JP2010522218A - Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体 - Google Patents

Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体 Download PDF

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Publication number
JP2010522218A
JP2010522218A JP2010500035A JP2010500035A JP2010522218A JP 2010522218 A JP2010522218 A JP 2010522218A JP 2010500035 A JP2010500035 A JP 2010500035A JP 2010500035 A JP2010500035 A JP 2010500035A JP 2010522218 A JP2010522218 A JP 2010522218A
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dihydro
oxo
carbonyl
amino
cyclopropyl
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JP2010500035A
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Japanese (ja)
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JP2010522218A5 (OSRAM
Inventor
バーチ，ジェイソン
ファラン，ジュリ
ハン，ヨンシン
スチューリノ，クラウディオ
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Merck Canada Inc
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Merck Canada Inc
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Publication of JP2010522218A publication Critical patent/JP2010522218A/ja
Publication of JP2010522218A5 publication Critical patent/JP2010522218A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
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  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
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  • Virology (AREA)
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JP2010500035A 2007-03-26 2008-03-25 Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体 Pending JP2010522218A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92001807P 2007-03-26 2007-03-26
PCT/CA2008/000561 WO2008116304A1 (en) 2007-03-26 2008-03-25 Naphthalene and quinoline sulfonylurea derivatives as ep4 receptor antagonists

Publications (2)

Publication Number Publication Date
JP2010522218A true JP2010522218A (ja) 2010-07-01
JP2010522218A5 JP2010522218A5 (OSRAM) 2011-05-06

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ID=39787996

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JP2010500035A Pending JP2010522218A (ja) 2007-03-26 2008-03-25 Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体

Country Status (7)

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US (1) US8003661B2 (OSRAM)
EP (1) EP2125724B1 (OSRAM)
JP (1) JP2010522218A (OSRAM)
CN (1) CN101636385B (OSRAM)
AU (1) AU2008232265B2 (OSRAM)
CA (1) CA2681146A1 (OSRAM)
WO (1) WO2008116304A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012503605A (ja) * 2008-09-25 2012-02-09 メルク カナダ インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのベータ−カルボリンスルホニルウレア誘導体

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110287112A1 (en) 2009-01-30 2011-11-24 Ono Pharmaceutical Co., Ltd. Prostate cancer progression inhibitor and progression inhibition method
WO2014143591A1 (en) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
AU2018268311B2 (en) 2017-05-18 2022-02-10 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as PGE2 receptor modulators
TW201900180A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 嘧啶衍生物
CN110612296A (zh) 2017-05-18 2019-12-24 爱杜西亚药品有限公司 作为pge2受体调节剂的苯基衍生物
JP7093791B2 (ja) 2017-05-18 2022-06-30 イドーシア ファーマシューティカルズ リミテッド Ｐｇｅ２レセプター調節剤としてのベンゾフラン及びベンゾチオフェン誘導体
MX394108B (es) 2017-05-18 2025-03-21 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituidos.
KR20230107228A (ko) 2020-11-13 2023-07-14 오노 야꾸힝 고교 가부시키가이샤 Ep4 길항약과 면역 체크포인트 저해 물질의 병용에 의한 암 치료

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004517099A (ja) * 2000-12-21 2004-06-10 グラクソ グループ リミテッド Ｅｐ４受容体に結合するナフタレン誘導体
JP2004517054A (ja) * 2000-10-19 2004-06-10 ファイザー株式会社 抗炎症剤及び鎮痛剤としてのアリール又はヘテロアリール縮合イミダゾール化合物
JP2005532291A (ja) * 2002-04-12 2005-10-27 ファイザー株式会社 抗炎症薬および鎮痛薬としてのピラゾール化合物
WO2006122403A1 (en) * 2005-05-19 2006-11-23 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists

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GB9417532D0 (en) 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds
GB9420557D0 (en) 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
US5834468A (en) 1995-07-07 1998-11-10 Zeneca Limited Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004517054A (ja) * 2000-10-19 2004-06-10 ファイザー株式会社 抗炎症剤及び鎮痛剤としてのアリール又はヘテロアリール縮合イミダゾール化合物
JP2004517099A (ja) * 2000-12-21 2004-06-10 グラクソ グループ リミテッド Ｅｐ４受容体に結合するナフタレン誘導体
JP2005532291A (ja) * 2002-04-12 2005-10-27 ファイザー株式会社 抗炎症薬および鎮痛薬としてのピラゾール化合物
WO2006122403A1 (en) * 2005-05-19 2006-11-23 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012503605A (ja) * 2008-09-25 2012-02-09 メルク カナダ インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのベータ−カルボリンスルホニルウレア誘導体

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CA2681146A1 (en) 2008-10-02
CN101636385A (zh) 2010-01-27
EP2125724A1 (en) 2009-12-02
US8003661B2 (en) 2011-08-23
WO2008116304A1 (en) 2008-10-02
CN101636385B (zh) 2012-09-05
EP2125724A4 (en) 2012-02-15
AU2008232265A1 (en) 2008-10-02
EP2125724B1 (en) 2014-12-03
US20100105718A1 (en) 2010-04-29
AU2008232265B2 (en) 2013-02-28

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