JP2010518091A5 - - Google Patents
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- JP2010518091A5 JP2010518091A5 JP2009549130A JP2009549130A JP2010518091A5 JP 2010518091 A5 JP2010518091 A5 JP 2010518091A5 JP 2009549130 A JP2009549130 A JP 2009549130A JP 2009549130 A JP2009549130 A JP 2009549130A JP 2010518091 A5 JP2010518091 A5 JP 2010518091A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- bryologs
- pharmaceutical
- activator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000003923 Protein Kinase C Human genes 0.000 claims description 7
- 108090000315 Protein Kinase C Proteins 0.000 claims description 7
- 239000012190 activator Substances 0.000 claims description 6
- 150000001982 diacylglycerols Chemical class 0.000 claims description 3
- OYHQOLUKZRVURQ-HZJYTTRNSA-N linoleic acid group Chemical class C(CCCCCCC\C=C/C\C=C/CCCCC)(=O)O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 3
- MJMJERJFCHYXEM-UHFFFAOYSA-N 5-chloro-N-heptyl-1-naphthalenesulfonamide Chemical group C1=CC=C2C(S(=O)(=O)NCCCCCCC)=CC=CC2=C1Cl MJMJERJFCHYXEM-UHFFFAOYSA-N 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 37
- -1 bicyclic triterpenoids Chemical class 0.000 claims 5
- 206010019196 Head injury Diseases 0.000 claims 3
- 150000004141 diterpene derivatives Chemical class 0.000 claims 3
- ZFIFHAKCBWOSRN-UHFFFAOYSA-N naphthalene-1-sulfonamide Chemical class C1=CC=C2C(S(=O)(=O)N)=CC=CC2=C1 ZFIFHAKCBWOSRN-UHFFFAOYSA-N 0.000 claims 3
- ZBCATMYQYDCTIZ-UHFFFAOYSA-N 4-methylcatechol Chemical compound CC1=CC=C(O)C(O)=C1 ZBCATMYQYDCTIZ-UHFFFAOYSA-N 0.000 claims 2
- 229940123948 Diacylglycerol kinase inhibitor Drugs 0.000 claims 2
- CGPFADLKIPZYRE-OWLUANBVSA-N daphnane Chemical compound C([C@]12CCC[C@H]1[C@]13CCC)C[C@H]4[C@]3(C)CC[C@H](C(C)C)[C@@H]1N2C4 CGPFADLKIPZYRE-OWLUANBVSA-N 0.000 claims 2
- 239000003047 diacylglycerol kinase inhibitor Substances 0.000 claims 2
- 229930004069 diterpene Natural products 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- RVAQSYWDOSHWGP-UHFFFAOYSA-N 1-[ethoxy(trichloromethyl)phosphoryl]oxyethane Chemical compound CCOP(=O)(C(Cl)(Cl)Cl)OCC RVAQSYWDOSHWGP-UHFFFAOYSA-N 0.000 claims 1
- LULAYUGMBFYYEX-UHFFFAOYSA-N 3-chlorobenzoic acid Chemical compound OC(=O)C1=CC=CC(Cl)=C1 LULAYUGMBFYYEX-UHFFFAOYSA-N 0.000 claims 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 208000014644 Brain disease Diseases 0.000 claims 1
- VEBVPUXQAPLADL-UHFFFAOYSA-N Ingenol Natural products C1=C(CO)C(O)C2(O)C(O)C(C)=CC32C(C)CC2C(C)(C)C2C1C3=O VEBVPUXQAPLADL-UHFFFAOYSA-N 0.000 claims 1
- GIMKEHNOTHXONN-QBZCICILSA-N Ingenol 3,20-dibenzoate Natural products O=C(OCC=1[C@@H](O)[C@]2(O)[C@@H](OC(=O)c3ccccc3)C(C)=C[C@@]32[C@@H](C)C[C@H]2C(C)(C)[C@@H]2[C@H](C3=O)C=1)c1ccccc1 GIMKEHNOTHXONN-QBZCICILSA-N 0.000 claims 1
- VDJHFHXMUKFKET-UHFFFAOYSA-N Ingenol mebutate Natural products CC1CC2C(C)(C)C2C2C=C(CO)C(O)C3(O)C(OC(=O)C(C)=CC)C(C)=CC31C2=O VDJHFHXMUKFKET-UHFFFAOYSA-N 0.000 claims 1
- GIMKEHNOTHXONN-UHFFFAOYSA-N Ingenol-3,20-dibenzoate Natural products OC1C2(O)C(OC(=O)C=3C=CC=CC=3)C(C)=CC2(C2=O)C(C)CC(C3(C)C)C3C2C=C1COC(=O)C1=CC=CC=C1 GIMKEHNOTHXONN-UHFFFAOYSA-N 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- UEZROEGYRDHMRV-UHFFFAOYSA-N [1,3]thiazolo[3,2-a]pyrimidin-5-one Chemical compound O=C1C=CN=C2SC=CN12 UEZROEGYRDHMRV-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical class COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 claims 1
- VEBVPUXQAPLADL-POYOOMFHSA-N ingenol Chemical compound C1=C(CO)[C@@H](O)[C@]2(O)[C@@H](O)C(C)=C[C@]32[C@H](C)C[C@H]2C(C)(C)[C@H]2[C@H]1C3=O VEBVPUXQAPLADL-POYOOMFHSA-N 0.000 claims 1
- VDJHFHXMUKFKET-WDUFCVPESA-N ingenol mebutate Chemical compound C[C@@H]1C[C@H]2C(C)(C)[C@H]2[C@@H]2C=C(CO)[C@@H](O)[C@]3(O)[C@@H](OC(=O)C(\C)=C/C)C(C)=C[C@]31C2=O VDJHFHXMUKFKET-WDUFCVPESA-N 0.000 claims 1
- 229960002993 ingenol mebutate Drugs 0.000 claims 1
- 150000003951 lactams Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 150000004633 phorbol derivatives Chemical class 0.000 claims 1
- 239000002644 phorbol ester Substances 0.000 claims 1
- 150000003505 terpenes Chemical class 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- CONYTTFKIUJZOF-UHFFFAOYSA-N 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoic acid Chemical compound CCCCCC1CC1CC1C(CCCCCCCC(O)=O)C1 CONYTTFKIUJZOF-UHFFFAOYSA-N 0.000 description 4
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90033807P | 2007-02-09 | 2007-02-09 | |
| US60/900,338 | 2007-02-09 | ||
| US92466307P | 2007-05-24 | 2007-05-24 | |
| US60/924,663 | 2007-05-24 | ||
| PCT/US2008/001755 WO2008100449A2 (en) | 2007-02-09 | 2008-02-11 | Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013261788A Division JP6199176B2 (ja) | 2007-02-09 | 2013-12-18 | 頭部外傷誘導性の記憶障害および脳障害におけるブリオスタチン、ブリオログ、および他の関連物質の治療効果 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518091A JP2010518091A (ja) | 2010-05-27 |
| JP2010518091A5 true JP2010518091A5 (cg-RX-API-DMAC7.html) | 2011-07-28 |
| JP5518489B2 JP5518489B2 (ja) | 2014-06-11 |
Family
ID=39690678
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549130A Active JP5518489B2 (ja) | 2007-02-09 | 2008-02-11 | 頭部外傷誘導性の記憶障害および脳障害におけるブリオスタチン、ブリオログ、および他の関連物質の治療効果 |
| JP2013261788A Expired - Fee Related JP6199176B2 (ja) | 2007-02-09 | 2013-12-18 | 頭部外傷誘導性の記憶障害および脳障害におけるブリオスタチン、ブリオログ、および他の関連物質の治療効果 |
| JP2016016127A Pending JP2016128486A (ja) | 2007-02-09 | 2016-01-29 | 頭部外傷誘導性の記憶障害および脳障害におけるブリオスタチン、ブリオログ、および他の関連物質の治療効果 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013261788A Expired - Fee Related JP6199176B2 (ja) | 2007-02-09 | 2013-12-18 | 頭部外傷誘導性の記憶障害および脳障害におけるブリオスタチン、ブリオログ、および他の関連物質の治療効果 |
| JP2016016127A Pending JP2016128486A (ja) | 2007-02-09 | 2016-01-29 | 頭部外傷誘導性の記憶障害および脳障害におけるブリオスタチン、ブリオログ、および他の関連物質の治療効果 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9974832B2 (cg-RX-API-DMAC7.html) |
| EP (4) | EP2121000B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5518489B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20090119894A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101848726A (cg-RX-API-DMAC7.html) |
| CA (2) | CA2873179A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2548766T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008100449A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1549721B (zh) | 2001-02-27 | 2012-03-07 | 布朗歇特洛克菲勒神经科学研究所 | 基于促分裂原活化的蛋白激酶的磷酸化诊断阿尔茨海默氏病 |
| US6825229B2 (en) | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| US20050065205A1 (en) | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
| TW201207390A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Method for screening agent for antidepressant activity |
| CA2617003A1 (en) | 2005-07-29 | 2007-02-08 | Blanchette Rockefeller Neurosciences Institute | Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory |
| US20090029873A1 (en) | 2005-10-11 | 2009-01-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb) |
| US9974832B2 (en) | 2007-02-09 | 2018-05-22 | Cognitive Research Enterprises, Inc. | Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury |
| CN101678080A (zh) * | 2007-02-09 | 2010-03-24 | 布朗歇特洛克菲勒神经科学研究所 | 苔藓抑素、苔藓抑素类似物和其它相关物质对缺血/中风引起的记忆缺陷和脑损伤的疗效 |
| WO2008143880A2 (en) * | 2007-05-24 | 2008-11-27 | Blanchette Rockefeller Neurosciences Institute | Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and traumatic brain injury |
| US20100168219A1 (en) * | 2008-12-31 | 2010-07-01 | Jonathan Steven Alexander | Chronic inflammation and transplantation |
| US9994585B2 (en) | 2007-12-31 | 2018-06-12 | Aphios Corporation | Transplantation therapies |
| US8822166B2 (en) | 2008-07-28 | 2014-09-02 | Blanchette Rockefeller Neurosciences Institute | Stimulus-elicited genomic profile markers of alzheimer's disease |
| US8163800B2 (en) | 2008-07-28 | 2012-04-24 | Blanchette Rockefeller Neurosciences Institute | PKC-activating compounds for the treatment of neurodegenerative diseases |
| US20110054040A1 (en) * | 2008-12-22 | 2011-03-03 | Department Of Biotechnology | Bicyclic Triterpenoid Iripallidal as a Novel Anti-Glioma and Anti-Neoplastic Therapy |
| CN102741696A (zh) | 2009-10-02 | 2012-10-17 | 布朗歇特洛克菲勒神经科学研究所 | 阿尔茨海默病外周细胞中pkc同工酶加工的异常改变 |
| US8658134B2 (en) | 2009-10-02 | 2014-02-25 | Blanchette Rockefeller Neurosciences Institute | Fibroblast growth patterns for diagnosis of Alzheimer's disease |
| JP6446624B2 (ja) | 2010-07-08 | 2019-01-09 | アルコン、ダニエル・エル． | 脳卒中の治療法におけるｐｋｃ活性化因子および抗凝血剤 |
| KR101467605B1 (ko) * | 2010-11-29 | 2014-12-04 | 충북대학교 산학협력단 | 신규의 다프난 디테르펜계 화합물 및 이를 유효성분으로 포함하는 피부 미백용 조성물 |
| JP6563193B2 (ja) | 2011-11-13 | 2019-08-21 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | Ｄｃｐｌａのエステル、およびそれを用いた処置の方法 |
| US9034347B2 (en) | 2011-12-19 | 2015-05-19 | Arphios Corporation | Drug delivery system and method for the treatment of neuro-degenerative disease |
| JP6579956B2 (ja) | 2012-11-28 | 2019-09-25 | アフィオス コーポレーション | 神経変性疾患および他の疾患の治療のための併用治療薬および方法 |
| CA2906164A1 (en) | 2013-03-15 | 2014-09-18 | Daniel L. Alkon | Methods for identifying neuroprotective pkc activators |
| EP3501519B1 (en) | 2016-08-18 | 2024-11-20 | National University Corporation Nara Institute of Science and Technology | Bryostatin 1 for use in treating ige mediated allergic diseases |
| EP3964210A1 (en) * | 2018-05-18 | 2022-03-09 | Neurotrope Bioscience, Inc. | Methods and compositions for treatment of alzheimer's disease |
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| CA2401452A1 (en) | 2001-09-04 | 2003-03-04 | Uri Saragovi | Combination of antioxidant substances for the treatment of alzheimer's disease |
| JP4568464B2 (ja) | 2001-11-07 | 2010-10-27 | 雪印乳業株式会社 | 記憶障害予防治療剤 |
| US20050065205A1 (en) * | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
| US6821979B2 (en) | 2002-03-07 | 2004-11-23 | Blanchette Rockefeller Neurosciences Institute | Synergistic enhancement of cognitive ability |
| US6825229B2 (en) * | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| AU2003281214A1 (en) * | 2002-07-02 | 2004-01-23 | Blanchette Rockefeller Neurosciences Institute | PKC ACTIVATION AS A MEANS FOR ENHANCING sAPPAlpha SECRETION AND IMPROVING COGNITION USING BRYOSTATIN TYPE COMPOUNDS |
| US20040229292A1 (en) * | 2002-11-26 | 2004-11-18 | Sebastiano Cavallaro | Use of FGF-18 in the diagnosis and treatment of memory disorders |
| US7803400B2 (en) * | 2002-12-03 | 2010-09-28 | Blanchette Rockefeller Neurosciences Institute | Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier |
| EA008864B1 (ru) | 2003-09-30 | 2007-08-31 | Нью Ривер Фармасьютикалз Инк. | Фармацевтические композиции для предотвращения передозировки или неправильного употребления лекарственных средств |
| TW201207390A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Method for screening agent for antidepressant activity |
| EP1761805B1 (en) | 2004-06-30 | 2013-05-01 | Shell Internationale Research Maatschappij B.V. | Determining in-situ the relation between seismic velocity and state of stress in an underground formation |
| CA2617003A1 (en) | 2005-07-29 | 2007-02-08 | Blanchette Rockefeller Neurosciences Institute | Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory |
| WO2007044094A1 (en) | 2005-10-11 | 2007-04-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
| KR20090038478A (ko) * | 2006-07-28 | 2009-04-20 | 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 | 세포 성장 자극, 시냅스 리모델링 및 장기간 기억 강화 방법 |
| US9974832B2 (en) | 2007-02-09 | 2018-05-22 | Cognitive Research Enterprises, Inc. | Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury |
| JP5987867B2 (ja) | 2014-07-10 | 2016-09-07 | コニカミノルタ株式会社 | シート搬送装置および画像形成システム |
-
2008
- 2008-02-11 US US12/068,742 patent/US9974832B2/en active Active
- 2008-02-11 KR KR1020097018890A patent/KR20090119894A/ko not_active Ceased
- 2008-02-11 EP EP08725395.1A patent/EP2121000B1/en not_active Not-in-force
- 2008-02-11 JP JP2009549130A patent/JP5518489B2/ja active Active
- 2008-02-11 ES ES08725395.1T patent/ES2548766T3/es active Active
- 2008-02-11 CA CA2873179A patent/CA2873179A1/en not_active Abandoned
- 2008-02-11 KR KR1020147006408A patent/KR20140049054A/ko not_active Ceased
- 2008-02-11 CN CN200880004009A patent/CN101848726A/zh active Pending
- 2008-02-11 WO PCT/US2008/001755 patent/WO2008100449A2/en not_active Ceased
- 2008-02-11 EP EP18153508.9A patent/EP3332797A3/en not_active Withdrawn
- 2008-02-11 CA CA002674773A patent/CA2674773A1/en not_active Withdrawn
- 2008-02-11 EP EP15002036.0A patent/EP2959914A1/en not_active Ceased
- 2008-02-11 EP EP14001303.8A patent/EP2754448A3/en not_active Withdrawn
-
2013
- 2013-12-18 JP JP2013261788A patent/JP6199176B2/ja not_active Expired - Fee Related
-
2016
- 2016-01-29 JP JP2016016127A patent/JP2016128486A/ja active Pending
-
2018
- 2018-04-17 US US15/954,693 patent/US20190083575A1/en not_active Abandoned
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