JP2010521476A5 - - Google Patents

Info

Publication number

JP2010521476A5

JP2010521476A5 JP2009553689A JP2009553689A JP2010521476A5 JP 2010521476 A5 JP2010521476 A5 JP 2010521476A5 JP 2009553689 A JP2009553689 A JP 2009553689A JP 2009553689 A JP2009553689 A JP 2009553689A JP 2010521476 A5 JP2010521476 A5 JP 2010521476A5

Authority

JP

Japan

Prior art keywords

alkyl

hcv

hydrogen

inhibitor

cycloalkyl

Prior art date

2008-03-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 41
• 229910052739 hydrogen Inorganic materials 0.000 claims 26
• 239000001257 hydrogen Substances 0.000 claims 26
• 150000001875 compounds Chemical class 0.000 claims 21
• 125000000753 cycloalkyl group Chemical group 0.000 claims 18
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 17
• 239000003112 inhibitor Substances 0.000 claims 12
• -1 hydroxy, benzyloxy Chemical group 0.000 claims 11
• 150000002431 hydrogen Chemical class 0.000 claims 9
• 229940121649 protein inhibitor Drugs 0.000 claims 8
• 239000012268 protein inhibitor Substances 0.000 claims 8
• 150000003839 salts Chemical class 0.000 claims 8
• 125000001188 haloalkyl group Chemical group 0.000 claims 7
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 6
• 125000003342 alkenyl group Chemical group 0.000 claims 5
• 125000002393 azetidinyl group Chemical group 0.000 claims 4
• 125000002757 morpholinyl group Chemical group 0.000 claims 4
• 125000004193 piperazinyl group Chemical group 0.000 claims 4
• 125000003386 piperidinyl group Chemical group 0.000 claims 4
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 4
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 4
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 4
• 125000004568 thiomorpholinyl group Chemical group 0.000 claims 4
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 3
• 108010036949 Cyclosporine Proteins 0.000 claims 3
• 229940122750 HCV entry inhibitor Drugs 0.000 claims 3
• 102000014150 Interferons Human genes 0.000 claims 3
• 108010050904 Interferons Proteins 0.000 claims 3
• 102000015696 Interleukins Human genes 0.000 claims 3
• 108010063738 Interleukins Proteins 0.000 claims 3
• 101800001019 Non-structural protein 4B Proteins 0.000 claims 3
• 101800001014 Non-structural protein 5A Proteins 0.000 claims 3
• 229940122055 Serine protease inhibitor Drugs 0.000 claims 3
• 101710102218 Serine protease inhibitor Proteins 0.000 claims 3
• 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 claims 3
• 125000003545 alkoxy group Chemical group 0.000 claims 3
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
• 125000003282 alkyl amino group Chemical group 0.000 claims 3
• 125000004448 alkyl carbonyl group Chemical group 0.000 claims 3
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 3
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
• 239000003795 chemical substances by application Substances 0.000 claims 3
• 229960001265 ciclosporin Drugs 0.000 claims 3
• 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 3
• 229930182912 cyclosporin Natural products 0.000 claims 3
• 125000004663 dialkyl amino group Chemical group 0.000 claims 3
• 125000004692 haloalkylcarbonyl group Chemical group 0.000 claims 3
• 125000001475 halogen functional group Chemical group 0.000 claims 3
• 108700008776 hepatitis C virus NS-5 Proteins 0.000 claims 3
• 229940079322 interferon Drugs 0.000 claims 3
• 239000003475 metalloproteinase inhibitor Substances 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 3
• 125000004076 pyridyl group Chemical group 0.000 claims 3
• 239000003001 serine protease inhibitor Substances 0.000 claims 3
• 230000001225 therapeutic effect Effects 0.000 claims 3
• 229940124683 HCV polymerase inhibitor Drugs 0.000 claims 2
• 229940121759 Helicase inhibitor Drugs 0.000 claims 2
• 208000005176 Hepatitis C Diseases 0.000 claims 2
• 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 208000010710 hepatitis C virus infection Diseases 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 108060004795 Methyltransferase Proteins 0.000 claims 1
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1