JP2010518160A5 - - Google Patents
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- Publication number
- JP2010518160A5 JP2010518160A5 JP2009549595A JP2009549595A JP2010518160A5 JP 2010518160 A5 JP2010518160 A5 JP 2010518160A5 JP 2009549595 A JP2009549595 A JP 2009549595A JP 2009549595 A JP2009549595 A JP 2009549595A JP 2010518160 A5 JP2010518160 A5 JP 2010518160A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- administered
- dose
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 6
- 230000006378 damage Effects 0.000 claims 6
- 230000037396 body weight Effects 0.000 claims 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 4
- 229960004316 cisplatin Drugs 0.000 claims 4
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 230000001186 cumulative effect Effects 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 230000005855 radiation Effects 0.000 claims 3
- 238000002512 chemotherapy Methods 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 229930182827 D-tryptophan Chemical group 0.000 claims 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical group C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 1
- CATMPQFFVNKDEY-YPMHNXCESA-N Golotimod Chemical compound C1=CC=C2C(C[C@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)=CNC2=C1 CATMPQFFVNKDEY-YPMHNXCESA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-Tryptophan Natural products C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- 125000002707 L-tryptophyl group Chemical group [H]C1=C([H])C([H])=C2C(C([C@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 claims 1
- 206010028116 Mucosal inflammation Diseases 0.000 claims 1
- 201000010927 Mucositis Diseases 0.000 claims 1
- 108010033276 Peptide Fragments Chemical group 0.000 claims 1
- 102000007079 Peptide Fragments Human genes 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 108010049353 golotimod Proteins 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- -1 heterocyclic amino acid Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229960004799 tryptophan Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90097707P | 2007-02-13 | 2007-02-13 | |
| PCT/US2008/001768 WO2008100458A2 (en) | 2007-02-13 | 2008-02-11 | Method of treating or preventing tissue deterioration, injury or damage due to disease of mucosa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010518160A JP2010518160A (ja) | 2010-05-27 |
| JP2010518160A5 true JP2010518160A5 (enExample) | 2011-04-07 |
Family
ID=39690681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549595A Withdrawn JP2010518160A (ja) | 2007-02-13 | 2008-02-11 | 粘膜の疾患による組織の崩壊、傷害又は損傷を治療又は予防する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7906486B2 (enExample) |
| EP (1) | EP2120986A4 (enExample) |
| JP (1) | JP2010518160A (enExample) |
| KR (1) | KR20090119897A (enExample) |
| CN (1) | CN101657210A (enExample) |
| AR (1) | AR065338A1 (enExample) |
| AU (1) | AU2008216799A1 (enExample) |
| CA (1) | CA2677749A1 (enExample) |
| IL (1) | IL200364A0 (enExample) |
| MX (1) | MX2009008641A (enExample) |
| NZ (1) | NZ579570A (enExample) |
| TW (1) | TW200845958A (enExample) |
| UA (1) | UA96980C2 (enExample) |
| WO (1) | WO2008100458A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2677749A1 (en) * | 2007-02-13 | 2008-08-21 | Sciclone Pharmaceuticals, Inc. | Method of treating or preventing tissue deterioration, injury or damage due to disease of mucosa |
| RU2436587C1 (ru) * | 2010-10-21 | 2011-12-20 | Общество с ограниченной ответственностью "ЦитоНИР" (ООО "ЦитоНИР") | N-изовалероил-l-глутамил-l-триптофан как средство, препятствующее язвообразованию в желудке и двенадцатиперстной кишке |
| CN109528202B (zh) * | 2018-11-14 | 2021-07-16 | 北京大学第一医院 | 一种头颈部放疗诊疗系统 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125626A (en) * | 1977-01-17 | 1978-11-14 | Mt. Sinai School Of Medicine Of The City University Of New York | Synthesis and use of L-γ-glutamyl-DOPA |
| US4568489A (en) * | 1984-06-29 | 1986-02-04 | E. R. Squibb & Sons, Inc. | N-Acyl-γ-glutamyl imino and amino acids and esters |
| US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4758551A (en) * | 1986-07-08 | 1988-07-19 | Cornell Research Foundation, Inc. | Methods for combatting renal toxicity due to metals or nephrotoxic drugs and for selectively modulating in vivo formation of leukotriene types |
| US4968672A (en) * | 1987-01-02 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Adenosine receptor prodrugs |
| US4895835A (en) * | 1987-11-20 | 1990-01-23 | Nisshin Oil Mills, Ltd. | Muramyl peptide derivatives and use thereof |
| US5728680A (en) * | 1987-12-30 | 1998-03-17 | Cytoven J.V. | Methods for normalizing numbers of lymphocytes |
| US5902790A (en) * | 1995-10-03 | 1999-05-11 | Cytran, Inc. | Pharmaceutical angiostatic dipeptide compositions and method of use thereof |
| US5206220A (en) * | 1990-04-23 | 1993-04-27 | Research Corporation Technologies, Inc. | Soluble and stable sources of tyrosine, cysteine and glutamine for total parenteral nutrition |
| WO1992017191A1 (en) | 1991-04-01 | 1992-10-15 | Cytoven | Pharmaceutical dipeptide compositions and methods of use thereof |
| WO1993008815A1 (en) | 1991-10-28 | 1993-05-13 | Cytoven | Pharmaceutical dipeptide compositions and methods of use thereof |
| WO1994020063A2 (en) | 1993-03-04 | 1994-09-15 | Cytoven International N.V. | Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof |
| GB9320820D0 (en) * | 1993-10-08 | 1993-12-01 | Biokine Tech Ltd | Compounds for medicinal use |
| RU2107692C1 (ru) * | 1995-06-07 | 1998-03-27 | Дейгин Владислав Исакович | Пептид и способ его получения |
| US5888980A (en) * | 1994-06-30 | 1999-03-30 | Bio-Logic Research And Development Corporation | Compositions for enhancing immune function |
| US5916878A (en) * | 1995-11-28 | 1999-06-29 | Edward T. Wei | γ-glutamyl and β-aspartyl containing immunomodulator compounds and methods therewith |
| US5744452A (en) * | 1995-11-28 | 1998-04-28 | Edward T. Wei | γ-L-glutamyl containing immunomodulator compounds and methods therewith |
| RU2120298C1 (ru) | 1995-11-28 | 1998-10-20 | Товарищество с ограниченной ответственностью "Верта" | Иммуностимулятор и препарат на его основе |
| WO1997019691A1 (en) | 1995-11-28 | 1997-06-05 | Wei, Edward, T. | Gamma-l-glutamyl containing immunomodulator compounds and methods therewith |
| US6060452A (en) * | 1996-03-13 | 2000-05-09 | Cytran, Inc. | Analogs of L-Glu-L-Trp having pharmacological activity |
| RU2141483C1 (ru) | 1997-07-04 | 1999-11-20 | Небольсин Владимир Евгеньевич | Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция |
| US7173013B2 (en) * | 2001-06-08 | 2007-02-06 | Sciclone Pharmaceuticals, Inc. | Treatment of tuberculosis using immunomodulator compounds |
| RU2229892C2 (ru) | 2001-06-08 | 2004-06-10 | Государственное учреждение "Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии" | Способ лечения туберкулеза легких |
| US20050256042A1 (en) * | 2003-05-09 | 2005-11-17 | Jeffers Michael E | Methods of preventing and treating alimentary mucositis |
| AU2005244826B2 (en) * | 2004-05-14 | 2010-07-29 | Sciclone Pharmaceuticals, Inc. | Treatment or prevention of respiratory viral infections with immunomodulator compounds |
| JP4874985B2 (ja) | 2004-10-27 | 2012-02-15 | サイクローン・ファーマシューティカルズ・インコーポレイテッド | 免疫調節化合物による出血性ウイルス感染の治療又は予防 |
| WO2006076169A2 (en) | 2004-12-28 | 2006-07-20 | Sciclone Pharmaceuticals, Inc. | Treatment or prevention of genital viral infections with immunomodulator compounds |
| US20090074815A1 (en) * | 2005-04-22 | 2009-03-19 | Sciclone Pharmaceuticals, Inc. | Immunomodulator Compounds as Vaccine Enhancers |
| AU2007240946A1 (en) * | 2006-04-20 | 2007-11-01 | Sciclone Pharmaceuticals, Inc. | Treatment of melanoma |
| JP2010513508A (ja) | 2006-12-18 | 2010-04-30 | アキリオン ファーマシューティカルズ，インコーポレーテッド | Ｃ型肝炎感染を処置するための併用療法 |
| CA2677749A1 (en) * | 2007-02-13 | 2008-08-21 | Sciclone Pharmaceuticals, Inc. | Method of treating or preventing tissue deterioration, injury or damage due to disease of mucosa |
| RU2007118237A (ru) | 2007-05-17 | 2008-11-27 | ООО "Научно-производственна фирма Верта" (RU) | Способ лечения аллергических заболеваний |
| US20110189305A1 (en) | 2007-08-23 | 2011-08-04 | Tuthill Cynthia W | Treatment of lung cancer |
| JP2011530519A (ja) | 2008-08-06 | 2011-12-22 | サイクローン・ファーマシューティカルズ・インコーポレイテッド | 免疫調節化合物を用いたｃ型肝炎の治療または予防の方法 |
-
2008
- 2008-02-11 CA CA002677749A patent/CA2677749A1/en not_active Abandoned
- 2008-02-11 US US12/526,585 patent/US7906486B2/en not_active Expired - Fee Related
- 2008-02-11 KR KR1020097018913A patent/KR20090119897A/ko not_active Withdrawn
- 2008-02-11 EP EP08725404A patent/EP2120986A4/en not_active Withdrawn
- 2008-02-11 MX MX2009008641A patent/MX2009008641A/es not_active Application Discontinuation
- 2008-02-11 UA UAA200909229A patent/UA96980C2/ru unknown
- 2008-02-11 NZ NZ579570A patent/NZ579570A/en not_active IP Right Cessation
- 2008-02-11 CN CN200880011935A patent/CN101657210A/zh active Pending
- 2008-02-11 JP JP2009549595A patent/JP2010518160A/ja not_active Withdrawn
- 2008-02-11 AU AU2008216799A patent/AU2008216799A1/en not_active Abandoned
- 2008-02-11 WO PCT/US2008/001768 patent/WO2008100458A2/en not_active Ceased
- 2008-02-13 AR ARP080100621A patent/AR065338A1/es not_active Application Discontinuation
- 2008-02-13 TW TW097105084A patent/TW200845958A/zh unknown
-
2009
- 2009-08-12 IL IL200364A patent/IL200364A0/en unknown
-
2011
- 2011-01-25 US US13/013,340 patent/US20110117211A1/en not_active Abandoned
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