JP2010517544A - ヒトサイトメガロウイルス（ｈｃｍｖ）の組換え抗原 - Google Patents

ヒトサイトメガロウイルス（ｈｃｍｖ）の組換え抗原 Download PDF

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Publication number
JP2010517544A
JP2010517544A JP2009548617A JP2009548617A JP2010517544A JP 2010517544 A JP2010517544 A JP 2010517544A JP 2009548617 A JP2009548617 A JP 2009548617A JP 2009548617 A JP2009548617 A JP 2009548617A JP 2010517544 A JP2010517544 A JP 2010517544A
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Japan
Prior art keywords
seq
hcmv
antigen
nucleotide sequence
chimeric
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Pending
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JP2009548617A
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Japanese (ja)
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JP2010517544A5 (enExample
Inventor
ニコーラ・ガルガノ
エリサ・ベゲット
アンドレア・スパドーニ
フランチェスカ・デ・パオリス
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Publication of JP2010517544A publication Critical patent/JP2010517544A/ja
Publication of JP2010517544A5 publication Critical patent/JP2010517544A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/03—Herpetoviridae, e.g. pseudorabies virus
    • G01N2333/04—Varicella-zoster virus
    • G01N2333/045—Cytomegalovirus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
JP2009548617A 2007-02-07 2008-02-05 ヒトサイトメガロウイルス（ｈｃｍｖ）の組換え抗原 Pending JP2010517544A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07101864 2007-02-07
PCT/EP2008/000876 WO2008095677A1 (en) 2007-02-07 2008-02-05 Recombinant antigens of human cytomegalovirus (hcmv)

Publications (2)

Publication Number Publication Date
JP2010517544A true JP2010517544A (ja) 2010-05-27
JP2010517544A5 JP2010517544A5 (enExample) 2011-03-24

Family

ID=38229391

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009548617A Pending JP2010517544A (ja) 2007-02-07 2008-02-05 ヒトサイトメガロウイルス（ｈｃｍｖ）の組換え抗原

Country Status (13)

Country Link
US (1) US20100068229A1 (enExample)
EP (1) EP2114991A1 (enExample)
JP (1) JP2010517544A (enExample)
KR (1) KR20090126256A (enExample)
CN (1) CN101605808A (enExample)
AU (1) AU2008213356A1 (enExample)
BR (1) BRPI0807095A2 (enExample)
CA (1) CA2677455A1 (enExample)
EA (1) EA200970731A1 (enExample)
IL (1) IL200187A0 (enExample)
MX (1) MX2009008248A (enExample)
SG (1) SG178761A1 (enExample)
WO (1) WO2008095677A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012005238A1 (ja) * 2010-07-07 2012-01-12 富士レビオ株式会社 ヒトサイトメガロウイルス感染の検出方法
JP2014504730A (ja) * 2011-01-18 2014-02-24 アメリカ合衆国 プリオンの増幅および検出のための方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012015523A2 (pt) 2009-12-23 2017-04-18 4-Antibody Ag membros de ligação do citomegalovirus humano, composição contendo os mesmos, método de tratamento, moléculas de anticorpo, método de produção, molecular de ácido nucléico, célula hospedeira, e, método de neutralização do hcmv.
CN102816246B (zh) * 2012-09-04 2014-07-23 成都蓉生药业有限责任公司 一种人巨细胞病毒免疫原融合蛋白及其制备方法和用途
US10611800B2 (en) 2016-03-11 2020-04-07 Pfizer Inc. Human cytomegalovirus gB polypeptide
US11174322B2 (en) 2017-07-24 2021-11-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies and peptides to treat HCMV related diseases
US11629172B2 (en) 2018-12-21 2023-04-18 Pfizer Inc. Human cytomegalovirus gB polypeptide
TWI810589B (zh) 2020-06-21 2023-08-01 美商輝瑞股份有限公司 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽

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IL60184A (en) * 1979-05-31 1984-05-31 Schering Ag Process for the specific cleavage of protein sequences from proteins
JPH01125328A (ja) * 1987-07-30 1989-05-17 Centro Natl De Biopreparados 髄膜炎菌ワクチン
CA2050425A1 (en) * 1990-09-03 1992-03-04 Yoshiaki Uda Pharmaceutical composition and its mucous use
SG48365A1 (en) * 1992-05-23 1998-04-17 Smithkline Beecham Biolog Combined vaccines comprising hepatitis b surface antigen and other antigens
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
US5846806A (en) 1994-07-29 1998-12-08 American Cyanamid Company Identification of a human cytomegalovirus gene region involved in down-regulation of MHC class I heavy chain expression
DK0960336T3 (da) * 1996-07-12 2003-02-10 Organon Teknika Bv Peptidreagens til påvisning af humant cytomelagovirus (CMV)
US6306404B1 (en) * 1998-07-14 2001-10-23 American Cyanamid Company Adjuvant and vaccine compositions containing monophosphoryl lipid A
AT408615B (de) * 1998-09-15 2002-01-25 Immuno Ag Neue influenzavirus-impfstoffzusammensetzung
WO2003010198A1 (en) 2001-07-26 2003-02-06 Kenton Srl Identification of specific tumour antigens by selection of cdna libraries with sera and use of said antigens in diagnostic techniques

Non-Patent Citations (8)

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Title
JPN6012046635; Ｊ．　Ｖｉｒｏｌ．　Ｍｅｔｈｏｄｓ Ｖｏｌ．　９６, 2001, ｐ．　１５７-１７０ *
JPN6012046636; Ｊ．　Ｃｌｉｎ．　Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．　３３，　Ｎｏ．　１０, 1995, ｐ．　２５３５-２５４２ *
JPN6012046637; Ｊ．　Ｖｉｒｏｌ．　Ｍｅｔｈｏｄｓ Ｖｏｌ．　６０, 1996, ｐ．　７３-８０ *
JPN6012046638; Ｍｉｃｒｏｂｉｏｌｏｇｉｃａ Ｖｏｌ．　１８, 1995, ｐ．　１-１２ *
JPN6012046640; Ｐｒｏｇｒｅｓｓ　ｉｎ　Ｃｙｔｏｍｅｇａｌｏｖｉｒｕｓ　Ｒｅｓｅａｒｃｈ , 1991, ｐ．　１９５-１９８ *
JPN6012046642; Ｊ．　Ｉｍｍｕｎｏｌ．　Ｍｅｔｈｏｄｓ Ｖｏｌ．　１７８, 1995, ｐ．　１-１２ *
JPN6012046644; Ｊ．　Ｖｉｒｏｌ． Ｖｏｌ．　７５，　Ｎｏ．　７, 2001, ｐ．　３２７７-３２９０ *
JPN6012046645; Ｊ．　Ｇｅｎ．　Ｖｉｒｏｌ． Ｖｏｌ．　８１, 2000, ｐ．　９９３-１０００ *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012005238A1 (ja) * 2010-07-07 2012-01-12 富士レビオ株式会社 ヒトサイトメガロウイルス感染の検出方法
JP2012018051A (ja) * 2010-07-07 2012-01-26 Fujirebio Inc ヒトサイトメガロウイルス感染の検出方法
JP2014504730A (ja) * 2011-01-18 2014-02-24 アメリカ合衆国 プリオンの増幅および検出のための方法
JP2017134080A (ja) * 2011-01-18 2017-08-03 アメリカ合衆国 プリオンの増幅および検出のための方法

Also Published As

Publication number Publication date
KR20090126256A (ko) 2009-12-08
BRPI0807095A2 (pt) 2014-04-22
IL200187A0 (en) 2010-04-15
MX2009008248A (es) 2009-08-12
AU2008213356A1 (en) 2008-08-14
US20100068229A1 (en) 2010-03-18
EA200970731A1 (ru) 2010-02-26
CA2677455A1 (en) 2008-08-14
WO2008095677A1 (en) 2008-08-14
SG178761A1 (en) 2012-03-29
EP2114991A1 (en) 2009-11-11
CN101605808A (zh) 2009-12-16

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