JP2010516678A - Ｔｒｅｍ−１による炎症治療、検出およびモニタリング - Google Patents

Ｔｒｅｍ−１による炎症治療、検出およびモニタリング Download PDF

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JP2010516678A
JP2010516678A JP2009546423A JP2009546423A JP2010516678A JP 2010516678 A JP2010516678 A JP 2010516678A JP 2009546423 A JP2009546423 A JP 2009546423A JP 2009546423 A JP2009546423 A JP 2009546423A JP 2010516678 A JP2010516678 A JP 2010516678A
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trem
subject
expression
antibody
spp1
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JP2010516678A5 (enExample
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ジュン・クアイ
ケン・ダウアー
ジェフリー・エル・フェルドマン
デブラ・ディ・ピットマン
モイトレイー・チャッテルジー−キショレ
デイビッド・ウィンクラー
リー−リン・リン
スコット・アラン・ジェリンスキー
カラ・ウィリアムズ
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Wyeth LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2267/03—Animal model, e.g. for test or diseases
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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JP2009546423A 2007-01-16 2008-01-16 Ｔｒｅｍ−１による炎症治療、検出およびモニタリング Pending JP2010516678A (ja)

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Application Number Priority Date Filing Date Title
US88080407P 2007-01-16 2007-01-16
US90426407P 2007-02-28 2007-02-28
US92313107P 2007-04-11 2007-04-11
US168707P 2007-11-02 2007-11-02
PCT/US2008/000629 WO2008088849A2 (en) 2007-01-16 2008-01-16 Inflammation treatment, detection and monitoring via trem-1

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JP2010516678A true JP2010516678A (ja) 2010-05-20
JP2010516678A5 JP2010516678A5 (enExample) 2012-03-22

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US (1) US20080247955A1 (enExample)
EP (1) EP2121750A2 (enExample)
JP (1) JP2010516678A (enExample)
CN (1) CN101687916A (enExample)
AU (1) AU2008205538A1 (enExample)
BR (1) BRPI0806680A2 (enExample)
CA (1) CA2675583A1 (enExample)
MX (1) MX2009007368A (enExample)
WO (1) WO2008088849A2 (enExample)

Cited By (4)

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Publication number Priority date Publication date Assignee Title
JP2011252784A (ja) * 2010-06-02 2011-12-15 St Marianna Univ School Of Medicine 再発性多発軟骨炎の検査方法およびそれに用いられる検査キット
KR20160046828A (ko) * 2013-08-09 2016-04-29 이노트렘 심혈관 질환 또는 문제 위험 예측용 방법 및 키트
JP2022528152A (ja) * 2019-03-22 2022-06-08 チャイニーズ・アカデミー・オブ・サイエンシーズ、アンスティテュ・パストゥール・オブ・シャンハイ Ｎｋ細胞免疫チェックポイントを標的とすることによる感染症処置のための方法
JP2022540674A (ja) * 2019-07-15 2022-09-16 ブリストル－マイヤーズ スクイブ カンパニー 抗ｔｒｅｍ－１抗体およびその使用

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JP2011093806A (ja) * 2008-02-20 2011-05-12 Tokyo Medical & Dental Univ 膠原病の予防・治療剤
US8513185B2 (en) 2009-10-13 2013-08-20 Alexander B. Sigalov Inhibition of TREM receptor signaling with peptide variants
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
LT2814842T (lt) 2012-02-15 2018-11-12 Novo Nordisk A/S Antikūnai, kurie suriša peptidoglikaną atpažįstantį baltymą 1
ES2750209T3 (es) * 2012-02-15 2020-03-25 Novo Nordisk As Anticuerpos que se unen a y bloquean al receptor desencadenante expresado en células mieloides-1 (TREM-1)
LT2814844T (lt) * 2012-02-15 2017-10-25 Novo Nordisk A/S Antikūnai, kurie jungiasi ir blokuoja ekspresuotą ant mieloidinių ląstelių inicijuojantį receptorių 1 (trem-1)
KR20150139537A (ko) * 2013-03-15 2015-12-11 더 브로드 인스티튜트, 인코퍼레이티드 수지상 세포의 반응 유전자 발현, 물질의 조성물 및 이의 사용 방법
AU2015235986B2 (en) * 2014-03-27 2020-12-03 Genentech, Inc. Methods for diagnosing and treating inflammatory bowel disease
CN106536559B (zh) 2014-07-17 2021-04-27 诺和诺德股份有限公司 定点诱变trem-1抗体以降低黏度
US11213598B2 (en) 2015-11-12 2022-01-04 The Board Of Trustees Of The Leland Stanford Junior University Labeled probe and methods of use
FR3044325B1 (fr) * 2015-12-01 2019-05-03 Biomerieux Procede d'evaluation du risque de complications chez les patients qui presentent un syndrome de reponse inflammatoire systemique (sirs)
CN106053831A (zh) * 2016-06-05 2016-10-26 潘时辉 一种用于自身免疫病检测的试剂盒
JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
MD3601358T2 (ro) * 2017-08-03 2023-10-31 Alector Llc Anticorpi anti-TREM2 și metode de utilizare a acestora
WO2019087200A1 (en) * 2017-11-06 2019-05-09 Rambam Med-Tech Ltd. Prognostic methods for anti-tnfa treatment
TWI790370B (zh) 2018-04-02 2023-01-21 美商必治妥美雅史谷比公司 抗trem-1抗體及其用途
CN108752482B (zh) * 2018-06-12 2019-04-30 南京卡提医学科技有限公司 携带截短或未截短的髓样细胞触发性受体信号结构的嵌合抗原受体及其应用
WO2020036987A1 (en) 2018-08-13 2020-02-20 Signablok, Inc. Peptides and compositions for targeted treatment and imaging
AU2020253486A1 (en) 2019-04-03 2021-11-04 University Of Florida Research Foundation, Incorporated Method of inhibiting trem-1
WO2021011681A1 (en) * 2019-07-15 2021-01-21 Bristol-Myers Squibb Company Antibodies against human trem-1 and uses thereof
CN111157741B (zh) * 2019-12-30 2022-08-16 广州市妇女儿童医疗中心 髓系细胞触发受体1在制备胃炎诊断或治疗试剂中的应用及试剂盒
CN111437380A (zh) * 2020-05-25 2020-07-24 南通大学 Trem-2在监测血吸虫病肝纤维化进程的方法及应用
CN112266956B (zh) * 2020-11-12 2021-09-10 四川大学 Map3k8检测试剂在制备牙髓炎筛查试剂盒及抑制剂在制备治疗牙髓炎的药物中的用途
US20240279332A1 (en) * 2021-06-25 2024-08-22 Amgen Inc. Treatment of Cardiovascular Disease with TREM-1 Antigen Binding Proteins

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JP2016527519A (ja) * 2013-08-09 2016-09-08 イノトレム 心血管疾患または心血管イベントを有するリスクを予測するための方法およびキット
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JP2022528152A (ja) * 2019-03-22 2022-06-08 チャイニーズ・アカデミー・オブ・サイエンシーズ、アンスティテュ・パストゥール・オブ・シャンハイ Ｎｋ細胞免疫チェックポイントを標的とすることによる感染症処置のための方法
JP2022540674A (ja) * 2019-07-15 2022-09-16 ブリストル－マイヤーズ スクイブ カンパニー 抗ｔｒｅｍ－１抗体およびその使用
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