JP2010512306A5 - - Google Patents
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- Publication number
- JP2010512306A5 JP2010512306A5 JP2009534723A JP2009534723A JP2010512306A5 JP 2010512306 A5 JP2010512306 A5 JP 2010512306A5 JP 2009534723 A JP2009534723 A JP 2009534723A JP 2009534723 A JP2009534723 A JP 2009534723A JP 2010512306 A5 JP2010512306 A5 JP 2010512306A5
- Authority
- JP
- Japan
- Prior art keywords
- region
- polypeptide
- sialic acid
- polysaccharide chain
- unpurified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 38
- 102000004196 processed proteins & peptides Human genes 0.000 claims 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims 38
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 14
- 150000004676 glycans Polymers 0.000 claims 14
- 150000004804 polysaccharides Polymers 0.000 claims 14
- 125000005629 sialic acid group Chemical group 0.000 claims 13
- 238000000034 method Methods 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 230000009450 sialylation Effects 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 230000003110 anti-inflammatory effect Effects 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 230000003013 cytotoxicity Effects 0.000 claims 3
- 231100000135 cytotoxicity Toxicity 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 102000003838 Sialyltransferases Human genes 0.000 claims 2
- 108090000141 Sialyltransferases Proteins 0.000 claims 2
- 229930182830 galactose Natural products 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 2
- 108010021468 Fc gamma receptor IIA Proteins 0.000 claims 1
- 108010021470 Fc gamma receptor IIC Proteins 0.000 claims 1
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 1
- 102100029206 Low affinity immunoglobulin gamma Fc region receptor II-c Human genes 0.000 claims 1
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 1
- 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 230000004988 N-glycosylation Effects 0.000 claims 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 206010043554 thrombocytopenia Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2006/041791 WO2007055916A2 (en) | 2005-11-07 | 2006-10-27 | Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof |
| PCT/US2007/008396 WO2007117505A2 (en) | 2006-04-05 | 2007-04-03 | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| PCT/US2007/072771 WO2008057634A2 (en) | 2006-10-26 | 2007-07-03 | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010512306A JP2010512306A (ja) | 2010-04-22 |
| JP2010512306A5 true JP2010512306A5 (enExample) | 2012-08-16 |
Family
ID=40792829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534723A Pending JP2010512306A (ja) | 2006-10-27 | 2007-07-03 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2010512306A (enExample) |
| CA (1) | CA2666308C (enExample) |
| IL (1) | IL197920A0 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR085302A1 (es) * | 2011-02-24 | 2013-09-18 | Sanofi Sa | Metodo de produccion de anticuerpos sialilados |
| UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| KR102420934B1 (ko) * | 2013-03-11 | 2022-07-15 | 젠자임 코포레이션 | 과글리코실화된 결합 폴리펩티드 |
| EP4640239A2 (en) | 2014-03-19 | 2025-10-29 | Genzyme Corporation | Site-specific glycoengineering of targeting moieties |
| EP3947458A1 (en) | 2019-04-03 | 2022-02-09 | Genzyme Corporation | Anti-alpha beta tcr binding polypeptides with reduced fragmentation |
| KR102549282B1 (ko) * | 2019-11-18 | 2023-06-30 | 건국대학교 산학협력단 | 시알산화된 면역글로불린을 유효성분으로 포함하는 염증성 질환의 치료용 조성물 |
| CN116705170A (zh) * | 2023-05-08 | 2023-09-05 | 宁波市医疗中心李惠利医院 | 基于maldi-tof ms联合lstm的大肠埃希菌菌株水平鉴定方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69823046T2 (de) * | 1997-01-16 | 2005-03-31 | Neose Technologies, Inc. | Praktische in vitro sialylierung von rekombinanten glykpproteinen |
| ATE289354T1 (de) * | 1999-04-15 | 2005-03-15 | Crucell Holland Bv | Verwendung von adenovirus e1 protein sequenzen kodierenden, zur herstellung von rekombinanten proteinen in menschlichen zellen. |
| AU2001294175A1 (en) * | 2000-10-06 | 2002-04-22 | Kyowa Hakko Kogyo Co. Ltd. | Method of purifying antibody |
-
2007
- 2007-07-03 JP JP2009534723A patent/JP2010512306A/ja active Pending
- 2007-07-03 CA CA2666308A patent/CA2666308C/en active Active
-
2009
- 2009-04-05 IL IL197920A patent/IL197920A0/en unknown
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