciclina com atividade controlada |
| CN110169973A (zh) * | 2019-06-11 | 2019-08-27 | 贾树森 | 一种用于颈椎康复的外用药物组合物 |
| CN111870607A (zh) * | 2020-07-09 | 2020-11-03 | 温州医科大学 | 盐酸米诺环素作为制备治疗自身免疫性葡萄膜炎药物的应用及其治疗方法 |
| KR102855121B1 (ko) * | 2021-12-17 | 2025-09-04 | 주식회사 케이씨앤씨 | 클로르테트라사이클린을 포함하는 고양이 전염성 복막염 치료용 조성물 |
| CN116655491B (zh) * | 2023-05-12 | 2025-01-28 | 常州大学 | 一种多功能抗菌纳米材料TCFNPs及其制备方法和应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2736725A (en) * | 1954-03-11 | 1956-02-28 | American Cyanamid Co | Complexes of tetracycline antibiotics and preparation of same |
| US2766124A (en) * | 1954-05-25 | 1956-10-09 | American Cyanamid Co | Antibiotic-containing ice composition |
| US2806789A (en) * | 1954-09-10 | 1957-09-17 | American Cyanamid Co | Enhancement of therapeutic efficacy of antibiotics |
| GB901209A (en) * | 1957-10-23 | 1962-07-18 | Pfizer & Co C | 6-deoxytetracyclines and compositions containing same |
| GB901107A (en) * | 1959-06-29 | 1962-07-11 | Pfizer | Therapeutic composition and method of preparing same |
| GB894619A (en) * | 1959-09-11 | 1962-04-26 | Pfizer & Co C | Stabilized liquid preparations comprising tetracycline antibiotics |
| FR1430859A (https=) * | 1960-05-23 | 1966-05-25 | ||
| US3275513A (en) * | 1963-05-29 | 1966-09-27 | American Cyanamid Co | Stable calcium tetracycline compositions |
| US4061676A (en) * | 1970-07-03 | 1977-12-06 | Ivan Villax | Recovery of doxycycline and products thereof |
| US3957980A (en) * | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
| US4060605A (en) * | 1973-09-28 | 1977-11-29 | Ankerfarm, S.P.A. | Water-soluble derivative of 6-deoxy-tetracyclines |
| DK153784C (da) * | 1973-09-28 | 1989-01-23 | Pfizer | Analogifremgangsmaade til fremstilling af 2-n-(methioninomethyl)doxycyclin eller salte deraf |
| US4150111A (en) * | 1974-05-28 | 1979-04-17 | Allister Warren | Enteric coated magnesium chloride |
| JPS51107134A (en) * | 1975-03-17 | 1976-09-22 | Asahi Optical Co Ltd | Shotenmenkenshutsusochi |
| US4081527A (en) * | 1976-12-07 | 1978-03-28 | Pfizer Inc. | Chlortetracycline compositions |
| US4126680A (en) * | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
| US4837030A (en) * | 1987-10-06 | 1989-06-06 | American Cyanamid Company | Novel controlled release formulations of tetracycline compounds |
| EP0327295A3 (en) * | 1988-02-01 | 1989-09-06 | F.H. FAULDING & CO. LTD. | Tetracycline dosage form |
| US5250442A (en) * | 1993-04-08 | 1993-10-05 | Orestes Cabezas | Method of treating rheumatoid arthritis using tetracycline |
| US5538954A (en) * | 1994-06-24 | 1996-07-23 | A/S Dumex (Dumex Ltd.) | Salts of tetracyclines |
| US5614206A (en) * | 1995-03-07 | 1997-03-25 | Wright Medical Technology, Inc. | Controlled dissolution pellet containing calcium sulfate |
| DE69627855T2 (de) * | 1995-06-13 | 2004-03-11 | Nippon Meat Packers, Inc. | Orales mittel gegen rheumatische arthritis und funktionelles nahrungsmittel |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US5968896A (en) * | 1998-01-16 | 1999-10-19 | Beth Israel Deaconess Medical Center | Nutritional supplement for preoperative feeding |
| CA2360938C (en) * | 1999-02-02 | 2008-01-08 | Warren Oliver Haggard | Controlled release composite |
| US6765000B2 (en) * | 1999-03-17 | 2004-07-20 | Bonner Jr Ernest L | Treatment for reactive arthritis or bursitis |
| US7884090B2 (en) * | 1999-03-17 | 2011-02-08 | Ernest L. Bonner, Jr. | Compositions and methods for the treatment of arthritis |
| US6946118B1 (en) * | 1999-09-14 | 2005-09-20 | Orapharma, Inc. | Formulations for treating or preventing mucositis |
| US6638532B2 (en) * | 2000-02-24 | 2003-10-28 | Advancis Pharmaceutical Corp. | Tetracycline—doxycycline antibiotic composition |
| US6887492B2 (en) * | 2000-12-14 | 2005-05-03 | Leiner Health Services Corp. | Magnesium plus interactive agent delivery |
| AU2002303250B2 (en) * | 2001-04-05 | 2006-05-25 | Collagenex Pharmaceuticals, Inc. | Methods of treating acne |
| US7211267B2 (en) * | 2001-04-05 | 2007-05-01 | Collagenex Pharmaceuticals, Inc. | Methods of treating acne |
| MXPA03009995A (es) * | 2001-05-09 | 2004-06-30 | Univ Michigan | Uso de composiciones para tratar rosacea. |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| US7122578B2 (en) * | 2001-09-11 | 2006-10-17 | Alain Martin | Method and composition for treating mammalian diseases and injuries which cause pain, erythema, swelling, crusting, ischemia scarring and excess white blood cell infiltration |
| NO315915B1 (no) * | 2002-02-25 | 2003-11-10 | Sintef Elektronikk Og Kybernet | Fj¶rvekt |
| AU2003245295B2 (en) * | 2002-05-20 | 2008-01-03 | Collagenex Pharmaceuticals, Inc. | Methods of treating allergic reactions |
| CN103040773A (zh) * | 2003-07-25 | 2013-04-17 | 沃纳奇尔科特有限责任公司 | 多西环素金属络合物固体剂型 |
| EP2269985A3 (en) * | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| AU2006206359B2 (en) * | 2005-01-21 | 2011-03-31 | Allergan Pharmaceuticals International Limited | A tetracycline metal complex in a solid dosage form |
| US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
-
2008
- 2008-03-20 AU AU2008231033A patent/AU2008231033B2/en not_active Ceased
- 2008-03-20 JP JP2010501103A patent/JP5395052B2/ja not_active Expired - Fee Related
- 2008-03-20 KR KR1020097021550A patent/KR20090122994A/ko not_active Ceased
- 2008-03-20 KR KR1020137028763A patent/KR20130137696A/ko not_active Abandoned
- 2008-03-20 CN CN2012101925621A patent/CN102688492A/zh active Pending
- 2008-03-20 EA EA200901289A patent/EA016206B1/ru not_active IP Right Cessation
- 2008-03-20 WO PCT/US2008/057646 patent/WO2008118744A1/en not_active Ceased
- 2008-03-20 EP EP08732557A patent/EP2125018A1/en not_active Ceased
- 2008-03-20 AP AP2009004979A patent/AP2657A/xx active
- 2008-03-20 CN CN200880016401A patent/CN101678108A/zh active Pending
- 2008-03-21 US US12/053,020 patent/US20080233206A1/en not_active Abandoned
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