JP2010512230A - 灌流臓器止血法 - Google Patents

灌流臓器止血法 Download PDF

Info

Publication number
JP2010512230A
JP2010512230A JP2009541532A JP2009541532A JP2010512230A JP 2010512230 A JP2010512230 A JP 2010512230A JP 2009541532 A JP2009541532 A JP 2009541532A JP 2009541532 A JP2009541532 A JP 2009541532A JP 2010512230 A JP2010512230 A JP 2010512230A
Authority
JP
Japan
Prior art keywords
polymer
transient
transient gel
certain embodiments
poloxamer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009541532A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010512230A5 (enExample
Inventor
ヴォージェル，ジャン−マリー
エイ ウィルキー，ジェイムズ
エヌ マドラス，ピーター
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pluromed Inc
Lahey Hospital & Medical Center
Original Assignee
Pluromed Inc
Lahey Hospital & Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pluromed Inc, Lahey Hospital & Medical Center filed Critical Pluromed Inc
Publication of JP2010512230A publication Critical patent/JP2010512230A/ja
Publication of JP2010512230A5 publication Critical patent/JP2010512230A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/11—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12195—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices comprising a curable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
    • A61B2017/00252—Making holes in the wall of the heart, e.g. laser Myocardial revascularization for by-pass connections, i.e. connections from heart chamber to blood vessel or from blood vessel to blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/11—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis
    • A61B2017/1107—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis for blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/11—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis
    • A61B2017/1135—End-to-side connections, e.g. T- or Y-connections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B2017/12004—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for haemostasis, for prevention of bleeding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2009541532A 2006-12-11 2007-12-11 灌流臓器止血法 Pending JP2010512230A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87406206P 2006-12-11 2006-12-11
US89399307P 2007-03-09 2007-03-09
PCT/US2007/087079 WO2008073938A2 (en) 2006-12-11 2007-12-11 Perfusive organ hemostasis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014048739A Division JP5931943B2 (ja) 2006-12-11 2014-03-12 灌流臓器止血法

Publications (2)

Publication Number Publication Date
JP2010512230A true JP2010512230A (ja) 2010-04-22
JP2010512230A5 JP2010512230A5 (enExample) 2011-02-10

Family

ID=39512452

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2009541532A Pending JP2010512230A (ja) 2006-12-11 2007-12-11 灌流臓器止血法
JP2014048739A Expired - Fee Related JP5931943B2 (ja) 2006-12-11 2014-03-12 灌流臓器止血法
JP2016089234A Pending JP2016135365A (ja) 2006-12-11 2016-04-27 灌流臓器止血法
JP2017187859A Pending JP2018000996A (ja) 2006-12-11 2017-09-28 灌流臓器止血法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2014048739A Expired - Fee Related JP5931943B2 (ja) 2006-12-11 2014-03-12 灌流臓器止血法
JP2016089234A Pending JP2016135365A (ja) 2006-12-11 2016-04-27 灌流臓器止血法
JP2017187859A Pending JP2018000996A (ja) 2006-12-11 2017-09-28 灌流臓器止血法

Country Status (5)

Country Link
US (4) US20080181952A1 (enExample)
EP (1) EP2094169A4 (enExample)
JP (4) JP2010512230A (enExample)
CN (2) CN101677822A (enExample)
WO (1) WO2008073938A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013077476A1 (ko) * 2011-11-21 2013-05-30 한국과학기술원 카테콜기가 결합된 키토산 또는 폴리아민 및 말단에 티올기가 결합된 폴락소머를 포함하는 하이드로젤 및 이의 제조방법 및 이를 이용한 지혈제
WO2015145860A1 (ja) * 2014-03-28 2015-10-01 テルモ株式会社 生体血管内血液置換用液体、生体血管内血液置換用液体製剤およびプレフィルドシリンジ
JP2017531035A (ja) * 2014-10-01 2017-10-19 エーエルエス マウンテン リミテッド ライアビリティ カンパニー 非イオン性界面活性剤を有するアスピリン、メトホルミン及びセロトニンを含む医薬組成物
JP6383133B1 (ja) * 2018-02-21 2018-08-29 国立大学法人信州大学 液体塞栓剤組成物

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2866133B2 (ja) 1989-07-25 1999-03-08 株式会社リコー 液体噴射記録装置及び方法
JP2989242B2 (ja) 1990-10-16 1999-12-13 株式会社リコー 液体噴射記録方法及び装置
JP2957676B2 (ja) 1990-10-16 1999-10-06 株式会社リコー 液体噴射記録装置及び方法
JP2989243B2 (ja) 1990-10-16 1999-12-13 株式会社リコー 液体噴射記録方法及び装置
US20080031847A1 (en) * 2005-12-22 2008-02-07 Pluromed, Inc. Methods and kits for treating lacerations and puncture wounds using inverse thermosensitive polymers
US8197499B2 (en) 2006-06-21 2012-06-12 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
AU2007260924A1 (en) 2006-06-21 2007-12-27 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
US8608760B2 (en) 2006-06-21 2013-12-17 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
CN101854960B (zh) 2006-12-15 2014-06-25 生命连结有限公司 明胶-转谷氨酰胺酶止血敷料和密封材料
EP2125092A4 (en) * 2007-02-22 2012-03-14 Pluromed Inc USE OF REVERSIBLE HEAT-SENSITIVE POLYMERS FOR FLOW CONTROL OF A BIOLOGICAL LIQUID AFTER MEDICAL USE
WO2009086206A2 (en) * 2007-12-20 2009-07-09 Synvascular, Inc. Compositions and methods for joining non-conjoined lumens
US20110201926A1 (en) * 2008-02-29 2011-08-18 Pluromed, Inc. Local embolization via heating of thermosensitive polymers
AR072657A1 (es) * 2008-02-29 2010-09-15 Genentech Inc Compuestos inhibidores de raf y metodos para su uso
MY161021A (en) 2008-05-14 2017-03-31 Otonomy Inc Controlled release corticosteroid and methods for the treatment of otic disorders
AU2009261559B2 (en) 2008-06-18 2014-01-16 Lifebond Ltd Improved cross-linked compositions
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US8563037B2 (en) * 2009-02-06 2013-10-22 Tautona Group, L.P. Compositions and methods for joining non-conjoined lumens
WO2011039780A2 (en) * 2009-09-22 2011-04-07 Vlife Sciences Technologies Pvt. Ltd. Topical formulation for diabetic foot ulcers
WO2011049958A2 (en) * 2009-10-21 2011-04-28 Otonomy, Inc. Modulation of gel temperature of poloxamer-containing formulations
EP2963111A1 (en) 2009-12-22 2016-01-06 Lifebond Ltd Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
DK2600910T3 (en) 2010-08-05 2016-04-04 Lifebond Ltd Wound dressings and adhesives COMPREHENSIVE DRYING FORMATIONS
US9060749B2 (en) 2011-08-12 2015-06-23 Boston Scientific Scimed, Inc. Methods, compositions and kits for performing anastomosis procedures in conjunction with a radical prostatectomy procedure
DE102013211316A1 (de) * 2013-06-17 2014-12-18 Aesculap Ag Hämostyptikum
CN105682742A (zh) 2013-08-27 2016-06-15 奥德纳米有限公司 小儿耳部病症的治疗
ITMI20131924A1 (it) * 2013-11-20 2015-05-21 Cosmo Technologies Ltd Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
ITMI20131927A1 (it) * 2013-11-20 2015-05-21 Cosmo Technologies Ltd Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection. emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
US20170274189A1 (en) * 2016-03-24 2017-09-28 Ethicon, Inc. Single lumen balloon delivery catheter with lumen bypass at balloon
CN108714243A (zh) * 2017-06-08 2018-10-30 重庆大学 用于脑出血术后止血的植入剂及其制备方法
EP3539571B1 (en) 2018-03-16 2023-05-31 Critical Innovations, LLC Systems and methods relating to medical applications of synthetic polymer formulations
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
CN112138204A (zh) * 2019-06-26 2020-12-29 广东博与再生医学有限公司 骨止血材料
JP7546265B2 (ja) * 2020-05-22 2024-09-06 ウェトラブホールディング株式会社 生体組織用二液型バインダーおよび生体組織用二液型充填材
CN111632189B (zh) * 2020-05-27 2021-12-14 深圳先进技术研究院 基于海洋源明胶的可注射水凝胶止血剂及应用和应用方法
US12410293B2 (en) 2022-11-07 2025-09-09 Critical Innovations Llc Systems and methods relating to medical applications of inverse thermosensitive polymer foam formulations
CN117084739A (zh) * 2023-08-31 2023-11-21 中国人民解放军陆军军医大学第一附属医院 一种血管穿孔封堵装置及其使用方法
CN121177556B (zh) * 2025-11-25 2026-04-07 江苏申命医疗科技有限公司 用于制备栓塞剂的预混剂、试剂盒及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037062A2 (en) * 2003-10-14 2005-04-28 Pluromed, Inc. Confinement of kidney-stone fragments during lithotripsy
JP2006521177A (ja) * 2003-03-24 2006-09-21 バイオスフィア メディカル， インコーポレーテッド 逆感熱性ポリマーを使用する一時的な塞栓形成

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3889685A (en) * 1973-11-02 1975-06-17 Cutter Lab Tubular unit with vessel engaging cuff structure
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4168708A (en) * 1977-04-20 1979-09-25 Medical Engineering Corp. Blood vessel occlusion means suitable for use in anastomosis
US4478822A (en) * 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US5567859A (en) * 1991-03-19 1996-10-22 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
US5843156A (en) * 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US4946463A (en) * 1989-04-10 1990-08-07 Pioneering Technologies, Inc. Vessel occluder
ATE130517T1 (de) * 1990-08-08 1995-12-15 Takeda Chemical Industries Ltd Intravaskulär embolisierendes mittel mit gehalt an einem die angiogenesis hemmenden stoff.
EP0576612B1 (en) * 1991-03-19 1999-12-01 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
US5696298A (en) * 1991-03-19 1997-12-09 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
US5939485A (en) * 1995-06-19 1999-08-17 Medlogic Global Corporation Responsive polymer networks and methods of their use
US5800711A (en) * 1996-10-18 1998-09-01 Mdv Technologies, Inc. Process for the fractionation of polyoxyalkylene block copolymers
US6120751A (en) * 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
EP1148895B1 (en) * 1999-02-05 2004-11-17 The Regents of the University of California Thermo-reversible polymer for intralumenal implant
WO2001072281A2 (en) * 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
US6761824B2 (en) * 2000-08-17 2004-07-13 Reeve Lorraine E Process for the fractionation of polymers
US7838699B2 (en) * 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
US7700086B2 (en) * 2003-11-06 2010-04-20 Pluromed, Inc. Internal clamp for surgical procedures
US20060253099A1 (en) * 2005-04-21 2006-11-09 Medtronic Vascular, Inc. Guiding catheter with resiliently compressible occluder
MX2007013827A (es) * 2005-05-02 2008-04-04 Pluromed Inc Terapia para piedras de rinon no por litiotricia.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006521177A (ja) * 2003-03-24 2006-09-21 バイオスフィア メディカル， インコーポレーテッド 逆感熱性ポリマーを使用する一時的な塞栓形成
WO2005037062A2 (en) * 2003-10-14 2005-04-28 Pluromed, Inc. Confinement of kidney-stone fragments during lithotripsy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6012067407; Ｂｏｏｄｈｗａｎｉ　Ｍ: 'Ｅｆｆｅｃｔｓ　ｏｆ　ｐｕｒｉｆｉｅｄ　ｐｏｌｏｘａｍｅｒ　４０７　ｇｅｌ　ｏｎ　ｖａｓｃｕｌａｒ　ｏｃｃｌｕｓｉｏｎ　ａｎｄ　ｔｈｅ　ｃｏｒｏｎａｒｙ　ｅｎｄｏｔｈｅｌｉｕｍ．' Ｅｕｒ　Ｊ　Ｃａｒｄｉｏｔｈｏｒａｃ　Ｓｕｒｇ． ２９（５）, 200605, ７３６-４１ *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013077476A1 (ko) * 2011-11-21 2013-05-30 한국과학기술원 카테콜기가 결합된 키토산 또는 폴리아민 및 말단에 티올기가 결합된 폴락소머를 포함하는 하이드로젤 및 이의 제조방법 및 이를 이용한 지혈제
KR101301276B1 (ko) 2011-11-21 2013-08-29 주식회사 이노테라피 카테콜기가 결합된 키토산 또는 폴리아민 및 말단에 티올기가 결합된 폴락소머를 포함하는 하이드로젤 및 이의 제조방법 및 이를 이용한 지혈제
US9433699B2 (en) 2011-11-21 2016-09-06 Innotherapy Inc. Hydrogel comprising catechol group-coupled chitosan or polyamine and poloxamer comprising thiol group coupled to end thereof, preparation method thereof, and hemostat using same
WO2015145860A1 (ja) * 2014-03-28 2015-10-01 テルモ株式会社 生体血管内血液置換用液体、生体血管内血液置換用液体製剤およびプレフィルドシリンジ
JPWO2015145860A1 (ja) * 2014-03-28 2017-04-13 テルモ株式会社 生体血管内血液置換用液体、生体血管内血液置換用液体製剤およびプレフィルドシリンジ
US10376601B2 (en) 2014-03-28 2019-08-13 Terumo Kabushiki Kaisha In-vivo intravascular blood replacing liquid, in-vivo intravascular blood replacing liquid formulation, and prefilled syringe
JP2017531035A (ja) * 2014-10-01 2017-10-19 エーエルエス マウンテン リミテッド ライアビリティ カンパニー 非イオン性界面活性剤を有するアスピリン、メトホルミン及びセロトニンを含む医薬組成物
JP6383133B1 (ja) * 2018-02-21 2018-08-29 国立大学法人信州大学 液体塞栓剤組成物
WO2019163012A1 (ja) * 2018-02-21 2019-08-29 国立大学法人信州大学 液体塞栓剤組成物
US11123453B2 (en) 2018-02-21 2021-09-21 Shinshu University Liquid embolic agent composition

Also Published As

Publication number Publication date
JP2018000996A (ja) 2018-01-11
EP2094169A1 (en) 2009-09-02
JP5931943B2 (ja) 2016-06-08
CN105251035A (zh) 2016-01-20
WO2008073938A2 (en) 2008-06-19
CN101677822A (zh) 2010-03-24
EP2094169A4 (en) 2016-05-04
JP2014100611A (ja) 2014-06-05
US20140205542A1 (en) 2014-07-24
JP2016135365A (ja) 2016-07-28
US20180117211A1 (en) 2018-05-03
US20170043050A1 (en) 2017-02-16
US20080181952A1 (en) 2008-07-31

Similar Documents

Publication Publication Date Title
JP5931943B2 (ja) 灌流臓器止血法
AU2008218225B2 (en) Use of reverse thermosensitive polymers to control biological fluid flow following a medical procedure
US7700086B2 (en) Internal clamp for surgical procedures
JP2010518990A5 (enExample)
JP4909071B2 (ja) 逆感熱性ポリマーを使用する一時的な塞栓形成
JP6049658B2 (ja) 精製逆感熱性ポリマーを使用する内視鏡的粘膜切除
JP2006521177A5 (enExample)

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101213

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101213

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110809

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121225

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130322

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130403

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130423

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130514

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130527

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130603

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130625

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20131112