JP2004500411A5 - - Google Patents
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- Publication number
- JP2004500411A5 JP2004500411A5 JP2001572094A JP2001572094A JP2004500411A5 JP 2004500411 A5 JP2004500411 A5 JP 2004500411A5 JP 2001572094 A JP2001572094 A JP 2001572094A JP 2001572094 A JP2001572094 A JP 2001572094A JP 2004500411 A5 JP2004500411 A5 JP 2004500411A5
- Authority
- JP
- Japan
- Prior art keywords
- tert
- composition
- nitrone
- hydroxyphenyl
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 20
- 235000005911 diet Nutrition 0.000 description 8
- 230000037213 diet Effects 0.000 description 7
- PSYHRZCRICXGJJ-WQLSENKSSA-N alpha-(4-hydroxyphenyl)-N-tert-butylnitrone Chemical compound CC(C)(C)[N+](\[O-])=C\C1=CC=C(O)C=C1 PSYHRZCRICXGJJ-WQLSENKSSA-N 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- RWHHJPINUDSOJL-UHFFFAOYSA-N n-tert-butyl-1-(3-hydroxyphenyl)methanimine oxide Chemical compound CC(C)(C)[N+]([O-])=CC1=CC=CC(O)=C1 RWHHJPINUDSOJL-UHFFFAOYSA-N 0.000 description 5
- 239000002516 radical scavenger Substances 0.000 description 5
- 229940123457 Free radical scavenger Drugs 0.000 description 4
- 230000003217 anti-cancerogenic effect Effects 0.000 description 4
- IYSYLWYGCWTJSG-XFXZXTDPSA-N n-tert-butyl-1-phenylmethanimine oxide Chemical group CC(C)(C)[N+](\[O-])=C\C1=CC=CC=C1 IYSYLWYGCWTJSG-XFXZXTDPSA-N 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- SQDFHQJTAWCFIB-UHFFFAOYSA-N n-methylidenehydroxylamine Chemical compound ON=C SQDFHQJTAWCFIB-UHFFFAOYSA-N 0.000 description 3
- HGLLGCIZHHMQDE-UHFFFAOYSA-N CC(C)(C)[N+]([O-])=CC1=CC=CC=C1O Chemical compound CC(C)(C)[N+]([O-])=CC1=CC=CC=C1O HGLLGCIZHHMQDE-UHFFFAOYSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- -1 nitrone free radical Chemical class 0.000 description 2
- 230000005748 tumor development Effects 0.000 description 2
- 241000711549 Hepacivirus C Species 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 230000004730 hepatocarcinogenesis Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19357200P | 2000-03-30 | 2000-03-30 | |
| PCT/US2001/010508 WO2001074349A1 (en) | 2000-03-30 | 2001-03-28 | Butylnitrone containing compositons for inhibition of cancer development |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004500411A JP2004500411A (ja) | 2004-01-08 |
| JP2004500411A5 true JP2004500411A5 (https=) | 2008-05-15 |
Family
ID=22714183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001572094A Pending JP2004500411A (ja) | 2000-03-30 | 2001-03-28 | 癌の発達の阻害のための、ブチルニトロンを含む組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6569902B2 (https=) |
| EP (1) | EP1267860A1 (https=) |
| JP (1) | JP2004500411A (https=) |
| AU (1) | AU785365B2 (https=) |
| CA (1) | CA2404291A1 (https=) |
| WO (1) | WO2001074349A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050059638A1 (en) * | 2003-08-04 | 2005-03-17 | Kelly Michael G. | Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders |
| US20050182060A1 (en) * | 2004-02-13 | 2005-08-18 | Kelly Michael G. | 2-Substituted and 4-substituted aryl nitrone compounds |
| US20060235370A1 (en) * | 2005-04-04 | 2006-10-19 | Oblong John E | Method of regulating mammalian keratinous tissue |
| CA2617492A1 (en) * | 2005-08-04 | 2007-02-15 | Oklahoma Medical Research Foundation | Adjuvant chemotherapy for anaplastic gliomas |
| JP5236641B2 (ja) * | 2006-07-25 | 2013-07-17 | ハフ イヤ インスティテュート | 急性音響外傷の治療方法 |
| AU2009288057B2 (en) | 2008-09-02 | 2014-07-03 | Oklahoma Medical Research Foundation | 2, 4-disulfonyl pheny tert-butyl nitrone for the treatment of gliomas |
| CN110373380B (zh) * | 2019-06-14 | 2022-01-28 | 中国科学院生态环境研究中心 | 一种肝脏类器官模型及其建立方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2069961C (en) * | 1989-10-17 | 2000-05-02 | John M. Carney | Method and compositions for inhibition of disorders associated with oxidative damage |
-
2001
- 2001-03-28 JP JP2001572094A patent/JP2004500411A/ja active Pending
- 2001-03-28 AU AU47915/01A patent/AU785365B2/en not_active Ceased
- 2001-03-28 WO PCT/US2001/010508 patent/WO2001074349A1/en not_active Ceased
- 2001-03-28 CA CA002404291A patent/CA2404291A1/en not_active Abandoned
- 2001-03-28 EP EP01920909A patent/EP1267860A1/en not_active Ceased
- 2001-03-28 US US09/819,570 patent/US6569902B2/en not_active Expired - Lifetime
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