JP2010509226A5 - - Google Patents
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- Publication number
- JP2010509226A5 JP2010509226A5 JP2009535362A JP2009535362A JP2010509226A5 JP 2010509226 A5 JP2010509226 A5 JP 2010509226A5 JP 2009535362 A JP2009535362 A JP 2009535362A JP 2009535362 A JP2009535362 A JP 2009535362A JP 2010509226 A5 JP2010509226 A5 JP 2010509226A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- virus
- concentration
- present
- serum albumin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 164
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 33
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 33
- 241000700605 Viruses Species 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 29
- 241000710831 Flavivirus Species 0.000 claims description 24
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 15
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 15
- 229930195725 Mannitol Natural products 0.000 claims description 15
- WDRWZVWLVBXVOI-QTNFYWBSSA-L dipotassium;(2s)-2-aminopentanedioate Chemical compound [K+].[K+].[O-]C(=O)[C@@H](N)CCC([O-])=O WDRWZVWLVBXVOI-QTNFYWBSSA-L 0.000 claims description 15
- 238000001035 drying Methods 0.000 claims description 15
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 15
- 239000008101 lactose Substances 0.000 claims description 15
- 239000000594 mannitol Substances 0.000 claims description 15
- 235000010355 mannitol Nutrition 0.000 claims description 15
- 235000013919 monopotassium glutamate Nutrition 0.000 claims description 15
- 238000007710 freezing Methods 0.000 claims description 12
- 230000008014 freezing Effects 0.000 claims description 12
- 230000002238 attenuated effect Effects 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 206010011985 Decubitus ulcer Diseases 0.000 claims description 8
- 208000001490 Dengue Diseases 0.000 claims description 8
- 206010012310 Dengue fever Diseases 0.000 claims description 8
- 208000004210 Pressure Ulcer Diseases 0.000 claims description 8
- 241000700618 Vaccinia virus Species 0.000 claims description 8
- 241000710772 Yellow fever virus Species 0.000 claims description 8
- 239000004067 bulking agent Substances 0.000 claims description 8
- 208000025729 dengue disease Diseases 0.000 claims description 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 8
- 229940127557 pharmaceutical product Drugs 0.000 claims description 8
- 229940051021 yellow-fever virus Drugs 0.000 claims description 8
- 229960005486 vaccine Drugs 0.000 claims description 7
- 206010054261 Flavivirus infection Diseases 0.000 claims description 6
- 241000710842 Japanese encephalitis virus Species 0.000 claims description 6
- 241000710886 West Nile virus Species 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 206010022000 influenza Diseases 0.000 claims description 6
- 206010014599 encephalitis Diseases 0.000 claims description 5
- 208000037384 Clostridium Infections Diseases 0.000 claims description 4
- 206010009657 Clostridium difficile colitis Diseases 0.000 claims description 4
- 206010054236 Clostridium difficile infection Diseases 0.000 claims description 4
- 241000700721 Hepatitis B virus Species 0.000 claims description 4
- 108010015780 Viral Core Proteins Proteins 0.000 claims description 4
- 229910052783 alkali metal Inorganic materials 0.000 claims description 4
- -1 alkali metal glutamate Chemical class 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 229930195712 glutamate Natural products 0.000 claims description 4
- 230000012743 protein tagging Effects 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- 235000000346 sugar Nutrition 0.000 claims description 4
- 150000005846 sugar alcohols Chemical class 0.000 claims description 4
- 150000008163 sugars Chemical class 0.000 claims description 4
- 101710091045 Envelope protein Proteins 0.000 claims description 3
- 102100034349 Integrase Human genes 0.000 claims description 3
- 108010052285 Membrane Proteins Proteins 0.000 claims description 3
- 101710188315 Protein X Proteins 0.000 claims description 3
- 101710172711 Structural protein Proteins 0.000 claims description 3
- 229940124965 ACAM2000 Drugs 0.000 claims description 2
- 241000707296 Alkhumra hemorrhagic fever virus Species 0.000 claims description 2
- 240000006108 Allium ampeloprasum Species 0.000 claims description 2
- 235000005254 Allium ampeloprasum Nutrition 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 241000907515 Apoi virus Species 0.000 claims description 2
- 208000037404 Central European encephalitis Diseases 0.000 claims description 2
- 241000193163 Clostridioides difficile Species 0.000 claims description 2
- 241000725619 Dengue virus Species 0.000 claims description 2
- 241000609530 Ilheus virus Species 0.000 claims description 2
- 241000710912 Kunjin virus Species 0.000 claims description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 2
- 241000710908 Murray Valley encephalitis virus Species 0.000 claims description 2
- 241000725177 Omsk hemorrhagic fever virus Species 0.000 claims description 2
- 241000538730 Rocio Species 0.000 claims description 2
- 241000710888 St. Louis encephalitis virus Species 0.000 claims description 2
- 208000004006 Tick-borne encephalitis Diseases 0.000 claims description 2
- 206010046865 Vaccinia virus infection Diseases 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 230000009191 jumping Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 208000007089 vaccinia Diseases 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims 2
- 241000907329 Russian Spring-Summer encephalitis virus Species 0.000 claims 1
- 108090000565 Capsid Proteins Proteins 0.000 description 1
- 102100023321 Ceruloplasmin Human genes 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85742406P | 2006-11-07 | 2006-11-07 | |
| US60/857,424 | 2006-11-07 | ||
| PCT/US2007/023421 WO2008057550A2 (en) | 2006-11-07 | 2007-11-07 | Stabilization of vaccines by lyophilization |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010509226A JP2010509226A (ja) | 2010-03-25 |
| JP2010509226A5 true JP2010509226A5 (https=) | 2011-03-31 |
| JP5687836B2 JP5687836B2 (ja) | 2015-03-25 |
Family
ID=39365126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535362A Active JP5687836B2 (ja) | 2006-11-07 | 2007-11-07 | 凍結乾燥によるワクチンの安定化 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9132184B2 (https=) |
| EP (3) | EP2086581B1 (https=) |
| JP (1) | JP5687836B2 (https=) |
| CN (2) | CN106890144A (https=) |
| AR (1) | AR063606A1 (https=) |
| AU (1) | AU2007317847B2 (https=) |
| BR (1) | BRPI0718548A2 (https=) |
| CA (1) | CA2668834C (https=) |
| CL (1) | CL2007003209A1 (https=) |
| IL (1) | IL198563A0 (https=) |
| MX (1) | MX2009004862A (https=) |
| RU (1) | RU2541784C2 (https=) |
| TW (1) | TWI417113B (https=) |
| WO (1) | WO2008057550A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009004862A (es) | 2006-11-07 | 2009-07-17 | Sanofi Pasteur Biologics Co | Estabilizacion de vacunas por liofilizacion. |
| PL2198007T3 (pl) | 2007-09-14 | 2018-03-30 | Sanofi Pasteur Biologics, Llc | Kompozycje farmaceutyczne zawierające toksoidy A i B Clostridium difficile |
| CN101959527B (zh) | 2008-03-05 | 2016-04-20 | 赛诺菲巴斯德有限公司 | 一种使含佐剂的疫苗组合物稳定的方法 |
| EP2143440A1 (fr) | 2008-07-09 | 2010-01-13 | Sanofi Pasteur | Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués |
| US7998488B2 (en) * | 2008-11-14 | 2011-08-16 | Baxter International Inc. | Vaccine formulations and uses thereof |
| WO2010116336A1 (en) * | 2009-04-08 | 2010-10-14 | Eu Yan Sang International Limited | Uses of red yeast rice in treating dengue virus infection |
| CN102260351A (zh) * | 2010-05-25 | 2011-11-30 | 吉林圣元科技有限责任公司 | 流感病毒M2e蛋白的制备及其在抗甲型流感病毒中的应用 |
| EP2646051A4 (en) * | 2010-12-02 | 2014-05-28 | Oncolytics Biotech Inc | FORMULATIONS OF LIQUID VIRUSES |
| MX349294B (es) * | 2010-12-02 | 2017-07-21 | Oncolytics Biotech Inc | Formulaciones virales liofilizadas. |
| EP2654784B1 (en) * | 2010-12-22 | 2016-12-07 | Wyeth LLC | Stable immunogenic compositions of staphylococcus aureus antigens |
| MX350096B (es) * | 2011-08-12 | 2017-08-25 | Merial Inc | Preservación asistida con vacío de productos biológicos, en particular de vacunas. |
| EP3246400B1 (en) * | 2012-01-09 | 2019-10-23 | Sanofi Pasteur Biologics, LLC | Purification of herpes virus |
| EP2852662B1 (en) * | 2012-05-21 | 2020-09-16 | Sanofi Pasteur Limited | Herpesvirus compositions and related methods |
| AP2015008733A0 (en) | 2013-03-14 | 2015-09-30 | Takeda Vaccines Inc | Compositions and methods for live, attenuated alphavirus formulations |
| WO2017056101A1 (en) | 2015-09-30 | 2017-04-06 | Panacea Biotec Limited | Stable live attenuated recombinant dengue vaccine |
| TW202309276A (zh) | 2016-08-03 | 2023-03-01 | 美商武田疫苗股份有限公司 | 用於與經改良之調配物一起穩定黃病毒的組成物及方法 |
| RU2637634C1 (ru) * | 2016-10-21 | 2017-12-05 | Владимир Иосифович Лозинский | Антибактериальная белковая губка для химиотерапии инфицированных ран и способ ее получения |
| CN116421734A (zh) * | 2021-12-30 | 2023-07-14 | 深圳复诺健生物科技有限公司 | 适用于溶瘤病毒的冻干保护剂及其应用 |
| WO2024195868A1 (ja) * | 2023-03-23 | 2024-09-26 | デンカ株式会社 | ノロウイルスワクチン組成物 |
| WO2025027616A1 (en) * | 2023-08-01 | 2025-02-06 | Serum Institute Of India Private Limited | Freeze-dried viral vaccine compositions and method of manufacturing thereof |
| CN120173893B (zh) * | 2025-05-21 | 2025-08-12 | 宁波三生生物科技股份有限公司 | 一种锦鲤疱疹病毒的低温冻存保护液及其制备方法和应用 |
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| US4337242A (en) * | 1980-02-05 | 1982-06-29 | Merck & Co., Inc. | Vaccine stabilizer containing L-glutamic acid and L-arginine |
| FR2505657A1 (fr) * | 1981-05-13 | 1982-11-19 | Pasteur Institut | Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation |
| JPS6013718A (ja) | 1983-07-05 | 1985-01-24 | Chemo Sero Therapeut Res Inst | Ｂ型肝炎ワクチン |
| US5173418A (en) | 1985-05-10 | 1992-12-22 | Benzon Pharma, A/S | Production in Escherichia coli of extracellular Serratia spp. hydrolases |
| IE61575B1 (en) | 1987-05-04 | 1994-11-16 | Merck & Co Inc | A stable lyophilized live herpes virus vaccine |
| FR2633518B1 (fr) | 1988-06-30 | 1991-03-22 | Merieux Inst | Procede de stabilisation des vaccins et associations de vaccins a virus attenues conserves sous forme lyophilisee, et compositions obtenues |
| US6676936B1 (en) | 1988-07-14 | 2004-01-13 | The United States Of America As Represented By The Department Of Health And Human Services. | Chimeric and/or growth-restricted flaviviruses |
| US6184024B1 (en) | 1988-07-14 | 2001-02-06 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric and/or growth-restricted flaviviruses |
| EP0728195A1 (en) | 1993-10-12 | 1996-08-28 | Chiron Corporation | Methods for preserving recombinant viruses |
| FR2719479B1 (fr) * | 1994-05-04 | 1996-07-26 | Sanofi Elf | Formulation stable lyophilisée comprenant une protéine: kit de dosage. |
| FR2740686B1 (fr) * | 1995-11-03 | 1998-01-16 | Sanofi Sa | Formulation pharmaceutique lyophilisee stable |
| US6290967B1 (en) * | 1996-12-20 | 2001-09-18 | Merck & Co., Inc. | Stabilizers for lyophilized vaccines |
| US6051238A (en) * | 1996-12-20 | 2000-04-18 | Merck & Co., Inc. | Stabilizers for lyophilized mumps vaccines |
| EP0977587B1 (en) * | 1997-02-28 | 2005-06-15 | Acambis Inc. | Chimeric flavivirus vaccines |
| US6962708B1 (en) * | 1997-02-28 | 2005-11-08 | Acambis, Inc. | Chimeric flavivirus vaccines |
| US20050096288A1 (en) * | 1997-06-13 | 2005-05-05 | Aragene, Inc. | Lipoproteins as nucleic acid vectors |
| US6210683B1 (en) * | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
| AU9794198A (en) * | 1997-10-08 | 1999-04-27 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Chimeric vaccine against tick-borne encephalitis virus |
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| DK1820516T3 (da) * | 1999-02-22 | 2013-10-28 | Univ Connecticut | Nye albuminfrie faktor VIII-præparater |
| AU1813901A (en) | 1999-12-01 | 2001-06-12 | Oravax, Inc | Chimeric flavivirus vaccines |
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| US9045727B2 (en) * | 2002-05-17 | 2015-06-02 | Emory University | Virus-like particles, methods of preparation, and immunogenic compositions |
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| WO2005066333A1 (en) | 2003-12-30 | 2005-07-21 | Aventis Pasteur, Inc. | Stabilizing compositions for recombinant viruses |
| BRPI0509117A (pt) | 2004-03-04 | 2007-08-28 | Wyeth Corp | método de liofilização para melhorar a cristalização de excipientes |
| US7749520B2 (en) * | 2004-07-07 | 2010-07-06 | Statens Serum Institut | Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids |
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| US20060167022A1 (en) * | 2004-09-08 | 2006-07-27 | Woodward John R | Method of female sexual enhancement |
| SG156666A1 (en) | 2004-10-20 | 2009-11-26 | Acambis Inc | Vaccines against japanese encephalitis virus and west nile virus |
| US20060121055A1 (en) * | 2004-12-06 | 2006-06-08 | Becton, Dickinson And Company, Inc. | Compositions with enhanced immunogenicity |
| CN101090966B (zh) | 2004-12-24 | 2012-07-04 | 财团法人阪大微生物病研究会 | 具有减毒日本脑炎病毒基因作为主链的减毒嵌合黄病毒 |
| CA2605924A1 (en) | 2005-04-24 | 2006-11-02 | Acambis Inc. | Recombinant flavivirus vaccines |
| MX2009004862A (es) | 2006-11-07 | 2009-07-17 | Sanofi Pasteur Biologics Co | Estabilizacion de vacunas por liofilizacion. |
-
2007
- 2007-11-07 MX MX2009004862A patent/MX2009004862A/es not_active Application Discontinuation
- 2007-11-07 US US12/513,935 patent/US9132184B2/en active Active
- 2007-11-07 AU AU2007317847A patent/AU2007317847B2/en active Active
- 2007-11-07 TW TW96141996A patent/TWI417113B/zh active
- 2007-11-07 CA CA2668834A patent/CA2668834C/en active Active
- 2007-11-07 CN CN201710026145.2A patent/CN106890144A/zh active Pending
- 2007-11-07 EP EP20070861777 patent/EP2086581B1/en active Active
- 2007-11-07 EP EP14180710.7A patent/EP2851087B2/en active Active
- 2007-11-07 CL CL2007003209A patent/CL2007003209A1/es unknown
- 2007-11-07 EP EP20120177150 patent/EP2535058A3/en not_active Withdrawn
- 2007-11-07 WO PCT/US2007/023421 patent/WO2008057550A2/en not_active Ceased
- 2007-11-07 AR ARP070104963 patent/AR063606A1/es not_active Application Discontinuation
- 2007-11-07 BR BRPI0718548 patent/BRPI0718548A2/pt not_active IP Right Cessation
- 2007-11-07 JP JP2009535362A patent/JP5687836B2/ja active Active
- 2007-11-07 CN CN200780049359A patent/CN101808657A/zh active Pending
- 2007-11-07 RU RU2009121566/10A patent/RU2541784C2/ru not_active Application Discontinuation
-
2009
- 2009-05-05 IL IL198563A patent/IL198563A0/en unknown
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