JP2009503072A5 - - Google Patents
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- Publication number
- JP2009503072A5 JP2009503072A5 JP2008525035A JP2008525035A JP2009503072A5 JP 2009503072 A5 JP2009503072 A5 JP 2009503072A5 JP 2008525035 A JP2008525035 A JP 2008525035A JP 2008525035 A JP2008525035 A JP 2008525035A JP 2009503072 A5 JP2009503072 A5 JP 2009503072A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- glioma
- tert
- butylnitrone
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 31
- 208000032612 Glial tumor Diseases 0.000 claims 13
- 206010018338 Glioma Diseases 0.000 claims 13
- 229940123457 Free radical scavenger Drugs 0.000 claims 8
- 239000002516 radical scavenger Substances 0.000 claims 8
- 230000001348 anti-glioma Effects 0.000 claims 5
- 235000012054 meals Nutrition 0.000 claims 5
- SQDFHQJTAWCFIB-UHFFFAOYSA-N n-methylidenehydroxylamine Chemical compound ON=C SQDFHQJTAWCFIB-UHFFFAOYSA-N 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 5
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 206010003571 Astrocytoma Diseases 0.000 claims 3
- HGLLGCIZHHMQDE-UHFFFAOYSA-N CC(C)(C)[N+]([O-])=CC1=CC=CC=C1O Chemical compound CC(C)(C)[N+]([O-])=CC1=CC=CC=C1O HGLLGCIZHHMQDE-UHFFFAOYSA-N 0.000 claims 3
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 3
- 201000010133 Oligodendroglioma Diseases 0.000 claims 3
- 230000037396 body weight Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 208000005017 glioblastoma Diseases 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- OEFVJAZWSLPDEP-UHFFFAOYSA-N n-(2,2-dimethylpropylidene)hydroxylamine Chemical compound CC(C)(C)C=NO OEFVJAZWSLPDEP-UHFFFAOYSA-N 0.000 claims 3
- LFBIMWGFXCMLMP-UHFFFAOYSA-N n-tert-butyl-1-(2-sulfooxyphenyl)methanimine oxide Chemical compound CC(C)(C)[N+]([O-])=CC1=CC=CC=C1OS(O)(=O)=O LFBIMWGFXCMLMP-UHFFFAOYSA-N 0.000 claims 3
- RWHHJPINUDSOJL-UHFFFAOYSA-N n-tert-butyl-1-(3-hydroxyphenyl)methanimine oxide Chemical compound CC(C)(C)[N+]([O-])=CC1=CC=CC(O)=C1 RWHHJPINUDSOJL-UHFFFAOYSA-N 0.000 claims 3
- IYSYLWYGCWTJSG-XFXZXTDPSA-N n-tert-butyl-1-phenylmethanimine oxide Chemical compound CC(C)(C)[N+](\[O-])=C\C1=CC=CC=C1 IYSYLWYGCWTJSG-XFXZXTDPSA-N 0.000 claims 3
- GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical group ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 235000012041 food component Nutrition 0.000 claims 2
- 239000005417 food ingredient Substances 0.000 claims 2
- 238000010253 intravenous injection Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000009469 supplementation Effects 0.000 claims 2
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims 1
- 102100021906 Cyclin-O Human genes 0.000 claims 1
- 101000897441 Homo sapiens Cyclin-O Proteins 0.000 claims 1
- 206010063157 Metastatic glioma Diseases 0.000 claims 1
- 150000004008 N-nitroso compounds Chemical class 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000000711 cancerogenic effect Effects 0.000 claims 1
- 231100000315 carcinogenic Toxicity 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000000378 dietary effect Effects 0.000 claims 1
- VLCYCQAOQCDTCN-UHFFFAOYSA-N eflornithine Chemical compound NCCCC(N)(C(F)F)C(O)=O VLCYCQAOQCDTCN-UHFFFAOYSA-N 0.000 claims 1
- 229960002247 lomustine Drugs 0.000 claims 1
- -1 nitrone free radical Chemical class 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70572105P | 2005-08-04 | 2005-08-04 | |
| PCT/US2006/029152 WO2007019065A2 (en) | 2005-08-04 | 2006-07-28 | Adjuvant chemotherapy for anaplastic gliomas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009503072A JP2009503072A (ja) | 2009-01-29 |
| JP2009503072A5 true JP2009503072A5 (https=) | 2009-09-10 |
Family
ID=37727837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525035A Withdrawn JP2009503072A (ja) | 2005-08-04 | 2006-07-28 | 退形成性神経膠腫に対する補助的化学療法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070032453A1 (https=) |
| EP (1) | EP1922075A4 (https=) |
| JP (1) | JP2009503072A (https=) |
| AU (1) | AU2006278741A1 (https=) |
| CA (1) | CA2617492A1 (https=) |
| WO (1) | WO2007019065A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003262642B2 (en) | 2002-08-14 | 2010-06-17 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
| US7723301B2 (en) * | 2007-08-29 | 2010-05-25 | The Board Of Trustees Of The University Of Arkansas | Pharmaceutical compositions comprising an anti-teratogenic compound and applications of the same |
| AU2009288057B2 (en) * | 2008-09-02 | 2014-07-03 | Oklahoma Medical Research Foundation | 2, 4-disulfonyl pheny tert-butyl nitrone for the treatment of gliomas |
| JP5242651B2 (ja) * | 2010-09-24 | 2013-07-24 | 株式会社東芝 | レポーター遺伝子構築物、アッセイキットおよび検出方法 |
| ES3063479T3 (en) | 2017-09-20 | 2026-04-16 | Oklahoma Med Res Found | Treatment of drug resistant gliomas |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4928835A (en) * | 1989-01-31 | 1990-05-29 | Continental Pet Technologies, Inc. | Injection molded preform, method of treating same and container formed therefrom |
| US5766909A (en) * | 1992-02-04 | 1998-06-16 | Merck & Co., Inc. | DNA encoding inducible nitric oxide synthase |
| US5569902A (en) * | 1995-01-17 | 1996-10-29 | Welch Allyn, Inc. | Contact two-dimensional bar code reader having pressure actuated switch |
| US5942385A (en) * | 1996-03-21 | 1999-08-24 | Sugen, Inc. | Method for molecular diagnosis of tumor angiogenesis and metastasis |
| US6479481B1 (en) * | 1999-06-04 | 2002-11-12 | Ed. Geistlich Soehne Ag Fur Chemische Industrie | Methods and compositions for treating primary and secondary tumors of the central nervous system (CNS) |
| JP2004500411A (ja) * | 2000-03-30 | 2004-01-08 | オクラホマ メディカル リサーチ ファウンデーション | 癌の発達の阻害のための、ブチルニトロンを含む組成物 |
| EP1525003A1 (en) * | 2002-06-28 | 2005-04-27 | Pharmacia Corporation | Methods and contrast agents useful in quantifying nitric oxide |
-
2006
- 2006-07-28 CA CA002617492A patent/CA2617492A1/en not_active Abandoned
- 2006-07-28 JP JP2008525035A patent/JP2009503072A/ja not_active Withdrawn
- 2006-07-28 AU AU2006278741A patent/AU2006278741A1/en not_active Abandoned
- 2006-07-28 EP EP06800378A patent/EP1922075A4/en not_active Withdrawn
- 2006-07-28 WO PCT/US2006/029152 patent/WO2007019065A2/en not_active Ceased
- 2006-07-28 US US11/460,866 patent/US20070032453A1/en not_active Abandoned
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