JP2010519930A5 - - Google Patents

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Publication number
JP2010519930A5
JP2010519930A5 JP2009552704A JP2009552704A JP2010519930A5 JP 2010519930 A5 JP2010519930 A5 JP 2010519930A5 JP 2009552704 A JP2009552704 A JP 2009552704A JP 2009552704 A JP2009552704 A JP 2009552704A JP 2010519930 A5 JP2010519930 A5 JP 2010519930A5
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JP
Japan
Prior art keywords
host cell
signal peptide
golgi
catalytic domain
recombinant glycoprotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009552704A
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English (en)
Japanese (ja)
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JP2010519930A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/002787 external-priority patent/WO2008112092A2/en
Publication of JP2010519930A publication Critical patent/JP2010519930A/ja
Publication of JP2010519930A5 publication Critical patent/JP2010519930A5/ja
Pending legal-status Critical Current

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JP2009552704A 2007-03-07 2008-03-03 糖タンパク質の修飾フコシル化を用いる産生 Pending JP2010519930A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90534507P 2007-03-07 2007-03-07
PCT/US2008/002787 WO2008112092A2 (en) 2007-03-07 2008-03-03 Production of glycoproteins with modified fucosylation

Publications (2)

Publication Number Publication Date
JP2010519930A JP2010519930A (ja) 2010-06-10
JP2010519930A5 true JP2010519930A5 (https=) 2013-11-14

Family

ID=39639063

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009552704A Pending JP2010519930A (ja) 2007-03-07 2008-03-03 糖タンパク質の修飾フコシル化を用いる産生

Country Status (11)

Country Link
US (1) US20100028951A1 (https=)
EP (1) EP2134834B1 (https=)
JP (1) JP2010519930A (https=)
KR (1) KR20090130029A (https=)
CN (1) CN101679934B (https=)
AU (1) AU2008227024A1 (https=)
CA (1) CA2679732A1 (https=)
RU (1) RU2479629C2 (https=)
SG (1) SG187521A1 (https=)
WO (1) WO2008112092A2 (https=)
ZA (1) ZA200905728B (https=)

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RU2584599C2 (ru) * 2008-12-19 2016-05-20 Дженневейн Биотехнологие Гмбх Синтез фукозилированных соединений
US8409838B2 (en) 2009-06-02 2013-04-02 Regeneron Pharmaceuticals, Inc. Fucosylation-deficient cells
RU2012140429A (ru) 2010-02-24 2014-03-27 Мерк Шарп Энд Домэ Корп. Способ увеличения занятости участков n-ликозилирования на терапевтических гликопротеинах, продуцируемых в p pastoris
TW201209160A (en) * 2010-04-27 2012-03-01 Lonza Ag Improved glycosylation of proteins in host cells
CN103764837A (zh) 2011-02-25 2014-04-30 默沙东公司 用于生产具有修饰的o-糖基化的蛋白的酵母菌株
CA2829110C (en) * 2011-03-06 2019-01-15 Merck Serono S.A. Low fucose cell lines and uses thereof
JP2014509864A (ja) 2011-03-23 2014-04-24 グリコド Ｇｄｐ−フコースを産生可能な酵母組換え細胞
EP2852610B1 (en) 2012-05-23 2018-07-11 Glykos Finland Oy Production of fucosylated glycoproteins
TWI682033B (zh) * 2014-03-17 2020-01-11 泉盛生物科技股份有限公司 製造具有經修飾的糖苷化作用之重組糖蛋白之方法
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
EP3042952A1 (en) 2015-01-07 2016-07-13 CEVEC Pharmaceuticals GmbH O-glycan sialylated recombinant glycoproteins and cell lines for producing the same
CA3019588A1 (en) 2016-04-20 2017-10-26 Merck Sharp & Dohme Corp. Cmv neutralizing antigen binding proteins
EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
CA3109366A1 (en) 2018-09-13 2020-03-19 The Board Of Regents Of The University Of Texas System Novel lilrb4 antibodies and uses thereof
AU2021236302A1 (en) 2020-03-12 2022-10-20 Immune-Onc Therapeutics, Inc. Novel anti-LILRB4 antibodies and derivative products
EP4255451A4 (en) 2020-12-03 2025-01-01 The Board Of Regents Of The University Of Texas System Methods for identifying lilrb-blocking antibodies
WO2025144795A1 (en) * 2023-12-28 2025-07-03 Dsm Ip Assets B.V. Cells and methods for the production of glycosylated compounds

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