JP2010509576A5 - - Google Patents

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Publication number

JP2010509576A5

JP2010509576A5 JP2009535559A JP2009535559A JP2010509576A5 JP 2010509576 A5 JP2010509576 A5 JP 2010509576A5 JP 2009535559 A JP2009535559 A JP 2009535559A JP 2009535559 A JP2009535559 A JP 2009535559A JP 2010509576 A5 JP2010509576 A5 JP 2010509576A5

Authority

JP

Japan

Prior art keywords

risk stratification

proavp

neurophysin

copeptin

fragments

Prior art date

2007-11-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 15
• 238000013517 stratification Methods 0.000 claims 10
• 208000017667 Chronic Disease Diseases 0.000 claims 9
• 102400000060 Copeptin Human genes 0.000 claims 6
• 101800000115 Copeptin Proteins 0.000 claims 6
• 208000032376 Lung infection Diseases 0.000 claims 6
• 102000002710 Neurophysins Human genes 0.000 claims 6
• 108010018674 Neurophysins Proteins 0.000 claims 6
• 239000012634 fragment Substances 0.000 claims 6
• 102000004196 processed proteins & peptides Human genes 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 239000003550 marker Substances 0.000 claims 5
• 238000005259 measurement Methods 0.000 claims 5
• 108010064409 proAVP hormone Proteins 0.000 claims 5
• 108010074051 C-Reactive Protein Proteins 0.000 claims 4
• 102100032752 C-reactive protein Human genes 0.000 claims 4
• 208000015181 infectious disease Diseases 0.000 claims 3
• 238000004393 prognosis Methods 0.000 claims 3
• 108010048233 Procalcitonin Proteins 0.000 claims 2
• 238000003745 diagnosis Methods 0.000 claims 2
• 238000003748 differential diagnosis Methods 0.000 claims 2
• 230000002757 inflammatory effect Effects 0.000 claims 2
• CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 claims 2
• 230000002685 pulmonary effect Effects 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 108090001005 Interleukin-6 Proteins 0.000 claims 1
• 108010063738 Interleukins Proteins 0.000 claims 1
• 102000015696 Interleukins Human genes 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 230000002411 adverse Effects 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 239000013610 patient sample Substances 0.000 claims 1
• 238000001050 pharmacotherapy Methods 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000000241 respiratory effect Effects 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1