TW200848058A - Compounds for the treatment of hepatitis C - Google Patents

Info

Publication number

TW200848058A

TW200848058A TW097108906A TW97108906A TW200848058A TW 200848058 A TW200848058 A TW 200848058A TW 097108906 A TW097108906 A TW 097108906A TW 97108906 A TW97108906 A TW 97108906A TW 200848058 A TW200848058 A TW 200848058A

Authority

TW

Taiwan

Prior art keywords

alkyl

group

hcv

cyclohexyl

hydrogen

Prior art date

2007-03-14

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 title claims abstract description 104
• 238000011282 treatment Methods 0.000 title claims description 11
• 208000005176 Hepatitis C Diseases 0.000 title claims 2
• 239000000203 mixture Substances 0.000 claims abstract description 96
• 150000003839 salts Chemical class 0.000 claims abstract description 25
• -1 dentylcarbonyl Chemical group 0.000 claims description 120
• 125000000217 alkyl group Chemical group 0.000 claims description 82
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 70
• 229910052739 hydrogen Inorganic materials 0.000 claims description 50
• 239000001257 hydrogen Substances 0.000 claims description 47
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 32
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 29
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 27
• 229910052757 nitrogen Inorganic materials 0.000 claims description 24
• 239000003814 drug Substances 0.000 claims description 23
• 239000003112 inhibitor Substances 0.000 claims description 23
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 19
• 239000003795 chemical substances by application Substances 0.000 claims description 18
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 17
• 229940079322 interferon Drugs 0.000 claims description 13
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
• 108010050904 Interferons Proteins 0.000 claims description 12
• 102000014150 Interferons Human genes 0.000 claims description 12
• 108700008776 hepatitis C virus NS-5 Proteins 0.000 claims description 12
• 125000003342 alkenyl group Chemical group 0.000 claims description 10
• 125000001188 haloalkyl group Chemical group 0.000 claims description 9
• 125000003545 alkoxy group Chemical group 0.000 claims description 7
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• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 6
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• 230000001225 therapeutic effect Effects 0.000 claims 2
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• 208000010710 hepatitis C virus infection Diseases 0.000 claims 1
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