CN101657455B - 用于治疗丙型肝炎的化合物 - Google Patents
用于治疗丙型肝炎的化合物 Download PDFInfo
- Publication number
- CN101657455B CN101657455B CN200880008369XA CN200880008369A CN101657455B CN 101657455 B CN101657455 B CN 101657455B CN 200880008369X A CN200880008369X A CN 200880008369XA CN 200880008369 A CN200880008369 A CN 200880008369A CN 101657455 B CN101657455 B CN 101657455B
- Authority
- CN
- China
- Prior art keywords
- hcv
- cyclohexyl
- indoles
- benzo
- aza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C[C@]([C@]1c(cc(cc2)OC)c2-c([n](C2)c3c4)c(C5CCCCC5)c3ccc4C(NS(N(C)C)(=O)=O)=O)[C@@]12C(N1C(C2)C*(C)C2C1)=O Chemical compound C[C@]([C@]1c(cc(cc2)OC)c2-c([n](C2)c3c4)c(C5CCCCC5)c3ccc4C(NS(N(C)C)(=O)=O)=O)[C@@]12C(N1C(C2)C*(C)C2C1)=O 0.000 description 16
- BFHBKNBAEGVCRH-KEASEGHRSA-N CC(C)(C)OC(c1ccc(c(C2CCCCC2)c(-c(cc2)c(C3C4)cc2OC)[n]2C[C@]34C(O)=O)c2c1)=O Chemical compound CC(C)(C)OC(c1ccc(c(C2CCCCC2)c(-c(cc2)c(C3C4)cc2OC)[n]2C[C@]34C(O)=O)c2c1)=O BFHBKNBAEGVCRH-KEASEGHRSA-N 0.000 description 1
- VLCNJBNLFZXGAN-UHFFFAOYSA-N CC(C)(C)S(NC(c1ccc(c(C2CCCCC2)c(-c(cc2)c(C3C4)cc2OC)[n]2CC34C(N3C4CN(C)CC3C4)=O)c2c1)=O)(=O)=O Chemical compound CC(C)(C)S(NC(c1ccc(c(C2CCCCC2)c(-c(cc2)c(C3C4)cc2OC)[n]2CC34C(N3C4CN(C)CC3C4)=O)c2c1)=O)(=O)=O VLCNJBNLFZXGAN-UHFFFAOYSA-N 0.000 description 1
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- ZYDQFDFBRXRKFR-UHFFFAOYSA-N CC(C)N(C1)CC2(C3CN(C)C2)C1N3C(C(C1)(C[n]2c3c4)C1c(cc(cc1)OC)c1-c2c(C1CCCCC1)c3ccc4C(NS(N(C)C)(=O)=O)=O)=O Chemical compound CC(C)N(C1)CC2(C3CN(C)C2)C1N3C(C(C1)(C[n]2c3c4)C1c(cc(cc1)OC)c1-c2c(C1CCCCC1)c3ccc4C(NS(N(C)C)(=O)=O)=O)=O ZYDQFDFBRXRKFR-UHFFFAOYSA-N 0.000 description 1
- LRBGVPWREYHSHO-UHFFFAOYSA-N CC(C)S(NC(c1ccc(c(C2CCCCC2)c(-c(cc2)c(C3C4)cc2OC)[n]2CC34C(O)=O)c2c1)=O)(=O)=O Chemical compound CC(C)S(NC(c1ccc(c(C2CCCCC2)c(-c(cc2)c(C3C4)cc2OC)[n]2CC34C(O)=O)c2c1)=O)(=O)=O LRBGVPWREYHSHO-UHFFFAOYSA-N 0.000 description 1
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- WNHVJOLIGBJPES-UHFFFAOYSA-N CN(CC1C2)CC2N1C(C(C1)(C[n]2c3c4)C1c(cc(cc1)OC)c1-c2c(C1CCCCC1)c3ccc4C(NS(CC1CC1)(=O)=O)=O)=O Chemical compound CN(CC1C2)CC2N1C(C(C1)(C[n]2c3c4)C1c(cc(cc1)OC)c1-c2c(C1CCCCC1)c3ccc4C(NS(CC1CC1)(=O)=O)=O)=O WNHVJOLIGBJPES-UHFFFAOYSA-N 0.000 description 1
- NIQQXNXPHDPQPZ-UHFFFAOYSA-N CN(CC1C2)CC2N1C(C(C1)(C[n]2c3c4)C1c(cc(cc1)OC)c1-c2c(C1CCCCC1)c3ccc4C(NS(N1CCOCC1)(=O)=O)=O)=O Chemical compound CN(CC1C2)CC2N1C(C(C1)(C[n]2c3c4)C1c(cc(cc1)OC)c1-c2c(C1CCCCC1)c3ccc4C(NS(N1CCOCC1)(=O)=O)=O)=O NIQQXNXPHDPQPZ-UHFFFAOYSA-N 0.000 description 1
- YCZNOFRNRXURSU-UHFFFAOYSA-N CN(CC1CC2)C2CN1C(C(C[n]1c2c3)=Cc(cccc4)c4-c1c(C1CCCCC1)c2ccc3C(OC)=O)=O Chemical compound CN(CC1CC2)C2CN1C(C(C[n]1c2c3)=Cc(cccc4)c4-c1c(C1CCCCC1)c2ccc3C(OC)=O)=O YCZNOFRNRXURSU-UHFFFAOYSA-N 0.000 description 1
- ZLKNRPJZYBRZSS-CMPNYDRPSA-N CN(C[C@@H]1COC2)CC2N1C([C@](C1)(C[n]2c3c4)C1c(cc(cc1)OC)c1-c2c(C1CCCCC1)c3ccc4C(NS(C1CCCCC1)(=O)=O)=O)=O Chemical compound CN(C[C@@H]1COC2)CC2N1C([C@](C1)(C[n]2c3c4)C1c(cc(cc1)OC)c1-c2c(C1CCCCC1)c3ccc4C(NS(C1CCCCC1)(=O)=O)=O)=O ZLKNRPJZYBRZSS-CMPNYDRPSA-N 0.000 description 1
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- XXEGWKFAPXGRMW-UHFFFAOYSA-N COC(C(C1)(C[n]2c3c4)C1c(cc(cc1)OC)c1-c2c(C1CCCCC1)c3ccc4C(NS(CCC(F)(F)F)(=O)=O)=O)=O Chemical compound COC(C(C1)(C[n]2c3c4)C1c(cc(cc1)OC)c1-c2c(C1CCCCC1)c3ccc4C(NS(CCC(F)(F)F)(=O)=O)=O)=O XXEGWKFAPXGRMW-UHFFFAOYSA-N 0.000 description 1
- UGLSWHQLBQJMIP-UHFFFAOYSA-N COC(C(C[n]1c2c3)=Cc(cc(cc4)OC)c4-c1c(C1CCCCC1)c2ccc3C(NS(N)(=O)=O)=O)=O Chemical compound COC(C(C[n]1c2c3)=Cc(cc(cc4)OC)c4-c1c(C1CCCCC1)c2ccc3C(NS(N)(=O)=O)=O)=O UGLSWHQLBQJMIP-UHFFFAOYSA-N 0.000 description 1
- PHHBALUTYVVXQJ-UHFFFAOYSA-N COC(c(cc1)cc2c1c(C1CCCCC1)c-1[n]2CC(C(O)=O)=Cc2c-1cccc2)=O Chemical compound COC(c(cc1)cc2c1c(C1CCCCC1)c-1[n]2CC(C(O)=O)=Cc2c-1cccc2)=O PHHBALUTYVVXQJ-UHFFFAOYSA-N 0.000 description 1
- WGKZELDPFBVJFS-UHFFFAOYSA-N COc(cc1)cc(C(C2)C2(C[n]2c3c4)C(N5C(CC6)CNC6C5)=O)c1-c2c(C1CCCCC1)c3ccc4C(NS(C1CCCCC1)(=O)=O)=O Chemical compound COc(cc1)cc(C(C2)C2(C[n]2c3c4)C(N5C(CC6)CNC6C5)=O)c1-c2c(C1CCCCC1)c3ccc4C(NS(C1CCCCC1)(=O)=O)=O WGKZELDPFBVJFS-UHFFFAOYSA-N 0.000 description 1
- KMQQSURVLHQYDK-UHFFFAOYSA-N COc(cc1)cc(C(C2)C2(C[n]2c3c4)C(N5C6CCCC5CCC6)=O)c1-c2c(C1CCCCC1)c3ccc4C(NS(N1CCOCC1)(=O)=O)=O Chemical compound COc(cc1)cc(C(C2)C2(C[n]2c3c4)C(N5C6CCCC5CCC6)=O)c1-c2c(C1CCCCC1)c3ccc4C(NS(N1CCOCC1)(=O)=O)=O KMQQSURVLHQYDK-UHFFFAOYSA-N 0.000 description 1
- CUFBGINHROHRCA-UHFFFAOYSA-N COc(cc1)cc(C(C2)C2(C[n]2c3c4)C(N5C6CN(Cc7ccccc7)CC5C6)=O)c1-c2c(C1CCCCC1)c3ccc4C(NS(C1CCCC1)(=O)=O)=O Chemical compound COc(cc1)cc(C(C2)C2(C[n]2c3c4)C(N5C6CN(Cc7ccccc7)CC5C6)=O)c1-c2c(C1CCCCC1)c3ccc4C(NS(C1CCCC1)(=O)=O)=O CUFBGINHROHRCA-UHFFFAOYSA-N 0.000 description 1
- GSEBJVSPOLELSY-PPUQQMLPSA-N C[C@@H]([C@H]1c(cc(cc2)OC)c2-c([n](C2)c3c4)c(C5CCCCC5)c3ccc4C(NS(N(C)C)(=O)=O)=O)[C@@]12C(O)=O Chemical compound C[C@@H]([C@H]1c(cc(cc2)OC)c2-c([n](C2)c3c4)c(C5CCCCC5)c3ccc4C(NS(N(C)C)(=O)=O)=O)[C@@]12C(O)=O GSEBJVSPOLELSY-PPUQQMLPSA-N 0.000 description 1
- UGMYVFMYZWXHTG-QSDUKLCHSA-N C[C@@](CN(C)C[C@@]1(C)C2)(CN2C(C(C2)(C[n]3c4c5)C2c(cc(cc2)OC)c2-c3c(C2CCCCC2)c4ccc5C(NS(N(C)C)(=O)=O)=O)=O)C1O Chemical compound C[C@@](CN(C)C[C@@]1(C)C2)(CN2C(C(C2)(C[n]3c4c5)C2c(cc(cc2)OC)c2-c3c(C2CCCCC2)c4ccc5C(NS(N(C)C)(=O)=O)=O)=O)C1O UGMYVFMYZWXHTG-QSDUKLCHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89488707P | 2007-03-14 | 2007-03-14 | |
| US60/894,887 | 2007-03-14 | ||
| US98947407P | 2007-11-21 | 2007-11-21 | |
| US60/989,474 | 2007-11-21 | ||
| PCT/US2008/055893 WO2008112473A1 (en) | 2007-03-14 | 2008-03-05 | Compounds for the treatment of hepatitis c |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101657455A CN101657455A (zh) | 2010-02-24 |
| CN101657455B true CN101657455B (zh) | 2013-02-06 |
Family
ID=39477552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880008369XA Expired - Fee Related CN101657455B (zh) | 2007-03-14 | 2008-03-05 | 用于治疗丙型肝炎的化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7547690B2 (enExample) |
| EP (1) | EP2118109B1 (enExample) |
| JP (1) | JP5232178B2 (enExample) |
| KR (1) | KR20100015304A (enExample) |
| CN (1) | CN101657455B (enExample) |
| AR (1) | AR065772A1 (enExample) |
| AU (1) | AU2008226639B2 (enExample) |
| BR (1) | BRPI0808763A2 (enExample) |
| CA (1) | CA2681093A1 (enExample) |
| CL (1) | CL2008000751A1 (enExample) |
| CO (1) | CO6180426A2 (enExample) |
| EA (1) | EA016614B1 (enExample) |
| IL (1) | IL200905A0 (enExample) |
| MX (1) | MX2009009473A (enExample) |
| NZ (1) | NZ579342A (enExample) |
| PE (1) | PE20090648A1 (enExample) |
| TW (1) | TW200848058A (enExample) |
| WO (1) | WO2008112473A1 (enExample) |
| ZA (1) | ZA200906129B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005049622A1 (ja) * | 2003-11-19 | 2005-06-02 | Japan Tobacco Inc. | ５－５員縮合複素環化合物及びそのｈｃｖポリメラーゼ阻害剤としての用途 |
| US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
| US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
| US7521443B2 (en) * | 2006-05-17 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US8143243B2 (en) * | 2007-08-09 | 2012-03-27 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US7642251B2 (en) * | 2007-08-09 | 2010-01-05 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US7652004B2 (en) * | 2007-08-09 | 2010-01-26 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| EP2209789B1 (en) * | 2007-11-20 | 2011-11-16 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors |
| US8124601B2 (en) | 2007-11-21 | 2012-02-28 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
| US8129367B2 (en) * | 2007-11-21 | 2012-03-06 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
| CN101910177B (zh) | 2007-12-24 | 2013-08-28 | 泰博特克药品公司 | 作为丙型肝炎病毒抑制剂的大环吲哚 |
| US8178523B2 (en) * | 2008-03-27 | 2012-05-15 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| KR20100126560A (ko) * | 2008-03-27 | 2010-12-01 | 브리스톨-마이어스 스큅 컴퍼니 | 피롤리딘 융합된 인돌로벤자디아제핀 ｈｃｖ ｎｓ5ｂ 억제제 |
| US8138171B2 (en) * | 2008-03-27 | 2012-03-20 | Bristol-Myers Squibb Company | Dioxolane and dioxolanone fused indolobenzadiazepine HCV NS5B inhibitors |
| US8133884B2 (en) * | 2008-05-06 | 2012-03-13 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US8143244B2 (en) * | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| AU2010328419A1 (en) * | 2009-12-07 | 2012-06-21 | Targacept, Inc. | 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands |
| US8716275B2 (en) * | 2011-10-20 | 2014-05-06 | Bristol-Myers Squibb Company | Compound for the treatment of hepatitis C |
| WO2014011863A1 (en) * | 2012-07-12 | 2014-01-16 | Targacept, Inc. | Method of treatment with 3-cyclopropylcarbonyl-3,6-diazabicyclo[3.1.1]heptane |
| EP3091022A3 (en) * | 2012-07-18 | 2016-12-14 | Bristol-Myers Squibb Holdings Ireland | Methods and intermediates for the preparation of (4bs,5ar)-12-cyclohexyl-n-(n,n-dimethylsulfamoyl)-3- methoxy-5a-((1r,5s)-3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-a]indole-9-carboxamide |
| AU2017233739A1 (en) | 2016-03-15 | 2018-09-20 | Bayer Cropscience Aktiengesellschaft | Substituted sulfonyl amides for controlling animal pests |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| CN110028510A (zh) * | 2019-05-22 | 2019-07-19 | 南京合巨药业有限公司 | 一种3-甲基-3,6-二氮杂-双环[3,1,1]庚烷二盐酸盐的制备方法 |
| EP4055010A1 (de) | 2019-11-07 | 2022-09-14 | Bayer Aktiengesellschaft | Substituierte sulfonylamide zur bekämpfung tierischer schädlinge |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
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| WO2005080399A1 (ja) | 2004-02-24 | 2005-09-01 | Japan Tobacco Inc. | ４環縮合複素環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用 |
| US7153848B2 (en) * | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| US7348425B2 (en) | 2004-08-09 | 2008-03-25 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| RU2007119562A (ru) | 2004-10-26 | 2008-12-10 | Институто Ди Ричерке Ди Биолоджиа Молеколаре П Анджелетти Спа (It) | Тетрациклические производные индолов в качестве противовирусных агентов |
| GB0518390D0 (en) | 2005-09-09 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| US7399758B2 (en) * | 2005-09-12 | 2008-07-15 | Meanwell Nicholas A | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US7473688B2 (en) * | 2005-09-13 | 2009-01-06 | Bristol-Myers Squibb Company | Indolobenzazepine HCV NS5B inhibitors |
| US7456165B2 (en) * | 2006-02-08 | 2008-11-25 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
| GB0608928D0 (en) | 2006-05-08 | 2006-06-14 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| US7456166B2 (en) * | 2006-05-17 | 2008-11-25 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US7521441B2 (en) * | 2006-05-22 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| DE602007006796D1 (de) * | 2006-05-25 | 2010-07-08 | Bristol Myers Squibb Co | Cyclopropyl-fusionierte indolbenzazepin-hcv-ns5b-hemmer |
| WO2007140200A2 (en) * | 2006-05-25 | 2007-12-06 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors |
| US7452876B2 (en) * | 2006-06-08 | 2008-11-18 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
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| US20080227769A1 (en) | 2008-09-18 |
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| BRPI0808763A2 (pt) | 2014-09-16 |
| JP5232178B2 (ja) | 2013-07-10 |
| CA2681093A1 (en) | 2008-09-18 |
| NZ579342A (en) | 2011-07-29 |
| CL2008000751A1 (es) | 2008-07-25 |
| KR20100015304A (ko) | 2010-02-12 |
| EA016614B1 (ru) | 2012-06-29 |
| EA200901241A1 (ru) | 2010-02-26 |
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| CO6180426A2 (es) | 2010-07-19 |
| AU2008226639B2 (en) | 2012-07-19 |
| EP2118109B1 (en) | 2014-11-26 |
| CN101657455A (zh) | 2010-02-24 |
| TW200848058A (en) | 2008-12-16 |
| AR065772A1 (es) | 2009-07-01 |
| IL200905A0 (en) | 2010-05-17 |
| AU2008226639A1 (en) | 2008-09-18 |
| JP2010521476A (ja) | 2010-06-24 |
| PE20090648A1 (es) | 2009-05-29 |
| MX2009009473A (es) | 2009-09-15 |
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