JP2010510211A - 免疫抑制用7−置換プリン誘導体 - Google Patents
免疫抑制用7−置換プリン誘導体 Download PDFInfo
- Publication number
- JP2010510211A JP2010510211A JP2009537135A JP2009537135A JP2010510211A JP 2010510211 A JP2010510211 A JP 2010510211A JP 2009537135 A JP2009537135 A JP 2009537135A JP 2009537135 A JP2009537135 A JP 2009537135A JP 2010510211 A JP2010510211 A JP 2010510211A
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- heterocyclyl
- compound
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 **N(c1nc(-[n]2c3cc(*)c(*)cc3nc2)cc(*)c1N1*)C1=O Chemical compound **N(c1nc(-[n]2c3cc(*)c(*)cc3nc2)cc(*)c1N1*)C1=O 0.000 description 6
- OPVVNOMDBDQRTM-UHFFFAOYSA-N CC(C)(C)OC(Nc(c([N+]([O-])=O)c1)ccc1F)=O Chemical compound CC(C)(C)OC(Nc(c([N+]([O-])=O)c1)ccc1F)=O OPVVNOMDBDQRTM-UHFFFAOYSA-N 0.000 description 2
- YRYPIFDYJXOLSM-UHFFFAOYSA-N COc1cc(OC)c(CNc(c(N)c2)ccc2C#N)cc1 Chemical compound COc1cc(OC)c(CNc(c(N)c2)ccc2C#N)cc1 YRYPIFDYJXOLSM-UHFFFAOYSA-N 0.000 description 2
- IVYOJVOUKFQVHZ-QMMMGPOBSA-N C[C@@H](CCC1)c2c1nccc2 Chemical compound C[C@@H](CCC1)c2c1nccc2 IVYOJVOUKFQVHZ-QMMMGPOBSA-N 0.000 description 2
- IVYOJVOUKFQVHZ-MRVPVSSYSA-N C[C@H]1c2cccnc2CCC1 Chemical compound C[C@H]1c2cccnc2CCC1 IVYOJVOUKFQVHZ-MRVPVSSYSA-N 0.000 description 2
- YQQLVNSNKMHJCI-UHFFFAOYSA-N Cc1cccc2c1CCCN2 Chemical compound Cc1cccc2c1CCCN2 YQQLVNSNKMHJCI-UHFFFAOYSA-N 0.000 description 2
- IBKSOWUYKOORFF-UHFFFAOYSA-N CC(C)(C)OC(Nc(c(N)c1)ccc1F)=O Chemical compound CC(C)(C)OC(Nc(c(N)c1)ccc1F)=O IBKSOWUYKOORFF-UHFFFAOYSA-N 0.000 description 1
- STNLQJRBZHAGSO-UHFFFAOYSA-N CC(C1CCNCC1)=O Chemical compound CC(C1CCNCC1)=O STNLQJRBZHAGSO-UHFFFAOYSA-N 0.000 description 1
- WCIXKWOJEMZXMK-UHFFFAOYSA-N CC(N(CCC1)C1C(OC)=O)=O Chemical compound CC(N(CCC1)C1C(OC)=O)=O WCIXKWOJEMZXMK-UHFFFAOYSA-N 0.000 description 1
- RNQRNUNVBDTGGO-UHFFFAOYSA-N CC(N)[n]1c(CC(C=C2)F)c2nc1 Chemical compound CC(N)[n]1c(CC(C=C2)F)c2nc1 RNQRNUNVBDTGGO-UHFFFAOYSA-N 0.000 description 1
- KDISMIMTGUMORD-UHFFFAOYSA-N CC(N1CCCCC1)=O Chemical compound CC(N1CCCCC1)=O KDISMIMTGUMORD-UHFFFAOYSA-N 0.000 description 1
- PKDPUENCROCRCH-UHFFFAOYSA-N CC(N1CCNCC1)=O Chemical compound CC(N1CCNCC1)=O PKDPUENCROCRCH-UHFFFAOYSA-N 0.000 description 1
- KYWXRBNOYGGPIZ-UHFFFAOYSA-N CC(N1CCOCC1)=O Chemical compound CC(N1CCOCC1)=O KYWXRBNOYGGPIZ-UHFFFAOYSA-N 0.000 description 1
- DLEWDCPFCNLJEY-UHFFFAOYSA-N CCC(N1CCOCC1)=O Chemical compound CCC(N1CCOCC1)=O DLEWDCPFCNLJEY-UHFFFAOYSA-N 0.000 description 1
- JQZNSTZRFSKAIC-UHFFFAOYSA-N CCCN(c1cnc(-[n]2c(cccc3)c3nc2)nc1N1C2c(c(F)ccc3F)c3OCC2)C1=O Chemical compound CCCN(c1cnc(-[n]2c(cccc3)c3nc2)nc1N1C2c(c(F)ccc3F)c3OCC2)C1=O JQZNSTZRFSKAIC-UHFFFAOYSA-N 0.000 description 1
- JAWOQWFMIHPIPG-QGZVFWFLSA-N CCN(c1cnc(-[n]2c(cc(cc3)C#N)c3nc2)nc1N1[C@H]2c(c(F)ccc3F)c3OCC2)C1=O Chemical compound CCN(c1cnc(-[n]2c(cc(cc3)C#N)c3nc2)nc1N1[C@H]2c(c(F)ccc3F)c3OCC2)C1=O JAWOQWFMIHPIPG-QGZVFWFLSA-N 0.000 description 1
- OFTDLUPOVLCCKS-GOSISDBHSA-N CCN(c1cnc(-[n]2c(cc(cc3)C#N)c3nc2)nc1N1[C@H]2c(cccc3F)c3OCC2)C1=O Chemical compound CCN(c1cnc(-[n]2c(cc(cc3)C#N)c3nc2)nc1N1[C@H]2c(cccc3F)c3OCC2)C1=O OFTDLUPOVLCCKS-GOSISDBHSA-N 0.000 description 1
- VKXGAIDOPOLSPC-UHFFFAOYSA-N CN(c1c(N2C3c(cccc4F)c4OCC3)nc(-[n]3c(cccc4)c4nc3)nc1)C2=O Chemical compound CN(c1c(N2C3c(cccc4F)c4OCC3)nc(-[n]3c(cccc4)c4nc3)nc1)C2=O VKXGAIDOPOLSPC-UHFFFAOYSA-N 0.000 description 1
- MIRYGYNFQCRCGL-UHFFFAOYSA-N CN(c1c(N2C3c4cc(F)ccc4OCC3)nc(-[n]3c(cccc4)c4nc3)nc1)C2=O Chemical compound CN(c1c(N2C3c4cc(F)ccc4OCC3)nc(-[n]3c(cccc4)c4nc3)nc1)C2=O MIRYGYNFQCRCGL-UHFFFAOYSA-N 0.000 description 1
- UKUKRIAPHYUYKH-QGZVFWFLSA-N CN(c1c(N2[C@H]3c(cccc4F)c4OCC3)nc(-[n]3c(cc(cc4)C#N)c4nc3)nc1)C2=O Chemical compound CN(c1c(N2[C@H]3c(cccc4F)c4OCC3)nc(-[n]3c(cc(cc4)C#N)c4nc3)nc1)C2=O UKUKRIAPHYUYKH-QGZVFWFLSA-N 0.000 description 1
- KFYISAULDUKHQC-QGZVFWFLSA-N CN(c1c(N2[C@H]3c4cc(F)ccc4OCC3)nc(-[n]3c(cc(cc4)C#N)c4nc3)nc1)C2=O Chemical compound CN(c1c(N2[C@H]3c4cc(F)ccc4OCC3)nc(-[n]3c(cc(cc4)C#N)c4nc3)nc1)C2=O KFYISAULDUKHQC-QGZVFWFLSA-N 0.000 description 1
- WKJMHVVDBCXTBG-UHFFFAOYSA-N COC(CC1)CCN1C(I)=O Chemical compound COC(CC1)CCN1C(I)=O WKJMHVVDBCXTBG-UHFFFAOYSA-N 0.000 description 1
- MJJPEOLXYAEWGG-LJQANCHMSA-N COCCN(c1cnc(-[n]2c(cc(cc3)C#N)c3nc2)nc1N1[C@H]2c(cccc3)c3OCC2)C1=O Chemical compound COCCN(c1cnc(-[n]2c(cc(cc3)C#N)c3nc2)nc1N1[C@H]2c(cccc3)c3OCC2)C1=O MJJPEOLXYAEWGG-LJQANCHMSA-N 0.000 description 1
- GALLUVHUAWBGAW-UHFFFAOYSA-N COc1cc(OC)c(CNc(c([N+]([O-])=O)c2)ccc2C#N)cc1 Chemical compound COc1cc(OC)c(CNc(c([N+]([O-])=O)c2)ccc2C#N)cc1 GALLUVHUAWBGAW-UHFFFAOYSA-N 0.000 description 1
- SZUXTNKPVFIPMS-UHFFFAOYSA-N COc1cc(OC)c(CNc(ccc(C#N)c2)c2Nc(nc2N=C=S)ncc2[N+]([O-])=O)cc1 Chemical compound COc1cc(OC)c(CNc(ccc(C#N)c2)c2Nc(nc2N=C=S)ncc2[N+]([O-])=O)cc1 SZUXTNKPVFIPMS-UHFFFAOYSA-N 0.000 description 1
- PAFZCZVVRQHYKJ-ZETCQYMHSA-N C[C@@H]1c(cccc2F)c2OCC1 Chemical compound C[C@@H]1c(cccc2F)c2OCC1 PAFZCZVVRQHYKJ-ZETCQYMHSA-N 0.000 description 1
- PAFZCZVVRQHYKJ-SSDOTTSWSA-N C[C@H]1c2cccc(F)c2OCC1 Chemical compound C[C@H]1c2cccc(F)c2OCC1 PAFZCZVVRQHYKJ-SSDOTTSWSA-N 0.000 description 1
- IQLWOYPHQUQJDJ-UHFFFAOYSA-N N#Cc(cc1)cc2c1nc[n]2-c(nc1N2C3c4cc(F)cc(F)c4OCC3)ncc1N(CCCO)C2=O Chemical compound N#Cc(cc1)cc2c1nc[n]2-c(nc1N2C3c4cc(F)cc(F)c4OCC3)ncc1N(CCCO)C2=O IQLWOYPHQUQJDJ-UHFFFAOYSA-N 0.000 description 1
- XNHDUPKWQUTNRA-UHFFFAOYSA-N N#Cc(cc12)ccc1nc[n]2-c(nc1)nc(N2C3CCOCC3)c1NC2=O Chemical compound N#Cc(cc12)ccc1nc[n]2-c(nc1)nc(N2C3CCOCC3)c1NC2=O XNHDUPKWQUTNRA-UHFFFAOYSA-N 0.000 description 1
- JXLWXPRRRMCCAA-QGZVFWFLSA-N N#Cc(cc12)ccc1nc[n]2-c(nc1)nc(N2[C@H]3c(cccc4)c4OCC3)c1NC2=O Chemical compound N#Cc(cc12)ccc1nc[n]2-c(nc1)nc(N2[C@H]3c(cccc4)c4OCC3)c1NC2=O JXLWXPRRRMCCAA-QGZVFWFLSA-N 0.000 description 1
- XJWGKOBGZZIMAU-QGZVFWFLSA-N N#Cc(cc12)ccc1nc[n]2-c(nc1)nc(N2[C@H]3c(cccc4F)c4OCC3)c1NC2=O Chemical compound N#Cc(cc12)ccc1nc[n]2-c(nc1)nc(N2[C@H]3c(cccc4F)c4OCC3)c1NC2=O XJWGKOBGZZIMAU-QGZVFWFLSA-N 0.000 description 1
- USIDQCCXMGJOJM-UHFFFAOYSA-N N#Cc1cccnc1F Chemical compound N#Cc1cccnc1F USIDQCCXMGJOJM-UHFFFAOYSA-N 0.000 description 1
- PMSVVUSIPKHUMT-UHFFFAOYSA-N N#Cc1nccnc1 Chemical compound N#Cc1nccnc1 PMSVVUSIPKHUMT-UHFFFAOYSA-N 0.000 description 1
- ORBSSWJRHPFEBR-UHFFFAOYSA-N NCc1cccnc1F Chemical compound NCc1cccnc1F ORBSSWJRHPFEBR-UHFFFAOYSA-N 0.000 description 1
- PUGDHSSOXPHLPT-UHFFFAOYSA-N Nc(c([N+]([O-])=O)c1)ccc1F Chemical compound Nc(c([N+]([O-])=O)c1)ccc1F PUGDHSSOXPHLPT-UHFFFAOYSA-N 0.000 description 1
- YQOWILHKLQYXKD-MRXNPFEDSA-N O=C1N([C@H]2c(cccc3F)c3OCC2)c(nc(-[n](cnc2c3)c2cc(Cl)c3Cl)nc2)c2N1 Chemical compound O=C1N([C@H]2c(cccc3F)c3OCC2)c(nc(-[n](cnc2c3)c2cc(Cl)c3Cl)nc2)c2N1 YQOWILHKLQYXKD-MRXNPFEDSA-N 0.000 description 1
- FPMUSEUHKXRVCM-MRXNPFEDSA-N O=C1N([C@H]2c(cccc3F)c3OCC2)c(nc(-[n]2c3cc(Cl)ccc3nc2)nc2)c2N1 Chemical compound O=C1N([C@H]2c(cccc3F)c3OCC2)c(nc(-[n]2c3cc(Cl)ccc3nc2)nc2)c2N1 FPMUSEUHKXRVCM-MRXNPFEDSA-N 0.000 description 1
- XYJNTLHGUZUAJJ-OAHLLOKOSA-N O=C1N([C@H]2c(cccc3F)c3OCC2)c2nc(-[n]3c4ccncc4nc3)ncc2N1 Chemical compound O=C1N([C@H]2c(cccc3F)c3OCC2)c2nc(-[n]3c4ccncc4nc3)ncc2N1 XYJNTLHGUZUAJJ-OAHLLOKOSA-N 0.000 description 1
- WHYJJSIVWCACIC-UHFFFAOYSA-N [O-][N+](c(c(N=C=S)n1)cnc1Cl)=O Chemical compound [O-][N+](c(c(N=C=S)n1)cnc1Cl)=O WHYJJSIVWCACIC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2006/061004 WO2008060301A1 (en) | 2006-11-16 | 2006-11-16 | 7-substituted purine derivatives for immunosuppression |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2010510211A true JP2010510211A (ja) | 2010-04-02 |
Family
ID=38578618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009537135A Withdrawn JP2010510211A (ja) | 2006-11-16 | 2006-11-16 | 免疫抑制用7−置換プリン誘導体 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP2099800A1 (ko) |
JP (1) | JP2010510211A (ko) |
KR (1) | KR20100014271A (ko) |
CN (1) | CN101595110A (ko) |
AU (1) | AU2006350748A1 (ko) |
BR (1) | BRPI0622030A2 (ko) |
CA (1) | CA2669686A1 (ko) |
CR (1) | CR10870A (ko) |
IL (1) | IL198761A0 (ko) |
MX (1) | MX2009005194A (ko) |
WO (1) | WO2008060301A1 (ko) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7884109B2 (en) * | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
US7989459B2 (en) * | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
CA2754890C (en) | 2009-03-13 | 2018-01-16 | Piet Herdewijn | Bicyclic heterocycles |
EP2419423A1 (en) | 2009-04-14 | 2012-02-22 | Cellzome Limited | Fluoro substituted pyrimidine compounds as jak3 inhibitors |
CA2771675A1 (en) | 2009-09-11 | 2011-03-17 | Cellzome Limited | Ortho substituted pyrimidine compounds as jak inhibitors |
KR20120102601A (ko) | 2009-10-20 | 2012-09-18 | 셀좀 리미티드 | Jak 저해제로서의 헤테로시클릴 피라졸로피리미딘 유사체 |
UA109775C2 (xx) | 2009-10-29 | 2015-10-12 | N-вмісні гетероарильні похідні як інгібітори jak3-кінази | |
SG184989A1 (en) | 2010-04-30 | 2012-11-29 | Cellzome Ltd | Pyrazole compounds as jak inhibitors |
GB201012889D0 (en) | 2010-08-02 | 2010-09-15 | Univ Leuven Kath | Antiviral activity of novel bicyclic heterocycles |
RS55184B1 (sr) | 2010-05-31 | 2017-01-31 | Ono Pharmaceutical Co | Derivat purinona kao inhibitor btk kinaze |
US20130165426A1 (en) * | 2010-07-06 | 2013-06-27 | Université de Montréal | Imidazopyridine, imidazopyrimidine and imidazopyrazine derivatives as melanocortin-4 receptor modulators |
US9040545B2 (en) | 2010-08-20 | 2015-05-26 | Cellzome Limited | Heterocyclyl pyrazolopyrimidine analogues as selective JAK inhibitors |
KR101227388B1 (ko) * | 2010-09-09 | 2013-01-30 | 주식회사 만도 | 3웨이 형식의 저압 배기가스 재순환 밸브 구조 |
GB201015411D0 (en) | 2010-09-15 | 2010-10-27 | Univ Leuven Kath | Anti-cancer activity of novel bicyclic heterocycles |
CA2825098C (en) | 2011-01-27 | 2020-03-10 | Universite De Montreal | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators |
WO2012143320A1 (en) | 2011-04-18 | 2012-10-26 | Cellzome Limited | (7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors |
EP2736901A1 (en) | 2011-07-28 | 2014-06-04 | Cellzome Limited | Heterocyclyl pyrimidine analogues as jak inhibitors |
WO2013017479A1 (en) | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
WO2013017480A1 (en) | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
WO2013025628A1 (en) | 2011-08-15 | 2013-02-21 | Ligand Pharmaceuticals Incorporated | Janus kinase inhibitor compounds and methods |
WO2013041605A1 (en) | 2011-09-20 | 2013-03-28 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as kinase inhibitors |
HUE031094T2 (en) | 2011-11-29 | 2017-07-28 | Ono Pharmaceutical Co | Purinone derivative hydrochloride |
CN104169272A (zh) | 2011-12-23 | 2014-11-26 | 赛尔佐姆有限公司 | 作为激酶抑制剂的嘧啶-2,4-二胺衍生物 |
US8501724B1 (en) * | 2012-01-31 | 2013-08-06 | Pharmacyclics, Inc. | Purinone compounds as kinase inhibitors |
WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
WO2015089218A1 (en) | 2013-12-10 | 2015-06-18 | David Wustrow | Monocyclic pyrimidine/pyridine compounds as inhibitors of p97 complex |
WO2015109285A1 (en) | 2014-01-20 | 2015-07-23 | Cleave Biosciences, Inc. | FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX |
ES2806506T3 (es) | 2014-03-25 | 2021-02-17 | Ono Pharmaceutical Co | Agente profiláctico y/o agente terapéutico para el linfoma difuso de células B grandes |
EP3281943B1 (en) | 2015-04-09 | 2023-06-28 | ONO Pharmaceutical Co., Ltd. | Process for producing purinone derivative |
MX2021001186A (es) | 2015-11-20 | 2022-10-11 | Forma Therapeutics Inc | Purinonas como inhibidores de proteasa especifica de ubiquitina 1. |
WO2018041989A1 (en) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating refractory celiac disease type 2 |
KR20200009001A (ko) * | 2017-05-17 | 2020-01-29 | 가부시끼가이샤 도꾸야마 | 디아미노벤젠 화합물의 제조 방법 |
EP3947737A2 (en) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
WO2020212395A1 (en) | 2019-04-16 | 2020-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels |
KR102516260B1 (ko) * | 2020-07-10 | 2023-03-31 | 울산과학기술원 | Trap1 선택적 억제제로서의 화합물 및 이를 포함하는 암 예방 또는 치료용 조성물 |
KR102579424B1 (ko) * | 2021-02-19 | 2023-09-18 | 울산과학기술원 | 미토콘드리아 내부 축적이 증가된 trap1 선택적 억제제로서의 화합물 및 이의 용도 |
WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1704145B1 (en) * | 2004-01-12 | 2012-06-13 | YM BioSciences Australia Pty Ltd | Selective kinase inhibitors |
AR054416A1 (es) * | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
CN101142218B (zh) * | 2005-02-03 | 2013-02-06 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的吡咯并嘧啶 |
RU2007140903A (ru) * | 2005-04-05 | 2009-05-20 | Фармакопия, Инк. (Us) | Производные пурина и имидазопиридина для иммуносупрессии |
-
2006
- 2006-11-16 WO PCT/US2006/061004 patent/WO2008060301A1/en active Application Filing
- 2006-11-16 KR KR1020097012508A patent/KR20100014271A/ko not_active Application Discontinuation
- 2006-11-16 EP EP06850161A patent/EP2099800A1/en not_active Withdrawn
- 2006-11-16 CA CA002669686A patent/CA2669686A1/en not_active Abandoned
- 2006-11-16 MX MX2009005194A patent/MX2009005194A/es not_active Application Discontinuation
- 2006-11-16 BR BRPI0622030-4A patent/BRPI0622030A2/pt not_active IP Right Cessation
- 2006-11-16 JP JP2009537135A patent/JP2010510211A/ja not_active Withdrawn
- 2006-11-16 AU AU2006350748A patent/AU2006350748A1/en not_active Abandoned
- 2006-11-16 CN CNA2006800567754A patent/CN101595110A/zh active Pending
-
2009
- 2009-05-14 IL IL198761A patent/IL198761A0/en unknown
- 2009-06-16 CR CR10870A patent/CR10870A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX2009005194A (es) | 2009-11-10 |
BRPI0622030A2 (pt) | 2014-04-22 |
AU2006350748A1 (en) | 2008-05-22 |
EP2099800A1 (en) | 2009-09-16 |
AU2006350748A2 (en) | 2009-08-06 |
WO2008060301A1 (en) | 2008-05-22 |
CN101595110A (zh) | 2009-12-02 |
IL198761A0 (en) | 2010-02-17 |
KR20100014271A (ko) | 2010-02-10 |
CA2669686A1 (en) | 2008-05-22 |
CR10870A (es) | 2009-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2010510211A (ja) | 免疫抑制用7−置換プリン誘導体 | |
US7884109B2 (en) | Purine and imidazopyridine derivatives for immunosuppression | |
US20080119496A1 (en) | 7-Substituted Purine Derivatives for Immunosuppression | |
US20070021443A1 (en) | Purine and imidazopyridine derivatives for immunosuppression | |
US7915268B2 (en) | 8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression | |
JP5816678B2 (ja) | PI3Kδ阻害剤としての縮合誘導体 | |
EP3523305B1 (en) | Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses | |
RU2652638C2 (ru) | Замещенные пиразолхиназолиновые производные в качестве ингибиторов киназы | |
US20100093748A1 (en) | Substituted piperidines having protein kinase inhibiting activity | |
JP2012500805A (ja) | 免疫抑制のための6−置換2−(ベンズイミダゾリル)プリンおよびプリノン誘導体ならびに6−置換2−(イミダゾロ[4,5−c]ピリジニル)プリンおよびプリノン誘導体 | |
EP2043655A2 (en) | Purine and deazapurine derivatives as pharmaceutical compounds | |
WO2011075630A1 (en) | Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors | |
WO2008039359A2 (en) | Bicyclic pyrimidine kinase inhibitors | |
JP2017516855A (ja) | 特定のタンパク質キナーゼ阻害剤 | |
JP2009513678A (ja) | 化合物 | |
CA2922044A1 (en) | Pyrazolo-, imidazolo- and pyrrolo-pyridine or -pyrimidine derivatives as inhibitors o brutons kinase (btk) | |
WO2009048474A1 (en) | 2,7,9-substituted purinone derivatives for immunosuppression | |
CA3124815A1 (en) | Quinoline analogs as phosphatidylinositol 3-kinase inhibitors | |
US20200172536A1 (en) | PYRIDO[2,3-d]PYRIMIDIN-7-ONES AND RELATED COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | |
EP4157844A1 (en) | 4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-3,6-dihydropyridine-1-(2h)-carboxamide derivatives as limk and/or rock kinases inhibitors for use in the treatment of cancer | |
WO2016127455A1 (zh) | 嘧啶衍生物、细胞毒性剂、药物组合物及其应用 | |
CN114728963B (zh) | 新型三唑吡啶衍生物和包括其的药物组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20120228 |