JP2010509965A5 - - Google Patents

Info

Publication number

JP2010509965A5

JP2010509965A5 JP2009536787A JP2009536787A JP2010509965A5 JP 2010509965 A5 JP2010509965 A5 JP 2010509965A5 JP 2009536787 A JP2009536787 A JP 2009536787A JP 2009536787 A JP2009536787 A JP 2009536787A JP 2010509965 A5 JP2010509965 A5 JP 2010509965A5

Authority

JP

Japan

Prior art keywords

tissue

optionally

solution

incubating

washing

Prior art date

2007-11-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 210000001519 tissue Anatomy 0.000 claims 26
• 238000000034 method Methods 0.000 claims 13
• KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical group CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims 8
• 239000000815 hypotonic solution Substances 0.000 claims 7
• 238000011534 incubation Methods 0.000 claims 7
• 238000005406 washing Methods 0.000 claims 7
• 230000008014 freezing Effects 0.000 claims 6
• 238000007710 freezing Methods 0.000 claims 6
• 239000007800 oxidant agent Substances 0.000 claims 5
• 238000010257 thawing Methods 0.000 claims 5
• 239000000872 buffer Substances 0.000 claims 4
• 239000000243 solution Substances 0.000 claims 4
• 108090000790 Enzymes Proteins 0.000 claims 3
• 102000004190 Enzymes Human genes 0.000 claims 3
• 101710163270 Nuclease Proteins 0.000 claims 3
• 239000003945 anionic surfactant Substances 0.000 claims 3
• 239000007853 buffer solution Substances 0.000 claims 3
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
• 239000002738 chelating agent Substances 0.000 claims 2
• 238000002513 implantation Methods 0.000 claims 2
• 210000004353 tibial menisci Anatomy 0.000 claims 2
• 108010039627 Aprotinin Proteins 0.000 claims 1
• 239000007983 Tris buffer Substances 0.000 claims 1
• 230000000735 allogeneic effect Effects 0.000 claims 1
• 229960004405 aprotinin Drugs 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 claims 1
• 210000000629 knee joint Anatomy 0.000 claims 1
• 230000005499 meniscus Effects 0.000 claims 1
• 230000001590 oxidative effect Effects 0.000 claims 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1