JP2010511707A5 - - Google Patents
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- JP2010511707A5 JP2010511707A5 JP2009540253A JP2009540253A JP2010511707A5 JP 2010511707 A5 JP2010511707 A5 JP 2010511707A5 JP 2009540253 A JP2009540253 A JP 2009540253A JP 2009540253 A JP2009540253 A JP 2009540253A JP 2010511707 A5 JP2010511707 A5 JP 2010511707A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- formulation
- sodium
- chlorite
- ophthalmic formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims 51
- 238000009472 formulation Methods 0.000 claims 50
- 238000000034 method Methods 0.000 claims 32
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 30
- -1 chlorite compound Chemical class 0.000 claims 23
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 20
- 229910001919 chlorite Inorganic materials 0.000 claims 20
- 229910052619 chlorite group Inorganic materials 0.000 claims 20
- 239000003755 preservative agent Substances 0.000 claims 19
- 239000000314 lubricant Substances 0.000 claims 17
- 230000002335 preservative effect Effects 0.000 claims 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 16
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 claims 12
- 229910052751 metal Inorganic materials 0.000 claims 12
- 239000002184 metal Substances 0.000 claims 12
- 239000004094 surface-active agent Substances 0.000 claims 11
- 239000008213 purified water Substances 0.000 claims 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 10
- 230000000844 anti-bacterial effect Effects 0.000 claims 9
- 230000000845 anti-microbial effect Effects 0.000 claims 8
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims 8
- 238000010979 pH adjustment Methods 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 8
- 239000011780 sodium chloride Substances 0.000 claims 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 6
- 239000004155 Chlorine dioxide Substances 0.000 claims 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 6
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 6
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 6
- 239000004599 antimicrobial Substances 0.000 claims 6
- 239000011575 calcium Substances 0.000 claims 6
- 229910052791 calcium Inorganic materials 0.000 claims 6
- 229920002678 cellulose Polymers 0.000 claims 6
- 235000019398 chlorine dioxide Nutrition 0.000 claims 6
- 239000011777 magnesium Substances 0.000 claims 6
- 229910052749 magnesium Inorganic materials 0.000 claims 6
- 150000003904 phospholipids Chemical class 0.000 claims 6
- 239000011591 potassium Substances 0.000 claims 6
- 229910052700 potassium Inorganic materials 0.000 claims 6
- 239000011734 sodium Substances 0.000 claims 6
- 229910052708 sodium Inorganic materials 0.000 claims 6
- 229940010747 sodium hyaluronate Drugs 0.000 claims 6
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 6
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 4
- 239000004327 boric acid Substances 0.000 claims 4
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 4
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims 4
- 235000019799 monosodium phosphate Nutrition 0.000 claims 4
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 4
- 230000002459 sustained effect Effects 0.000 claims 4
- 229920006318 anionic polymer Polymers 0.000 claims 3
- 238000004140 cleaning Methods 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- 206010011985 Decubitus ulcer Diseases 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 208000004210 Pressure Ulcer Diseases 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002301 cellulose acetate Polymers 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 2
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 229940023490 ophthalmic product Drugs 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 claims 2
- 229960002218 sodium chlorite Drugs 0.000 claims 2
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 claims 2
- 159000000000 sodium salts Chemical class 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 208000001860 Eye Infections Diseases 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000000607 artificial tear Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 claims 1
- 208000011323 eye infectious disease Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 206010023332 keratitis Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/633,355 US20070104798A1 (en) | 1999-10-04 | 2006-12-04 | Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide |
| PCT/US2007/024815 WO2008070063A1 (en) | 2006-12-04 | 2007-12-04 | Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010511707A JP2010511707A (ja) | 2010-04-15 |
| JP2010511707A5 true JP2010511707A5 (https=) | 2011-01-27 |
Family
ID=39492544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540253A Pending JP2010511707A (ja) | 2006-12-04 | 2007-12-04 | 亜塩素酸塩および過酸化水素を含む相乗的抗菌製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US20070104798A1 (https=) |
| EP (2) | EP2099296B1 (https=) |
| JP (1) | JP2010511707A (https=) |
| CN (1) | CN101600348A (https=) |
| ES (1) | ES2551120T3 (https=) |
| HK (1) | HK1222131A1 (https=) |
| MX (1) | MX2009005836A (https=) |
| WO (1) | WO2008070063A1 (https=) |
Families Citing this family (32)
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| US20070104798A1 (en) | 1999-10-04 | 2007-05-10 | S.K. Pharmaceuticals, Inc. | Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide |
| US20090004288A1 (en) * | 2007-06-29 | 2009-01-01 | Collins Gary L | Stabilized ophthalmic solutions |
| US20090220618A1 (en) * | 2008-02-29 | 2009-09-03 | Erning Xia | Pharmaceutical formulations comprising polyanionic materials and source of hydrogen peroxide |
| US20090239954A1 (en) * | 2008-03-19 | 2009-09-24 | Collins Gary L | Phosphate buffered ophthalmic solutions displaying improved efficacy |
| US8669241B2 (en) * | 2008-12-02 | 2014-03-11 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic composition |
| US20100226999A1 (en) * | 2009-03-06 | 2010-09-09 | Tracy Quevillon-Coleman | Process for forming stabilized ophthalmic solutions |
| TW201127423A (en) * | 2009-12-17 | 2011-08-16 | Alcon Res Ltd | Ophthalmic solutions with improved disinfection profiles |
| CN101785786B (zh) * | 2010-02-20 | 2012-09-05 | 北京欧凯纳斯科技有限公司 | 一种用于治疗脚气的二氧化氯软膏 |
| US9675065B2 (en) | 2011-02-14 | 2017-06-13 | Truox, Inc. | Biocide and bleach compositions and related methods |
| WO2013093891A1 (en) * | 2011-12-22 | 2013-06-27 | Nuvo Research Gmbh | Liposomal chlorite or chlorate compositions |
| US9433643B2 (en) | 2013-04-30 | 2016-09-06 | Truox, Inc. | Microbicidal composition comprising hydrogen peroxide and aminocarboxylic acids |
| JP2015071581A (ja) * | 2013-05-20 | 2015-04-16 | 本部三慶株式会社 | 亜塩素酸水含有ウイルス殺傷剤 |
| US10131574B2 (en) | 2013-06-17 | 2018-11-20 | Corning Incorporated | Antimicrobial glass articles and methods of making and using same |
| GB2534049B (en) * | 2013-10-03 | 2020-05-06 | Halliburton Energy Services Inc | Solvent extraction and analysis of formation fluids from formation solids at a well site |
| CN106773120A (zh) * | 2015-11-25 | 2017-05-31 | 鸿富锦精密工业（深圳）有限公司 | 隐形眼镜镜片材料及隐形眼镜镜片 |
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| CN108552216B (zh) * | 2018-01-25 | 2021-05-25 | 湖北荷普药业股份有限公司 | 一种杀孢子剂及其制备方法与应用 |
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| KR20210005936A (ko) * | 2018-05-02 | 2021-01-15 | 오큐소프트, 인코포레이티드 | 차아염소산 기반 눈꺼풀 세정제 |
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| CN109846847B (zh) * | 2019-04-04 | 2021-08-10 | 石家庄卫科生物科技有限公司 | 一种用于治疗动物皮肤病的泡腾片及其制备方法 |
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| JP2023522398A (ja) * | 2020-04-21 | 2023-05-30 | ライフアクティバス プライベート リミテッド | 呼吸器ウイルス感染症治療用塩素の医薬組成物 |
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| CN111602655A (zh) * | 2020-05-09 | 2020-09-01 | 武汉中科先进技术研究院有限公司 | 抗病毒双壳微胶囊及其制备方法和具有该抗病毒双壳微胶囊的消毒涂料及其制备方法和应用 |
| CA3207295A1 (en) * | 2021-02-02 | 2022-08-11 | Autumn RYAN | Formulation comprising chlorite and percarbonate salts |
| CN113491711A (zh) * | 2021-06-09 | 2021-10-12 | 广州丰歌生物科技有限责任公司 | 一种抗菌氧溶液及其制备方法和应用 |
| SE2350131A1 (en) * | 2022-02-23 | 2023-08-24 | V3Bio Sdn Bhd | Wound hydrogel for managing acute and chronic wounds in human and animals |
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| US6033704A (en) * | 1998-08-14 | 2000-03-07 | Charvid Limited Liability Co. | Method and apparatus for preserving fruits and vegetables |
| MXPA01003507A (es) * | 1998-10-08 | 2002-06-26 | Hampar L Karagoezian | Antimicrobiano sinergico, preparaciones dermatologicas y oftalmicas que contienen clorito y peroxido de hidrogeno. |
| EP1119347B1 (en) * | 1998-10-08 | 2005-03-02 | Hampar L. Karagoezian | Synergistic antimicrobial, dermatological and ophthalmic preparations containing chlorite and hydrogen peroxide |
| US20070104798A1 (en) | 1999-10-04 | 2007-05-10 | S.K. Pharmaceuticals, Inc. | Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide |
| US6592907B2 (en) * | 1999-10-04 | 2003-07-15 | Hampar L. Karagoezian | Synergistic antimicrobial ophthalmic and dermatologic preparations containing chlorite and hydrogen peroxide |
| US20040037891A1 (en) * | 1999-10-04 | 2004-02-26 | Karagoezian Hampar L. | Synergistic antimicrobial ophthalmic and dermatologic preparations containing chlorite and hydrogen peroxide |
| WO2005110439A2 (en) | 2004-05-07 | 2005-11-24 | S.K. Pharmaceuticals, Inc. | Stabilized hyaluronan preparations and related methods |
-
2006
- 2006-12-04 US US11/633,355 patent/US20070104798A1/en not_active Abandoned
-
2007
- 2007-12-04 JP JP2009540253A patent/JP2010511707A/ja active Pending
- 2007-12-04 CN CNA2007800489270A patent/CN101600348A/zh active Pending
- 2007-12-04 ES ES07862490.5T patent/ES2551120T3/es active Active
- 2007-12-04 MX MX2009005836A patent/MX2009005836A/es active IP Right Grant
- 2007-12-04 EP EP07862490.5A patent/EP2099296B1/en not_active Revoked
- 2007-12-04 EP EP15186300.8A patent/EP2990044A1/en not_active Withdrawn
- 2007-12-04 WO PCT/US2007/024815 patent/WO2008070063A1/en not_active Ceased
-
2010
- 2010-09-02 US US12/874,443 patent/US8460701B2/en not_active Expired - Fee Related
- 2010-09-10 US US12/879,989 patent/US20110008420A1/en not_active Abandoned
-
2012
- 2012-10-23 US US13/658,609 patent/US20130195995A1/en not_active Abandoned
-
2013
- 2013-12-31 US US14/145,126 patent/US8784901B2/en not_active Expired - Fee Related
-
2014
- 2014-06-18 US US14/307,706 patent/US9072712B2/en not_active Expired - Fee Related
-
2015
- 2015-05-21 US US14/718,852 patent/US9622480B2/en not_active Expired - Fee Related
-
2016
- 2016-09-01 HK HK16110425.6A patent/HK1222131A1/en unknown
-
2017
- 2017-03-09 US US15/454,859 patent/US10010081B2/en not_active Expired - Fee Related
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