JP2010520761A5 - - Google Patents
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- Publication number
- JP2010520761A5 JP2010520761A5 JP2009553137A JP2009553137A JP2010520761A5 JP 2010520761 A5 JP2010520761 A5 JP 2010520761A5 JP 2009553137 A JP2009553137 A JP 2009553137A JP 2009553137 A JP2009553137 A JP 2009553137A JP 2010520761 A5 JP2010520761 A5 JP 2010520761A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- disease
- polypeptide
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims description 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 27
- 150000007523 nucleic acids Chemical group 0.000 claims description 22
- 210000004027 cell Anatomy 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 19
- 108020004707 nucleic acids Proteins 0.000 claims description 18
- 102000039446 nucleic acids Human genes 0.000 claims description 18
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims description 16
- 210000002997 osteoclast Anatomy 0.000 claims description 8
- 208000023275 Autoimmune disease Diseases 0.000 claims description 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 6
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 238000001476 gene delivery Methods 0.000 claims description 6
- 208000027866 inflammatory disease Diseases 0.000 claims description 6
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 6
- 208000027418 Wounds and injury Diseases 0.000 claims description 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 210000000130 stem cell Anatomy 0.000 claims description 4
- 210000001519 tissue Anatomy 0.000 claims description 4
- 208000024827 Alzheimer disease Diseases 0.000 claims description 3
- 208000018737 Parkinson disease Diseases 0.000 claims description 3
- 238000003745 diagnosis Methods 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 208000001132 Osteoporosis Diseases 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 238000001415 gene therapy Methods 0.000 claims description 2
- 239000007943 implant Substances 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000002407 tissue scaffold Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 11
- 108700010070 Codon Usage Proteins 0.000 description 1
- 108091081021 Sense strand Proteins 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE20070170 | 2007-03-12 | ||
| IE20080015 | 2008-01-11 | ||
| PCT/EP2008/052959 WO2008110578A2 (en) | 2007-03-12 | 2008-03-12 | Markers, antibodies and recombinant scfvs for mesenchymal stem cell-sub-populations and osteoclasts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010520761A JP2010520761A (ja) | 2010-06-17 |
| JP2010520761A5 true JP2010520761A5 (enExample) | 2012-05-10 |
Family
ID=39540751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009553137A Pending JP2010520761A (ja) | 2007-03-12 | 2008-03-12 | 間葉系幹細胞亜集団および破骨細胞に対するマーカー、抗体および組換えｓｃＦｖ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100062038A1 (enExample) |
| EP (1) | EP2118272A2 (enExample) |
| JP (1) | JP2010520761A (enExample) |
| AU (1) | AU2008225828A1 (enExample) |
| CA (1) | CA2688121A1 (enExample) |
| WO (1) | WO2008110578A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7655041B2 (en) | 2007-05-01 | 2010-02-02 | Moximed, Inc. | Extra-articular implantable mechanical energy absorbing systems and implantation method |
| FR2953023B1 (fr) * | 2009-11-23 | 2011-12-09 | Commissariat Energie Atomique | Utilisation d'une isoforme d'hla-g comme marqueur de l'osteogenese |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001239729A1 (en) * | 2000-09-12 | 2002-03-26 | Human Genome Sciences, Inc. | 22 human secreted proteins |
-
2008
- 2008-03-12 JP JP2009553137A patent/JP2010520761A/ja active Pending
- 2008-03-12 AU AU2008225828A patent/AU2008225828A1/en not_active Abandoned
- 2008-03-12 US US12/529,789 patent/US20100062038A1/en not_active Abandoned
- 2008-03-12 WO PCT/EP2008/052959 patent/WO2008110578A2/en not_active Ceased
- 2008-03-12 EP EP08717705A patent/EP2118272A2/en not_active Withdrawn
- 2008-03-12 CA CA2688121A patent/CA2688121A1/en not_active Abandoned
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