JP2010509352A - 抗酸化性の食物サプリメントの組成物および健康な皮膚を維持するための方法 - Google Patents
抗酸化性の食物サプリメントの組成物および健康な皮膚を維持するための方法 Download PDFInfo
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- JP2010509352A JP2010509352A JP2009536430A JP2009536430A JP2010509352A JP 2010509352 A JP2010509352 A JP 2010509352A JP 2009536430 A JP2009536430 A JP 2009536430A JP 2009536430 A JP2009536430 A JP 2009536430A JP 2010509352 A JP2010509352 A JP 2010509352A
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Abstract
Description
本発明は、健康な皮膚を維持するために、ならびに皮膚の紅化、炎症、過敏症、および皮膚の老化のような皮膚状態を緩和するために、抗酸化性の食物サプリメントを単独で使用すること、および、上記食物サプリメントを、上記皮膚状態への局所治療と共に使用することに関する。
適切な食事は、健康な皮膚を維持することにおいて寄与する要因である。ヒトの皮膚状態に影響を及ぼす多様な食物サプリメントが存在する。(International Cosmetic Ingredient Dictionary and Handbook, 2004; およびU.S. Pharmacopoeia Dietary Supplement Monographs)。
本発明は、ニキビ、慢性皮脂腺炎症、および炎症に関連して、しばしば生じる、突発性、および再発性の皮膚の紅化を含む皮膚状態の症状を緩和するために使用される経口的に投与される組成物に関する。上記組成物は、植物組織内に分散したままのリコピンを含有するトマトの固形分を含む。上記組成物は、マンゴー、リンゴ、またはパイナップルに由来するようなフルーツ由来の構成要素も含有し得る。
本発明は、健康な皮膚を維持するための抗酸化性の食物サプリメントを含む組成物、および方法に関する。また、本発明は、炎症、過敏症、および皮膚の老化のような皮膚疾患と関連する皮膚の紅化および炎症を含む、数多くの各皮膚状態を緩和するための、抗酸化性の食物サプリメントを含む組成物、並びに、方法に関する。本発明から利益を受ける皮膚疾患の例は、ニキビおよび慢性皮脂腺炎症を含む。
以下の経口摂取のための各サプリメントは、単独で、またはシクロヘキサノール誘導体を含む局所用組成物と共に使用された。局所用組成物は、朝および晩に皮膚の紅化した領域に対して1日2回塗布した。0.5%のカーボマー940(Carbomer 940)(Spectrum Quality Products, Gardena, CA)、1%の1,4−シクロヘキサンジオール(cis/trans)、0.3%のグリセリン、および水(合わせて100%となる量)を含む。上記溶液を水酸化ナトリウムにてpH7.0に調整した。
1.トマトジュースを好きですか? はい−125人(74%)、いいえ−44人(26%)
2.少なくとも1箇月に1回トマトジュースを飲みますか? はい−36人(21%)、いいえ−133人(79%)
3.少なくとも1箇月に1回トマトジュースではない他のジュースを飲みますか? はい−116人(69%)、いいえ−53人(31%)
参加者の数は169人(100%)。
1.1リットルあたりナトリウム4.76g、カリウム3.0g、砂糖29gを含むアメリカ企業の主要ブランドのトマトジュース、
2.実施例2に記載のトマト−マンゴージュース、
3.酸抽出が施された実施例6に記載のトマト−グレープフルーツジュース(酸性の水での抽出が施されたトマト固形分にて作製した)。
1.実施例1に記載の減塩(0.2g/l)のトマト飲料、
2.実施例2に記載のトマト−マンゴージュース飲料、
3.酸抽出が施された実施例6に記載のトマト−グレープフルーツジュース。
1.3つの各製品のうち、何れかと他とが実質的に異なっており、かつ質が劣っていますか?
2.残った各製品のうちどちらを好みますか?
以下の表は、これらの2つの質問に対して試験者がそれぞれの製品をどう評価したのかを示す。
Boileau T.W.Mら、Prostate Carcinogenesis in N-methyl-N-nitrosourea(NMU)-Testosterone-Treated Rats fed Tomato Powdere, lycopene, or Energy-Restricted Diets, J Natl Canc Inst 95, 1578-1586, 2003.
Deming, D.M.およびErdman,.I.W., Mammalian Carotenoid Absorption and Metabolism,Pure Appl Chem, 71, 2213-2223.
Hof,K.H.ら、Carotenoid Bioavailability in Humans from Tomatoes Processed in Different Ways Determined from the Carotenoid Response in the Triglyceride Rich Lipoprotein Fraction of Plasma after Single Consumption and in Plasma after Four Days of Consumption, J.Nutr, 2000, 130, 1189-1196.
Khachik, Fら、Chemistry, Distribution, and Metabolism of Tomato Carotenoids and Their Impact on Human Health, Exp Biol Med 2002, 227, 845-851.
Kiら.,Cocoa Has More Phenolic Phytochemicals and a Higher Antioxidant Capacity than Teas and Red Wine, J. Agric. Food Chem., 21(25):7292-7295(2003).
Tyssandier, V.ら., Processing of Vegetable-Borne Carotenoids in the Human Stomach and Duodenum, A.J.Pyhysiol Gastroinest Liver Physiol, 284, G913-G923.
H.J.Heinz Company, sponsor, www.lycopene.org.
National Rosacea Society, www.lycopene.org.
ERS.USDA Briefing,
http://usda.mannlib.cornell.edu/reports/erssor/specialty/vgs-bb/2000/vgs2 82.pdf
ERS.USDA Publications,
www.ers.usda.gov/publications/fts/aug03/fts30501/
Claims (23)
- トマト原料に対する水抽出した後に不溶性物質として残る、リコピン含有のトマト組成物、ならびに、ジュース、ピューレ、ペースト、および粉末から選択されたフルーツ由来原料を含み、
上記フルーツ由来原料は、最終組成物の全乾燥質量の約5%から約80%を構成する、経口摂取のための組成物。 - 上記水抽出は、約6未満のpHで実行される、請求項1に記載の組成物。
- 上記水抽出は、約1.5から約4.5までのpHで実行される、請求項2に記載の組成物。
- 上記水抽出は、蒸気を用いて実行される、請求項1に記載の組成物。
- 上記リコピン含有の組成物は、実質的に、トマト原料の風味特性が低減された、または取り除かれたものである、請求項1に記載の組成物。
- リコピンを含まない植物原料をさらに含む、請求項1に記載の組成物。
- 上記フルーツ由来原料は、マンゴー由来、リンゴ由来、およびパイナップル由来の各原料、または上記各原料の混合物から選択される、請求項1に記載の組成物。
- ビタミン類、抗酸化剤類、微量元素類、天然抽出物類、食品添加物類、ホルモン類、タンパク質類、脂肪酸類、オイル類、アルコール、炭水化物、およびそれらの混合物から選択される補助の原料をさらに含む、請求項7に記載の組成物。
- 実質的に高純度の抗酸化剤と、生姜、または生姜抽出物、ミント、ミント抽出物、ミントオイル、メンソール、およびそれらの混合物から選択された原料の有効量とをさらに含む、請求項1に記載の組成物。
- 上記抗酸化剤は、没食子酸、アスコルビン酸、没食子酸の薬学的な活性誘導体、およびアスコルビン酸の薬学的な活性誘導体、ならびにそれらの混合物を含む、請求項9に記載の組成物。
- トマト固形分内に分散したリコピンを得るためのトマト原料の加工方法であって、
上記トマト固形分は、トマト原材料に対する、水および/または蒸気の抽出工程を含んで、トマト原材料の風味特性が、実質的に低減、または除去されたものである、トマト原料の加工方法。 - 上記抽出工程は、蒸気による抽出である、請求項11に記載の方法。
- 上記抽出工程は、約6未満のpHで実行される、請求項12に記載の方法。
- 上記抽出工程は、約1.5から約4.5までのpHで実行される、請求項13に記載の方法。
- 健康の皮膚を維持し、かつ、ニキビ、慢性皮脂腺炎症、炎症、過敏症、および皮膚の老化に関連する皮膚の各状態を緩和する方法であって、
(a)上記皮膚の状態の部位に対して上記状態のための局所的な治療と共に(b)1つ以上の抗酸化剤の有効量を含む組成物の上記ヒトへの経口投与、を必要としている上記ヒトへの投与を含む、方法。 - 上記化合物は、1,2−シクロヘキサンジオール、1,3−シクロヘキサンジオール、1,4−シクロヘキサンジオール、1,2,3−シクロヘキサントリオール、1,3,5−シクロヘキサントリオール、およびそれらの混合物から選択される、請求項16に記載の方法。
- 上記経口投与のための組成物は、蒸気および/または水での抽出が施された、リコピン含有する原料を含む、請求項15に記載の方法。
- 上記抽出は、蒸気によりなされる、請求項18に記載の方法。
- 上記抽出は、約6未満のpHで実行される、請求項19に記載の方法。
- 上記抽出は、約1.5から約4までのpHで実行される、請求項20に記載の方法。
- 上記経口投与のための組成物は、リコピン含有のトマト組成物と、フルーツ由来の組成物とを含み、かつ、
上記経口投与のための上記組成物は、リコピンを含むトマト組成物と、フルーツ由来の組成物との混合物の全乾燥質量として計算された、約5%から約80%までのフルーツ由来の組成物を含む、請求項15に記載の方法。 - リコピンを含有するトマト成分と、マンゴー由来成分とを含み、
上記マンゴー由来成分は、乾燥物として計算されたトマト成分に対して、少なくとも5%にて存在する、経口摂取のための組成物。
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US11/559,205 US20070122509A1 (en) | 2004-12-02 | 2006-11-13 | Antioxidant dietary supplement compositions and methods for maintaining healthy skin |
PCT/US2007/083696 WO2008063857A2 (en) | 2006-11-13 | 2007-11-06 | Antioxidant dietary supplement compositions and methods for maintaining healthy skin |
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EP (1) | EP2079320A2 (ja) |
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KR (1) | KR20090081427A (ja) |
CN (1) | CN101616604A (ja) |
AU (1) | AU2007324036B2 (ja) |
CA (1) | CA2668471A1 (ja) |
IL (1) | IL198625A0 (ja) |
WO (1) | WO2008063857A2 (ja) |
Cited By (2)
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JP2013126965A (ja) * | 2011-11-14 | 2013-06-27 | Fujifilm Corp | 正常皮膚細胞用Nrf2活性化剤 |
JP2014507419A (ja) * | 2011-01-31 | 2014-03-27 | ルコラス−エム.ディー.リミテッド | 医薬的使用 |
Families Citing this family (4)
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US9579298B2 (en) | 2004-12-02 | 2017-02-28 | Piotr Chomczynski | Antioxidant dietary supplement compositions and methods for maintaining healthy skin |
US8795749B2 (en) | 2010-03-26 | 2014-08-05 | Conopco, Inc. | Process for preparing a heat processed blend from two or more fresh plant materials |
GB201121519D0 (en) * | 2011-12-14 | 2012-01-25 | Ip Science Ltd | Fat-based food products |
FR3039397B1 (fr) * | 2015-07-28 | 2018-08-17 | Laboratoires M&L | Utilisation cosmetique d'une puree vegetale |
Citations (1)
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WO2006060470A1 (en) * | 2004-12-02 | 2006-06-08 | Piotr Chomczynski | Antioxidant dietary supplement compositions and methods for maintaining healthy skin |
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RU2039473C1 (ru) * | 1993-03-22 | 1995-07-20 | Акционерное общество "Кон Сов-Холдинг" | Способ производства томатного соуса "экзотика" |
US5962517A (en) * | 1997-01-31 | 1999-10-05 | Murad; Howard | Pharmaceutical compositions and methods for treating acne |
US6048846A (en) * | 1998-02-26 | 2000-04-11 | Cochran; Timothy M. | Compositions used in human treatment |
AT407821B (de) * | 1998-03-24 | 2001-06-25 | Franz Dr Stueckler | Mittel auf der basis von naturstoffen |
AUPP291598A0 (en) * | 1998-04-14 | 1998-05-07 | Allrad 3 Pty Ltd | Food supplement |
CN1209966A (zh) * | 1998-09-16 | 1999-03-10 | 赖伟民 | 番茄汁饮料及制备方法 |
US6235721B1 (en) * | 1999-02-17 | 2001-05-22 | Natreon Inc. | Stabilization of vitamin C |
IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
EP1051918A1 (en) * | 1999-05-12 | 2000-11-15 | Société des Produits Nestlé S.A. | Method for extracting carotenoids and other anti-oxidants; extracts obtained by this method; food and pet food containing these extracts |
US6103756A (en) * | 1999-08-11 | 2000-08-15 | Vitacost Inc. | Ocular orally ingested composition for prevention and treatment of individuals |
GB9919487D0 (en) * | 1999-08-17 | 1999-10-20 | Nestle Sa | Moulded onfectionery product comprising vegetables |
FR2799370B1 (fr) * | 1999-10-07 | 2005-08-19 | Oreal | Utilisation du lycopene dans des compositions destinees a traiter les signes cutanes du vieillissement |
US20010047032A1 (en) * | 1999-12-30 | 2001-11-29 | Castillo Gerardo M. | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases |
US6630158B2 (en) * | 2000-10-31 | 2003-10-07 | Stiefel Laboratories, Inc. | Dietary supplement composition and method for improving and maintaining healthy skin |
JP2002338485A (ja) * | 2001-05-22 | 2002-11-27 | Hideko Iizuka | 病気の治療の為のジュースの作り方 |
US20030008048A1 (en) * | 2001-06-08 | 2003-01-09 | David Winston | Methods and compositions for helping the body resist the effects of the aging process |
DE10129504A1 (de) * | 2001-06-19 | 2003-01-09 | Beiersdorf Ag | Verwendung von Carnitin und/oder einem oder mehreren Acyl-Carnitinen zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Behandlung und/oder Prophylaxe von Pigmentierungsstörungen |
AU2002950308A0 (en) * | 2002-07-23 | 2002-09-12 | Phoenix Eagle Company Pty Ltd | Topically applied composition |
US20040161435A1 (en) * | 2003-02-14 | 2004-08-19 | Gupta Shyam K. | Skin Firming Anti-Aging Cosmetic Mask Compositions |
US20090297683A1 (en) * | 2004-10-26 | 2009-12-03 | Lycored Natural Products Industries Ltd. | A method for fortifying food stuff with phytonutrients and food products obtained thereby |
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2006
- 2006-11-13 US US11/559,205 patent/US20070122509A1/en not_active Abandoned
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2007
- 2007-11-06 CA CA002668471A patent/CA2668471A1/en not_active Abandoned
- 2007-11-06 JP JP2009536430A patent/JP2010509352A/ja active Pending
- 2007-11-06 AU AU2007324036A patent/AU2007324036B2/en active Active
- 2007-11-06 EP EP07863927A patent/EP2079320A2/en not_active Withdrawn
- 2007-11-06 KR KR1020097012074A patent/KR20090081427A/ko not_active Application Discontinuation
- 2007-11-06 WO PCT/US2007/083696 patent/WO2008063857A2/en active Application Filing
- 2007-11-06 CN CN200780044580A patent/CN101616604A/zh active Pending
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Patent Citations (2)
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WO2006060470A1 (en) * | 2004-12-02 | 2006-06-08 | Piotr Chomczynski | Antioxidant dietary supplement compositions and methods for maintaining healthy skin |
JP2008521912A (ja) * | 2004-12-02 | 2008-06-26 | チョムゼンスキー,ピオトル | 健康な皮膚を維持するための抗酸化栄養補助食品組成物及び方法 |
Cited By (2)
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JP2014507419A (ja) * | 2011-01-31 | 2014-03-27 | ルコラス−エム.ディー.リミテッド | 医薬的使用 |
JP2013126965A (ja) * | 2011-11-14 | 2013-06-27 | Fujifilm Corp | 正常皮膚細胞用Nrf2活性化剤 |
Also Published As
Publication number | Publication date |
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WO2008063857A3 (en) | 2008-08-28 |
IL198625A0 (en) | 2010-02-17 |
CN101616604A (zh) | 2009-12-30 |
US20070122509A1 (en) | 2007-05-31 |
WO2008063857A2 (en) | 2008-05-29 |
KR20090081427A (ko) | 2009-07-28 |
AU2007324036A1 (en) | 2008-05-29 |
EP2079320A2 (en) | 2009-07-22 |
CA2668471A1 (en) | 2008-05-29 |
AU2007324036B2 (en) | 2013-11-07 |
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