JP2010510809A5 - - Google Patents
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- Publication number
- JP2010510809A5 JP2010510809A5 JP2009539435A JP2009539435A JP2010510809A5 JP 2010510809 A5 JP2010510809 A5 JP 2010510809A5 JP 2009539435 A JP2009539435 A JP 2009539435A JP 2009539435 A JP2009539435 A JP 2009539435A JP 2010510809 A5 JP2010510809 A5 JP 2010510809A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- group
- ovr110
- antigen
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 16
- 108091007433 antigens Proteins 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 210000000822 natural killer cell Anatomy 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 230000004663 cell proliferation Effects 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 229940127121 immunoconjugate Drugs 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 230000009545 invasion Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 230000001629 suppression Effects 0.000 claims 3
- 230000003844 B-cell-activation Effects 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 230000006051 NK cell activation Effects 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 230000006044 T cell activation Effects 0.000 claims 2
- 230000006052 T cell proliferation Effects 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 230000004709 cell invasion Effects 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 230000002018 overexpression Effects 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 108700012359 toxins Proteins 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010003445 Ascites Diseases 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 108010039491 Ricin Proteins 0.000 claims 1
- 108010084592 Saporins Proteins 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
- 229930195731 calicheamicin Natural products 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 230000001293 nucleolytic effect Effects 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 239000003330 peritoneal dialysis fluid Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86165706P | 2006-11-27 | 2006-11-27 | |
| US60/861,657 | 2006-11-27 | ||
| PCT/US2007/085585 WO2008067283A2 (en) | 2006-11-27 | 2007-11-27 | Ovr110 antibody compositions and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010510809A JP2010510809A (ja) | 2010-04-08 |
| JP2010510809A5 true JP2010510809A5 (cg-RX-API-DMAC7.html) | 2012-04-05 |
| JP5391073B2 JP5391073B2 (ja) | 2014-01-15 |
Family
ID=39468637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539435A Expired - Fee Related JP5391073B2 (ja) | 2006-11-27 | 2007-11-27 | Ｏｖｒ１１０抗体組成物および使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8444971B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2962697A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5391073B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007325283B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2670696A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2543350T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008067283A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (54)
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| US7619068B2 (en) * | 2003-05-09 | 2009-11-17 | Diadexus, Inc. | Ovr110 antibody compositions and methods of use |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| ES2442024T3 (es) | 2008-07-15 | 2014-02-07 | Academia Sinica | Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados |
| TW202442680A (zh) | 2008-12-09 | 2024-11-01 | 美商建南德克公司 | 抗pd-l1抗體及其於增進t細胞功能之用途 |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
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| CA2853943C (en) | 2011-11-02 | 2015-12-08 | University Of Rochester | Anti-glucosaminidase passive immunization for staphylococcus aureus infections |
| WO2013067492A1 (en) * | 2011-11-03 | 2013-05-10 | The Trustees Of The University Of Pennsylvania | Isolated b7-h4 specific compositions and methods of use thereof |
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| CA2950423A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| KR102512592B1 (ko) | 2014-05-27 | 2023-03-21 | 아카데미아 시니카 | 항-ｈｅｒ2 글리코항체 및 이의 용도 |
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| EP3191518B1 (en) * | 2014-09-12 | 2020-01-15 | Genentech, Inc. | Anti-b7-h4 antibodies and immunoconjugates |
| JP6681905B2 (ja) | 2014-09-13 | 2020-04-15 | ノバルティス アーゲー | Ａｌｋ阻害剤の併用療法 |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| KR102691114B1 (ko) | 2015-01-24 | 2024-08-01 | 아카데미아 시니카 | 신규한 글리칸 콘주게이트 및 이를 사용하는 방법 |
| WO2016123591A2 (en) * | 2015-01-30 | 2016-08-04 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| AR105910A1 (es) | 2015-09-04 | 2017-11-22 | Obi Pharma Inc | Matrices de glicano y método de uso |
| TW201808978A (zh) | 2016-03-08 | 2018-03-16 | 中央研究院 | N-聚醣及其陣列之模組化合成方法 |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| BR112018070097A2 (pt) * | 2016-03-29 | 2019-02-12 | Obi Pharma, Inc. | anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos |
| TWI697333B (zh) | 2016-04-22 | 2020-07-01 | 台灣浩鼎生技股份有限公司 | 經由Globo系列抗原之免疫活化或免疫調節之癌症免疫療法 |
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| JP7121724B2 (ja) | 2016-07-29 | 2022-08-18 | オービーアイ ファーマ，インコーポレイテッド | ヒト抗体、医薬組成物及び方法 |
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| US10736976B2 (en) | 2016-12-01 | 2020-08-11 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-PD-L1 antibodies for immuno-PET imaging |
| TWI870011B (zh) * | 2017-08-25 | 2025-01-11 | 美商戊瑞治療有限公司 | Ｂ７－ｈ４抗體及其使用方法 |
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| WO2020006176A1 (en) | 2018-06-27 | 2020-01-02 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| CN110095463B (zh) * | 2019-03-15 | 2021-10-22 | 中国人民解放军陆军军医大学第二附属医院 | 一种乳糜定性检测的试剂盒 |
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-
2007
- 2007-11-27 WO PCT/US2007/085585 patent/WO2008067283A2/en not_active Ceased
- 2007-11-27 AU AU2007325283A patent/AU2007325283B2/en not_active Ceased
- 2007-11-27 EP EP15168204.4A patent/EP2962697A1/en not_active Withdrawn
- 2007-11-27 EP EP07868854.6A patent/EP2104513B1/en active Active
- 2007-11-27 US US12/516,397 patent/US8444971B2/en not_active Expired - Fee Related
- 2007-11-27 CA CA002670696A patent/CA2670696A1/en not_active Abandoned
- 2007-11-27 ES ES07868854.6T patent/ES2543350T3/es active Active
- 2007-11-27 JP JP2009539435A patent/JP5391073B2/ja not_active Expired - Fee Related
-
2013
- 2013-04-24 US US13/869,448 patent/US8906369B2/en not_active Expired - Fee Related
-
2014
- 2014-12-04 US US14/559,946 patent/US20150175701A1/en not_active Abandoned
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